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Prophylactic antibiotics for inhibiting preterm labour with intact membranes

  1. Vicki Flenady1,*,
  2. Glenda Hawley2,
  3. Owen M Stock3,
  4. Sara Kenyon4,
  5. Nadia Badawi5

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 5 DEC 2013

Assessed as up-to-date: 3 OCT 2013

DOI: 10.1002/14651858.CD000246.pub2


How to Cite

Flenady V, Hawley G, Stock OM, Kenyon S, Badawi N. Prophylactic antibiotics for inhibiting preterm labour with intact membranes. Cochrane Database of Systematic Reviews 2013, Issue 12. Art. No.: CD000246. DOI: 10.1002/14651858.CD000246.pub2.

Author Information

  1. 1

    Mater Health Services, Translating Research Into Practice (TRIP) Centre - Mater Research, Woolloongabba, Queensland, Australia

  2. 2

    Mater Health Services, Mater Medical Research Institute, Wooloongabba, Queensland, Australia

  3. 3

    Mater Mothers' Hospital, Mater Health Services, Department of Obstetrics and Gynaecology, Brisbane, Queensland, Australia

  4. 4

    University of Birmingham, School of Health and Population Sciences, Edgbaston, UK

  5. 5

    The Children's Hospital at Westmead, Grace Centre for Newborn Care, Sydney, NSW, Australia

*Vicki Flenady, Translating Research Into Practice (TRIP) Centre - Mater Research, Mater Health Services, Level 2 Quarters Building, Annerley Road, Woolloongabba, Queensland, 4102, Australia. vflenady@mmri.mater.org.au.

Publication History

  1. Publication Status: New search for studies and content updated (conclusions changed)
  2. Published Online: 5 DEC 2013

