Intervention Review

Antipsychotic medication for challenging behaviour in people with learning disability

  1. Jane Brylewski2,
  2. Lorna Duggan1,*

Editorial Group: Cochrane Developmental, Psychosocial and Learning Problems Group

Published Online: 19 JUL 2004

Assessed as up-to-date: 30 NOV 2003

DOI: 10.1002/14651858.CD000377.pub2


How to Cite

Brylewski J, Duggan L. Antipsychotic medication for challenging behaviour in people with learning disability. Cochrane Database of Systematic Reviews 2004, Issue 3. Art. No.: CD000377. DOI: 10.1002/14651858.CD000377.pub2.

Author Information

  1. 1

    Care Principles Ltd, Newmarket, Suffolk, UK

  2. 2

    Oxford, UK

*Lorna Duggan, Care Principles Ltd, Oaks Lodge, Fordham Road, Newmarket, Suffolk, CB8 7XN, UK. lornaduggan@yahoo.co.uk. Lorna.Duggan@careprinciples.com.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 19 JUL 2004

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Abstract

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

Background

The term 'challenging behaviour', in the absence of psychiatric disorder, encompasses a wide range of behaviours that may be harmful to people or property, may be difficult to manage and may limit access to community facilities. Antipsychotic medications have been used to modify such behaviours in people with learning disability, but there is little evidence to suggest that the benefits outweigh the risks.

Objectives

To determine the effectiveness of antipsychotic medication for people with learning disability and challenging behaviour without additional mental illness.

Search methods

Biological Abstracts, the Cochrane Library, EMBASE, MEDLINE, PsycINFO and BIOSIS were searched. Further references were sought from published trials and pharmaceutical companies. Trials were reliably identified and data extracted.

Selection criteria

All randomised controlled trials of antipsychotic medication versus placebo.

Data collection and analysis

Reviewers independently evaluated and analysed data on an intention to treat basis. Data were evaluated at 4, 8 and 12 weeks as longer follow-up data were not available. Reviewers assumed that those subjects lost to follow-up had a bad outcome.

Main results

Only nine randomised controlled trials could be included in the analyses. These provided no evidence of whether antipsychotic medication helps or harms adults with learning disability and challenging behaviour.

Authors' conclusions

There are limited data on this important issue and more research is urgently needed.

 

Plain language summary

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

Antipsychotic medication for challenging behaviour in people with learning disability

The term 'challenging behaviour', in the absence of psychiatric disorder, encompasses a wide range of behaviours that may be harmful to people or property, may be difficult to manage and may limit access to community facilities. Antipsychotic medications have been used to modify such behaviours in people with learning disability, but there is no randomised controlled trial-based information that suggests antipsychotic medication is either helpful or harmful for adults with learning disability and challenging behaviour.

 

摘要

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

背景

使用抗精神病藥物 (Antipsychotic medication) 治療有學習障礙病人的挑戰性行為 (challenging behaviour)

沒有精神疾病的挑戰性行為包羅萬象,這些行為可能對人或物有害ˋ可能不容易控制且可能限制病人使用社區設施。抗精神病藥物已經被用於治療有學習障礙病人的挑戰性行為,但沒什麼證據顯示此治療的益處勝過風險。

目標

確認抗精神病藥物用於矯正有學習障礙和挑戰性行為但沒有其他精神疾病的病人之藥效

搜尋策略

搜尋Biological Abstracts, the Cochrane Library, EMBASE, MEDLINE, PsycINFO 和 BIOSIS.進一步文獻來源為已發表的試驗和藥廠。試驗經可靠的確認且節錄資料。

選擇標準

所有比較抗精神病藥物和安慰劑的隨機對照試驗。

資料收集與分析

撰文者獨立評估和分析意圖治療 (intention to treat) 族群的資料。因為沒有更長期追蹤的資料,故分析第4ˋ8ˋ12週的資料。撰文者假設失去追蹤的受試者有不好的結果。

主要結論

只有9個隨機對照試驗可被納入此分析。這些試驗結果表示:沒有證據可證明抗精神病藥物有助或是有害於有學習障礙和挑戰性行為的成人

作者結論

在此重要議題上只有有限資料,急需更多研究。

翻譯人

本摘要由成功大學附設醫院尹子真翻譯。

此翻譯計畫由臺灣國家衛生研究院 (National Health Research Institutes, Taiwan) 統籌。

總結

尚缺摘要