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Intervention Review

Lobeline for smoking cessation

  1. Lindsay F Stead1,*,
  2. John R Hughes2

Editorial Group: Cochrane Tobacco Addiction Group

Published Online: 21 JUL 1997

Assessed as up-to-date: 7 JAN 2009

DOI: 10.1002/14651858.CD000124

How to Cite

Stead LF, Hughes JR. Lobeline for smoking cessation. Cochrane Database of Systematic Reviews 1997, Issue 3. Art. No.: CD000124. DOI: 10.1002/14651858.CD000124.

Author Information

  1. 1

    University of Oxford, Department of Primary Health Care, Oxford, UK

  2. 2

    University of Vermont, Human Behavioral Pharmacology Lab, Dept of Psychiatry, Burlington, Vermont, USA

*Lindsay F Stead, Department of Primary Health Care, University of Oxford, Rosemary Rue Building, Old Road Campus, Oxford, OX3 7LF, UK.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 21 JUL 1997


This is not the most recent version of the article. View current version (15 FEB 2012)



  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要


Lobeline is a partial nicotine agonist, which has been used in a variety of commercially available preparations to help stop smoking.


The objective of this review was to assess the effects of lobeline on long term smoking cessation.

Search methods

We searched the Cochrane Tobacco Addiction Group trials register (most recent search January 2009).

Selection criteria

Randomized trials comparing lobeline to placebo or an alternative therapeutic control, which reported smoking cessation with at least six months follow-up.

Data collection and analysis

We extracted data in duplicate on the type of subjects, the dose and form of lobeline, the outcome measures, method of randomisation, and completeness of follow-up.

Main results

We identified no trials meeting the full inclusion criteria including long term follow-up.

Authors' conclusions

There is no evidence available from long term trials that lobeline can aid smoking cessation.


Plain language summary

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

Can lobeline help people to quit smoking

Lobeline is an alkaloid derived from the leaves of an Indian tobacco plant, and has been widely used in commercial smoking remedies. Its adverse effects include dizziness, nausea, and vomiting, and tablets and pastilles containing Lobeline may lead to throat irritation. The review found no adequate long-term trials which could provide evidence that Lobeline can help people stop smoking. Even short-term studies do not indicate a consistent effect on smoking behaviour.



  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要



Lobeline是一種尼古丁感受器的局部促動劑(partial agonist),在產業上已被廣泛地以多種配製形式,使用於戒菸。




我們搜尋了低Cochrane Tobacco Addiction Group trials register(其中最新的相關研究是發表於2006年4月)。











此翻譯計畫由臺灣國家衛生研究院(National Health Research Institutes, Taiwan)統籌。