This is not the most recent version of the article. View current version (28 FEB 2013)

Intervention Review

You have free access to this content

Colloids versus crystalloids for fluid resuscitation in critically ill patients

  1. Pablo Perel*,
  2. Ian Roberts

Editorial Group: Cochrane Injuries Group

Published Online: 16 MAR 2011

Assessed as up-to-date: 29 SEP 2008

DOI: 10.1002/14651858.CD000567.pub4

How to Cite

Perel P, Roberts I. Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Database of Systematic Reviews 2011, Issue 3. Art. No.: CD000567. DOI: 10.1002/14651858.CD000567.pub4.

Author Information

  1. London School of Hygiene & Tropical Medicine, Cochrane Injuries Group, London, UK

*Pablo Perel, Cochrane Injuries Group, London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 16 MAR 2011


This is not the most recent version of the article. View current version (28 FEB 2013)


References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Boldt 1986 {published data only}
  • Boldt J, von Bormann B, Kling D, Borner U, Mulch J, Hempelmann G. Volume replacement with a new hydroxyethyl starch preparation (3 percent HES 200/0.5) in heart surgery [Volumenersatz mit einem neuen hydroxyathylstarke - praparat (3% HAS 200/0.5) in der herzchirurgie]. Infusionstherapie und Klinische Ernährung 1986;13(3):145-51.
Boldt 1993 {published data only}
  • Boldt J, Knothe C, Zickmann B, Andres P, Dapper F, Hempelmann G. Influence of different intravascular volume therapies on platelet function in patients undergoing cardiopulmonary bypass. Anesthesia and Analgesia 1993;76(6):1185-90.
Boldt 2001 {published data only}
  • Boldt J, Suttner S, Huttner I, Kumle B, Piper S, Krumholz W. Are costs of a crystalloid-based volume replacement regimen lower than of a colloid-based volume replacement stategy. Infusion Therapy and Transfusion Medicine 2001;28:144-9.
Boutros 1979 {published data only}
  • Boutros AR, Ruess R, Olson L, Hoyt JL, Baker WH. Comparison of hemodynamic, pulmonary, and renal effects of use of three types of fluids after major surgical procedures on the abdominal aorta. Critical Care Medicine 1979;7(1):9-13.
Bowser-Wallace 1986 {published data only}
  • Bowser-Wallace BH, Caldwell FT Jr. A prospective analysis of hypertonic lactated saline v. Ringer's lactate-colloid for the resuscitation of severely burned children. Burns 1986;12(6):402-9.
Brunkhorst 2008 {published and unpublished data}
  • Brunkhorst M. Supplementary Appendix. Provided from Dr. Brunkhorst on 26 March, 2009.
  • Brunkhorst M, Engel C, Bloos F. Intensive insulin therapy and pentastarch resuscitation in severe sepsis. New England Journal of Medicine 2008;358:125-39.
Chavez-Negrete 1991 {published data only}
  • Chavez-Negrete A, Lajluf Cruz S, Frati Munari A, Perches A, Argulero R. Treatment of hemorrhagic shock with intraosseus or intravenous infusion of hypertonic saline eextran solution. European Surgical Research 1991;23(2):123-9.
Cifra 2003 {published data only}
  • Cifra HL, Velasco JNJ. A comparative study of the efficacy of 6% Haes-Steril and Ringer's Lactate in the management of dengue shock syndrome 555. Critical Care & Shock 2003;6:95-100.
Dawidson 1991 {published data only}
  • Dawidson IJ, Willms CD, Sandor ZF, Coorpender LL, Reisch JS, Fry WJ. Ringer's lactate with or without 3% dextran-60 as volume expanders during abdominal aortic surgery. Critical Care Medicine 1991;19(1):36-42.
Dehne 2001 {published data only}
  • Dehne MG, Muhling J, Sablotzki A, Dehn K-L, Sucke N, Hempelmann G. Hydroxyethyl starch (HES) does not directly affect renal function in patients with no prior renal impairment. Journal of Clinical Anaesthesia 2001;13(2):103-11.
Eleftheriadis 1995 {published data only}
