Intervention Review

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Drugs for treating Schistosoma mansoni infection

  1. Anthony Danso-Appiah1,*,
  2. Piero L Olliaro2,
  3. Sarah Donegan1,
  4. David Sinclair1,
  5. Jürg Utzinger3,4

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 28 FEB 2013

Assessed as up-to-date: 16 OCT 2012

DOI: 10.1002/14651858.CD000528.pub2


How to Cite

Danso-Appiah A, Olliaro PL, Donegan S, Sinclair D, Utzinger J. Drugs for treating Schistosoma mansoni infection. Cochrane Database of Systematic Reviews 2013, Issue 2. Art. No.: CD000528. DOI: 10.1002/14651858.CD000528.pub2.

Author Information

  1. 1

    Liverpool School of Tropical Medicine, International Health Group, Liverpool, UK

  2. 2

    World Health Organization, UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), Geneva, Switzerland

  3. 3

    Swiss Tropical and Public Health Institute, Department of Epidemiology and Public Health, Basel, Switzerland

  4. 4

    University of Basel, Basel, Switzerland

*Anthony Danso-Appiah, International Health Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK. tdappiah@yahoo.co.uk.

Publication History

  1. Publication Status: New search for studies and content updated (conclusions changed)
  2. Published Online: 28 FEB 2013

