Intravenous dexamethasone for extubation of newborn infants

  • Review
  • Intervention


  • Peter G Davis,

    Corresponding author
    1. Royal Women's Hospital, Department of Paediatrics, Parkville, Victoria, Australia
    • Peter G Davis, Department of Paediatrics, Royal Women's Hospital, 20 Flemington Rd, Parkville, Victoria, 3052, Australia.

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  • David J Henderson-Smart

    1. Queen Elizabeth II Research Institute, NSW Centre for Perinatal Health Services Research, Sydney, NSW, Australia
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Endotracheal tubes are foreign bodies that may injure the upper airway causing laryngeal edema. This in turn may result in failure of extubation in preterm infants. Corticosteroids have been used prophylactically to reduce upper airway obstruction and facilitate extubation.


To determine the effects of intravenous corticosteroids on the incidence of endotracheal reintubation, stridor, atelectasis and adverse side effects in newborn infants having their endotracheal tube removed following a period of intermittent positive pressure ventilation (IPPV).

Search methods

Searches were made of the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library) (dexamethasone and extub*), MEDLINE (MeSH search terms "dexamethasone", "extubat*" and "exp infant, newborn"), previous reviews including cross references, abstracts of conferences and symposia proceedings, expert informants and journal handsearching mainly in the English language. These searches were updated in August 2007.

Selection criteria

Trials were included that used random or quasi-random patient allocation and compared intravenous steroids given immediately prior to a planned extubation with placebo.

Data collection and analysis

Data were extracted independently by the two authors and analysed in RevMan for all trials. Prespecified subgroup analyses were performed to examine differences in response between infants at high risk for upper airway edema and those receiving routine prophylaxis prior to extubation.

Main results

Administration of dexamethasone prior to extubation significantly reduced the need for reintubation of the trachea. This result applies to both the high-risk group and to the total population of infants enrolled. However, the incidence of extubation failure was zero in the trial that attempted to exclude infants at high risk of airway edema. The side effects of higher blood sugar levels and glycosuria were found in the two trials where these were sought.

Authors' conclusions

Implications for practice
Dexamethasone reduces the need for endotracheal reintubation of neonates after a period of IPPV. In view of the lack of effect in low-risk infants and the documented and potential side effects, it appears reasonable to restrict its use to infants at increased risk for airway edema and obstruction, such as those who have received repeated or prolonged intubations.

Implications for research
Issues of dosage and applicability to the extremely low birthweight population could be addressed in future trials. Outcomes such as chronic lung disease, duration of assisted ventilation and length of hospital stay as well as long-term neurodevelopment should also be examined.






決定經過一段時間間歇性正壓呼吸 (intermittent positive pressure ventilation) 後,新生兒拔管前靜脈注射類固醇是否能減少再插管、喘鳴、肺蹋陷或其他不良反應的機率。


搜尋了2007年八月之前的Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library) 資料庫 (使用dexamethasone和拔管搜尋) 、MEDLINE資料庫 (MeSH搜尋 ‘dexamethasone’ 、 ‘拔管’ 及 ‘exp infant, newborn’) ,以及主要以英文發表的回顧性文獻包括交叉比對,學術會議的摘要、專家意見及論文搜尋。











此翻譯計畫由臺灣國家衛生研究院 (National Health Research Institutes, Taiwan) 統籌。


在高危險產生併發症的嬰兒脫離呼吸器支持時,使用dexamethasone可能帶來助益;呼吸器治療的氣管內管放在嬰兒呼吸道可能造成傷害,拔管時可能產生併發症。此次回顧發現預計拔管時給予dexamethasone (一種類固醇藥物) 可以預防幼兒喉嚨水腫、減少再插管;然而此次回顧也發現dexamethasone的副作用,因此只有在高危險產生併發症的幼兒才有顯著效益,如接受數次插管或插管時間太久。

Plain language summary

Intravenous dexamethasone for extubation of newborn infants

Dexamethasone may help babies at high risk of complications when being taken off mechanical breathing support. The tube that is placed in the baby's airway to enable mechanical ventilation (machine-assisted breathing) can cause injury. This can lead to complications when the tube is removed (extubation). This review found that giving dexamethasone (a corticosteroid drug) around the time of extubation can help prevent swelling in the baby's throat that might require reinsertion of the tube. However, the review found that there are adverse effects of dexamethasone. The benefits only outweigh the risks for babies at high risk of complication (such as those who have received several, or prolonged, intubations).