  • Eleftheriadis S, Sedemund-Adib B, Klotz K-F, Hubner N, Kuppe H. Volume replacement after cardiac surgery: comparison of Ringer, HES 6% and Gelatine 3.5%. Intensive Care Medicine 1995;21(suppl 1):S216.
Ernest 1999 {published data only}
Evans 1996 {published and unpublished data}
  • Evans PA, Garnett M, Boffard K, Kirkman E, Jacobson BF. Evaluation of the effect of colloid (Haemaccel) on the bleeding time in the trauma patient. Journal of the Royal Society of Medicine 1996;89(2):101-4.
Evans 2003 {published data only}
Fries 2004 {published data only}
  • Fries D, Streif W, Margreiter J, Klingler A, Kuhbacher G, Schobersberger W, et al. The effects of perioperatively administered crystalloids and colloids on concentrations of molecular markers of activated coagulation and fibrinolysis. Blood Coagulation & Fibrinolysis 2004;15:213-9.
Gallagher 1985 {published data only}
  • Gallagher JD, Moore RA, Kerns D, Jose AB, Botros SB, Flicker S, et al. Effects of colloid or crystalloid administration on pulmonary extravascular water in the postoperative period after coronary artery bypass grafting. Anesthesia and Analgesia 1985;64(8):753-8.
Goodwin 1983 {published data only}
  • Goodwin CW, Dorethy J, Lam V, Pruitt BA Jr. Randomized trial of efficacy of crystalloid and colloid resuscitation on hemodynamic response and lung water following thermal injury. Annals of Surgery 1983;197(5):520-31.
Grundmann 1982 {published data only}
Guo 2003 {published data only}
  • Guo XY, Xu ZH, Ren HZ, Luo AL, Huang YG, Ye TH. Effect of volume replacement with hydroxyethyl starch solution for blood loss on splanchnic oxygenation in patients undergoing cytoreductive surgery for ovarian carcinoma. Zhonghua Yi Xue Za Zhi 2003;83:114-7.
Hall 1978 {published data only}
  • Hall K, Sorensen B. The treatment of burn shock. Scandinavian Journal of Plastic and Reconstructive Surgery 1973;7:67-73.
  • Hall K, Sorensen B. The treatment of burns shock. In: Vrabec R, Konickova L, Moserova J editor(s). Basic problems in burns. Berlin: Springer-Verlag, 1975.
  • Hall KV, Sorensen B. The treatment of burn shock: results of a 5-year randomized, controlled clinical trial of Dextran 70 v Ringer lactate solution. Burns 1978;5(1):107-12.
Hartmann 1993 {published data only}
  • Hartmann M, Jonsson K, Zederfeldt B. Effects of dextran and crystalloids on subcutaneous oxygen tension and collagen accumulation. A randomized study in surgical patients. European Surgical Research 1993;25:270-7.
Jelenko 1978 {published data only}
  • Jelenko C 3rd. Fluid therapy and the HALFD method. Journal of Trauma 1979;19(11 Suppl):866-7.
  • Jelenko C 3rd, Solenberger RI, Wheeler ML, Callaway BD. Shock and resuscitation. III. Accurate refractometric COP determinations in hypovolemia treated with HALFD. JACEP 1979;8(7):253-6.
  • Jelenko C 3rd, Wheeler ML, Callaway BD, Divilio LT, Bucklen KR, Holdredge TD. Shock and resuscitation. II: Volume repletion with minimal edema using the "HALFD"(Hypertonic Albuminated Fluid Demand) regimen. JACEP 1978;7(9):326-33.
  • Jelenko C 3rd, Williams JB, Wheeler ML, et al. Studies in shock and resuscitation, I: use of a hypertonic, albumin-containing, fluid demand regimen (HALFD) in resuscitation. Crit Care Med 1979;7(4):157-67.
Karanko 1987 {published data only}
  • Karanko M, Klossner J, Laksonen V. Restoration of volume by crystalloid versus colloid after coronary artery bypass: haemodynamics, lung water, oxygenation and outcome. Critical Care Medicine 1987;15:559-66.
Lang 2001 {published data only}
  • Lang K, Boldt J, Suttner S, Haisch G. Colloids versus crystalloids and tissue oxygen tension in patients undergoing major abdominal surgery. Anesthesia and Analgesia 2001;93(2):405-9.
Lang 2003 {published data only}
  • Lang K, Suttner S, Boldt J, Kumle B, Nagel D. Volume replacement with HES 130/0.4 may reduce the inflammatory response in patients undergoing major abdominal surgery. Canadian Journal of Anaesthesia 2003;50:1009-16.
