This is not the most recent version of the article. View current version (23 JUL 2015)

Intervention Review

You have free access to this content

Deworming drugs for soil-transmitted intestinal worms in children: effects on nutritional indicators, haemoglobin and school performance

  1. David C Taylor-Robinson1,*,
  2. Nicola Maayan2,
  3. Karla Soares-Weiser2,
  4. Sarah Donegan1,
  5. Paul Garner1

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 11 JUL 2012

Assessed as up-to-date: 31 MAY 2012

DOI: 10.1002/14651858.CD000371.pub4


How to Cite

Taylor-Robinson DC, Maayan N, Soares-Weiser K, Donegan S, Garner P. Deworming drugs for soil-transmitted intestinal worms in children: effects on nutritional indicators, haemoglobin and school performance. Cochrane Database of Systematic Reviews 2012, Issue 7. Art. No.: CD000371. DOI: 10.1002/14651858.CD000371.pub4.

Author Information

  1. 1

    Liverpool School of Tropical Medicine, International Health Group, Liverpool, Merseyside, UK

  2. 2

    Enhance Reviews Ltd, Wantage, UK

*David C Taylor-Robinson, International Health Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, Merseyside, L3 5QA, UK. David.Taylor-Robinson@liverpool.ac.uk.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 11 JUL 2012

SEARCH

This is not the most recent version of the article. View current version (23 JUL 2015)