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Abdel Rahim 1988 SDN {published data only}
  • Abdel Rahim IM, Haridi AA, Abdel-Hameed AA. Field study of different oxamniquine dose for Schistosoma mansoni in Gezira, Sudan. Journal of Tropical Medicine and Hygiene 1988;91(3):131-7.
  • Abdel-Rahim IM, Haridi AA, Abdel-Hameed AA. A field evaluation of three dose levels of oxamniquine in Gezira- Sudan. East African Medical Journal 1988;65(11):771-7.
Al Aska 1990 SAU {published data only}
  • Al-Aska AK, Al-Mofleh IA, Al-Rashed R, Hafez MA, Al-Nozha M, Abu-Aisha H, et al. Praziquantel, oxamniquine, and metrifonate in the treatment of schistosomiasis in Riyadh. Annals of Saudi Medicine 1990;10(3):296-8.
Ayele 1984 ETH {published data only}
  • Ayele T. Preliminary clinical trial of oral oxamniquine in the treatment of Schistosoma mansoni in Ethiopia. East African Medical Journal 1984;61(8):632-6.
Ayele 1986 ETH {published data only}
  • Ayele T. Preliminary clinical trial of oral oxamniquine in the treatment of Schistosoma mansoni in children in Ethiopia. East African Medical Journal 1986;63(4):291-4.
Barakat 2005 EGY {published data only}
  • Barakat R, Elmorshedy H, Fenwick A. Efficacy of myrrh in the treatment of human schistosomiasis mansoni. American Journal of Tropical Medicine and Hygiene 2005;73(2):365-7.
Botros 2005 EGY {published data only}
  • Botros S, Sayed H, El-Dusoki H, Sabry H, Rabie I, El-Ghannam M, et al. Efficacy of mirazid in comparison with praziquantel in Egyptian Schistosoma mansoni-infected school children and households. American Journal of Tropical Medicine and Hygiene 2005;72(2):119-23.
Branchini 1982 BRA {published data only}
  • Branchini ML, Pedro R J de, Dias LC, Deberaldini ER. Double-blind clinical trial comparing praziquantel with oxamniquine in the treatment of patients with schistosomiasis mansoni. Revista do Instituto de Medicina Tropical de São Paulo 1982;24(5):315-21.
Creasey 1986 ZWE {published data only}
  • Creasey AM, Taylor P, Thomas JE. Dosage trial of a combination of oxamniquine and praziquantel in the treatment of schistosomiasis in Zimbabwean schoolchildren. Central African Journal of Medicine 1986;32(7):165-7.
da Cunha 1986 BRA {published data only}
  • da Cunha AS, Pedrosa RC. Double-blind therapeutical evaluation based on the quantitative oogram technique, comparing praziquantel and oxamniquine in human Schistosomiasis mansoni. Revista do Instituto de Medicina Tropical de São Paulo 1986;28(5):337-51.
da Cunha 1987 BRA {published data only}
  • da Cunha AS, Cançado JR, de Rezende GL. Therapeutical evaluation of different dose regimens of praziquantel in schistosomiasis mansoni, based on the quantitative oogram technique. Revista do Instituto de Medicina Tropical de São Paulo 1987;29(5):295-304.
da Silva 1986 BRA {published data only}
  • da Silva LC, Zeitune JM, Rosa-Eid LM, Lima DM, Antonelli RH, Christo CH, et al. Treatment of patients with schistosomiasis mansoni: a double blind clinical trial comparing praziquantel with oxamniquine. Revista do Instituto de Medicina Tropical de São Paulo 1986;28(3):174-80.
de Clarke 1976a ZWE {published data only}
  • de Clarke V, Blair DM, Weber MC, Garnett PA. Dose-finding trials of oral oxamniquine in Rhodesia. South African Medical Journal 1976;50(46):1867-71.
de Clarke 1976b ZWE {published data only}
  • de Clarke V, Blair DM, Weber MC, Garnett PA. Dose-finding trials of oral oxamniquine in Rhodesia. South African Medical Journal 1976;50(46):1867-71.
de Clarke 1976c ZWE {published data only}
  • de Clarke V, Blair DM, Weber MC, Garnett PA. Dose-finding trials of oral oxamniquine in Rhodesia. South African Medical Journal 1976;50(46):1867-71.
de Clarke 1976d ZWE {published data only}
  • de Clarke V, Blair DM, Weber MC, Garnett PA. Dose-finding trials of oral oxamniquine in Rhodesia. South African Medical Journal 1976;50(46):1867-71.
De Clercq 2000 SEN {published data only}
  • De Clercq D, Vercruysse J, Verle P, Kongs A, Diop M. What is the effect of combining artesunate and praziquantel in the treatment of Schistosoma mansoni infections?. Tropical Medicine and International Health 2000;5(10):744-6.