Ley 1990 {published data only}
Lowe 1977 {published data only}
  • Lowe RJ, Moss GS, Jilek J, Levine HD. Crystalloid versus colloid in the etiology of pulmonary failure after trauma - a randomized trial in man. Critical Care Medicine 1979;7(3):107-12.
  • Lowe RJ, Moss GS, Jilek J, Levine HD. Crystalloid vs colloid in the etiology of pulmonary failure after trauma: a randomized trial in man. Surgery 1977;1(6):676-83.
  • Moss GS, Lowe RJ, Jilek J, Levine HD. Colloid or crystalloid in the resuscitation of hemorrhagic shock: a controlled clinical trial. Surgery 1981;89(4):434-8.
Lucas 1978 {published data only}
  • Clift DR, Lucas CE, Ledgerwood AM, Sardesai V, Kithier K, Grabow D. The effect of albumin resuscitation for shock on the immune response to tetanus toxoid. Journal of Surgical Research 1982;32:449-52.
  • Johnson SD, Lucas CE, Gerrick SJ, Ledgerwood AM, Higgins R. Altered coagulation after albumin supplements for treatment of oligaemic shock. Archives of Surgery 1979;114:379-83.
  • Lucas CE, Bouwman DL, Ledgerwood AM, Higgins R. Differential serum protein changes following supplemental albumin resuscitation for hypovolemic shock. Journal of Trauma 1980;20(1):47-51.
  • Lucas CE, Weaver D, Higgins RF, Ledgerwood AM, Johnson SD, Bouwman DL. Effects of albumin versus non-albumin resuscitation on plasma volume and renal excretory function. Journal of Trauma 1978;18:565-70.
  • Weaver DW, Ledgerwood AM, Lucas CE, Higgins R, Bouwman DL, Johnson SD. Pulmonary effects of albumin resuscitation for severe hypovolaemic shock. Archives of Surgery 1978;113:387-92.
Maitland 2005 {published data only}
  • Maitland K, Pamba A, English M, Peshu N, Marsh K, Newton C, et al. Randomized trial of volume expansion with albumin or saline in children with severe malaria: preliminary evidence of albumin benefit. Clinical Infectious Diseases 2005;40(4):538-45.
Mattox 1991 {published data only}
  • Maningas PA, Mattox KL, Pepe PE, Jones RL, Feliciano DV, Burch JM. Hypertonic saline-dextran solutions for the prehospital management of traumatic hypotension. American Journal of Surgery 1989;157(5):528-33.
  • Mattox KL, Maningas PA, Moore EE, Mateer JR, Marx JA, Aprahamian C, et al. Prehospital hypertonic saline/dextran infusion for post-traumatic hypotension. The U.S.A. Multicenter Trial. Annals of Surgery 1991;213(5):482-91.
Mazher 1998 {published data only}
  • Mazher R, Samenesco A, Royston D, Rees A. Cardiopulmonary effects of 7.2% saline solution compared with gelatin infusion in the early postoperative period after coronary artery bypass grafting. Journal of Thoracic and Cardiovascular Surgery 1998;115(1):178-87.
McNulty 1993 {published data only}
  • McNulty SE, Sharkey SJ, Asam B, Lee JH. Evaluation of STAT-CRIT Hematocrit Determination in comparison to Coulter and Centrifuge: the effects of isotonic hemodilution and albumin administration. Anesthesia and Analgesia 1993;76:830-4.
Metildi 1984 {published data only}
  • Metildi LA, Shackford SR, Virgilio RW, Peters RM. Crystalloid versus colloid in fluid resuscitation of patients with severe pulmonary insufficiency. Surgery, Gynecology and Obstetrics 1984;158(3):207-12.
Modig 1983 {published data only}
  • Modig J. Advantages of dextran 70 over Ringer acetate solution in shock treatment and in prevention of adult respiratory distress syndrome. A randomized study in man after traumatic-haemorrhagic shock. Resuscitation 1983;10(4):219-26.
  • Modig J. Effectiveness of dextran 70 versus Ringer's acetate in traumatic shock and adult respiratory distress syndrome. Critical Care Medicine 1986;14(5):454-7.
Moretti 2003 {published data only}
  • Moretti EW, Robertson KM, El Moalem H, Gan TJ. Intraoperative colloid administration reduces postoperative nausea and vomiting and improves postoperative outcomes compared with crystalloid administration. Anesthesia and Analgesia 2003;96:611-7.
