Intervention Review

Carbohydrate supplementation of human milk to promote growth in preterm infants

  1. Carl A Kuschel1,*,
  2. Jane E Harding2

Editorial Group: Cochrane Neonatal Group

Published Online: 26 APR 1999

Assessed as up-to-date: 9 APR 2002

DOI: 10.1002/14651858.CD000280

How to Cite

Kuschel CA, Harding JE. Carbohydrate supplementation of human milk to promote growth in preterm infants. Cochrane Database of Systematic Reviews 1999, Issue 2. Art. No.: CD000280. DOI: 10.1002/14651858.CD000280.

Author Information

  1. 1

    The Royal Women's Hospital, Neonatal Services, Carlton, Victoria, Australia

  2. 2

    University of Auckland, Department of Paediatrics, Auckland, New Zealand

*Carl A Kuschel, Neonatal Services, The Royal Women's Hospital, 132 Grattan Street, Carlton, Victoria, 3053, Australia. carl.kuschel@rwh.org.au.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 26 APR 1999

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Abstract

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

Background

This section is under preparation and will be included in the next issue.

Objectives

The main objective was to determine if addition of carbohydrate supplements to human milk leads to improved growth and neurodevelopmental outcomes without significant adverse effects in preterm infants.

Search methods

The standard search strategy of the Neonatal Review Group was used. This includes searches of the Oxford Database of Perinatal Trials, MEDLINE (1966-Apr 2002), Cochrane Controlled Trials Register (The Cochrane Library, Issue 2, 2002), previous reviews including cross references, abstracts, conferences and symposia proceedings, expert informants, journal handsearching mainly in the English language.

Selection criteria

All trials utilising random or quasi-random allocation evaluating the supplementation of human milk with carbohydrate in preterm infants within a nursery setting were eligible.

Data collection and analysis

Not applicable.

Main results

No eligible trials were found.

Authors' conclusions

There are no studies which have specifically evaluated the addition of carbohydrate alone for the purpose of improving growth and neurodevelopmental outcomes. No recommendations for practice can be made. Research should be directed towards comparison of different quantities and types of carbohydrate in multicomponent fortifiers containing protein and minerals, specifically evaluating short-term growth and long-term growth and neurodevelopmental outcomes.

 

Plain language summary

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

Carbohydrate supplementation of human milk to promote growth in preterm infants

No evidence to show the effect of adding carbohydrate to breast milk to promote growth in babies born preterm. Breast milk is the best source of nutrition for full-term babies for at least the first six months of life. Babies born preterm (before 37 weeks) have different nutritional needs and it is possible that premature breast milk may not meet all these needs. Adding carbohydrate to breast milk may help. It may help gain weight, without the problems that can come from protein supplements (see Cochrane review on protein supplements). However carbohydrate supplements may cause diarrhea and feeding problems. There have been no published trials evaluating the effect of adding carbohydrate to breast milk to promote growth in preterm babies. More research is needed.

 

摘要

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

背景

碳水化合物輔以人乳促進早產兒生長

本部分仍在準備之中,將在下一期中補上。

目標

主要目的是確定在人乳喂養中增加碳水化合物添加劑是否改善早產兒的生長和神經發育而無不良影響。

搜尋策略

使用Neonatal Review Group的標準檢索策略進行檢索。包括Oxford Database of Perinatal Trials、MEDLINE(1966年至2002年4月)、Cochrane Controlled Trials Register (The Cochrane Library,2002年第2期)、先前回顧包括參考文獻、摘要,會議與研討會論文集、專家訊息,另主要對英文雜誌進行了手工檢索。

選擇標準

有使用隨機或半隨機分配法對托兒機構的早產兒用碳水化合物補充人乳的餵養進行評估的試驗均為合格試驗。

資料收集與分析

無適用資訊

主要結論

無合格試驗。

作者結論

沒有特別針對為改善生長和神經發育目的添加碳水化合物進行評估的研究。無法提出醫療實務建議。應將研究設定針對比較於含蛋白質和礦物質多種成分強化劑中不同碳水化合物種類和份量,特別是評估短期生長和長期生長及神經發育的結果。

翻譯人

本摘要由臺中榮民總醫院葉惠英翻譯。

此翻譯計畫由臺灣國家衛生研究院(National Health Research Institutes, Taiwan)統籌。

總結

沒有證據支持在哺乳中加入碳水化合物促進早產兒生長。至少在足月產嬰兒出生後六個月哺乳是最佳的營養來源。早產兒(懷孕37週前出生)有不同的營養需求而早產哺乳可能無法滿足這些需求。添加碳水化合物到哺乳中可能有幫忙。它可能有助於體重增加,而沒有蛋白質添加物會造成的問題(參考Cochrane對於蛋白質添加物的回顧)。然而碳水化合物可能引起腹瀉與餵食的問題。未曾有試驗評估對早產兒在哺乳中添加碳水化合物促進生長的影響。需要更多研究評估。