de Jonge 1990 SDN {published data only}
  • de Jonge N, Schommer G, Feldmeier H, Krijger FW, Dafalla AA, Bienzle U, et al. Mixed Schistosoma haematobium and S. mansoni infection: effect of different treatments on the serum level of circulating anodic antigen (CAA). Acta Tropica 1990;48(1):25-35.
  • Doehring E, Ehrich JH, Vester U, Feldmeier H, Poggensee U, Brodehl J. Proteinuria, hematuria, and leukocyturia in children with mixed urinary and intestinal schistosomiasis. Kidney International 1985;28(3):520-5.
  • Doehring E, Poggensee U, Feldmeier H. The effect of metrifonate in mixed Schistosoma haematobium and Schistosoma mansoni infections in humans. American Journal of Tropical Medicine and Hygiene 1986;35(2):323-9.
  • Feldmeier H, Gastl GA, Poggensee U, Kortmann C, Daffalla AA, Peter HH. Relationship between intensity of infection and immunomodulation in human schistosomiasis. II. NK cell activity and in vitro lymphocyte proliferation. Clinical and Experimental Immunology 1985;60(2):234-40.
  • Feldmeier H, Nogueira-Queiroz JA, Peixoto-Queiroz MA, Doehring E, Dessaint JP, de Alencar JE, et al. Detection and quantification of circulating antigen in schistosomiasis by monoclonal antibody. II. The quantification of circulating antigens in human schistosomiasis mansoni and haematobium: relationship to intensity of infection and disease status. Clinical and Experimental Immunology 1986;65(2):232-43.
Fernandes 1986 BRA {published data only}
  • Fernandes P, Oliveira CC. Efficacy of two regimes of praziquantel versus oxamniquine [Estudo comparativo da eficacia do praziquantel, em dois esquemas posologicos, e da oxaminiquina no tratamento da esquistossomose mansonica]. Folha Medica 1986;93(5-6):389-93.
Ferrari 2003 BRA {published data only}
  • Ferrari ML, Coelho PM, Antunes CM, Tavares CA, da Cunha AS. Efficacy of oxamniquine and praziquantel in the treatment of Schistosoma mansoni infection: a controlled trial. Bulletin of the World Health Organization 2003;81(3):190-6.
Gryseels 1989a BDI {published data only}
  • Gryseels B, Nkulikyinka L. Two-year follow-up of Schistosoma mansoni infection and morbidity after treatment with different regimens of oxamniquine and praziquantel. Transactions of the Royal Society of Tropical Medicine and Hygiene 1989;83(2):219-28.
Gryseels 1989b BDI {published data only}
  • Gryseels B, Nkulikyinka L. Two-year follow-up of Schistosoma mansoni infection and morbidity after treatment with different regimens of oxamniquine and praziquantel. Transactions of the Royal Society of Tropical Medicine and Hygiene 1989;83(2):219-28.
Gryseels 1989c BDI {published data only}
  • Gryseels B, Nkulikyinka L. Two-year follow-up of Schistosoma mansoni infection and morbidity after treatment with different regimens of oxamniquine and praziquantel. Transactions of the Royal Society of Tropical Medicine and Hygiene 1989;83(2):219-28.
Guisse 1997 SEN {published data only}
  • Guisse F, Polman K, Stelma FF, Mbaye A, Talla I, Niang M, et al. Therapeutic evaluation of two different dose regimens of praziquantel in a recent Schistosoma mansoni focus in Northern Senegal. American Journal of Tropical Medicine and Hygiene 1997;56(5):511-4.
Gupta 1984 ZMB {published data only}
Homeida 1989 SDN {published data only}
  • Homeida MM, Eltom IA, Sulaiman SM, Ali HM, Bennett JL. Tolerance of two brands of praziquantel. Lancet 1989;334(8659):391.
Ibrahim 1980 SDN {published data only}
Jaoko 1996 KEN {published data only}
  • Jaoko WG, Muchemi G, Oguya FO. Praziquantel side effects during treatment of Schistosoma mansoni infected pupils in Kibwezi, Kenya. East African Medical Journal 1996;73(8):499-501.
Kardaman 1983 SDN {published data only}
  • Kardaman MW, Amin MA, Fenwick A, Cheesmond AK, Dixon HG. A field trial using praziquantel (Biltricide) to treat Schistosoma mansoni and Schistosoma haematobium infection in Gezira, Sudan. Annals of Tropical Medicine and Parasitology 1983;77(3):297-304.
