Intervention Review

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Antibiotics for the common cold and acute purulent rhinitis

  1. Tim Kenealy*,
  2. Bruce Arroll

Editorial Group: Cochrane Acute Respiratory Infections Group

Published Online: 4 JUN 2013

Assessed as up-to-date: 26 FEB 2013

DOI: 10.1002/14651858.CD000247.pub3

How to Cite

Kenealy T, Arroll B. Antibiotics for the common cold and acute purulent rhinitis. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD000247. DOI: 10.1002/14651858.CD000247.pub3.

Author Information

  1. University of Auckland, Department of General Practice and Primary Health Care, Auckland, New Zealand

*Tim Kenealy, Department of General Practice and Primary Health Care, University of Auckland, Private Bag 92019, Auckland, New Zealand. t.kenealy@cochraneprimarycare.org.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 4 JUN 2013

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
De Sutter 2002 {published data only}
  • De Sutter AI, De Meyere MJ, Christiaens TC, van Duriel ML, Peersman W, De Maeseneer JM. Does amoxicillin improve outcomes in patients with purulent rhinorrhea?. Journal of Family Practice 2002;51:317-23.
Gordon 1974 {published data only}
Herne 1980 {published data only}
  • Herne N. Double blinded randomized trial comparing xibornol, tetracycline and placebo in seasonal upper respiratory tract infections [Essai comparatif en doble aveugle randomise xibornol, tetracycline et placebo dans les infections saisonnieres des vioes aeriennes superiours]. Medicines et Maladies Infectieuses 1980;10:185-90.
Hoaglund 1950 {published data only}
Howie 1970 {published data only}
  • Howie JG, Clark GA. Double-blind trial of early demethylchlortetracycline in minor respiratory illness in general practice. Lancet 1970;2:1099-102.
Kaiser 1996 {published data only}
  • Kaiser L, Lew D, Hirshel B, Auckenthaler R, Morabia A, Heald A, et al. Effects of antibiotic treatment in the subset of common-cold patients who have bacteria in nasopharyngeal secretions. Lancet 1996;1996:1507-10.
Lexomboon 1971 {published data only}
  • Lexomboon U, Duangmani C, Kusalasai V, Sunakorn P, Olson LC, Noyes HE. Evaluation of orally administered antibiotics for treatment of upper respiratory infections in Thai children. Journal of Pediatrics 1971;78:772-8.
McKerrow 1961 {published data only}
  • McKerrow CB, Oldham PD, Thomson S. Antibiotics and the common cold. Lancet 1961;1:185-7.
Taylor 1977 {published data only}
  • Taylor B, Abbott GD, Kerr MM. Amoxycillin and co-trimoxazole in presumed viral respiratory infections in childhood: a placebo controlled trial. BMJ 1977;2:552-4.
Todd 1984 {published data only}
  • Todd JK, Todd N, Damanto J, Todd WA. Bacteriology and treatment of purulent nasopharyngitis: a double blind, placebo-controlled evaluation. Pediatric Infectious Diseases 1984;3:226-32.
Vogt 1966 {published data only}
  • Vogt FC. Medical management of purulent rhinitis. A double-blind comparison of vasoconstrictor agent alone with a combination of vasoconstrictor and antimicrobial drugs. Clinical Pediatrics 1966;5(9):547-9.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Ackerman 1968 {published data only}
Banks 1965 {published data only}
  • Banks HS. Common cold: controlled clinical trials. British Medical Journal 1965;2:650.
Banks 1969 {published data only}
  • Banks HS, Ritchies JM. Re-appraisal: a new look at the common cold. Journal of the Royal College of General Practitioners 1969;18:166-72.
Bateson 1961 {published data only}
  • Bateson PR, Allison RM, Wall T, Sons. The treatment of the common cold with antibiotics in a factory population. British Journal of Clinical Practice 1961;15:543-9.
Bessel-Lorck 1959 {published data only}
  • Bessel-Lorck. Prophylaxis for common cold in adolescents in a skiing camp. Die Medizinische Welt 1959;10:2126-7.
Burke 1956 {published data only}
  • Burke JB. Prophylactic sulphadimidine in children subject to recurrent infections of upper respiratory tract. British Medical Journal 1956;March 10:538-41.
Cronk 1954 {published data only}
Darelid 1993 {published data only}