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Adams 1994 {published data only}
  • Adams EJ, Stephenson LS, Latham MC, Kinoti SN. Physical activity and growth of Kenyan school children with hookworm, Trichuris trichiura and Ascaris lumbricoides infections are improved after treatment with albendazole. Journal of Nutrition 1994;124(8):1199-206.
Alderman 2006 (Cluster) {published data only}
  • Alderman H, Konde-Lule J, Sebuliba I, Bundy D, Hall A. Effect on weight gain of routinely giving albendazole to preschool children during child health days in Uganda: cluster randomised controlled trial. BMJ 2006;333(7559):122.
Awasthi 2000 {published and unpublished data}
  • Awasthi S, Pande VK, Fletcher RS. Effectiveness and cost-effectiveness of albendazole in improving nutritional status of pre-school children in urban slums. Indian Pediatrics 2000;37(1):19-29.
Awasthi 2001 (Cluster) {published data only}
  • Awasthi S, Pande VK. Six-monthly de-worming in infants to study effects on growth. Indian Journal of Pediatrics 2001;68(9):823-7.
Awasthi 2008 (Cluster) {published data only}
  • Awasthi S, Peto R, Fletcher R, Glick H. Controlling parasitic infection in children under five years of age: giving albendazole in conjunction with an Indian government Vitamin A supplement program. Treating parasitic infestations in children [Monograph No. 3]. Philadelphia: International Clinical Epidemiology Network (INCLEN), 1995.
  • Awasthi S, Peto R, Pande VK, Fletcher RH, Read S, Bundy DA. Effects of deworming on malnourished preschool children in India: an open-labelled, cluster-randomized trial. PLoS Neglected Tropical Diseases 2008;2(4):e223.
Beach 1999 {published data only}
  • Beach MJ, Streit TG, Addiss DG, Prospere R, Roberts JM, Lammie PJ. Assessment of combined ivermectin and albendazole for treatment of intestinal helminth and Wuchereria bancrofti infections in Haitian schoolchildren. American Journal of Tropical Medicine and Hygiene 1999;60(3):479-86.
DEVTA (unpublished) {unpublished data only}
  • Awasthi S, Peto R, Read S, Richards S, Pande V, Bundy DA and the DEVTA team. Population de-worming with 6-monthly albendazole: DEVTA, a cluster-randomised trial among 1 million preschool children in North India. [unpublished manuscript].
  • University of Oxford and the United States Agency for International Development (USAID). Deworming and Enhanced Vitamin A Supplementation DEVTA Project(The DEVTA Trial). Registered September 13, 2005; Completed October 27, 2005;Clinical Trials Register Number NCT00222547:Information obtained from ClinicalTrials.gov on February 23, 2012.
Donnen 1998 {published data only}
  • Donnen P, Brasseur D, Dramaix M, Vertongen F, Zihindula M, Muhamiriza M, et al. Vitamin A Supplemenation but not deworming improves growth of malnourished preschool children in eastern Zaire. Journal of Nutrition 1998;128(8):1320-7.
Dossa 2001 {published data only}
  • Dossa RA, Ategbo EA, de Koning FL, van Raaij JM, Hautvast JG. Impact of iron supplementation and deworming on growth performance in preschool Beninese children. European Journal of Clinical Nutrition 2001;55(4):223-8.
Fox 2005 {published data only}
  • Fox LM, Furness BW, Haser JK, Desire D, Brissau JM, Milord MD, et al. Tolerance and efficacy of combined diethylcarbamazine and albendazole for treatment of Wuchereria bancrofti and intestinal helminth infections in Haitian children. American Journal of Tropical Medicine and Hygiene 2005;73(1):115-21.
Freij 1979a {published data only}
  • Freij L, Meeuwisse GW, Berg NO, Wall S, Gebre-Medhin M. Ascariasis and malnutrition. A study in urban Ethiopian children. American Journal of Clinical Nutrition 1979;32(7):1545-53.
Freij 1979b {published data only}
  • Freij L, Meeuwisse GW, Berg NO, Wall S, Gebre-Medhin M. Ascariasis and malnutrition. A study in urban Ethiopian children. American Journal of Clinical Nutrition 1979;32(7):1545-53.
Garg 2002 {published data only}
  • Garg R, Lee LA, Beach MJ, Wamae CN, Ramakrishnan U, Deming MS. Evaluation of the Integrated Management of Childhood Illness guidelines for treatment of intestinal helminth infections among sick children aged 2-4 years in western Kenya. Transactions of the Royal Society of Tropical Medicine and Hygiene 2002;96(5):543-8.
Goto 2009 {published data only}
  • Goto R, Mascie-Taylor CG, Lunn PG. Impact of anti-Giardia and anthelminthic treatment on infant growth and intestinal permeability in rural Bangladesh: a randomised double-blind controlled study. Transactions of the Royal Society of Tropical Medicine and Hygiene 2009;103:520-9.
