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Intervention Review

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Nicotine replacement therapy for smoking cessation

  1. Lindsay F Stead1,*,
  2. Rafael Perera1,
  3. Chris Bullen2,
  4. David Mant1,
  5. Tim Lancaster1

Editorial Group: Cochrane Tobacco Addiction Group

Published Online: 23 JAN 2008

Assessed as up-to-date: 31 OCT 2007

DOI: 10.1002/14651858.CD000146.pub3

How to Cite

Stead LF, Perera R, Bullen C, Mant D, Lancaster T. Nicotine replacement therapy for smoking cessation. Cochrane Database of Systematic Reviews 2008, Issue 1. Art. No.: CD000146. DOI: 10.1002/14651858.CD000146.pub3.

Author Information

  1. 1

    University of Oxford, Department of Primary Health Care, Oxford, UK

  2. 2

    University of Auckland, Clinical Trials Research Unit, Auckland, New Zealand

*Lindsay F Stead, Department of Primary Health Care, University of Oxford, Rosemary Rue Building, Old Road Campus, Oxford, OX3 7LF, UK. lindsay.stead@dphpc.ox.ac.uk.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 23 JAN 2008

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This is not the most recent version of the article. View current version (14 NOV 2012)

[Analysis 1.1]
Analysis 1.1. Comparison 1 Any type of NRT versus placebo/ no NRT control, Outcome 1 Smoking cessation at 6+ months follow up.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Subgroup: Definition of abstinence, Outcome 1 Nicotine gum. Smoking cessation.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Subgroup: Definition of abstinence, Outcome 2 Nicotine patch: Smoking cessation.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Subgroup: Level of behavioural support, Outcome 1 Nicotine gum. Smoking cessation.
[Analysis 3.2]
Analysis 3.2. Comparison 3 Subgroup: Level of behavioural support, Outcome 2 Nicotine patch. Smoking cessation.
[Analysis 3.3]
Analysis 3.3. Comparison 3 Subgroup: Level of behavioural support, Outcome 3 Long versus short support.
[Analysis 4.1]
Analysis 4.1. Comparison 4 Subgroup: Recruitment /treatment setting, Outcome 1 Nicotine gum. Smoking cessation.
[Analysis 4.2]
Analysis 4.2. Comparison 4 Subgroup: Recruitment /treatment setting, Outcome 2 Nicotine patch. Smoking cessation.
[Analysis 4.3]
Analysis 4.3. Comparison 4 Subgroup: Recruitment /treatment setting, Outcome 3 Nicotine Inhaler/inhalator. Smoking cessation.
[Analysis 4.4]
Analysis 4.4. Comparison 4 Subgroup: Recruitment /treatment setting, Outcome 4 Nicotine tablet/lozenge. Smoking cessation.
[Analysis 4.5]
Analysis 4.5. Comparison 4 Subgroup: Recruitment /treatment setting, Outcome 5 Nicotine Intranasal spray. Smoking cessation.
[Analysis 4.6]
Analysis 4.6. Comparison 4 Subgroup: Recruitment /treatment setting, Outcome 6 Combination of NRT. Smoking cessation.
[Analysis 4.7]
Analysis 4.7. Comparison 4 Subgroup: Recruitment /treatment setting, Outcome 7 Choice of NRT. Smoking cessation.
[Analysis 5.1]
Analysis 5.1. Comparison 5 Nicotine gum: 4mg versus 2mg dose, Outcome 1 Smoking Cessation.
[Analysis 6.1]
Analysis 6.1. Comparison 6 Nicotine gum: Fixed versus ad lib dose schedule, Outcome 1 Smoking cessation.
[Analysis 7.1]
Analysis 7.1. Comparison 7 Nicotine patch: High versus standard dose patches, Outcome 1 Smoking cessation at maximum follow up.
[Analysis 8.1]
Analysis 8.1. Comparison 8 Nicotine patch: 16hr or 24hr use, subgroups & direct comparison, Outcome 1 Smoking Cessation.
[Analysis 9.1]
Analysis 9.1. Comparison 9 Nicotine patch: Duration of therapy, subgroups & direct comparison, Outcome 1 Smoking Cessation.
[Analysis 10.1]
Analysis 10.1. Comparison 10 Nicotine patch: Effect of weaning/tapering dose at end of treatment, Outcome 1 Smoking Cessation.
[Analysis 11.1]
Analysis 11.1. Comparison 11 Combinations of different types of NRT, Outcome 1 Long-term smoking cessation.
[Analysis 12.1]
Analysis 12.1. Comparison 12 Purchased NRT without support versus physician support, Outcome 1 Smoking cessation using physician prescribed NRT versus NRT without support (all NRT purchased).
[Analysis 13.1]
Analysis 13.1. Comparison 13 Direct comparisons between NRT types, Outcome 1 Smoking cessation.
[Analysis 14.1]
Analysis 14.1. Comparison 14 Precessation treatment with nicotine patch, Outcome 1 Smoking cessation.
[Analysis 15.1]
Analysis 15.1. Comparison 15 Nicotine patch and bupropion; direct comparisons and combinations, Outcome 1 Smoking cessation at longest follow up.