Kardaman 1985 SDN {published data only}
  • Kardaman MW, Fenwick A, el Igail AB, el Tayeb M, Daffalla AA, Dixon HG. Treatment with praziquantel of schoolchildren with concurrent Schistosoma mansoni and S. haematobium infections in Gezira, Sudan. Journal of Tropical Medicine and Hygiene 1985;88(2):105-9.
Katz 1979a BRA {published data only}
Katz 1979b BRA {published data only}
Katz 1981 BRA {published data only}
  • Katz N. Clinical trials with praziquantel in schistosomiasis mansoni. Revista do Instituto de Medicina Tropical de São Paulo 1981;23(2):72-8.
Katz 1982 BRA {published data only}
  • Katz N, Rocha RS. Double-blind clinical trial comparing praziquantel with oxamniquine in schistosomiasis mansoni. Revista do Instituto de Medicina Tropical de São Paulo 1982;24(5):310-4.
Lambertucci 1982 BRA {published data only}
  • Lambertucci JR, Greco DB, Pedroso ER, da Costa Rocha MO, Salazar HM, de Lima DP. A double blind trial with oxamniquine in chronic schistosomiasis mansoni. Transactions of the Royal Society of Tropical Medicine and Hygiene 1982;76(6):751-5.
Metwally 1995 EGY {published data only}
Olds 1999 KEN {published data only}
  • Olds GR, King CH, Hewlett J, Olveda R, Wu G, Ouma J, et al. Double-blind placebo-controlled study of concurrent administration of albendazole and praziquantel in schoolchildren with schistosomiasis and geohelminths. Journal of Infectious Diseases 1999;179(4):996-1003.
Olliaro 2011 BRA {published data only}
  • Olliaro P, Vaillant M, Belizario V, Lwambo N, Ouldabdallahi M, Pieri OS, et al. A multicentre randomized controlled trial of the efficacy and safety of single-dose praziquantel at 40 mg/kg versus 60 mg/kg for treating intestinal schistosomiasis in the Philippines, Mauritania, Tanzania and Brazil. PLoS Neglected Tropical Diseases 2011;5(6):e1165.
Olliaro 2011 MRT {published data only}
  • Olliaro P, Vaillant M, Belizario V, Lwambo N, Ouldabdallahi M, Pieri OS, et al. A multicentre randomized controlled trial of the efficacy and safety of single-dose praziquantel at 40 mg/kg versus 60 mg/kg for treating intestinal schistosomiasis in the Philippines, Mauritania, Tanzania and Brazil. PLoS Neglected Tropical Diseases 2011;5(6):e1165.
Olliaro 2011 TZA {published data only}
  • Olliaro P, Vaillant M, Belizario V, Lwambo N, Ouldabdallahi M, Pieri OS, et al. A multicentre randomized controlled trial of the efficacy and safety of single-dose praziquantel at 40 mg/kg versus 60 mg/kg for treating intestinal schistosomiasis in the Philippines, Mauritania, Tanzania and Brazil. PLoS Neglected Tropical Diseases 2011;5(6):e1165.
Omer 1978 SDN {published data only}
Omer 1981 SDN {published data only}
Queiroz 2010 BRA {published data only}
  • Queiroz LC, Drummond SC, Matos ML, Paiva MB, Batista TS, Kansaon AZ, et al. Comparative randomised trial of high and conventional doses of praziquantel in the treatment of schistosomiasis mansoni. Memorias do Instituto Oswaldo Cruz 2010;105(4):445-8.
Rezende 1985 BRA {published data only}
  • Rezende GL de. Survey on the clinical results achieved in Brazil comparing praziquantel and oxamniquine in the treatment of S. mansoni schistosomiasis. Revista do Instituto de Medicina Tropical de São Paulo 1985;27(6):328-68.
Rugemalila 1984 TZA {published data only}
  • Rugemalila JB, Asila J, Chimbe A. Randomized comparative trials of single doses of the newer antischistosomal drugs at Mwanza, Tanzania. I. Praziquantel and oxamniquine for the treatment of schistosomiasis mansoni. Journal of Tropical Medicine and Hygiene 1984;87(6):231-5.
Shafei 1979 NGA {published data only}
  • Shafei AZ. A preliminary report on the treatment of intestinal schistosomiasis with oxamniquine. Journal of Tropical Medicine and Hygiene 1979;82(1):18-20.
Stelma 1997 SEN {published data only}
  • Stelma FF, Sall S, Daff B, Sow S, Niang M, Gryseels B. Oxamniquine cures Schistosoma mansoni infection in a focus in which cure rates with praziquantel are unusually low. Journal of Infectious Diseases 1997;176(1):304-7.
Sukwa 1993 ZMB {published data only}