  • Darelid J, Lofgren S, Malmvall BE. Erythromycin treatment is beneficial for longstanding Moraxella catarrhalis associated cough in children. Scandinavian Journal of Infectious Diseases 1993;25:323-9.
Fraser 1962 {published data only}
  • Fraser PK, Hatch LA, Hughes KEA. A comparison between aspirin and antibiotics in the treatment of minor respiratory infections. Lancet 1962;1:614-7.
Gottfarb 1994 {published data only}
Gupta 1997 {published data only}
  • Gupta S, Bhushan V, Srivastava G. The therapeutic trial of chloramphenicol, Eskaycillin (ampicillin) and co-trimoxazole in respiratory tract infection of childhood. Indian Paediatrics 1977;14:391-3.
Haight 1954 {published data only}
  • Haight TH, Kahn FH, Ziegra SR. Efficacy of erythromycin in the treatment of acute respiratory infections. US Armed Forces Medical Journal 1954;5:1405-22.
Hardy 1956 {published data only}
Haye 1998 {published data only}
  • Haye R, Lingaas E, Hoivik HO, Odegard T. Azithromycin versus placebo in acute infectious rhinitis with clinical symptoms but without radiological signs of maxillary sinusitis. European Journal of Clinical Microbiology and Infectious Diseases 1998;17:309-12.
Jones 1953 {published data only}
  • Jones PN, Bigham RS Jr, Manning PR. Use of antibiotics in nonbacterial respiratory infections. Journal of the American Medical Association 1953;153(4):262-4.
Knox 1962 {published data only}
  • Knox JDE. Comparison between aspirin and anti-biotics in minor respiratory infections. Lancet 1962;1:1358-9.
Kuh 1949 {published data only}
  • Kuh C, Collen MF. Mass penicillin prophylaxis: an experiment with negative results. Journal of the American Medical Association 1949;140:1324-8.
Lapin 1984 {published data only}
Lockhart 1961 {published data only}
  • Lockhart R. Treatment of common cold by Terramycin. Health Bulletin 1961;19:12-3.
Marlow 1989 {published data only}
  • Marlow RA, Torrez AJ, Haxby D. The treatment of non-streptococcal pharyngitis with erythromycin. A preliminary study. Family Medicine 1989;21:425-7.
McLane 1952 {published data only}
  • McLane RA. Clinical evaluation of combined drug therapy in acute upper respiratory infections. Journal of the Medical Society of New Jersey 1952;49:509-10.
Reinert 1991 {published data only}
  • Reinert P, Narcy P, Paliwoda A, Rouffiac E. Evaluation of tisocortal pivalate-neomycin combination versus a placebo excipient in acute rhinopharyngitis in children. Annals de Pediatrie 1991;38:503-8.
Ritchie 1958 {published data only}
  • Ritchie JM. Antibiotics in small doses for the common cold. Lancet 1958;1:618-21.
Seal 1953 {published data only}
  • Seal JR. The prophylaxis of acute respiratory infections with oral penicillin or chlortetracycline - proceedings of the symposium on antibiotics. Antibiotics Annual. Medical Encyclopedia Inc, 1953-4.
Sulman 1958 {published data only}
  • Sulman FG. Chloramphenicol and control of the common cold. Lancet 1958;ii:1355-6.
Sutrisna 1991 {published data only}
Townsend 1960 {published data only}
Townsend 1962 {published data only}
Traisman 1955 {published data only}
  • Traisman HS. A controlled study in the uses of chemotherapeutic and antibiotic agents in uncomplicated upper respiratory infections in children. Illinois Medical Journal 1955;107:221-4.
Wald 1991 {published data only}
Walker 1955 {published data only}
  • Walker SH. Tetracycline in the control of upper respiratory infections of infants. Antibiotics Annual. First Edition. New York: Medical Encyclopedia, Inc, 1955-6:341-4.
Wynn-Williams 1961 {published data only}
  • Wynn-Williams SH. Tetracycline in the control of common upper respiratory infections of infants. Antibiotic Annual. First Edition. New York: Medical Encyclopedia, Inc, 1961:341-4.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Arason 1996
  • Arason A, Kristinsson KG, Sigurdsson JA, Stefansdottir G, Molstad S, Gudmundsson S. Do antimicrobials increase the carriage rate of penicillin resistant pneumococci in children? Cross sectional prevalence study. BMJ 1996;313:387-91.
Arroll 2000
  • Arroll B, Goodyear-Smith F. General practitioner management of upper respiratory tract infections: when are antibiotics prescribed?. New Zealand Medical Journal 2000;113:493-6.
