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Early trophic feeding versus enteral fasting for very preterm or very low birth weight infants

  1. Jessie Morgan1,
  2. Sarah Bombell2,
  3. William McGuire1,*

Editorial Group: Cochrane Neonatal Group

Published Online: 28 MAR 2013

Assessed as up-to-date: 27 DEC 2012

DOI: 10.1002/14651858.CD000504.pub4


How to Cite

Morgan J, Bombell S, McGuire W. Early trophic feeding versus enteral fasting for very preterm or very low birth weight infants. Cochrane Database of Systematic Reviews 2013, Issue 3. Art. No.: CD000504. DOI: 10.1002/14651858.CD000504.pub4.

Author Information

  1. 1

    Hull York Medical School & Centre for Reviews and Dissemination, University of York, York, UK

  2. 2

    Australian National University, Centre for Newborn Care, Canberra, Australia

*William McGuire, Hull York Medical School & Centre for Reviews and Dissemination, University of York, York, Y010 5DD, UK. William.McGuire@hyms.ac.uk.

Publication History

  1. Publication Status: New search for studies and content updated (conclusions changed)
  2. Published Online: 28 MAR 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Becerra 1996 {published and unpublished data}
  • Becerra M, Ambiado S, Kuntsman G, Figueroa A, Balboa P, Fernandez P, et al. Feeding VLBW infants; Effect of early enteral stimulation (EES) [abstract]. Pediatric Research 1996;39:304A.
Dunn 1988 {published data only}
  • Dunn L, Hulman S, Weiner J, Kleigman R. Beneficial effects of early hypocaloric enteral feeding on neonatal gastrointestinal function: preliminary report of a randomized trial. Journal of Pediatrics 1988;112(4):622-9.
McClure 2000 {published and unpublished data}
  • McClure RJ, Newell SJ. Randomised controlled trial of clinical outcome following trophic feeding. Archives of Disease in Childhood. Fetal and Neonatal Edition 2000;82(1):F29-F33.
  • McClure RJ, Newell SJ. Randomised controlled trial of trophic feeding and gut motility. Archives of Disease in Childhood. Fetal and Neonatal Edition 1999;80(1):F54-8.
  • McClure RJ, Newell SJ. Randomized controlled study of digestive enzyme activity following trophic feeding. Acta Paediatrica 2002;91(3):292-6.
Meetze 1992 {published data only}
  • Meetze WH, Valentine C, McGuigan JE, Conlon M, Sacks N, Neu J. Gastrointestinal priming prior to full enteral nutrition in very low birth weight infants. Journal of Pediatric Gastroenterology and Nutrition 1992;15(2):163-70.
Mosqueda 2008 {published data only}
  • Mosqueda E, Sapiegiene L, Glynn L, Wilson-Costello D, Weiss M. The early use of minimal enteral nutrition in extremely low birth weight newborns. Journal of Perinatology 2008;28(4):264-9.
Sáenz de Pipaón 2003 {published and unpublished data}
  • Sáenz de Pipaón M, VanBeek RH, Quero J, Perez J, Wattimena DJ, Sauer PJ. Effect of minimal enteral feeding on splanchnic uptake of leucine in the postabsorptive state in preterm infants. Pediatric Research 2003;53(2):281-7.
Schanler 1999 {published and unpublished data}
  • Schanler RJ, Shulman RJ, Lau C, Smith EO, Heitkemper MM. Feeding strategies for premature infants: randomized trial of gastrointestinal priming and tube-feeding method. Pediatrics 1999;103(2):434-9.
  • Shulman RJ, Schanler RJ, Lau C, Heitkemper M, Ou C, Smith EO. Early feeding, antenatal glucocorticoids, and human milk decrease intestinal permeability in preterm infants. Pediatric Research 1998;44(4):519-23.
  • Shulman RJ, Schanler RJ, Lau C, Heitkemper M, Ou C, Smith EO. Early feeding, feeding tolerance, and lactase activity in preterm infants. Journal of Pediatrics 1998;133(5):645-9.
Troche 1995 {published data only}
  • Troche B, Harvey-Wilkes K, Engle WD, Nielsen HC, Frantz ID, Mitchell ML, et al. Early minimal feedings promote growth in critically ill premature infants. Biology of the Neonate 1995;67(3):172-81.
van Elburg 2004 {published data only}
  • van Elburg RM, van den Berg A, Bunkers CM, van Lingen RA, Smink EW, van Eyck J, et al. Minimal enteral feeding, fetal blood flow pulsatility, and postnatal intestinal permeability in preterm infants with intrauterine growth retardation. Archives of Disease in Childhood, Fetal and Neonatal Edition 2004;89(4):F293-6.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Berseth 1992 {published data only}
Berseth 1993 {published data only}
  • Berseth CL, Nordyke C. Enteral nutrients promote postnatal maturation of intestinal motor activity in preterm infants. American Journal of Physiology 1993;264(6 Pt 1):G1046-51.