Greenberg 1981 {published data only}
  • Greenberg BL, Gilman RH, Shapiro H, Gilman JB, Mondal G, Maksud M, et al. Single dose piperazine therapy for Ascaris lumbricoides: an unsuccessful method of promoting growth. American Journal of Clinical Nutrition 1981;34(11):2508-16.
Hadju 1996 {published data only}
  • Hadju V, Stephenson LS, Abadi K, Mohammed HO, Bowman DD, Parker RS. Improvements in appetite and growth in helminth-infected schoolboys three and seven weeks after a single dose of pyrantel pamoate. Parasitology 1996;113(Pt 5):497-504.
Hadju 1997 {published data only}
  • Hadju V, Satriono, Abadi K, Stephenson LS. Relationship between soil-transmitted helminthiases and growth in urban slum school children in Ujung Pandang, Indonesia. International Journal of Food Sciences and Nutrition 1997;48(2):85-93.
Hall 2006 (Cluster) {unpublished data only}
  • Hall A, Nguyen Bao Khanh L, Bundy D, Quan Dung N, Hong Son T, Lansdown R. A randomized trial of six monthly deworming on the growth and educational achievements of Vietnamese school children. Unpublished manuscript.
Kirwan 2010 {published data only}
  • Kirwan P, Asaolu SO, Molloy SF, Abiona TC, Jackson AL, Holland CV. Patterns of soil-transmitted helminth infection and impact of four monthly albendazole treatments in preschool children from semi-urban communities in Nigeria: a double-blind placebo-controlled randomised trial. BMC Infectious Diseases 2009;9:20.
  • Kirwan P, Jackson AL, Asaolu SO, Molloy SF, Abiona TC, Bruce MC, et al. Impact of repeated four-monthly anthelmintic treatment on Plasmodium infection in preschool children: a double-blind placebo-controlled randomized trial. BMC Infectious Diseases 2010;10:277.
Kloetzel 1982 {published data only}
Koroma 1996 {published data only}
  • Koroma MM, Williams RA, de la Haye RR, Hodges M. Effects of albendazole on growth of primary school children and the prevalence and intensity of soil-transmitted helminths in Sierra Leone. Journal of Tropical Pediatrics 1996;42(6):371-2.
Kruger 1996 {published data only}
  • Kruger M, Badenhorst CJ, Mansvelt EPG, Laubscher JA, Benade AJS. The effect of iron fortification in a school feeding scheme and anthelminthic therapy on the iron status and growth of 6-8 year old school children. Food and Nutrition Bulletin 1996;17(1):11-21.
Kvalsvig 1991a {published data only}
  • Kvalsvig JD, Cooppan RM, Connolly KJ. The effects of parasite infections on cognitive processes in children. Annals of Tropical Medicine and Parasitology 1991;85(5):551-68.
Lai 1995 {published data only}
  • Lai KP, Kaur H, Mathias RG, Ow-Yang CK. Ascaris and Trichuris do not contribute to growth retardation in primary school children. Southeast Asian Journal of Tropical Medicine and Public Health 1995;26(2):322-8.
Le Huong 2007 {published data only}
  • Le Huong T, Brouwer ID, Nguyen KC, Burema J, Kok FJ. The effect of iron fortification and de-worming on anaemia and iron status of Vietnamese schoolchildren. British Journal of Nutrition 2007;97(5):955-62.
Michaelsen 1985 {published data only}
  • Michaelsen KF. Hookworm infection in Kweneng District, Botswana. A prevalence survey and a controlled treatment trial. Transactions of the Royal Society of Tropical Medicine and Hygiene 1985;79(6):848-51.
Miguel 2004 (Cluster) {published data only}
Nga 2009 {published data only}
  • Nga TT, Winichagoon P, Dijkhuizen MA, Khan NC, Wasantwisut E, Furr H, et al. Multi-micronutrient-fortified biscuits decreased prevalence of anemia and improved micronutrient status and effectiveness of deworming in rural Vietnamese school children. Journal of Nutrition 2009;139(5):1013-21.
  • Nga TT, Winichagoon P, Dijkhuizen MA, Khan NC, Wasantwisut E, Wieringa FT. Decreased parasite load and improved cognitive outcomes caused by deworming and consumption of multi-micronutrient fortified biscuits in rural Vietnamese schoolchildren. American Journal of Tropical Medicine and Hygiene 2011;85(2):333-40.
Nokes 1992 {published data only}
  • Nokes C, Grantham-McGregor SM, Sawyer AW, Cooper ES, Bundy DA. Parasitic helminth infection and cognitive function in school children. Proceedings of The Royal Society of London. Series B: Biological sciences 1992;247(1319):77-81.
  • Nokes C, Grantham-McGregor SM, Sawyer AW, Cooper ES, Robinson BA, Bundy DA. Moderate to heavy infections of Trichuris trichiura affect cognitive function in Jamaican school children. Parasitology 1992;104(Pt 3):539-47.
Olds 1999 {published data only}
