![[Figure 1]](http://onlinelibrary.wiley.com/store/mrw_content/cochrane/clsysrev/articles/CD000320/image_t/tCD000320-AFig-FIG01.png?v=1&t=h2plp8p9&s=e527ff204a8a27b9fdacc2752c4a4015da06357d) | Figure 1. Forest plot of comparison: 1 Ivermectin versus placebo, outcome: 1.1 Treatment failure in clinically diagnosed cases. |
![[Figure 2]](http://onlinelibrary.wiley.com/store/mrw_content/cochrane/clsysrev/articles/CD000320/image_t/tCD000320-AFig-FIG02.png?v=1&t=h2plp8pb&s=ea809b97f5fe38d34e61019c48e4736b8964f01f) | Figure 2. Forest plot of comparison: 2 Ivermectin versus permethrin, outcome: 2.1 Treatment failure in clinically diagnosed cases. |
![[Figure 3]](http://onlinelibrary.wiley.com/store/mrw_content/cochrane/clsysrev/articles/CD000320/image_t/tCD000320-AFig-FIG03.png?v=1&t=h2plp8pc&s=fbf56ed09918d66168dab93c62ad4005908e677d) | Figure 3. Forest plot of comparison: 3 Ivermectin versus lindane, outcome: 3.1 Treatment failure in clinically diagnosed cases. |
![[Figure 4]](http://onlinelibrary.wiley.com/store/mrw_content/cochrane/clsysrev/articles/CD000320/image_t/tCD000320-AFig-FIG04.png?v=1&t=h2plp8pe&s=e68338461081be3a88c1154f5efcfb73dbf0c632) | Figure 4. Forest plot of comparison: 4 Ivermectin versus benzyl benzoate, outcome: 4.1 Treatment failure in clinically diagnosed cases. |
![[Figure 5]](http://onlinelibrary.wiley.com/store/mrw_content/cochrane/clsysrev/articles/CD000320/image_t/tCD000320-AFig-FIG05.png?v=1&t=h2plp8pg&s=b6f4b166a29d455b3d787d397f683b3c5cadb68d) | Figure 5. Forest plot of comparison: 4 Ivermectin versus benzyl benzoate, outcome: 4.2 Itch persistence. |
![[Figure 6]](http://onlinelibrary.wiley.com/store/mrw_content/cochrane/clsysrev/articles/CD000320/image_t/tCD000320-AFig-FIG06.png?v=1&t=h2plp8ph&s=b146b6940724721dbd92a984c9c57730020b86b5) | Figure 6. Forest plot of comparison: 5 Permethrin versus crotamiton, outcome: 5.1 Treatment failure in clinically diagnosed cases. |
![[Figure 7]](http://onlinelibrary.wiley.com/store/mrw_content/cochrane/clsysrev/articles/CD000320/image_t/tCD000320-AFig-FIG07.png?v=1&t=h2plp8pj&s=6cd53005780c298072439ec171d207916b10b9a4) | Figure 7. Forest plot of comparison: 5 Permethrin versus crotamiton, outcome: 5.2 Treatment failure in microscopically diagnosed cases. |
![[Figure 8]](http://onlinelibrary.wiley.com/store/mrw_content/cochrane/clsysrev/articles/CD000320/image_t/tCD000320-AFig-FIG08.png?v=1&t=h2plp8pk&s=7e5e5ed6150cb7567dd1dae3ee44d566598ea10c) | Figure 8. Forest plot of comparison: 5 Permethrin versus crotamiton, outcome: 5.3 Itch persistence. |
![[Figure 9]](http://onlinelibrary.wiley.com/store/mrw_content/cochrane/clsysrev/articles/CD000320/image_t/tCD000320-AFig-FIG09.png?v=1&t=h2plp8pm&s=2baf9bc28edcfb69e43fa7565f50c253b7117b88) | Figure 9. Forest plot of comparison: 6 Permethrin versus lindane, outcome: 6.1 Treatment failure in clinically diagnosed cases. |