  • Sukwa TY. A community-based randomized trial of praziquantel to control schistosomiasis morbidity in schoolchildren in Zambia. Annals of Tropical Medicine and Parasitology 1993;87(2):185-94.
Taddese 1988 ETH {published data only}
  • Taddese K, Zein ZA. Comparison between the efficacy of oxamniquine and praziquantel in the treatment of Schistosoma mansoni infections on a sugar estate in Ethiopia. Annals of Tropical Medicine and Parasitology 1988;82(2):175-80.
Taylor 1988 ZWE {published data only}
  • Taylor P, Murare HM, Manomano K. Efficacy of low doses of praziquantel for Schistosoma mansoni and S. haematobium. Journal of Tropical Medicine and Hygiene 1988;91(1):13-7.
Teesdale 1984 MWI {published data only}
Tweyongyere 2009 UGA {published data only}
  • Tweyongyere R, Mawa PA, Emojong NO, Mpairwe H, Jones FM, Duong T, et al. Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on intensity of infection and antibody responses to schistosome antigens: results of a randomised, placebo-controlled trial. BMC Infectious Diseases 2009;9:32.
  • Tweyongyere R, Mawa PA, Ngom-Wegi S, Ndibazza J, Duong T, Vennervald BJ, et al. Effect of praziquantel treatment during pregnancy on cytokine responses to schistosome antigens: results of a randomized, placebo-controlled trial. Journal of Infectious Diseases 2008;198(12):1870-9.
Zwingenberger 1987 BRA {published data only}
  • Zwingenberger K, Queiroz JA, Poggensee U, Alencar JE, Valdegunas J, Esmeralda F, et al. Efficacy of oxamniquine, praziquantel and a combination of both drugs in schistosomiasis mansoni in Brazil. Revista do Instituto de Medicina Tropical de São Paulo 1987;29(5):305-11.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Abu-Elyazeed 1997 {published data only}
  • Abu-Elyazeed RR, Youssef FG, Merrell BR, El-Gamal RL, El-Khoby TA, Hassanein YA, et al. Praziquantel in the treatment of Schistosoma mansoni infection: comparison of 40 and 60 mg/kg bodyweight regimens. American Journal of Tropical Medicine and Hygiene 1997;56(4):404-7.
Adam 2008 {published data only}
  • Adam I, Elhardello OA, Elhadi MO, Abdalla E, Elmardi KA, Jansen FH. The antischistosomal efficacies of artesunate-sulfamethoxypyrazine-pyrimethamine and artemether-lumefantrine administered as treatment for uncomplicated Plasmodium falciparum malaria. Annals of Tropical Medicine and Parasitology 2008;102(1):39-44.
Almeida 2012 {published data only}
  • Almeida MCF, Lima GS, Cardoso LS, Souza RPD, Campos RA, Cruz AA, et al. The effect of antihelminthic treatment on subjects with asthma from an endemic area of schistosomiasis: A randomized, double-blinded, and placebo-controlled trial. Journal of Parasitology Research 2012;2012(296856):1-11.
Assis 1998 {published data only}
  • Assis AM, Barreto ML, Prado MS, Reis MG, Parraga IM, Blanton RE. Schistosoma mansoni infection and nutritional status in schoolchildren: a randomized, double-blind trial in northeastern Brazil. American Journal of Clinical Nutrition 1998;86(6):1247-53.
Boisier 1998 {published data only}
  • Boisier P, Ramarokoto CE, Ravaoalimalala VE, Rabarijaona L, Serieye J, Roux J, et al. Reversibility of Schistosoma mansoni-associated morbidity after yearly mass praziquantel therapy: ultrasonographic assessment. Transactions of the Royal Society of Tropical Medicine and Hygiene 1998;92(4):451-3.
Coura 1980 {published data only}
  • Coura JR, Argento CA, Conceição MJ, Lewis EM, dos Santos ML, Magalhães P. Field experiences with oral oxamniquine in the treatment of schistosomiasis mansoni. Revista do Instituto de Medicina Tropical de São Paulo 1980;22(1 Suppl 4):77-84.
De Clercq 2000b {published data only}
  • De Clercq D, Vercruysse J, Verlé P, Niasse F, Kongs A, Diop M. Efficacy of artesunate against Schistosoma mansoni infections in Richard Toll, Senegal. Transactions of the Royal Society of Tropical Medicine and Hygiene 2000;94(1):90-1.
Doehring 1992 {published data only}
  • Doehring-Schwerdtfeger E, Abdel-Rahim IM, Kardorff R, Kaiser C, Franke D, Schlake J, et al. Ultrasonographical investigation of periportal fibrosis in children with Schistosoma mansoni infection: reversibility of morbidity twenty-three months after treatment with praziquantel. American Journal of Tropical Medicine and Hygiene 1992;46(4):409-15.