  • Olds GR, King C, Hewlett J, Olveda R, Wu G, Ouma J, et al. Double-blind placebo-controlled study of concurrent administration of albendazole and praziquantel in school children with schistosomiasis and geohelminths. The Journal of Infectious Diseases 1999;179(4):996-1003.
Palupi 1997 {published data only}
  • Palupi L, Schultink W, Achadi E, Gross R. Effective community intervention to improve hemoglobin status in preschoolers receiving once-weekly iron supplementation. American Journal of Clinical Nutrition 1997;65(4):1057-61.
Rousham 1994 (Cluster) {published data only}
  • Northrop-Clewes CA, Rousham EK, Mascie-Taylor CN, Lunn PG. Anthelmintic treatment of rural Bangladeshi children: effect on host physiology, growth, and biochemical status. American Journal of Clinical Nutrition 2001;73(1):53-60.
  • Rousham EK, Mascie-Taylor CG. An 18-month study of the effect of periodic anthelminthic treatment on the growth and nutritional status of pre-school children in Bangladesh. Annals of Human Biology 1994;21(4):315-24.
Sarkar 2002 {published data only}
  • Sarkar NR, Anwar KS, Biswas KB, Mannan MA. Effect of deworming on nutritional status of ascaris infested slum children of Dhaka, Bangladesh. Indian Pediatrics 2002;39(11):1021-6.
Simeon 1995 {published data only}
  • Gardner JM, Grantham-McGregor S, Baddeley A. Trichuris trichiura infection and cognitive function in Jamaican school children. Annals of Tropical Medicine and Parasitology 1996;90(1):55-63.
  • Simeon DT, Grantham-McGregor SM, Callender JE, Wong MS. Treatment of Trichuris trichiura infections improves growth, spelling scores and school attendance in some children. Journal of Nutrition 1995;125(7):1875-83.
  • Simeon DT, Grantham-McGregor SM, Wong MS. Trichuris trichiura infection and cognition in children: results of a randomized clinical trial. Parasitology 1995;110(Pt 4):457-64.
Solon 2003 {published data only}
  • Solon FS, Sarol JN, Bernardo ABI, Solon JA, Mehansho H, Sanchez-Fermin LE, et al. Effect of a multiple-micronutrient-fortified fruit powder beverage on the nutrition status, physical fitness, and cognitive performance of schoolchildren in the Philippines. Food and Nutrition Bulletin 2003;24(4):S129-40.
Stephenson 1989 {published data only}
  • Stephenson LS, Latham MC, Kinoti SN, Kurz KM, Brigham H. Improvements in physical fitness of Kenyan school boys infected with hookworm, Trichuris trichiura, and Ascaris lumbricoides following a single dose of albendazole. Transactions of the Royal Society of Tropical Medicine and Hygiene 1990;84(2):277-82.
  • Stephenson LS, Latham MC, Kurz KM, Kinoti SN, Brigham H. Treatment with a single dose of albendazole improves growth of Kenyan schoolchildren with hookworm, Trichuris trichiura, and Ascaris lumbricoides infections. American Journal of Tropical Medicine and Hygiene 1989;41(1):78-87.
Stephenson 1993 {published data only}
  • Stephenson LS, Latham MC, Adams EJ, Kinoti SN, Pertet A. Physical fitness, growth and appetite of Kenyan school boys with hookworm, Trichuris trichiura and Ascaris lumbricoides infections are improved four months after a single dose of albendazole. Journal of Nutrition 1993;123(6):1036-46.
  • Stephenson LS, Latham MC, Adams EJ, Kinoti SN, Pertet A. Weight gain of Kenyan school children infected with hookworm, Trichuris trichiura and Ascaris lumbricoides is improved following once- or twice-yearly treatment with albendazole. Journal of Nutrition 1993;123(4):656-65.
Stoltzfus 1997 (Cluster) {published and unpublished data}
  • Stoltzfus RJ, Albonico M, Chwaya HM, Tielsch JM, Schulze KJ, Savioli L. Effects of the Zanzibar school-based deworming program on iron status of children. American Journal of Clinical Nutrition 1998;68(1):179-86.
  • Stoltzfus RJ, Albonico M, Tielsch JM, Chwaya HM, Savioli L. School-based deworming program yields small improvement in growth of Zanzibari school children after one year. Journal of Nutrition 1997;127(11):2187-93.
Stoltzfus 2001 {published data only}
  • Stoltzfus RJ, Chway HM, Montresor A, Tielsch JM, Jape JK, Albonico M, et al. Low dose daily iron supplementation improves iron status and appetite but not anemia, whereas quarterly anthelminthic treatment improves growth, appetite and anemia in Zanzibari preschool children. Journal of Nutrition 2004;134(2):348-56.
  • Stoltzfus RJ, Kvalsvig JD, Chwaya HM, Montresor A, Albonico M, Tielsch JM, et al. Effects of iron supplementation and anthelmintic treatment on motor and language development of preschool children in Zanzibar: double blind, placebo controlled study. BMJ 2001;323(7326):1389-93.
Sur 2005 {published data only}
