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Corticosteroids for acute traumatic brain injury

  1. Phil Alderson1,*,
  2. Ian Roberts2

Editorial Group: Cochrane Injuries Group

Published Online: 8 JUL 2009

Assessed as up-to-date: 6 JAN 2008

DOI: 10.1002/14651858.CD000196.pub2

Database Title

Additional Information

How to Cite

Alderson P, Roberts I. Corticosteroids for acute traumatic brain injury. Cochrane Database of Systematic Reviews 2005, Issue 1. Art. No.: CD000196. DOI: 10.1002/14651858.CD000196.pub2.

Author Information

  1. 1

    National Institute for Health and Clinical Excellence, Manchester, UK

  2. 2

    London School of Hygiene & Tropical Medicine, Cochrane Injuries Group, London, UK

*Phil Alderson, National Institute for Health and Clinical Excellence, Level 1A, City Tower,, Piccadilly Plaza, Manchester, M1 4BD, UK. Philip.Alderson@nice.org.uk.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 8 JUL 2009

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Alexander 1972 {published data only}
  • Alexander E. Medical management of closed head injuries. Clinical Neurosurgery 1972;19:210-50.
Braakman 1983 {published data only}
Braun 1986 {published data only}
Chacon 1987 {published data only}
  • Chacon L. Edema cerebral en traumatismo craneoencefalico severo en ninos tatados con y sin dexametasona. Medicina Critica Venezolana 1987;2:75-9.
Cooper 1979 {published data only}
CRASH 2005 {published data only}
  • CRASH Trial Collaborators. Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial. Lancet 2004;364:1321-8.
  • CRASH Trial Collaborators. Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury - outcomes at 6 months. Lancet 2005;365:1957-9.
Dearden 1986 {published data only}
Faupel 1976 {published data only}
  • Faupel G. The influence of dexamethasone on the midbrain syndrome after severe head injury. In: Hartmann A, Brock M editor(s). Treatment of cerebral edema. Berlin: Springer-Verlag, 1982:107-14.
  • Faupel G, Reulen HJ, Muller D, Schurmann. Clinical double blind study on the effects of dexamethasone on severe closed head injuries. Acta neurochirurgica 1977;36:277-8.
  • Faupel G, Reulen HJ, Muller D, Schurmann K. Double-blind study on the effects of steroids on severe closed head injury. In: Pappius MM, Feindel W editor(s). Dynamics of Brain Edema. Berlin: Springer-Verlag, 1976:337-43.
Gaab 1994 {published data only}
  • Gaab MR, Trost HA, Alcantara A, Karimi-Nejad A, Moskopp D, Schultheiss R, et al. "Ultrahigh" dexamethasone in acute brain injury. Zentralblatt fur Neurochirurgie 1994;55:135-43.
Giannotta 1984 {published data only}
Grumme 1995 {published data only}
  • Grumme T, Baethmann A, Kolodziejczyk D, Krimmer J, Fischer M, Eisenhart Rothe BV, et al. Treatment of patients with severe head injury by triamcinolone: a prospective, controlled multicenter trial of 396 cases. Research in Experimental Medicine 1995;195:217-29.
Hernesniemi 1979 {unpublished data only}
  • Hernesniemi J, Troupp H. A clinical retrospective and a double blind study of betamethasone in severe closed brain injuries. Acta Neurochrurgica 1979;28(2):499.
Hoyt 1972 {published data only}
  • Hoyt HJ, Goldstein FP, Reigel DH, Holst R. Clinical evaluation of highly water-soluble steroids in the treatment of cerebral edema of traumatic origin (a double blind study). Pharmacology and Therapeutics 1972;13:141.
Pitts 1980 {unpublished data only}
  • Pitts LH, Kaktis JV. Effect of megadose steroids on ICP in traumatic coma. In: Shulman K, Marmarou A, Miller JD editor(s). Intracranial Pressure. Vol. IV, Berlin: Springer-Verlag, 1980:638-42.
Ransohoff 1972 {published data only}
  • Ransohoff J. The effects of steroids on brain edema in man. In: Reulen H J, Schurmann K editor(s). Steroids and Brain Edema. Berlin/Heidelberg/New York: Springer-Verlag, 1972:211-3.
Saul 1981 {published data only}
Stubbs 1989 {published data only}
  • Stubbs DF, Stiger TR, Harris WR. Multinational controlled trial of high-dose methylprednisolone in moderately severe head injury. In: Capildeo editor(s). Steroids in diseases of the central nervous system. Chichester: John Wiley & Sons, 1989:163-8.
Tahara 1972 {published data only}
  • Tahara I, Fujii C, Tanaka N, Ogawa M, Katsurada K. Effects of steroid therapy on acute head injury. Neurologia medico-chirurgica 1972;12:111-2.
Zagara 1987 {published data only}
  • Zagara G, Scaravilli P, Carmen Belluci M, Seveso M. Effect of dexamethasone on nitrogen metabolism in brain-injured patients. Journal of Neurosurgery 1987;31:207-12.
Zarate 1995 {published data only}
  • Zarate IO, Guerrero JG. Coprticosteroids in paediatric patients with head and brain trauma [Corticosteroides en pacientes pediatricos con traumatismo craneoencefalico]. Practica Pediatrica 1995;4:7-14.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Cheng 1991 {published data only}
  • Cheng Z. Effect of postoperative megadose dexamethasone on delayed traumatic brain edema. Chinese Journal of Traumatology 1991;8:65.
  • Cheng Z. Effect of postoperative megadose dexamethasone on delayed traumatic brain edema. Chinese Medical Journal 1992;105:788.
Fanconi 1988 {published data only}
Gobiet 1976 {published data only}
  • Gobiet W, Bock WJ, Liesegang J, et al. Treatment of acute cerebral edema with high dose of dexamethasone. In: Becks JWF, Bosch DA, Brock M editor(s). Intracranial Pressure. Vol. III, Berlin/Heidelberg/New York: Springer-Verlag, 1976:231-5.
James 1979 {published data only}
Robertson 1985 {published data only}

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Bracken 1990
  • Bracken MB, Shepard MJ, Collins WF, Holford TR, et al. A randomised controlled trial of methylprednisolone or naloxone in the treatment of acute spinal cord injury. New England Journal of Medicine 1990;322:1405-11.
Galicich 1961
  • Galicich J H, French L A. Use of dexamethasone in the treatment of cerebral edema resulting from brain tumours and brain surgery. American Practitioner and Digest of Treatment 1961;12:169-74.
Higgins 2008
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1 [updated September 2008]. The Cochrane Collaboration, 2008. Available from www.cochrane-handbook.org.
Jeevaratnam 1996
Jennett 1975
Jennett 1996
Kraus 1993
  • Kraus JF. Epidemiology of head injury. In: Cooper PR editor(s). Head injury. 3rd Edition. Baltimore: William Wilkins, 1993:1-25.
Miller 1992
  • Miller JD, Jones PA, Dearden NM, Tocher JL. Progress in the management of head injury. British Journal of Surgery 1992;79:60-4.
    Direct Link:
Murray 1994
  • Murray CJL, Lopez AD, eds. Global comparative assessments in the health sector. Geneva: World Health Organisation, 1994.
Pickard 1993
Roberts 1995

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Alderson 1997
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