Eigege 2008 {published data only}
  • Eigege A, Pede E, Miri E, Umaru J, Ogbu Pearce P, Jinadu MY, et al. Triple drug administration (TDA), with praziquantel, ivermectin and albendazole, for the prevention of three neglected tropical diseases in Nigeria. Annals of Tropical Medicine and Parasitology 2008;102(2):177-9.
el Guiniady 1994 {published data only}
  • el Guiniady MA, el Touny MA, Abdel-Bary MA, Abdel-Fatah SA, Metwally A. Clinical and pharmacokinetic study of praziquantel in Egyptian schistosomiasis patients with and without liver cell failure. American Journal of Tropical Medicine and Hygiene 1994;51(6):809-18.
el-Hawey 1991 {published data only}
  • el-Hawey AM, Massoud AM, el-Rakieby A, Royzeik MS, Nassar MO. Study of some aspects of cell mediated immune response in bilharzial children on a field level. Journal of the Egyptian Society of Parasitology 1991;21(2):411-6.
Friis 1997 {published data only}
  • Friis H, Ndhlovu P, Mduluza T, Kaondera K, Sandström B, Michaelsen KF, et al. The impact of zinc supplementation on growth and body composition: a randomized, controlled trial among rural Zimbabwean schoolchildren. European Journal of Clinical Nutrition 1997;51(1):38-45.
Friis 2003 {published data only}
  • Friis H, Mwaniki D, Omondi B, Muniu E, Thiong'o F, Ouma J, et al. Effects on haemoglobin of multi-micronutrient supplementation and multi-helminth chemotherapy: a randomized, controlled trial in Kenyan school children. European Journal of Clinical Nutrition 2003;57(4):573-9.
Gryseels 1987 {published data only}
  • Gryseels B, Nkulikyinka L, Coosemans MH. Field trials of praziquantel and oxamniquine for the treatment of schistosomiasis mansoni in Burundi. Transactions of the Royal Society of Tropical Medicine and Hygiene 1987;81(4):641-4.
Homeida 1988 {published data only}
  • Homeida M, Abdel-Gadir AF, Cheever AW, Bennett JL, Arbab BM, Ibrahium SZ, et al. Diagnosis of pathologically confirmed Symmers' periportal fibrosis by ultrasonography: a prospective blinded study. American Journal of Tropical Medicine and Hygiene 1988;38(1):86-91.
Kabatereine 2003 {published data only}
  • Kabatereine NB, Kemijumbi J, Ouma JH, Sturrock RF, Butterworth AE, Madsen H, et al. Efficacy and side effects of praziquantel treatment in a highly endemic Schistosoma mansoni focus at Lake Albert, Uganda. Transactions of the Royal Society of Tropical Medicine and Hygiene 2003;97(5):599-603.
Katz 1973 {published data only}
  • Katz N, Pellegrino J, Grinbaum E, Chaves A, Zicker F. Preliminary clinical trials with oxamniquine, a new antischistosomal agent. Revisto do Instituto de Medecina Tropical de São Paulo 1973;15(1):25-9.
Mohamed 2009 {published data only}
  • Mohamed AA, Mahgoub HM, Magzoub M, Gasim GI, Eldein WN, Ahmed AA, et al. Artesunate plus sulfadoxine/pyrimethamine versus praziquantel in the treatment of Schistosoma mansoni in eastern Sudan. Transactions of the Royal Society of Tropical Medicine and Hygiene 2009;103(10):1062-4.
Navaratnam 2012 {published data only}
  • Navaratnam AMD, Sousa-Figueiredo JC, Stothard JR, Kabatereine NB, Fenwick A, Mutumba-Nakalembe MJ. Efficacy of praziquantel syrup versus crushed praziquantel tablets in the treatment of intestinal schistosomiasis in Ugandan preschool children, with observation on compliance and safety. Transactions of the Royal Society of Tropical Medicine and Hygiene 2012;106(7):400-7.
Obonyo 2010 {published data only}
  • Obonyo CO, Muok MO, Mwinzi NM. Efficacy of artesunate with sulfalene plus pyrimethamine versus praziquantel for treatment of Schistosoma mansoni in Kenyan children: an open-label randomised controlled trial. Lancet Infectious Diseases 2010;10(9):603-11.
Odongo-Aginya 1996 {published data only}
  • Odongo-Aginya EI, Doehring M, Lakwo TL, Etyono S, Luyinda LB, Roth J, et al. Integrated control trial of schistosomiasis at Nakiwogo fishing village near Entebbe, Uganda. East African Medical Journal 1996;73(8):495-8.
