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Multicomponent fortified human milk for promoting growth in preterm infants

  1. Carl A Kuschel1,*,
  2. Jane E Harding2

Editorial Group: Cochrane Neonatal Group

Published Online: 26 JAN 2004

Assessed as up-to-date: 28 AUG 2003

DOI: 10.1002/14651858.CD000343.pub2


How to Cite

Kuschel CA, Harding JE. Multicomponent fortified human milk for promoting growth in preterm infants. Cochrane Database of Systematic Reviews 2004, Issue 1. Art. No.: CD000343. DOI: 10.1002/14651858.CD000343.pub2.

Author Information

  1. 1

    The Royal Women's Hospital, Neonatal Services, Carlton, Victoria, Australia

  2. 2

    University of Auckland, Department of Paediatrics, Auckland, New Zealand

*Carl A Kuschel, Neonatal Services, The Royal Women's Hospital, 132 Grattan Street, Carlton, Victoria, 3053, Australia. carl.kuschel@rwh.org.au.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 26 JAN 2004

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This is not the most recent version of the article. View current version (08 MAY 2016)

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Carey 1987 {published data only}
  • Carey DE, Rowe JC, Goetz CA, Horak E, Clark RM, Goldberg B. Growth and phosphorus metabolism in premature infants fed human milk, fortified human milk, or special premature formula. Use of serum procollagen as a marker of growth. Am J Dis Child 1987;141:511-15.
Faerk 2000 {published data only}
Greer 1988 {published and unpublished data}
Gross 1987 (1) {published data only}
Gross 1987 (2) {published data only}
Kashyap 1990 {published and unpublished data}
  • Kashyap S, Schulze KF, Forsyth M, Dell RB, Ramakrishnan R, Heird WC. Growth, nutrient retention, and metabolic response of low-birth-weight infants fed supplemented and unsupplemented preterm human milk. Am J Clin Nutr 1990;52:254-62.
  • Kashyap S, Schulze KF, Ramakrishnan R, Dell RB, Forsyth M, Zucker C, Heird WC. Growth, nutrient retention and metabolic response of low birth weight (LBW) infants fed human milk (HM). Pediatr Res 1988;23:486A.
Lucas 1996 {published and unpublished data}
  • Lucas A, Fewtrell MS, Morley R, Lucas PJ, Baker BA, Lister G, Bishop NJ. Randomized outcome trial of human milk fortification and developmental outcome in preterm infants. Am J Clin Nutr 1996;64:142-51.
Modanlou 1986 {published data only}
  • Modanlou HD, Lim MO, Hansen JW, Sickles V. Growth, biochemical status, and mineral metabolism in very-low-birth-weight infants receiving fortified preterm human milk. J Pediatr Gastroenterol Nutr 1986;5:762-67.
Nicholl 1999 {published data only}
Pettifor 1989 {published and unpublished data}
  • Pettifor JM, Rajah R, Venter A, Moodley GP, Opperman L, Cavaleros M, Ross FP. Bone mineralization and mineral homeostasis in very low-birth-weight infants fed either human milk or fortified human milk. J Pediatr Gastroenterol Nutr 1989;8:217-24.
Polberger 1989 {published data only}
  • Polberger SKT, Axelsson IA, Räihä NCE. Growth of very low birth weight infants on varying amounts of human milk protein. Pediatr Res 1989;25:414-19.
  • Polberger SKT, Axelsson IE, Räihä NCR. Amino acid concentrations in plasma and urine in very low birth weight infants fed protein-unenriched or human milk protein-enriched human milk. Pediatrics 1990;86:909-15.
  • Polberger SKT, Fex GA, Axelsson IE, Räihä NCR. Eleven plasma proteins as indicators of protein nutritional status in very low birth weight infants. Pediatrics 1990;86:916-21.
Wauben 1998 {published and unpublished data}
  • Wauben I, Gibson R, Atkinson S. Premature infants fed mothers' milk to 6 months corrected age demonstrate adequate growth and zinc status in the first year. Early Human Dev 1999;54(2):181-94.
  • Wauben IP, Atkinson SA, Grad TL, Shah JK, Paes B. Moderate nutrient supplementation of mother's milk for preterm infants supports adequate bone mass and short-term growth: a randomized, controlled trial. Am J Clin Nutr 1998;67:465-72.
  • Wauben IPM, Atkinson SA, Shah JK, Paes B. Growth and body composition of preterm infants: influence of nutrient fortification of mother's milk in hospital and breastfeeding post-hospital discharge. Acta Paediatr 1998;87(7):780-85.
Zuckerman 1994 {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Boehm 1991 {published data only}
  • Boehm G, Borte M, Müller DM, Senger H, Rademacher C. Nutrition of preterm infants with supplemented human milk: EOPROTIN vs human albumin [Die Ernahrug Fruhgeborener mit angereicherter Frauenmilch: EOPROTIN 60 im Vergleich mit Humanalbumin]. Kinderarztl Praxis 1991;59:S 293-98.