SEARCH

[Figure 1]
Figure 1. 'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 2]
Figure 2. 'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.
[Figure 3]
Figure 3. Funnel plot of comparison: 1 Any antibiotics versus no antibiotics, outcome: 1.1 Perinatal mortality.
[Figure 4]
Figure 4. Funnel plot of comparison: 1 Any antibiotics versus no antibiotics, outcome: 1.12 Preterm birth (< 36 or < 37 weeks).
[Figure 5]
Figure 5. Funnel plot of comparison: 1 Any antibiotics versus no antibiotics, outcome: 1.20 Neonatal sepsis.
[Figure 6]
Figure 6. Funnel plot of comparison: 1 Any antibiotics versus no antibiotics, outcome: 1.9 Maternal infection.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Any antibiotics versus no antibiotics, Outcome 1 Perinatal mortality.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Any antibiotics versus no antibiotics, Outcome 2 Stillbirth.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Any antibiotics versus no antibiotics, Outcome 3 Neonatal death.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Any antibiotics versus no antibiotics, Outcome 4 Infant death.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Any antibiotics versus no antibiotics, Outcome 5 Any functional impairment at 7 years of age..
[Analysis 1.6]
Analysis 1.6. Comparison 1 Any antibiotics versus no antibiotics, Outcome 6 Moderate/severe functional impairment at 7 years of age..
[Analysis 1.7]
Analysis 1.7. Comparison 1 Any antibiotics versus no antibiotics, Outcome 7 Cerebral palsy at 7 years.
[Analysis 1.8]
Analysis 1.8. Comparison 1 Any antibiotics versus no antibiotics, Outcome 8 Maternal adverse drug reaction requiring cessation of treatment.
[Analysis 1.9]
Analysis 1.9. Comparison 1 Any antibiotics versus no antibiotics, Outcome 9 Maternal infection.
[Analysis 1.10]
Analysis 1.10. Comparison 1 Any antibiotics versus no antibiotics, Outcome 10 Delay in birth (subgrouped by interval).
[Analysis 1.11]
Analysis 1.11. Comparison 1 Any antibiotics versus no antibiotics, Outcome 11 Interval between randomisation and birth (days).
[Analysis 1.12]
Analysis 1.12. Comparison 1 Any antibiotics versus no antibiotics, Outcome 12 Preterm birth (< 36 or < 37 weeks).
[Analysis 1.13]
Analysis 1.13. Comparison 1 Any antibiotics versus no antibiotics, Outcome 13 Gestational age at birth.
[Analysis 1.14]
Analysis 1.14. Comparison 1 Any antibiotics versus no antibiotics, Outcome 14 Birthweight.
[Analysis 1.15]
Analysis 1.15. Comparison 1 Any antibiotics versus no antibiotics, Outcome 15 Birthweight < 2500 g.
[Analysis 1.16]
Analysis 1.16. Comparison 1 Any antibiotics versus no antibiotics, Outcome 16 Admission to neonatal intensive or special care nursery.
[Analysis 1.17]
Analysis 1.17. Comparison 1 Any antibiotics versus no antibiotics, Outcome 17 Neonatal mechanical ventilation.
[Analysis 1.18]
Analysis 1.18. Comparison 1 Any antibiotics versus no antibiotics, Outcome 18 Respiratory distress syndrome.
[Analysis 1.19]
Analysis 1.19. Comparison 1 Any antibiotics versus no antibiotics, Outcome 19 Neonatal positive blood culture.
[Analysis 1.20]
Analysis 1.20. Comparison 1 Any antibiotics versus no antibiotics, Outcome 20 Neonatal sepsis.
[Analysis 1.21]
Analysis 1.21. Comparison 1 Any antibiotics versus no antibiotics, Outcome 21 Intraventricular haemorrhage.
[Analysis 1.22]
Analysis 1.22. Comparison 1 Any antibiotics versus no antibiotics, Outcome 22 Necrotising enterocolitis.
[Analysis 1.23]
Analysis 1.23. Comparison 1 Any antibiotics versus no antibiotics, Outcome 23 Major cerebral abnormality.
[Analysis 1.24]
Analysis 1.24. Comparison 1 Any antibiotics versus no antibiotics, Outcome 24 Chronic neonatal lung disease.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Antibiotics versus no antibiotics (subgrouped by type of antibiotic), Outcome 1 Perinatal mortality.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Antibiotics versus no antibiotics (subgrouped by type of antibiotic), Outcome 2 Stillbirth.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Antibiotics versus no antibiotics (subgrouped by type of antibiotic), Outcome 3 Neonatal death.
[Analysis 2.4]
Analysis 2.4. Comparison 2 Antibiotics versus no antibiotics (subgrouped by type of antibiotic), Outcome 4 Infant death.
[Analysis 2.5]
Analysis 2.5. Comparison 2 Antibiotics versus no antibiotics (subgrouped by type of antibiotic), Outcome 5 Any functional impairment at 7 years of age..
[Analysis 2.6]
Analysis 2.6. Comparison 2 Antibiotics versus no antibiotics (subgrouped by type of antibiotic), Outcome 6 Moderate/severe functional impairment at 7 years of age..
[Analysis 2.7]
Analysis 2.7. Comparison 2 Antibiotics versus no antibiotics (subgrouped by type of antibiotic), Outcome 7 Cerebral palsy at 7 years of age.
[Analysis 2.8]
Analysis 2.8. Comparison 2 Antibiotics versus no antibiotics (subgrouped by type of antibiotic), Outcome 8 Maternal adverse drug reaction requiring cessation of treatment.