Berseth 2003 {published and unpublished data}
  • Berseth CL, Bisquera JA, Paje VU. Prolonging small feeding volumes early in life decreases the incidence of necrotizing enterocolitis in very low birth weight infants. Pediatrics 2003;111(3):529-34.
LaGamma 1985 {published data only}
  • LaGamma EF, Ostertag S, Birenbaum H. Failure of delayed oral feedings to prevent necrotizing enterocolitis. American Journal of Diseases of Children 1985;139(4):385-9.
Ostertag 1986 {published data only}
  • Ostertag SG, LaGamma EF, Reisen CE, Ferrentino FL. Early enteral feeding does not affect the incidence of necrotizing enterocolitis. Pediatrics 1986;77(3):275-80.
Said 2008 {published data only}
  • Said H, Elmetwally D, Said D. Randomised controlled trial of early versus late enteral feeding of prematurely born infants with birth weight <1200 grams. Kasr El Aini Medical Journal 2008;14:1-10.
Slagle 1988 {published data only}
Weiler 2006 {published data only}
  • Weiler HA, Fitzpatrick-Wong SC, Schellenberg JM, Fair DE, McCloy UR, Veitch RR, et al. Minimal enteral feeding within 3 d of birth in prematurely born infants with birth weight < or = 1200 g improves bone mass by term age. American Journal of Human Nutrition 2006;83(1):155-62.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Aynsley-Green 1983
  • Aynsley-Green A. Hormones and postnatal adaptation to enteral nutrition. Journal of Pediatric Gastroenterology and Nutrition 1983;2(3):418-27.
Bernstein 2000
  • Bernstein IM, Horbar JD, Badger GJ, Ohlsson A, Golan A. Morbidity and mortality among very-low-birth-weight neonates with intrauterine growth restriction. The Vermont Oxford Network. American Journal of Obstetrics and Gynecology 2000;182(1 Pt 1):198-206.
Berseth 1990
Dorling 2005
  • Dorling J, Kempley S, Leaf A. Feeding growth restricted preterm infants with abnormal antenatal Doppler results. Archives of Disease in Childhood. Fetal and Neonatal Edition 2005;90(5):F359-63.
Flidel-Rimon 2004
  • Flidel-Rimon O, Friedman S, Lev E, Juster-Reicher A, Amitay M, Shinwell ES. Early enteral feeding and nosocomial sepsis in very low birthweight infants. Archives of Disease in Childhood. Fetal and Neonatal Edition 2004;89(4):289-92.
Flidel-Rimon 2006
Henderson 2009
  • Henderson G, Craig S, Brocklehurst P, McGuire W. Enteral feeding regimens and necrotising enterocolitis in preterm infants: a multicentre case-control study. Archives of Disease in Childhood. Fetal and Neonatal Edition 2009;94(2):F120-3.
Johnson 1976
Klingenberg 2012
  • Klingenberg C, Embleton ND, Jacobs SE, O’Connell LAF, Kuschel CA. Enteral feeding practices in very preterm infants: an international survey. Archives of Disease in Childhood. Fetal and Neonatal Edition 2012;97(1):F56-61.
Lucas 1990
McClure 2001
  • McClure RJ. Trophic feeding of the preterm infant. Acta Paediatrica. Supplement 2001;90(436):19-21.
McHale 2010
Meinzen-Derr 2009
  • Meinzen-Derr J, Poindexter B, Wrage L, Morrow AL, Stoll B, Donovan EF. Role of human milk in extremely low birth weight infants' risk of necrotizing enterocolitis or death. Journal of Perinatology 2009;29(1):57-62.
Morgan 2011a
  • Morgan J, Young L, McGuire W. Delayed introduction of progressive enteral feeds to prevent necrotising enterocolitis in very low birth weight infants. Cochrane Database of Systematic Reviews 2011, Issue 3. [DOI: 10.1002/14651858.CD001970.pub3]
Morgan 2011b
  • Morgan J, Young L, McGuire W. Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants. Cochrane Database of Systematic Reviews 2011, Issue 3. [DOI: 10.1002/14651858.CD001241.pub3]
Patole 2005
  • Patole SK, de Klerk N. Impact of standardised feeding regimens on incidence of neonatal necrotising enterocolitis: a systematic review and meta-analysis of observational studies. Archives of Disease in Childhood. Fetal and Neonatal Edition 2005;90(2):147-51.
Premji 2011
Quigley 2007
Rees 2007
  • Rees CM, Pierro A, Eaton S. Neurodevelopmental outcomes of neonates with medically and surgically treated necrotizing enterocolitis. Archives of Disease in Childhood. Fetal and Neonatal Edition 2007;92(3):193-8.
Tyson 2007
Walsh 1986

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Bombell 2009
Tyson 1997
  • Tyson JE, Kennedy KA. Minimal enteral nutrition for promoting feeding tolerance and preventing morbidity in parenterally fed infants. Cochrane Database of Systematic Reviews 1997, Issue 4. [DOI: 10.1002/14651858.CD000504]
Tyson 2005