The term 'challenging behaviour', in the absence of psychiatric disorder, encompasses a wide range of behaviours that may be harmful to people or property, may be difficult to manage and may limit access to community facilities. Antipsychotic medications have been used to modify such behaviours in people with learning disability, but there is little evidence to suggest that the benefits outweigh the risks.
To determine the effectiveness of antipsychotic medication for people with learning disability and challenging behaviour without additional mental illness.
Biological Abstracts, the Cochrane Library, EMBASE, MEDLINE, PsycINFO and BIOSIS were searched. Further references were sought from published trials and pharmaceutical companies. Trials were reliably identified and data extracted.
All randomised controlled trials of antipsychotic medication versus placebo.
Data collection and analysis
Reviewers independently evaluated and analysed data on an intention to treat basis. Data were evaluated at 4, 8 and 12 weeks as longer follow-up data were not available. Reviewers assumed that those subjects lost to follow-up had a bad outcome.
Only nine randomised controlled trials could be included in the analyses. These provided no evidence of whether antipsychotic medication helps or harms adults with learning disability and challenging behaviour.
There are limited data on this important issue and more research is urgently needed.
使用抗精神病藥物 (Antipsychotic medication) 治療有學習障礙病人的挑戰性行為 (challenging behaviour)
搜尋Biological Abstracts, the Cochrane Library, EMBASE, MEDLINE, PsycINFO 和 BIOSIS.進一步文獻來源為已發表的試驗和藥廠。試驗經可靠的確認且節錄資料。
撰文者獨立評估和分析意圖治療 (intention to treat) 族群的資料。因為沒有更長期追蹤的資料，故分析第4ˋ8ˋ12週的資料。撰文者假設失去追蹤的受試者有不好的結果。
此翻譯計畫由臺灣國家衛生研究院 (National Health Research Institutes, Taiwan) 統籌。