![[Figure 10]](http://onlinelibrary.wiley.com/store/mrw_content/cochrane/clsysrev/articles/CD000320/image_t/tCD000320-AFig-FIG10.png?v=1&t=h2plp8pn&s=da20b079e366eae92f6cd74c4b2126306cfa52b5) | Figure 10. Forest plot of comparison: 6 Permethrin versus lindane, outcome: 6.2 Treatment failure in microscopically diagnosed cases. |
![[Figure 11]](http://onlinelibrary.wiley.com/store/mrw_content/cochrane/clsysrev/articles/CD000320/image_t/tCD000320-AFig-FIG11.png?v=1&t=h2plp8pp&s=839c6c5061c3df7d30ebcf3dc27219e27c28ea2c) | Figure 11. Forest plot of comparison: 6 Permethrin versus lindane, outcome: 6.3 Itch persistence. |
![[Figure 12]](http://onlinelibrary.wiley.com/store/mrw_content/cochrane/clsysrev/articles/CD000320/image_t/tCD000320-AFig-FIG12.png?v=1&t=h2plp8pq&s=6bfa1a0e78ad82d29b1b57c6877aea81b0d17846) | Figure 12. Forest plot of comparison: 7 Permethrin versus benzyl benzoate, outcome: 7.1 Treatment failure in clinically diagnosed cases. |
![[Figure 13]](http://onlinelibrary.wiley.com/store/mrw_content/cochrane/clsysrev/articles/CD000320/image_t/tCD000320-AFig-FIG13.png?v=1&t=h2plp8ps&s=57fc38c48e8bc0148b940f5024d89c0c5428d6e4) | Figure 13. Forest plot of comparison: 8 Permethrin versus natural synergized pyrethrins, outcome: 8.1 Itch persistence. |
![[Figure 14]](http://onlinelibrary.wiley.com/store/mrw_content/cochrane/clsysrev/articles/CD000320/image_t/tCD000320-AFig-FIG14.png?v=1&t=h2plp8pt&s=d27ef3e3a20e3f8efc0b4dd0f28fd1d442e2d13f) | Figure 14. Forest plot of comparison: 9 Crotamiton versus lindane, outcome: 9.1 Treatment failure in clinically diagnosed cases. |
![[Figure 15]](http://onlinelibrary.wiley.com/store/mrw_content/cochrane/clsysrev/articles/CD000320/image_t/tCD000320-AFig-FIG15.png?v=1&t=h2plp8pv&s=abf281bf95c682e9c178d5297237ba486c4302c5) | Figure 15. Forest plot of comparison: 9 Crotamiton versus lindane, outcome: 9.2 Treatment failure in microscopically diagnosed cases. |
![[Figure 16]](http://onlinelibrary.wiley.com/store/mrw_content/cochrane/clsysrev/articles/CD000320/image_t/tCD000320-AFig-FIG16.png?v=1&t=h2plp8pw&s=122d4a44e22d2c8e602c2f7d18bb12d28f88a338) | Figure 16. Forest plot of comparison: 10 Lindane versus sulfur, outcome: 10.1 Treatment failure in clinically diagnosed cases. |
![[Figure 17]](http://onlinelibrary.wiley.com/store/mrw_content/cochrane/clsysrev/articles/CD000320/image_t/tCD000320-AFig-FIG17.png?v=1&t=h2plp8py&s=a5c81ed18a80187648b7c8608a1eb3e5cd0dc5b3) | Figure 17. Forest plot of comparison: 10 Lindane versus sulfur, outcome: 10.2 Itch persistence. |
![[Figure 18]](http://onlinelibrary.wiley.com/store/mrw_content/cochrane/clsysrev/articles/CD000320/image_t/tCD000320-AFig-FIG18.png?v=1&t=h2plp8pz&s=27717eca6b73ecddcd7041ff9abd55c2000a8006) | Figure 18. Forest plot of comparison: 11 Benzyl benzoate versus sulfur, outcome: 11.1 Treatment failure in clinically diagnosed cases. |
![[Figure 19]](http://onlinelibrary.wiley.com/store/mrw_content/cochrane/clsysrev/articles/CD000320/image_t/tCD000320-AFig-FIG19.png?v=1&t=h2plp8q1&s=4b7e64014269169da2e6bd589f098d2f0aea2767) | Figure 19. Forest plot of comparison: 12 Benzyl benzoate versus natural synergized pyrethrins, outcome: 12.1 Treatment failure in clinically diagnosed cases. |