  • Sur D, Saha DR, Manna B, Rajendran K, Bhattacharya SK. Periodic deworming with albendazole and its impact on growth status and diarrhoeal incidence among children in an urban slum of India. Transactions of the Royal Society of Tropical Medicine and Hygiene 2005;99(4):261-7.
Watkins 1996 {published data only}
Willett 1979 {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Araujo 1987 {published data only}
  • Araujo RL, Araujo MB, Machado RD, Braga AA, Leite BV, Oliveira JR. Evaluation of a program to overcome vitamin A and iron deficiencies in areas of poverty in Minas Gerais, Brazil. Archivos Latinoamericanos de Nutricion 1987;37(1):9-22.
Beasley 1999 {published data only}
Bhargava 2003 {published data only}
  • Bhargava A, Jukes M, Lambo J, Kihamia CM, Lorri W, Nokes C, et al. Anthelmintic treatment improves the hemoglobin and serum ferritin concentrations of Tanzanian schoolchildren. Food and Nutrition Bulletin 2003;24(4):332-42.
Bhutta 2009 {published data only}
  • Bhutta Z, Klemm R, Shahid F, Rizvi A, Rah JH, Christian P. Treatment response to iron and folic acid alone is the same as with multivitamins and/or anthelminthics in severely anemic 6- to 24-month-old children. The Journal of Nutrition 2009;139(8):1568-74.
Boivin 1993 {published data only}
  • Boivin MJ, Giordani B. Improvements in cognitive performance for schoolchildren in Zaire, Africa, following an iron supplement and treatment for intestinal parasites. Journal of Pediatric Psychology 1993;18(2):249-64.
Cooper 2006 {published data only}
  • Cooper PJ, Chico ME, Vaca MG, Moncayo AL, Bland JM, Mafla E, et al. Effect of albendazole treatments on the prevalence of atopy in children living in communities endemic for geohelminth parasites: a cluster-randomised trial. Lancet 2006;367(9522):1598-603.
Cowden 2000 {published data only}
Diouf 2002 {published data only}
  • Diouf S, Diagne I, Moreira C, Signate SY, Faye O, Ndiaye O, et al. Integrated treatment of iron deficiency, vitamin A deficiency and intestinal parasitic diseases: impact on Senegalese children's growth [Traitement integre de la carence en fer, de l'avitaminose A et des parasitoses intestinales: impact sur la croissance des enfants senegalais]. Archives de Pédiatrie 2002;9(1):102-3.
Evans 1986 {unpublished data only}
  • Evans J, Martin J, Mascie-Taylor CGN. The effect of periodic deworming with pyrantel pamoate on the growth and nutritional status of pre-school children in northern Bangladesh [Monograph No. 3]. London: Save the Children Fund, 1986.
Fernando 1983 {published and unpublished data}
  • Fernando MA, Balasuriya, Somaratne. Effect of Ascaris lumbricoides infestation on growth of children. Indian Pediatrics 1983;20(10):721-31.
Forrester 1998 {published data only}
Friis 2003 {published data only}
  • Friis H, Mwaniki D, Omondi B, Muniu E, Thiong'o F, Ouma J, et al. Effects on haemoglobin of multi-micronutrient supplementation and multi-helminth chemotherapy: a randomized, controlled trial in Kenyan school children. European Journal of Clinical Nutrition 2003;57(4):573-9.
Gilgen 2001 {published data only}
Gupta 1982 {published data only}
  • Gupta MC, Urrutia JJ. Effect of periodic antascaris and antigiardia treatment on nutritional status of preschool children. American Journal of Clinical Nutrition 1982;36(1):79-86.
Hadidjaja 1998 {published data only}
  • Hadidjaja P, Bonang E, Suyardi MA, Abidin SA, Ismid IS, Margono SS. The effect of intervention methods on nutritional status and cognitive function of primary school children infected with Ascaris lumbricoides. American Journal of Tropical Medicine and Hygiene 1998;59(5):791-5.
Hathirat 1992 {published data only}
  • Hathirat P, Valyasevi A, Kotchabhakdi NJ, Rojroongwasinkul N, Pollitt E. Effects of an iron supplementation trial on the Fe status of Thai schoolchildren. The British Journal of Nutrition 1992;68(1):245-52.
Jalal 1998 {published data only}
  • Jalal F, Nesheim MC, Agus Z, Sanjur D, Habicht JP. Serum retinol concentrations in children are affected by food sources of beta-carotene, fat intake, and anthelmintic drug treatment. American Journal of Clinical Nutrition 1998;68(3):623-9.
Jinabhai 2001a {published data only}
  • Jinabhai CC, Taylor M, Coutsoudis A, Coovadia HM, Tomkins AM, Sullivan KR. Epidemiology of helminth infections: implications for parasite control programmes, a South African perspective. Public Health Nutrition 2001;4(6):1211-9.
Jinabhai 2001b {published data only}
  • Jinabhai CC, Taylor M, Coutsoudis A, Coovadia HM, Tomkins AM, Sullivan KR. A randomized controlled trial of the effect of antihelminthic treatment and micronutrient fortification on health status and school performance of rural primary school children. Annals of Tropical Paediatrics 2001;21(4):319-33.