Arroll 2001
Del Mar 1992
  • Del Mar C. Managing sore throat: a literature review, II. Do antibiotics confer benefit?. Medical Journal of Australia 1992;156:644-9.
Fahey 1998
  • Fahey T, Stocks N, Thomas T. Quantitative systematic review of randomised controlled trials comparing antibiotic with placebo for acute cough in adults. BMJ 1998;316:906-10.
Gadomski 1993
  • Gadomski AM. Potential interventions for preventing pneumonia among young children: lack of effect of antibiotic treatment for upper respiratory infections. Pediatric Infectious Disease Journal 1993;12:115-20.
Gonzales 1999
  • Gonzales R, Barrett P, Steiner J. The relation between purulent manifestations and antibiotic treatment of upper respiratory tract infections. Journal of General Internal Medicine 1999;14:151-6.
Higgins 2011
  • Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011]. The Cochrane Collaboration. Available from www.cochrane-handbook.org 2011.
ICHPPC 1986
  • ICHPPC-2. International Classification of Health Problems in Primary Care. Third Edition. Oxford: Oxford University Press, 1986.
Kaplan 1971
  • Kaplan EL, Top FH, Dudding BA, Wannamake L. Diagnosis of streptococcal pharyngitis: differentiation of active infection from the carrier state in the symptomatic child. Journal of Infectious Diseases 1971;123:490-501.
Lefebvre 2011
  • Lefebvre C, Manheimer E, Glanville J. Chapter 6: Searching for studies. In: Higgins JPT, Green S editor(s). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011]. The Cochrane Collaboration. Available from www.cochrane-handbook.org. Chichester: Wiley-Blackwell, 2011.
Mainous 1997
McAvoy 1994
  • McAvoy B, Davis P, Raymont A, Gribben B. The Waikato Medical Care Survey. New Zealand Medical Journal 1994;107:387-433.
McGregor 1995
Morris 2007
  • Morris PS, Leach AJ. Antibiotics for persistent nasal discharge (rhinosinusitis) in children. Cochrane Database of Systematic Reviews 2007, Issue 3. [DOI: 10.1002/14651858.CD001094.pub2]
Ochoa 2000
  • Ochoa C, Eiros JM, Inglada L, Vallano A, Guerra L. Assessment of antibiotic prescription in acute respiratory infections in adults. The Spanish study group on antibiotic treatment. Journal of Infection 2000;41:73-80.
Pharmac 2008
  • Pharmac. Annual review. www.pharmac.govt.nz (accessed 5 January 2010) 2008; Vol. section 2:16.
RevMan 2012
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
Reynolds 1996
  • Reynolds JEF, Parfitt K (editors). Martindale: The Extra Pharmacopeia. 1st Edition. London: Royal Pharmaceutical Society, 1996.
Rosenstein 1998
  • Rosenstein N, Phillips W, Gerber M, Marcy S, Schwartz B, Dowell S. The common cold - principles of judicious use of antimicrobial agents. Pediatrics 1998;101:181-4.
Smith 2011
  • Smith S, Fahey T, Smucny J, Becker L. Antibiotics for acute bronchitis. Cochrane Database of Systematic Reviews 2011, Issue 11. [DOI: 10.1002/14651858.CD000245.pub2]
Snow 2001
  • Snow V, Mottur-Pilson C, Gonzales R. Principles of appropriate antibiotic use for treatment of non specific upper respiratory tract infections in adults. Annals of Internal Medicine 2001;134:487-9.
Spector 1995
Spinks 2011
  • Spinks A, Glasziou PP, Del Mar C. Antibiotics for sore throat. Cochrane Database of Systematic Reviews 2011, Issue 9. [DOI: 10.1002/14651858.CD000023.pub3]
Stott 1976
  • Stott NC, West RR. Randomised controlled trial of antibiotics in patients with cough and purulent sputum. British Medical Journal 1976;2:556-9.
Venekamp 2013
  • Venekamp RP, Sanders S, Glasziou PP, Del Mar CB, Rovers MM. Antibiotics for acute otitis media in children. Cochrane Database of Systematic Reviews 2013, Issue 1. [DOI: 10.1002/14651858.CD000219.pub3]
Verkatesum 1995

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Arroll 1998
  • Arroll B, Kenealy T. Antibiotics for the common cold and acute purulent rhinitis. Cochrane Database of Systematic Reviews 1998, Issue 4. [DOI: 10.1002/14651858.CD000247.pub2]
Arroll 2002
Arroll 2005
Arroll 2010
  • Arroll B, Kenealy T. Antibiotics for the common cold and acute purulent rhinitis. Cochrane Database of Systematic Reviews 2010, Issue 2. [DOI: 10.1002/14651858.CD000247.pub2]