Nagy 1993 {published data only}
  • Nagy KK, Davis J, Duda J, Fildes J, Roberts R, Barrett J. A comparison of pentastarch and lactated Ringer's solution in the resuscitation of patients with hemorrhagic shock. Circulatory Shock 1993;40(4):289-94.
Ngo 2001 {published data only}
  • Ngo NT, Cao XT, Kneen R, Wills B, Nguyen VM, Nguyen TQ, et al. Acute management of dengue shock syndrome: a randomised double-blind comparison of 4 intravenous fluid regimes in the first hour. Clinical Infectious Diseases 2001;32(2):204-13.
Nielsen 1985 {published data only}
  • Nielsen OM, Engell HC. Extracellular fluid volume and distribution in relation to changes in plasma colloid osmotic pressure after major surgery. A Randomised Study. Acta Chir Scand 1985;151:221-5.
Pockaj 1994 {published data only}
  • Pockaj BA, Yang JC, Lotze MT, Lange JR, Spencer WF, Steinberg SM, et al. A prospective randomized trial evaluating colloid versus crystalloid resuscitation in the treatment of the vascular leak syndrome associated with interleukin-2 therapy. Journal of Immunotherapy 1994;15(1):22-8.
Prien 1990 {published data only}
  • Prein T, Backhaus N, Pelster F, Pircher W, Buente H, Lawin P. Effect of intraoperative fluid administration and colloid osmotic pressure on the formation of intestinal edema during gastrointestinal surgery. Journal of Clinical Anesthesia 1990;2:317-23.
Rackow 1983 {published data only}
  • Haupt, MT, Rackow, EC. Colloid osmotic pressure and fluid resuscitation with hetastarch, albumin, and saline solutions. Critical Care Medicine 1982;10(3):159-62.
  • Kaufman BS, Rackow EC, Falk JL. Fluid resuscitation in circulatory shock. Colloids versus crystalloids. Current Studies in Hematology and Blood Transfusion 1986;53:186-98.
  • Rackow EC, Falk JL, Fein IA, Siegel JS, Packman MI, Haupt MT, et al. Fluid resuscitation in circulatory shock: a comparison of the cardiorespiratory effects of albumin, hetastarch, and saline solutions in patients with hypovolemic and septic shock. Critical Care Medicine 1983;11(11):839-50.
Rocha e Silva 1994 {published data only (unpublished sought but not used)}
  • Rocha e Silva M, Poli de Figueiredo LF. Hypertonic-hyperoncotic saline solution for the treatment of post-traumatic hypotension in the emergency room. The Brazilian multi-center trial. SALT 6. International Conference on Hypertonic Resuscitation, Teton Village. June 2-3 1994.
SAFE 2004 {published data only}
Shah 1977 {published data only}
  • Shah DM, Broner BD, Dutton RE, Newell JC, Powers SR. Cardiac output and pulmonary wedge pressure. Use for evaluation of fluid replacement in trauma patients. Archives of Surgery 1977;112:1161-8.
Shires 1983 {published data only}
Sirieix 1999 {published data only}
  • Sirieix D, Hongnat J-M, Delayance S, D'Attellis N, Vicaut E, Berribi A, et al. Comparison of the acute haemodynamic effects of hypertonic or colloid infusions immediately after mitral valve repair. Critical Care Medicine 1999;27:2159-65.
Skillman 1975 {published data only}
Tollofsrud 1995 {published data only}
Tollofsrud 1998 {published data only}
Upadhyay 2004 {published data only}
  • Upadhyay M, Singhi S, Murlidharan J, Kaur N, Majumdar S. Randomized evaluation of fluid resuscitation with crystalloid (saline) and colloid (polymer from degraded gelatin in saline) in pediatric septic shock. Indian Pediatrics Indian Pediatrics 2004;42(3):223-31.
Vassar 1990 {published data only}
Vassar 1991 {published data only}
Vassar 1993a {published data only}
  • Vassar MJ, Perry CA, Holcroft JW. Prehospital resuscitation of hypotensive trauma patients with 7.5% NaCl versus 7.5% NaCl with added dextran: a controlled trial. Journal of Trauma 1993;34(5):622-32.