Olsen 2000 {published data only}
  • Olsen A, Nawiri J, Friis H. The impact of iron supplementation on reinfection with intestinal helminths and Schistosoma mansoni in western Kenya. Transactions of the Royal Society of Tropical Medicine and Hygiene 2000;94(5):493-99.
Olsen 2003 {published data only}
  • Olsen A, Thiong'o FW, Ouma JH, Mwaniki D, Magnussen P, Michaelsen KF, et al. Effects of multimicronutrient supplementation on helminth reinfection: a randomized, controlled trial in Kenyan schoolchildren. Transactions of the Royal Society of Tropical Medicine and Hygiene 2003;97(1):109-14.
Pitchford 1978 {published data only}
Polderman 1988 {published data only}
  • Polderman AM, Gryseels B, de Caluwe P. Cure rates and egg reduction in treatment of intestinal schistosomiasis with oxamniquine and praziquantel in Maniema, Zaire. Transactions of the Royal Society of Tropical Medicine and Hygiene 1988;82(1):115-6.
Utzinger 2000a {published data only}
Utzinger 2000b {published data only}
van Lieshout 1994 {published data only}
  • van Lieshout L, de Jonge N, el-Masry N, Mansour MM, Bassily S, Krijger FW, et al. Monitoring the efficacy of different doses of praziquantel by quantification of circulating antigens in serum and urine of schistosomiasis patients. Parasitology 1994;108(Pt 5):519-26.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Allan 2001
  • Allan RW. The Johns Hopkins Hospital, Department of Pathology. Johns Hopkins Microbiology Newsletter 2001;20:30.
Andersson 2007
  • Andersson KL, Chung RT. Hepatic schistosomiasis: Current Treatment Options. Gastroenterology 2007;10(6):504-12.
Bergquist 2009
Booth 2003
  • Booth M, Vounatsou P, N'Goran EK, Tanner M, Utzinger J. The influence of sampling effort and the performance of the Kato-Katz technique in diagnosing Schistosoma mansoni and hookworm co-infections in rural Côte d'Ivoire. Parasitology 2003;127(Pt 6):525-31.
Borrmann 2001
  • Borrmann S, Szlezák N, Faucher JF, Matsiegui PB, Neubauer R, Binder RK, et al. Artesunate and praziquantel for the treatment of Schistosoma haematobium infections: a double-blind, randomized, placebo-controlled study. Journal of Infectious Diseases 2001;184(10):1363-6.
Boulanger 2007
  • Boulanger D, Dieng Y, Cisse B, Remoue F, Capuano F, Dieme JL, et al. Antischistosomal efficacy of artesunate combination therapies administered as curative treatments for malaria attacks. Transactions of the Royal Society of Tropical Medicine and Hygiene 2007;101(2):113-6.
Braun-Munzinger 1992
  • Braun-Munzinger RA, Southgate BA. Repeatability and reproducibility of egg counts of Schistosoma haematobium in urine. Tropical Medicine and Parasitology 1992;43(3):149-54.
Caulibaly 2011
  • Coulibaly JT, Knopp S, N'Guessan NA, Silué KD, Fürst T, Lohourignon LK, et al. Accuracy of urine circulating cathodic antigen (CCA) test for Schistosoma mansoni diagnosis in different settings of Côte d'Ivoire. PLoS Neglected Tropical Diseases 2011;5(11):e1384.
Chitsulo 2000
Cioli 1995
Cnops 2012
CWG 1992
Danso-Appiah 2002
Danso-Appiah 2004
  • Danso-Appiah A, de Vlas SJ, Bosompem KM, Habbema JDF. Determinants of health-seeking behaviour for schistosomiasis-related symptoms in the context of integrating schistosomiasis control within the regular health services in Ghana. Tropical Medicine and International Health 2004;9(7):784–94.
Danso-Appiah 2008
  • Danso-Appiah A, Utzinger J, Liu J, Olliaro PL. Drugs for treating urinary schistosomiasis. Cochrane Database of Systematic Reviews 2008, Issue Issue 3. Art. No: CD000053. DOI: 10.1002/14651858.CD000053.pub2.
Danso-Appiah 2009
  • Danso-Appiah A, Garner P, Olliaro PL, Utzinger J. Treatment of urinary schistosomiasis: methodological issues and research needs identified through a Cochrane systematic review. Parasitology 2009;136(13):1837-49.
Davis 2009
  • Davis A. Schistosomiasis [Section 11, Chapter 82: Helminth infections]. Manson's Tropical Diseases. 22nd Edition. WB Saunders, 2009:1425-60.
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