Creams for preventing stretch marks in pregnancy

  • Review
  • Intervention




Striae gravidarum (stretch marks developing during pregnancy) occur in over 50% of women. There is no evidence that any treatment removes striae once they have appeared. Some women are upset about the change in the appearance of their skin.


To assess the effects of topical treatments in preventing the development of stretch marks.

Search methods

We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (April 2004). We updated this search on 1 October 2009 and added the results to the awaiting classification section.

Selection criteria

Randomised trials comparing active creams with either no treatment or placebo for the treatment of stretch marks in pregnant women.

Data collection and analysis

Two review authors assessed trial quality and extracted data independently.

Main results

Two studies, involving 130 women in total, were included.

One study, involving 80 women, indicated that, compared to placebo, massage with a cream (Trofolastin) containing Centella asiatica extract, alpha tocopherol and collagen-elastin hydrolysates was associated with less women developing stretch marks (odds ratio (OR) 0.41, 95% confidence interval (CI) 0.17 to 0.99). A second study of 50 women compared massage using an ointment (Verum) containing tocopherol, panthenol, hyaluronic acid, elastin and menthol with no treatment. Massage with the ointment was associated with less women developing stretch marks (OR 0.26, 95% CI 0.08 to 0.84)

Authors' conclusions

Trofolastin cream appears to help prevent the development of stretch marks in pregnancy in some women. Verum ointment may be helpful but the trial had no placebo and may show the benefit of massage alone.

[Note: The three citations in the awaiting classification section of the review may alter the conclusions of the review once assessed.]








我們搜尋了Cochrane Pregnancy and Childbirth Group trials註冊資料庫(2004年4月)






我們收納了總共130位女性的兩篇文獻。其中一篇包含80位女性的研究指出使用centella asiatica萃取物、alpha tocopherol與collagenelastin hydrolysates的除紋霜(Trofolastin)來按摩和較少的妊娠紋發生有相關(O .41,95% confidence interval (CI) 0.17 to 0.99)。第二篇研究包含50位女性,比較併用含tocopherol、panthenol、hyaluronic acid、elastin與menthol的軟膏按摩和不治療的差別。併用軟膏的按摩和較少的妊娠紋發生有相關(OR 0.26, 98% CI 0.08 to 0.84)




本摘要由周產期醫學會(Taiwan Society of Perinatology)張致遠翻譯

此翻譯計畫由臺灣國家衛生研究院(National Health Research Institutes, Taiwan)統籌



Plain language summary

Creams for preventing stretch marks in pregnancy

Stretch marks may be prevented in some women by daily massage but it is unclear if any particular ingredients bring special benefit.

Stretch marks are common by the end of pregnancy, occurring in most women. Though they later shrink and fade somewhat, they do not go away. Therefore, any treatment which prevented them would be welcomed by many women. The two papers reviewed may show that any cream massaged onto the abdomen, thighs and breasts (areas most affected by stretch marks) may help a little. There may be additional benefit from certain ingredients in the cream and the ointment described but it is unknown which constituent(s) is beneficial. Neither preparation is widely available.