![[Figure 20]](http://onlinelibrary.wiley.com/store/mrw_content/cochrane/clsysrev/articles/CD000320/image_t/tCD000320-AFig-FIG20.png?v=1&t=h2plp8q2&s=026bb4a45575fefd249227a45988f535fe5627fd) | Figure 20. Forest plot of comparison: 12 Benzyl benzoate versus natural synergized pyrethrins, outcome: 12.2 Treatment failure in microscopically diagnosed cases. |
![[Figure 21]](http://onlinelibrary.wiley.com/store/mrw_content/cochrane/clsysrev/articles/CD000320/image_t/tCD000320-AFig-FIG21.png?v=1&t=h2plp8q4&s=123404e8e5db37fee83ce97e98e0d06c159ae5d8) | Figure 21. Forest plot of comparison: 12 Benzyl benzoate versus natural synergized pyrethrins, outcome: 12.3 Itch persistence. |
![[Figure 22]](http://onlinelibrary.wiley.com/store/mrw_content/cochrane/clsysrev/articles/CD000320/image_t/tCD000320-AFig-FIG22.png?v=1&t=h2plp8q6&s=93b3eecb3896a083603a5dd7c87fe7832b929c82) | Figure 22. Forest plot of comparison: 13 Benzyl benzoate: one application versus two applications, outcome: 13.1 Treatment failure in clinically diagnosed cases. |
![[Figure 23]](http://onlinelibrary.wiley.com/store/mrw_content/cochrane/clsysrev/articles/CD000320/image_t/tCD000320-AFig-FIG23.png?v=1&t=h2plp8q7&s=00b09d8e0e08a4d42405a5f2defde65c13a5c6fe) | Figure 23. Forest plot of comparison: 14 Lindane: short application versus long application, outcome: 14.1 Itch persistence. |
![[Figure 24]](http://onlinelibrary.wiley.com/store/mrw_content/cochrane/clsysrev/articles/CD000320/image_t/tCD000320-AFig-FIG24.png?v=1&t=h2plp8q9&s=2f8232aec14af51dd9246ab8abf22b525110ca85) | Figure 24. Forest plot of comparison: 15 Sulfur: pork fat vehicle versus cold cream vehicle, outcome: 15.1 Treatment failure in clinically diagnosed cases. |
![[Analysis 1.1]](/images/14651858/forrest_default.gif) | Analysis 1.1. Comparison 1 Ivermectin versus placebo, Outcome 1 Treatment failure in clinically diagnosed cases. |
![[Analysis 2.1]](/images/14651858/forrest_default.gif) | Analysis 2.1. Comparison 2 Ivermectin versus permethrin, Outcome 1 Treatment failure in clinically diagnosed cases. |
![[Analysis 3.1]](/images/14651858/forrest_default.gif) | Analysis 3.1. Comparison 3 Ivermectin versus lindane, Outcome 1 Treatment failure in clinically diagnosed cases. |
![[Analysis 4.1]](/images/14651858/forrest_default.gif) | Analysis 4.1. Comparison 4 Ivermectin versus benzyl benzoate, Outcome 1 Treatment failure in clinically diagnosed cases. |
![[Analysis 4.2]](/images/14651858/forrest_default.gif) | Analysis 4.2. Comparison 4 Ivermectin versus benzyl benzoate, Outcome 2 Itch persistence. |
![[Analysis 5.1]](/images/14651858/forrest_default.gif) | Analysis 5.1. Comparison 5 Permethrin versus crotamiton, Outcome 1 Treatment failure in clinically diagnosed cases. |
![[Analysis 5.2]](/images/14651858/forrest_default.gif) | Analysis 5.2. Comparison 5 Permethrin versus crotamiton, Outcome 2 Treatment failure in microscopically diagnosed cases. |