dos Santos 1997 {published data only}
  • dos Santos MM, Martinez FE, Sieber V, Pinhata M, Felin ML. Acceptability and growth of VLBW-infants fed with own mother's milk enriched with a natural or commercial human milk fortifier (HMF). Pediatr Res 1997;41:231A, #1370.
Ewer 1996 {published data only}
Gupta (unpublished) {unpublished data only}
  • Gupta G. Thesis (unpublished).
Lucas 1984 {published data only}
McClure 1996 {published data only}
Metcalf 1994 {published data only}
Moyer-Mileur 1992 {published data only}
  • Moyer-Mileur L, Chan GM, Gill G. Evaluation of liquid or powdered fortification of human milk on growth and bone mineralization status of preterm infants. J Pediatr Gastroenterol Nutr 1992;15:370-74.
Plath 1988 {published data only}
  • Plath Chr, Heine W, Uhlemann M, Wutzke KD, Muller M, Kracht M. 15N-tracer kinetic studies regarding whole body protein metabolism in very small preterm infants for evaluation of human milk fortifier [abstract]. Clin Nutr 1988;7 Spec Suppl:11.
Porcelli 2000 {published data only}
  • Porcelli P, Schanler R, Greer F, Chan G, Gross S, Mehta N, Spear M, Kerner J, Euler AR. Growth in human milk-fed very low birth weight infants receiving a new human milk fortifier. Ann Nutr Metab 2000;44:2-10.
  • Porcelli P, Schanler RJ, Greer F, Chan G, Gross S, Mehta N, Spear M, Kerner J, Flores L, Terry D, Minervini G, Euler A. A new human milk fortifier (HMF): A multicenter report. Pediatr Res 1996;40:548.
Reis 2000 {published data only}
Ronnholm 1982 {published data only}
  • Rönnholm KAR, Perheentupa J, Siimes MA. Supplementation with human milk protein improves growth of small premature infants fed human milk. Pediatrics 1986;77:649-53.
  • Rönnholm KAR, Siimes MA. Haemoglobin concentration depends on protein intake in small preterm infants fed human milk. Arch Dis Child 1985;60:99-104.
  • Rönnholm KAR, Simell O, Siimes MA. Human milk protein and medium-chain triglyceride oil supplementation of human milk: plasma amino acids in very low-birth-weight infants. Pediatrics 1984;74:792-99.
  • Rönnholm KAR, Sipila O, Siimes MA. Human milk protein supplementation for the prevention of hypoproteinemia without metabolic imbalance in breast milk-fed, very low-birth-weight infants. J Pediatr 1982;101:243-47.
Sankaran 1996 {published data only}
  • Sankaran K, Papageorgiou A, Ninan A, Sankaran R. A randomized, controlled evaluation of two commercially available human breast milk fortifiers in healthy preterm neonates. J Am Diet Assoc 1996;96:1145-49.
Schanler 1995 {published data only}
Venkataraman 1988 {published data only}
  • Venkataraman PS, Blick KE. Effect of mineral supplementation of human milk on bone mineral content and trace element metabolism. J Pediatr 1988;113:220-24.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
54th WHA
  • The World Health Organization. 54th World Health Assemby 2001; Vol. WHA54.2. [: http://www.who.int/gb/EB_WHA/PDF/WHA54/ea54R2.pdf]
Atkinson 1983
Cooper 1984
  • Cooper PA, Rothberg AD, Pettifor JM, Bolton KD, Devenhuis S. Growth and biochemical responses of premature infants fed pooled preterm milk or special formula. J Pediatr Gastroent Nutr 1984;3:749-54.
Kuschel 1999a
Kuschel 1999b
Kuschel 1999c
  • Kuschel CA, Harding JE. Fat supplementation of human milk to promote growth in preterm infants. Cochrane Database of Systematic Reviews 1999, Issue 3. [DOI: 10.1002/14651858.CD000341]
Kuschel 2001
  • Kuschel CA, Harding JE. Calcium and phosphorus supplementation of human milk for preterm infants. Cochrane Database of Systematic Reviews 2001, Issue 4. [DOI: 10.1002/14651858.CD003310]
Lucas 1990
McGuire 2001
  • McGuire W, Anthony MY. Formula milk versus term human milk for feeding preterm or low birth weight infants. Cochrane Database of Systematic Reviews 2001, Issue 4. [DOI: 10.1002/14651858.CD002971]
McGuire 2003
  • McGuire W, Anthony MY. Donor human milk versus formula for prevention of necrotising enterocolitis in preterm infants: systematic review. Arch Dis Child Fetal Neonatal Ed 2003;88:F11-14.
Morley 1998
Roberts 1987
  • Roberts SB, Lucas A. Energetic efficiency and nutrient accretion in preterm infants fed extremes of dietary intake. Human Nutr - Clin Nutr 1987;41:105-13.
Schanler 2001
Sinclair 1992
  • Sinclair JC, Bracken MB. Effective Care of the Newborn Infant. Oxford: Oxford University Press, 1992.

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Kuschel 2000
  • Kuschel CA, Harding JE. Multicomponent fortified human milk for promoting growth in preterm infants. Cochrane Database of Systematic Reviews 2000, Issue 2. [DOI: 10.1002/14651858.CD000343.pub2]