[Analysis 2.9]
Analysis 2.9. Comparison 2 Antibiotics versus no antibiotics (subgrouped by type of antibiotic), Outcome 9 Maternal infection.
[Analysis 2.10]
Analysis 2.10. Comparison 2 Antibiotics versus no antibiotics (subgrouped by type of antibiotic), Outcome 10 Birth within 48 hours of randomisation.
[Analysis 2.11]
Analysis 2.11. Comparison 2 Antibiotics versus no antibiotics (subgrouped by type of antibiotic), Outcome 11 Interval between randomisation and birth (days).
[Analysis 2.12]
Analysis 2.12. Comparison 2 Antibiotics versus no antibiotics (subgrouped by type of antibiotic), Outcome 12 Preterm birth (< 36 or < 37 weeks' gestation).
[Analysis 2.13]
Analysis 2.13. Comparison 2 Antibiotics versus no antibiotics (subgrouped by type of antibiotic), Outcome 13 Respiratory distress syndrome.
[Analysis 2.14]
Analysis 2.14. Comparison 2 Antibiotics versus no antibiotics (subgrouped by type of antibiotic), Outcome 14 Necrotising enterocolitis.
[Analysis 2.15]
Analysis 2.15. Comparison 2 Antibiotics versus no antibiotics (subgrouped by type of antibiotic), Outcome 15 Intraventricular haemorrhage.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Any macrolide versus no macrolide, Outcome 1 Perinatal mortality.
[Analysis 3.2]
Analysis 3.2. Comparison 3 Any macrolide versus no macrolide, Outcome 2 Stillbirth.
[Analysis 3.3]
Analysis 3.3. Comparison 3 Any macrolide versus no macrolide, Outcome 3 Neonatal death.
[Analysis 3.4]
Analysis 3.4. Comparison 3 Any macrolide versus no macrolide, Outcome 4 Infant death.
[Analysis 3.5]
Analysis 3.5. Comparison 3 Any macrolide versus no macrolide, Outcome 5 Any functional impairment at 7 years of age..
[Analysis 3.6]
Analysis 3.6. Comparison 3 Any macrolide versus no macrolide, Outcome 6 Moderate/severe functional impairment at 7 years of age..
[Analysis 3.7]
Analysis 3.7. Comparison 3 Any macrolide versus no macrolide, Outcome 7 Cerebral palsy at 7 years.
[Analysis 3.8]
Analysis 3.8. Comparison 3 Any macrolide versus no macrolide, Outcome 8 Maternal adverse drug reaction requiring cessation of treatment.
[Analysis 3.9]
Analysis 3.9. Comparison 3 Any macrolide versus no macrolide, Outcome 9 Maternal infection.
[Analysis 3.10]
Analysis 3.10. Comparison 3 Any macrolide versus no macrolide, Outcome 10 Birth within 48 hours of randomisation.
[Analysis 3.11]
Analysis 3.11. Comparison 3 Any macrolide versus no macrolide, Outcome 11 Interval between randomisation and birth (days).
[Analysis 3.12]
Analysis 3.12. Comparison 3 Any macrolide versus no macrolide, Outcome 12 Preterm birth (< 36 or < 37 weeks).
[Analysis 3.13]
Analysis 3.13. Comparison 3 Any macrolide versus no macrolide, Outcome 13 Respiratory distress syndrome.
[Analysis 3.14]
Analysis 3.14. Comparison 3 Any macrolide versus no macrolide, Outcome 14 Intraventricular haemorrhage.
[Analysis 3.15]
Analysis 3.15. Comparison 3 Any macrolide versus no macrolide, Outcome 15 Necrotising enterocolitis.
[Analysis 4.1]
Analysis 4.1. Comparison 4 Any beta-lactam versus no beta-lactam, Outcome 1 Perinatal mortality.
[Analysis 4.2]
Analysis 4.2. Comparison 4 Any beta-lactam versus no beta-lactam, Outcome 2 Stillbirth.
[Analysis 4.3]
Analysis 4.3. Comparison 4 Any beta-lactam versus no beta-lactam, Outcome 3 Neonatal death.
[Analysis 4.4]
Analysis 4.4. Comparison 4 Any beta-lactam versus no beta-lactam, Outcome 4 Infant death.
[Analysis 4.5]
Analysis 4.5. Comparison 4 Any beta-lactam versus no beta-lactam, Outcome 5 Any functional impairment at 7 years of age..
[Analysis 4.6]
Analysis 4.6. Comparison 4 Any beta-lactam versus no beta-lactam, Outcome 6 Moderate/severe functional impairment at 7 years of age..
[Analysis 4.7]
Analysis 4.7. Comparison 4 Any beta-lactam versus no beta-lactam, Outcome 7 Cerebral palsy at 7 years.
[Analysis 4.8]
Analysis 4.8. Comparison 4 Any beta-lactam versus no beta-lactam, Outcome 8 Maternal adverse drug reaction requiring cessation of treatment.
[Analysis 4.9]
Analysis 4.9. Comparison 4 Any beta-lactam versus no beta-lactam, Outcome 9 Maternal infection.
[Analysis 4.10]
Analysis 4.10. Comparison 4 Any beta-lactam versus no beta-lactam, Outcome 10 Birth within 48 hours of randomisation.
[Analysis 4.11]
Analysis 4.11. Comparison 4 Any beta-lactam versus no beta-lactam, Outcome 11 Interval between randomisation and birth (days).
[Analysis 4.12]
Analysis 4.12. Comparison 4 Any beta-lactam versus no beta-lactam, Outcome 12 Preterm birth (< 36 or < 37 weeks).
[Analysis 4.13]
Analysis 4.13. Comparison 4 Any beta-lactam versus no beta-lactam, Outcome 13 Respiratory distress syndrome.
[Analysis 4.14]
Analysis 4.14. Comparison 4 Any beta-lactam versus no beta-lactam, Outcome 14 Intraventricular haemorrhage.
[Analysis 4.15]
Analysis 4.15. Comparison 4 Any beta-lactam versus no beta-lactam, Outcome 15 Necrotising enterocolitis.