![[Analysis 5.3]](/images/14651858/forrest_default.gif) | Analysis 5.3. Comparison 5 Permethrin versus crotamiton, Outcome 3 Itch persistence. |
![[Analysis 6.1]](/images/14651858/forrest_default.gif) | Analysis 6.1. Comparison 6 Permethrin versus lindane, Outcome 1 Treatment failure in clinically diagnosed cases. |
![[Analysis 6.2]](/images/14651858/forrest_default.gif) | Analysis 6.2. Comparison 6 Permethrin versus lindane, Outcome 2 Treatment failure in microscopically diagnosed cases. |
![[Analysis 6.3]](/images/14651858/forrest_default.gif) | Analysis 6.3. Comparison 6 Permethrin versus lindane, Outcome 3 Itch persistence. |
![[Analysis 7.1]](/images/14651858/forrest_default.gif) | Analysis 7.1. Comparison 7 Permethrin versus benzyl benzoate, Outcome 1 Treatment failure in clinically diagnosed cases. |
![[Analysis 8.1]](/images/14651858/forrest_default.gif) | Analysis 8.1. Comparison 8 Permethrin versus natural synergized pyrethrins, Outcome 1 Itch persistence. |
![[Analysis 9.1]](/images/14651858/forrest_default.gif) | Analysis 9.1. Comparison 9 Crotamiton versus lindane, Outcome 1 Treatment failure in clinically diagnosed cases. |
![[Analysis 9.2]](/images/14651858/forrest_default.gif) | Analysis 9.2. Comparison 9 Crotamiton versus lindane, Outcome 2 Treatment failure in microscopically diagnosed cases. |
![[Analysis 10.1]](/images/14651858/forrest_default.gif) | Analysis 10.1. Comparison 10 Lindane versus sulfur, Outcome 1 Treatment failure in clinically diagnosed cases. |
![[Analysis 10.2]](/images/14651858/forrest_default.gif) | Analysis 10.2. Comparison 10 Lindane versus sulfur, Outcome 2 Itch persistence. |
![[Analysis 11.1]](/images/14651858/forrest_default.gif) | Analysis 11.1. Comparison 11 Benzyl benzoate versus sulfur, Outcome 1 Treatment failure in clinically diagnosed cases. |
![[Analysis 12.1]](/images/14651858/forrest_default.gif) | Analysis 12.1. Comparison 12 Benzyl benzoate versus natural synergized pyrethrins, Outcome 1 Treatment failure in clinically diagnosed cases. |
![[Analysis 12.2]](/images/14651858/forrest_default.gif) | Analysis 12.2. Comparison 12 Benzyl benzoate versus natural synergized pyrethrins, Outcome 2 Treatment failure in microscopically diagnosed cases. |
![[Analysis 12.3]](/images/14651858/forrest_default.gif) | Analysis 12.3. Comparison 12 Benzyl benzoate versus natural synergized pyrethrins, Outcome 3 Itch persistence. |
![[Analysis 13.1]](/images/14651858/forrest_default.gif) | Analysis 13.1. Comparison 13 Benzyl benzoate: one application versus two applications, Outcome 1 Treatment failure in clinically diagnosed cases. |
![[Analysis 14.1]](/images/14651858/forrest_default.gif) | Analysis 14.1. Comparison 14 Lindane: short application versus long application, Outcome 1 Itch persistence. |
![[Analysis 15.1]](/images/14651858/forrest_default.gif) | Analysis 15.1. Comparison 15 Sulfur: pork fat vehicle versus cold cream vehicle, Outcome 1 Treatment failure in clinically diagnosed cases. |