Karyadi 1996 {published data only}
  • Karyadi E, Gross R, Sastroamidjojo S, Dillon D, Richards AL, Sutanto I. Anthelminithic treatment raises plasma iron levels but dose not decrease the acute-phase response in Jakarta School children. Southeast Asian Journal of Tropical Medicine and Public Health 1996;27(4):742-53.
Krubwa 1974 {published data only}
  • Krubwa F, Gatti F, Lontie M, Nguete M, Vandepitte J, Thiepont D. Quarterly administration of mebendazole to suburban school children [Administration trimestrielle de mebendazole en milieu scolaire suburbain]. Medecine Tropicale 1974;34(5):679-87.
Kvalsvig 1991b {published data only}
  • Kvalsvig JD, Cooppan RM, Connolly KJ. The effects of parasite infections on cognitive processes in children. Annals of Tropical Medicine and Parasitology 1991;85(5):551-68.
Latham 1990 {published data only}
  • Latham MC, Stephenson LS, Kurz KM, Kinoti SN. Metrifonate or praziquantel treatment improves physical fitness and appetite of Kenyan schoolboys with Schistosoma haematobium and hookworm infections. American Journal of Tropical Medicine and Hygiene 1990;43(2):170-9.
Marinho 1991 {published data only}
  • Marinho HA, Shrimpton R, Giugliano R, Burini RC. Influence of enteral parasites on the blood vitamin A levels in preschool children orally supplemented with retinol and/or zinc. European Journal of Clinical Nutrition 1991;45(11):539-44.
Mwaniki 2002 {published data only}
  • Mwaniki D, Omondi B, Muniu E, Thiong’o F, Ouma J, Magnussen P, et al. Effects on serum retinol of multi-micronutrient supplementation and multi-helminth chemotherapy: a randomised, controlled trial in Kenyan school children. European Journal of Clinial Nutrition 2002;56(7):666-73.
Pollitt 1991 {published data only}
  • Pollitt E, Wayne W, Perez-Escamilla R, Latham M, Stephenson LS. Double blind clinical trial on the effects of helminth infection on cognition. FASEB Journal 1991;5:A1081.
Rohner 2010 {published data only}
  • Rohner F, Zimmermann MB, Amon RJ, Vounatsou P, Tschannen AB, N’Goran EK, et al. In a randomized controlled trial of iron fortification, anthelmintic treatment and intermittent preventive treatment of malaria for anemia control in Ivorian children, only anthelmintic treatment shows modest benefit. Journal of Nutrition 2010;140(3):635-41. [DOI: 10.3945/jn.109.114256]
Steinmann 2008 {published data only}
  • Steinmann P, Zhou XN, Du ZW, Jiang JY, Xiao SH, Wu ZX, et al. Tribendimidine and albendazole for treating soil-transmitted helminths, Strongyloides stercoralis and Taenia spp.: open-label randomized trial. PLoS Neglected Tropical Diseases 2008;2(10):e322.
Stephenson 1980 {published data only}
  • Stephenson LS, Crompton DW, Latham MC, Schulpen TW, Nesheim MC, Jansen AA. Relationships between Ascaris infection and growth of malnourished preschool children in Kenya. American Journal of Clinical Nutrition 1980;33(5):1165-72.
Stephenson 1985 {published data only}
  • Stephenson LS, Latham MC, Kurz KM, Kinoti SN, Oduori ML, Crompton DW. Relationships of Schistosoma hematobium, hookworm and malarial infections and metrifonate treatment to hemoglobin level in Kenyan school children. American Journal of Tropical Medicine and Hygiene 1985;34(3):519-28.
Tanumihardjo 1996 {published data only}
  • Tanumihardjo SA, Permaesih D, Muherdiyantiningsih, Rustan E, Rusmil K, Fatah AC, et al. Vitamin A status of Indonesian children infected with Ascaris lumbricoides after dosing with vitamin A supplements and albendazole. Journal of Nutrition 1996;126(2):451-7.
Tanumihardjo 2004 {published data only}
  • Tanumihardjo SA, Permaesih D, Muhilal. Vitamin A status and hemoglobin concentrations are improved in Indonesian children with vitamin A and deworming interventions. European Journal of Clinical Nutrition 2004;58(9):1223-30.
Taylor 2001 {published data only}
  • Taylor M, Jinabhai CC, Couper I, Kleinschmidt I, Jogessar VB. The effect of different anthelmintic treatment regimens combined with iron supplementation on the nutritional status of schoolchildren in KwaZulu-Natal, South Africa: a randomized controlled trial. Transactions of the Royal Society of Tropical Medicine and Hygiene 2001;95(2):211-6.
Thein-Hlaing 1991 {published data only}
  • Thein-Hlaing, Thane-Toe, Than-Saw, Myat-Lay-Kyin, Myint-Lwin. A controlled chemotherapeutic intervention trial on the relationship between Ascaris lumbricoides infection and malnutrition in children. Transactions of the Royal Society of Tropical Medicine and Hygiene 1991;85(4):523-8.
