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Magnesium supplementation in pregnancy

  1. Maria Makrides1,2,*,
  2. Danielle D Crosby3,4,
  3. Emily Bain3,
  4. Caroline A Crowther3,5

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 3 APR 2014

Assessed as up-to-date: 31 MAR 2013

DOI: 10.1002/14651858.CD000937.pub2


How to Cite

Makrides M, Crosby DD, Bain E, Crowther CA. Magnesium supplementation in pregnancy. Cochrane Database of Systematic Reviews 2014, Issue 4. Art. No.: CD000937. DOI: 10.1002/14651858.CD000937.pub2.

Author Information

  1. 1

    South Australian Health and Medical Research Institute, Healthy Mothers, Babies and Children, North Adelaide, SA, Australia

  2. 2

    The University of Adelaide, School of Paediatrics and Reproductive Health, Adelaide, South Australia, Australia

  3. 3

    The University of Adelaide, ARCH: Australian Research Centre for Health of Women and Babies, The Robinson Institute, Discipline of Obstetrics and Gynaecology, Adelaide, Australia

  4. 4

    Lyell McEwin Hospital, Department of Obstetrics and Gynaecology, Adelaide, Australia

  5. 5

    The University of Auckland, Liggins Institute, Auckland, New Zealand

*Maria Makrides, Healthy Mothers, Babies and Children, South Australian Health and Medical Research Institute, C/- WCHRI, 72 King William Road, North Adelaide, SA, 5006, Australia. maria.makrides@health.sa.gov.au.

Publication History

  1. Publication Status: New search for studies and content updated (conclusions changed)
  2. Published Online: 3 APR 2014

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[Figure 1]
Figure 1. 'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 2]
Figure 2. 'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 1 Perinatal mortality.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 2 Small-for-gestational age (< 10th percentile).
[Analysis 1.3]
Analysis 1.3. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 3 Pre-eclampsia.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 4 Stillbirth.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 5 Neonatal death prior to hospital discharge.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 6 Miscarriage (< 20 weeks' gestation).
[Analysis 1.7]
Analysis 1.7. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 7 Gestational age at birth (weeks).
[Analysis 1.8]
Analysis 1.8. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 8 Preterm birth < 37 weeks' gestation.
[Analysis 1.9]
Analysis 1.9. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 9 Low birthweight.
[Analysis 1.10]
Analysis 1.10. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 10 Birthweight (g).
[Analysis 1.11]
Analysis 1.11. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 11 Baby admitted to the neonatal unit.
[Analysis 1.12]
Analysis 1.12. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 12 Apgar score.
[Analysis 1.13]
Analysis 1.13. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 13 Late fetal heart rate decelerations.
[Analysis 1.14]
Analysis 1.14. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 14 Meconium-stained liquor.
[Analysis 1.15]
Analysis 1.15. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 15 Meconium aspiration.
[Analysis 1.16]
Analysis 1.16. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 16 Breech presentation.
[Analysis 1.17]
Analysis 1.17. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 17 Placental abruption.
[Analysis 1.18]
Analysis 1.18. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 18 Placental weight (g).
[Analysis 1.19]
Analysis 1.19. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 19 Hypoxic-ischaemic encephalopathy.
[Analysis 1.20]
Analysis 1.20. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 20 Significant congenital abnormality.
[Analysis 1.21]
Analysis 1.21. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 21 Maternal side effects.
[Analysis 1.22]
Analysis 1.22. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 22 Systolic blood pressure near birth (mm Hg).
[Analysis 1.23]
Analysis 1.23. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 23 Diastolic blood pressure near birth (mm Hg).
[Analysis 1.24]
Analysis 1.24. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 24 Pregnancy-induced hypertension.
[Analysis 1.25]
Analysis 1.25. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 25 Eclampsia.
[Analysis 1.26]
Analysis 1.26. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 26 Need for maternal hospitalisation.
[Analysis 1.27]
Analysis 1.27. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 27 Antepartum haemorrhage.
[Analysis 1.28]
Analysis 1.28. Comparison 1 Magnesium supplementation versus no magnesium, Outcome 28 Length of labour (hours).
[Analysis 2.1]
Analysis 2.1. Comparison 2 Subgroup analysis based on study design, Outcome 1 Perinatal mortality.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Subgroup analysis based on study design, Outcome 2 Small-for-gestational age (< 10th percentile).
[Analysis 3.1]
Analysis 3.1. Comparison 3 Sensitivity analysis based on the ICC, Outcome 1 Perinatal mortality.
[Analysis 3.2]
Analysis 3.2. Comparison 3 Sensitivity analysis based on the ICC, Outcome 2 Stillbirth.
[Analysis 3.3]
Analysis 3.3. Comparison 3 Sensitivity analysis based on the ICC, Outcome 3 Neonatal death prior to hospital discharge.
[Analysis 4.1]
Analysis 4.1. Comparison 4 Sensitivity analysis by quality rating, Outcome 1 Perinatal mortality.
[Analysis 4.2]
Analysis 4.2. Comparison 4 Sensitivity analysis by quality rating, Outcome 2 Small-for-gestational age (< 10th percentile).
[Analysis 4.3]
Analysis 4.3. Comparison 4 Sensitivity analysis by quality rating, Outcome 3 Pre-eclampsia.