Vassar 1993b {published data only}
  • Vassar MJ, Fischer RP, O'Brien PE, Bachulis BL, Chambers JA, Hoyt DB, et al. A multicenter trial for resuscitation of injured patients with 7.5% sodium chloride. The effect of added dextran 70. The Multicenter Group for the Study of Hypertonic Saline in Trauma Patients. Archives of Surgery 1993;128(9):1003-11.
Verheij 2006 {published data only}
  • Verheij J, van Lingen A, Beishuizen A, Christiaans HM, de Jong JR, Girbes AR, et al. Cardiac response is greater for colloid than saline fluid loading after cardiac or vascular surgery. Intensive Care Medicine 2006;32(7):1030-8.
Virgilio 1979 {published data only}
  • Virgilio RW, Rice CL, Smith DE, James DR, Zarins CK, Hobelmann CF, et al. Crystalloid vs. colloid resuscitation: is one better? A randomized clinical study. Surgery 1979;85(2):129-39.
Wahba 1996 {published data only}
Wills 2005 {published data only}
  • Wills BA, Nguyen MD, Ha TL, Dong TH, Tran TN, Le TT, et al. Comparison of three fluid solutions for resuscitation in dengue shock syndrome. The New England Journal of Medicine 2005;353:877-89.
Woittiez 1997 {published and unpublished data}
  • Hondebrink Y, Jeekel L, Oude Nijhuis J, Woittiez AJJ. Restoration of colloid osmotic pressure in hypoalbuminaemic patients. Intensive Care Medicine 1997;23(supp 1):S184.
Wu 2001 {published data only}
  • Wu J, Huang M, Tang G, Kao W, Shih H, Su C, et al. Hemodynamic response of modified fluid gelatin compared with lactated ringer's solution for volume expansion in emergency resuscitation of hypovolemic shock patients: preliminary report of a prospective, randomized trial. World Journal of Surgery 2001;25(5):598-602.
Younes 1992 {published data only}
  • Younes RN, Aun F, Accioly CQ, Casale LP, Szajnbok I, Birolini D. Hypertonic solutions in the treatment of hypovolemic shock: a prospective, randomized study in patients admitted to the emergency room. Surgery 1992;111(4):380-5.
Younes 1994 {published data only}
  • Younes R, Aun F, Ching C, Goldenberg D, Franco M, Miura F, et al. Prognostic factors to predict outcome following the administration of hypertonic/hyperoncotic solution in hypovolaemic patients. Shock 1997;7:79-83.
  • Younes RN, Aun F, Ching C, et al. Prognosis following the administration of hypertonic/hyperoncotic solutions in hypovolemic patients. SALT 6. International Conference on Hypertonic Resuscitation. Teton Village. June 2-3 1994.
Younes 1998 {published data only}
  • Younes R, Yin K, Amino C, Itinoshe M, Rocha e Silva M, Birolini D. Use of pentastarch solution in the treatment of patients with hemorrhagic hypovolemia: randomized phase II study in the emergency room. World Journal of Surgery 1998;22:2-5.
Zetterstrom 1981a {published data only}
  • Zetterstrom H, Hedstrand U. Albumin treatment following major surgery. I. Effects on plasma oncotic pressure, renal function and peripheral oedema. Acta Anaesthesiologica Scandinavica 1981;25:125-32.
Zetterstrom 1981b {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Artru 1989 {published data only}
  • Artru F, Philippon B, Flachaire E, Peyrieux JC, Boissel JP, Ferry S, et al. A controlled study of Dextran 40: effect on cerebral blood flow and metabolic rates in acute head trauma. Intensive Care Medicine 1989;15(8):499-504.
Bocanegra 1966 {published data only}
  • Bocanegra M, Hinostroza F, Kefalides NA, Markley K, Rosenthal SM. A long-term study of early fluid therapy in severely burned adults. 3. Simultaneous comparison of saline solution alone or combined with plasma. Journal of the American Medical Association 1966;195(4):268-74.
Boldt 1996 {published data only}
Boldt 2007 {published data only}
  • Boldt J, Schollhorn T, Munchbach J. A total balanced volume replacement strategy using a new balanced hydroxyethyl starch preparation (6% HES 130/0.42) in patients undergoing major abdominal surgery. European Journal of Medicine 2007;24:267-75.