Uscátegui 2009 {published data only}
  • Uscátegui RM, Correa AM, Carmona-Fonseca J. Changes in retinol, hemoglobin and ferritin concentrations in Colombian children with malaria. Biomédica: revista del Instituto Nacional de Salud 2009;29(2):270-81.
Wright 2009 {published data only}
  • Wright VJ, Ame SM, Haji HS, Weir RE, Goodman D, Pritchard DI, et al. Early exposure of infants to GI nematodes induces Th2 dominant immune responses which are unaffected by periodic anthelminthic treatment. PLoS Neglected Tropical Diseases 2009;3(5):e433.
Yang 2003 {published data only}
  • Yang WP, Shao JO, Chen YJ. Effect of chemotherapeutic regimens on soil-transmitted nematode infections in areas with low endemicity. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 2003;21(2):128.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Alam 2006 {unpublished data only}
  • Alam MM, Principal Investigator, ICDDR, B: Centre for Health and Population Research. Relative efficacy of two regimens of ante-helminthic treatment. ClinicalTrials.gov identifier: NCT00367627.
Elliot 2007 {published data only}
  • Elliott AM, Kizza M, Quigley MA, Ndibazza J, Nampijja M, Muhangi L, et al. The impact of helminths on the response to immunization and on the incidence of infection and disease in childhood in Uganda: design of a randomized, double-blind, placebo-controlled, factorial trial of deworming interventions delivered in pregnancy and early childhood [ISRCTN32849447].. Clinical Trials (London, England). 2007; 4(1):42-57; ISSN: CN-00587053.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Albonico 2008
  • Albonico M, Allen H, Chitsulo L, Engels D, Gabrielli AF, Savioli L. Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy. PLoS Neglected Tropical Diseases 2008;2(3):e126.
Anderson 1991
  • Anderson RM, May RM. Infectious diseases of humans: dynamics and control. Oxford: Oxford University Press, 1991.
Bethony 2006
Bleakely 2004
Bundy 2000
  • Bundy D, Peto R. Treatment for intestinal helminth infection. Studies of short term treatment cannot assess long term benefits of regular treatment. BMJ (Clinical research ed.) 2000;321(7270):1225.
Bundy 2009
  • Bundy DA, Kremer M, Bleakley H, Jukes MC, Miguel E. Deworming and development: asking the right questions, asking the questions right. PLoS Neglected Tropical Diseases 2009;3(1):e362.
Callender 1998
Cappello 2004
Chan 1997
Cochrane Collaboration 2002
  • Alderson P, Green S (editors). Meta-analysis of continuous data: Deciding on a change (from baseline). The Cochrane Collaboration: Open learning material for reviewers (Available at http://www.cochrane-net.org/openlearning/html/modA1-6.htm). 2002.
Cooper 2000
Copenhagen Consensus Center 2012
  • Copenhagen Consensus Center. Copenhagen Consensus 2012. http://www.copenhagenconsensus.com/Default.aspx?ID=1626 (accessed 22nd May 2012).
Crompton 2000
Crompton 2003
  • Crompton DWT, Torlesse H, Hodges ME. Hookworm infection and iron status. In: Crompton DWT, Montresor A, Nesheim MC, Savioli L editor(s). Controlling disease due to helminth infections. Geneva: World Health Organization, 2003:23-32.
Danso-Appiah 2008
de Silva 2003a
de Silva 2003b
Deworm the World 2012
  • Deworm the World. [The Evidence For School-Based Deworming]. http://www.dewormtheworld.org/?q=node/105 (accessed 22nd May 2012).
Engels 2009
GiveWell 2011
  • GiveWell 2011. Errors in DCP2 cost-effectiveness estimate for deworming. http://blog.givewell.org/2011/09/29/errors-in-dcp2-cost-effectiveness-estimate-for-deworming/ (accessed 22nd May 2012).
GRADE 2004
  • Jan Brozek, Andrew Oxman, Holger Schunemann. GRADEpro. Version 3.2 for Windows. Jan Brozek, Andrew Oxman, Holger Schunemann, 2008.
Gulani 2007
  • Gulani A, Nagpal J, Osmond C, Sachdev HP. Effect of administration of intestinal anthelmintic drugs on haemoglobin: systematic review of randomised controlled trials. BMJ 2007;334(7603):1095.
Haider 2009
Hall 2008
Higgins 2011a
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Higgins 2011b
  • Higgins JP, Altman DG, Gotzsche PC, Juni P, Moher D, Oxman AD, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ 2011; Vol. 343:d5928.
Horton 2003
Hotez 2006b
  • Hotez P, Bundy D, Beegle K, Brooker S, Drake L, se Silva N, et al. Helminth infections: Soil-transmitted helminth infections and schistosomiasis. Disease control priorities in developing countries. 2nd Edition. New York: Oxford University Press, 2006:467-82.
Hotez 2009
Hotez 2011a
