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Antibiotic prophylaxis for surgery for proximal femoral and other closed long bone fractures

  1. William J Gillespie1,*,
  2. Geert HIM Walenkamp2

Editorial Group: Cochrane Bone, Joint and Muscle Trauma Group

Published Online: 17 MAR 2010

Assessed as up-to-date: 14 FEB 2010

DOI: 10.1002/14651858.CD000244.pub2


How to Cite

Gillespie WJ, Walenkamp GHIM. Antibiotic prophylaxis for surgery for proximal femoral and other closed long bone fractures. Cochrane Database of Systematic Reviews 2010, Issue 3. Art. No.: CD000244. DOI: 10.1002/14651858.CD000244.pub2.

Author Information

  1. 1

    University of Hull, Hull York Medical School, Hull, UK

  2. 2

    Maastricht University Medical Center, Research Institute Caphri, Department of Orthopaedics, Maastricht, Netherlands

*William J Gillespie, Hull York Medical School, University of Hull, Cottingham Road, Hull, HU6 7RX, UK. bill.gillespie@hyms.ac.uk. bill.gillespie@yahoo.co.nz.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 17 MAR 2010

SEARCH

[Figure 1]
Figure 1. Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies.
[Figure 2]
Figure 2. Methodological quality summary: review authors' judgements about each methodological quality item for each included study.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Antibiotic agent (multiple dose) versus placebo or no treatment, Outcome 1 Deep surgical site infection.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Antibiotic agent (multiple dose) versus placebo or no treatment, Outcome 2 Superficial surgical site infection.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Antibiotic agent (multiple dose) versus placebo or no treatment, Outcome 3 Urinary tract infection.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Antibiotic agent (multiple dose) versus placebo or no treatment, Outcome 4 Respiratory infection.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Antibiotic agent (single dose) versus placebo or no treatment, Outcome 1 Deep surgical site infection.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Antibiotic agent (single dose) versus placebo or no treatment, Outcome 2 Superficial surgical site infection.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Antibiotic agent (single dose) versus placebo or no treatment, Outcome 3 Urinary tract infection.
[Analysis 2.4]
Analysis 2.4. Comparison 2 Antibiotic agent (single dose) versus placebo or no treatment, Outcome 4 Respiratory infection.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Single dose short-acting versus multiple dose - same agent, Outcome 1 Deep surgical site infection.
[Analysis 3.2]
Analysis 3.2. Comparison 3 Single dose short-acting versus multiple dose - same agent, Outcome 2 Superficial surgical site infection.
[Analysis 3.3]
Analysis 3.3. Comparison 3 Single dose short-acting versus multiple dose - same agent, Outcome 3 Urinary tract infection.
[Analysis 4.1]
Analysis 4.1. Comparison 4 Single dose long acting versus any multiple dose regimen, Outcome 1 Deep wound infection.
[Analysis 4.2]
Analysis 4.2. Comparison 4 Single dose long acting versus any multiple dose regimen, Outcome 2 Superficial wound infection.
[Analysis 4.3]
Analysis 4.3. Comparison 4 Single dose long acting versus any multiple dose regimen, Outcome 3 Urinary tract infection.
[Analysis 4.4]
Analysis 4.4. Comparison 4 Single dose long acting versus any multiple dose regimen, Outcome 4 Respiratory infection.
[Analysis 5.1]
Analysis 5.1. Comparison 5 Operative day only versus longer prophylaxis, Outcome 1 Deep surgical site infection.
[Analysis 5.2]
Analysis 5.2. Comparison 5 Operative day only versus longer prophylaxis, Outcome 2 Superficial surgical site infection.
[Analysis 6.1]
Analysis 6.1. Comparison 6 Oral versus parenteral administration of antibiotic agent, Outcome 1 Deep surgical site infection.
[Analysis 6.2]
Analysis 6.2. Comparison 6 Oral versus parenteral administration of antibiotic agent, Outcome 2 Superficial surgical site infection.
[Analysis 6.3]
Analysis 6.3. Comparison 6 Oral versus parenteral administration of antibiotic agent, Outcome 3 Urinary tract infection.
[Analysis 7.1]
Analysis 7.1. Comparison 7 Antibiotic agent versus control or no treatment (infection-related death and adverse drug events), Outcome 1 Surgical site infection-associated death.
[Analysis 7.2]
Analysis 7.2. Comparison 7 Antibiotic agent versus control or no treatment (infection-related death and adverse drug events), Outcome 2 Gastro-intestinal symptoms.
[Analysis 7.3]
Analysis 7.3. Comparison 7 Antibiotic agent versus control or no treatment (infection-related death and adverse drug events), Outcome 3 Skin reactions.
[Analysis 7.4]
Analysis 7.4. Comparison 7 Antibiotic agent versus control or no treatment (infection-related death and adverse drug events), Outcome 4 Infusion site thrombophlebitis.