Bothner 1998 {published data only}
  • Bothner U, Georgieff M, Vogt N. Assessment of the safety and tolerance of 6% hydroxyethyl starch (200/0.5) solution: a randomized, controlled epidemiology study. Anesthesia and Analgesia 1998;86:850-5.
Breheme 1993 {published data only}
  • Brehme S, Keysser G, Turowski A, Schmidt HH. Hemorheologic effects of hydroxyethyl starch 200/0.5, dextran 40, oxypolygelatine and full electrolyte solution over 48 hours [Hamorheologische Wirkungen von Hydroxyathylstarke 200/0,5, Dextran 40, Oxypolygelatine und Vollelektrolytlosung uber 48 Stunden]. Zeitschrift für die gesamte innere Medizin und ihre Grenzgebiete 1993;48(10):506-10.
Bueno R 2004 {published data only}
  • Bueno R, Resende AC, Melo R, Neto VA, Stolf NA. Effects of hypertonic saline-dextran solution in cardiac valve surgery with cardiopulmonary bypass. Annals of Thoracic Surgery 2004;77(2):604-11.
Chin 2006 {published data only}
  • Chin Y, Macachor J, Ong KC, Ong BC. A comparison of 5% dextrose in 0.9% normal saline versus non-dextrose-containing crystalloids as the initial intravenous replacement fluid in elective surgery. Anasthesia and Intensive Care 2006;34(5):613-7.
Golub 1994 {published data only}
  • Golub R, Sorrento JJ Jr, Cantu R Jr, Nierman DM, Moideen A, Stein HD. Efficacy of albumin supplementation in the surgical intensive care unit: a prospective, randomized study. Critical Care Medicine 1994;22(4):613-9.
Goslinga 1992 {published data only}
  • Goslinga H, Eijzenbach V, Heuvelmans JH, van de Nes JC, Kurk RM, Bezemer PD. [Individualized hemodilution in acute brain infarct using a 20% albumin solution and physiological saline solution]. Nederlands Tijdschrift voor Geneeskunde 1992;136(49):2422-8.
  • Goslinga H, Eijzenbach V, Heuvelmans JH, van der Laan de Vries E, Melis VM, Schmid-Schönbein H, et al. Custom-tailored hemodilution with albumin and crystalloids in acute ischemic stroke. Stroke 1992;23(2):181-8.
  • Goslinga H, Heuvelmans JH, Schmid Schonbein H. Hemodilution and rehydration in acute ischemic stroke. A preliminary report on the Amsterdam Stroke Study. Acta Medica Austriaca 1991;18(Suppl 1):41-4.
Green 2008 {published data only}
  • Green RS, Hall RI. Con: starches are not preferable to albumin during cardiac surgery: a contrary opinion. Journal of Cardiothoracic and Vascular Anesthesia 2008;22(3):485-91.
Greenhalgh 1995 {published data only}
  • Greenhalgh DG, Housinger TA, Kagan RJ, Rieman M, James L, Novak S, et al. Maintenance of serum albumin levels in pediatric burn patients: a prospective, randomized trial. Journal of Trauma 1995;39(1):67-73; discussion 73-4.
Hauser 1980 {published data only}
  • Hauser CJ, Shoemaker WC, Turpin I, Goldberg SJ. Oxygen transport response to colloids and crystalloids in critically ill surgical patients. Surgery 1980;150(6):811-6.
Ko 2007 {published data only}
  • Ko JS, Kim CS Cho HS, Choi DH. A randomized trial of crystalloid versus colloid solution for prevention of hypotension during spinal or low-dose combined spinal-epidural anesthesia for elective cesarean delivery. International Journal of Obstetric Anesthesia 2007;16(1):8-12.
Krasheninnikov 2007 {published data only}
  • Krasheninnikov SV, Levit AL, Malkova OG. Effect of various colloidal solutions on pulmonary oxygenizing function in patients with acute lung lesion. Anestiziologiia i Reanimatologiia 2007;3:20-2.
Lagonidis 1995 {published data only}
  • Lagonidis D, Magder S. Acute volume loading with colloid vs. crystalloid after coronary artery bypass. Intensive Care Medicine 1992;18:(suppl 2):S225.
Lobo 2008 {published data only}