  • Hotez PJ. New antipoverty drugs, vaccines, and diagnostics: a research agenda for the US President's Global Health Initiative (GHI). PLoS Neglected Tropical Diseases 2011;5(5):e1133.
Hotez 2011b
  • Hotez PJ. Unleashing “Civilian Power”: A new American diplomacy through neglected tropical disease control, elimination, research, and development. PLoS Neglected Tropical Diseases 2011;5(6):e1134.
Jamison 2006
  • Jamison DT, Breman JG, Measham AR, Alleyne G, Claeson M. Evans DB, et al (editors). Disease Control Priorities in Developing Countries. 2nd Edition. New York: Oxford University Press and the World Bank, 2006.
Kvalsvig 2003
  • Kvalsvig JD. Parasites, nutrition, child development and public policy. In: Crompton DWT, Montresor A, Nesheim MC, Savioli L editor(s). Controlling disease due to helminth infections. Geneva: World Health Organization, 2003:55-65.
Lefebvre 2011
  • Lefebvre C, Manheimer E, Glanville J. Chapter 6: Searching for studies. In: Higgins JPT, Green S editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1 (updated March 2011). The Cochrane Collaboration, 2011.
Moher 2001
  • Moher D, Schulz KF, Altman DG for the CONSORT Group. The CONSORT statement: Revised recommendations for improving the quality of reports of parallel group randomized trials 2001. www.consort-statement.org/Statement/revisedstatement.htm (accessed 3 August 2005).
Molyneux 2005
  • Molyneux DH, Hotez PJ, Fenwick A. "Rapid-impact interventions": How a policy of integrated control for Africa's neglected tropical diseases could benefit the poor. PLoS Medicine 2005;2(11):e336.
Montresor 2002
  • Montresor A, Crompton DWT, Gyorkos TW, Savioli L. Helminth control in school-age children: a guide for managers of control programmes. Geneva: World Health Organization, 2002.
Review Manager 5
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.1 for Windows. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2011.
Sakti 1999
Savioli 2000
  • Savioli L, Neira M, Albonico M, Beach MJ, Chwaya HM, Crompton DW, et al. Treatment for intestinal helminth infection. Review needed to take account of all relevant evidence, not only effects on growth and cognitive performance. BMJ 2000;321(7270):1226-7.
Savioli 2002
  • Savioli L, Montresor A, Albonico M. Control strategies. In: Holland CV, Kennedy MW editor(s). The geohelminths: Ascaris, Trichuris and Hookworm. Netherlands: Kluwer Academic Publishers, 2002:25-37.
Stephenson 2000
Taylor-Robinson 2007
WHO 2002
  • WHO Expert Committee on the Control of Schistosomiasis (2001: Geneva, Switzerland). Prevention and control of schistosomiasis and soil-transmitted helminthiasis: report of a WHO expert committee. WHO technical report series no. 912. Geneva: World Health Organization, 2002.
WHO 2005
  • World Health Organization. Strategy Development and Monitoring for Parasitic Diseases and Vector Control Team. Deworming: The Millennium Development Goals. The evidence is in: deworming helps meet the Millennium Development Goals [WHO/CDS/CPE/PVC/2005.12]. Geneva: World Health Organization, 2005.
WHO 2006a
  • World Health Organization. WHO Essential Medicines Library. mednet3.who.int/emlib/ 2006 (accessed 13 June 2007).
WHO 2006b
  • WHO. Preventive chemotherapy in human helminthiasis: coordinated use of anthelminthic drugs in control interventions: a manual for health professionals and programme managers. Accessed at http://whqlibdoc.who.int/publications/2006/9241547103_eng.pdf. WHO, 2006.
WHO 2007
  • WHO. Action against worms. http://www.who.int/wormcontrol/newsletter/PPC8_eng.pdf 2007.
WHO 2010
  • WHO. Monitoring drug coverage for preventive chemotherapy. http://whqlibdoc.who.int/publications/2010/9789241599993_eng.pdf 2010.
World 2011
  • World Bank. School Deworming http://web.worldbank.org/WBSITE/EXTERNAL/TOPICS/EXTHEALTHNUTRITIONANDPOPULATION/EXTPHAAG/0,,contentMDK:20785786˜menuPK:1314819˜pagePK:64229817˜piPK:64229743˜theSitePK:672263,00.html(accessed 10th Jan 2012). 2011.
World Bank 1993
  • The World Bank. World Development Report 1993: Investing in health. Oxford: Oxford University Press, 1993.

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Dickson 2000a
  • Dickson R, Awasthi S, Demellweek C, Williamson P. Anthelmintic drugs for treating worms in children: effects on growth and cognitive performance. Cochrane Database of Systematic Reviews 2000, Issue 2. [DOI: 10.1002/14651858.CD000371]
Dickson 2000b
  • Dickson R, Awasthi S, Williamson P, Demellweek C, Garner P. Effects of treatment for intestinal helminth infection on growth and cognitive performance in children: systematic review of randomised trials. BMJ 2000;320(7251):1697-701.