  • Lobo SM, Orrico SR, Queiroz MM, Contrim LM, Cury PM. Comparison of the effects of the lactated Ringer solution with and without hydroxyethyl starch fluid resuscitation on gut edema during severe splanchnic ischemia. Brazilian Journal of Medical and Biological Research 2008;41(7):634-9.
Marhofer 1999 {published data only}
  • Marhofer P, Faryniak B, Oismuller C, Koinig H, Kapral S, Mayer N. Cardiovascular effects of 6% hetastarch and lactated Ringer's solution during spinal anaesthesia. Regional Anesthesia and Pain Medicine 1999;24:399-404.
Mittermayr 2007 {published data only}
  • Mittermayr M, Streif W, Haas T, Fries D, Velik-Salchner C, Klingler A, et al. Hemostatic changes after crystalloid or colloid fluid administration during major orthopedic surgery: the role of fibrinogen administration. British Journal of Anaesthesia 2007;105(4):905-17.
Mittermayr 2008 {published data only}
  • Mittermayr M, Streif W, Haas T, Fries D, Velik-Salchner C, Klingler A, et al. Effects of colloid and crystalloid solutions on endogenous activation of fibrinolysis and resistance of polymerized fibrin to recombinant tissue plasminogen activator added ex vivo. British Journal of Anaesthesia 2008;100(3):307-14.
Niemi 2008 {published data only}
  • Niemi T, Schramko A, Kuitunen A, Kukkonen S, Suojaranta-Ylinen R. Haemodynamics and Acid-base equilibrium after cardiac surgery: comparison of rapidly degradable hydroxyethyl starch solutions and albumin. Scandinavian Journal of Surgery 2008;97(3):259-65.
Nilsson 1980 {published data only}
Oliviera 2002 {published data only}
  • Oliviera RP, Weingartner R, Ribas EO, Moraes RS, Friedman G. Acute haemodynamic effects of a hypertonic saline/dextran solution in stable patients with severe sepsis. Intensive Care Medicine 2002;28(11):1574-81.
Paton-Gay 2007 {published data only}
  • Paton-Gay JD, Brindley PG, McDermid RC. Best evidence in critical care medicine: fluid management in acute lung injury: friend or foe?. Canadian Journal of Anesthesia 2007;54(1):73-5.
Paul 2003 {published data only}
Rehm 2001 {published data only}
  • Rehm M, Haller M, Orth V, Kreimeier U, Jacob M, Dressel H, et al. Changes in blood volume and hematocrit during acute preoperative volume loading with 5% albumin or 6% hetastarch solutions in patients before radical hysterectomy. Anesthesiology 2001;95(4):849-56.
Steinberg 1989 {published data only}
  • Steinberg B, Kochs E, Bause H, Schulte am Esch J. Effects of low molecular weight hydroxyethyl starch (HES 40) in comparison with Ringer solution on oxygen tension in skeletal muscles of infected patients. Anästhesie, Intensivtherapie, Notfallmedizin 1989;24(6):377-81.
Tiryakioglu 2008 {published data only}
  • Tiryakioglu O, Yildiz G, Vural H, Goncu T, Ozyazicioglu A, Yavuz S. Hydroxethyl starch versus Ringer solution in cardiopulmonary bypass prime solutions (a randomized controlled trial). Journal of Cardiothoracic Surgery 2008;3(45):1-6.
Tseng 2008 {published data only}
  • Tseng M, Hutchinson Y, Kirkpatrick P. Effects of fluid therapy following aneurysmal subarachnoid haemorrhage: a prospective clinical study. British Journal of Neurosurgery 2008;22(2):257-68.
Valetova 2007 {published data only}
  • Valetova VV, Khudenko NV, Sakharova EA, Timerbaev VK. Role of starch preparations in the intraoperative correction of hypovolemia in patients with large-size uterine myomas. Anesteziologiia i Reanimatologiia 2007;2:31-4.
Vercueil 2006 {published data only}
  • Vercueil A, Levett D, Grocott M. Resuscitation fluids in trauma, part II: which fluid should I give?. Trauma 2006;8(2):111-21.
Wilkes 2001 {published data only}
  • Wilkes N, Woolf R, Mutch M, Mallett S, Peache T, Stephens R, et al. The effects of balanced versus saline-based heta-starch and crystalloid solutions on acid-base and electrolyte status and gastric mucosal perfusion in elderly surgical patients. Anaesthesia and Analgesia 2001;93(4):811-6.
Woods 1993 {published data only}

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Armstrong 1994
  • Armstrong RF, Bullen C, Cohen SL, Singer M, Webb AR. Critical Care Algorithms. Oxford: Oxford University Press, 1994.
Bickell 1994
  • Bickell WH, Wall MJ, Pepe PE, Martin R, Ginger VF, Allen MK, et al. Immediate versus delayed resuscitation for hypotensive patients with penetrating torso injuries. New England Journal of Medicine 1994;331:1105-9.
Bisonni 1991
  • Bisonni RS, Holtgrave DR, Lawler F, Marley DS. Colloids versus crystalloids in fluid resuscitation: an analysis of randomized controlled trials. Journal of Family Practice 1991;32(4):387-90.
Boldt 2009
  • Boldt J, Suttner S, Brosch C, Lehmann A, Roehm K, Mengitsu A. Cardiopulminary bypass priming using a high dose of a balanced hydroxyethyl starch versus an albumin-based priming strategy. Anesthesia & Analgesia 2009;109:1752-62.
Fakhry 1995
  • Fakhry SM, Alexander J, Smith D, Meyer AA, Peterson HD. Regional and institutional variation in burn care. Journal of Burn Care and Rehabilitation 1995;16(1):86-90.
Gosling 1998
Higgins 2008
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.0.1 [updated September 2008]. The Cochrane Collaboration, 2008. Available from
Oxman 1994
Reinhart 2011
Shafer 2011
Velanovich 1989
Vermeulen 1995
  • Vermeulen LC, Ratko TA, Erstad BL, Brecher ME, Matuszewski KA. A paradigm for consensus. The University Hospital Consortium guidelines for the use of albumin, nonprotein colloid, and crystalloid solutions. Archives of Internal Medicine 1995;155(4):373-9.
Victorian DUAC 1991
  • Subcommittee of the Victorian Drug Usage Advisory Committee. Human albumin solutions: an audit of use in three major metropolitan hospitals. Medical Journal of Australia 1991;154(10):657-60.
Yim 1995
  • Yim JM, Vermeulen LC, Erstad BL, Matuszewski KA, Burnett DA, Vlasses PH. Albumin and nonprotein colloid solution use in US academic health centers. Archives of Internal Medicine 1995;155(22):2450-5.

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Schierhout 1998