Intervention Review

You have free access to this content

Fully intermittent dosing with drugs for treating tuberculosis in adults

  1. Henry C Mwandumba1,*,
  2. Stephen B Squire2

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 21 JAN 2009

Assessed as up-to-date: 5 SEP 2005

DOI: 10.1002/14651858.CD000970

Database Title

Additional Information

How to Cite

Mwandumba HC, Squire SB. Fully intermittent dosing with drugs for treating tuberculosis in adults. Cochrane Database of Systematic Reviews 2001, Issue 4. Art. No.: CD000970. DOI: 10.1002/14651858.CD000970.

Author Information

  1. 1

    University of Liverpool, Department of Pharmacology & Therapeutics, Liverpool, Merseyside, UK

  2. 2

    Liverpool School of Tropical Medicine, Clinical Group, Liverpool, Merseyside, UK

*Henry C Mwandumba, Department of Pharmacology & Therapeutics, University of Liverpool, Ashton Street, Liverpool, Merseyside, L69 3GE, UK. H.C.Mwandumba@liv.ac.uk.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 21 JAN 2009

SEARCH

ARTICLE TOOLS

View Full Article (HTML) Summary (55K)Standard (170K)Full (209K)

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Hong Kong 1981 {published data only}
  • Hong Kong Chest Service/ British Medical Research Council. Controlled trial of four thrice weekly regimens and a daily regimen all given for 6 months for pulmonary tuberculosis. Lancet 1981;1:171-4.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Brazil 1989 {published data only}
Hong Kong 1974 {published data only}
  • Hong Kong Tuberculosis Treatment Services/Brompton Hospital/British Medical Research Council. A controlled clinical trial of daily and intermittent regimens of rifampicin plus ethambutol in the retreatment of patients with pulmonary tuberculosis in Hong Kong. Tubercle 1974;55:1-27.
Hong Kong 1982 {published data only}
  • Hong Kong Chest Service/British Medical Research Council. Controlled trial of 4 three-times-weekly regimens and a daily regimen all given for 6 months for pulmonary tuberculosis. Second report: the results up to 24 months. Tubercle 1982;63:89-98.
Hong Kong 1987 {published data only}
  • Hong Kong Chest Service/British Medical Research Council. Five-year follow-up of a controlled trial of five 6-month regimens of chemotherapy for pulmonary tuberculosis. American Review of Respiratory Disease 1987;136:1339-42.
India 1990 {published data only}
  • Kumar L, Dhand R, Singhi PD, Rao KLN, Katariya S. A randomized trial of fully intermittent vs. daily followed by intermittent short course chemotherapy for childhood tuberculosis. Paediatric Infectious Disease Journal 1990;9(11):802-6.
Korea 1988 {published data only}
  • Hong YP, Kim SC, Chang SC, Kim SJ, Jin BW, Park CD. Comparison of a daily and three intermittent retreatment regimens for pulmonary tuberculosis administered under programme conditions. Tubercle 1988;69:241-53.
South Africa 2000 {published data only}
  • Te Water Naude JM, Donald PR, Hussey GD, Kibel MA, Louw A, Perkins DR, et al. Twice weekly vs. daily chemotherapy for childhood tuberculosis. Pediatric Infectious Disease Journal 2000;19(5):405-10.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Alwood 1994
Anonymous 1993
  • Anonymous. Approaches to improving adherence to antituberculosis therapy--South Carolina and New York, 1986-1991. MMWR. Morbidy and Mortality Weekly Report 1993;42:74-5,81.
Bechan 1997
  • Bechan S, Connolly C, Short GM, Standing E, Wilkinson D. Directly observed therapy for tuberculosis given twice weekly in the workplace in urban South Africa. Transactions of the Royal Society of Tropical Medicine and Hygiene 1997;91:704-7.
BTS 1984
  • British Thoracic Society. A controlled trial of 6 months chemotherapy in pulmonary tuberculosis, final report : results during the 36 months after the end of chemotherapy and beyond. British Journal of Diseases of the Chest 1984;78:330-6.
Caminero 1996
  • Caminero JA, Pavon JM, Rodriguez de Castro F, Diaz F, Julia G, Cayla JA, et al. Evaluation of a directly observed six month fully intermittent treatment regimens for tuberculosis in patients suspected of poor compliance. Thorax 1996;51:1130-3.
Chaulk 1995
China 1996
  • China Tuberculosis Control Collaboration. Results of a directly observed short course chemotherapy in 112842 Chinese patients with smear positive tuberculosis. Lancet 1996;343:358-62.
Clarke 2002
  • Clarke M, Oxman AD, editors. Optimal search strategy. Cochrane Reviewers' Handbook 4.1.5 [updated April 2002]; Appendix 5c. In: The Cochrane Library [database on disk and CDROM]. The Cochrane Collaboration. Oxford: Update Software; 2002, Issue 4.
Cohn 1990
  • Cohn DL, Catlin BJ, Peterson KL, Judson FN, Sbarbaro JA. A 62-dose, 6 months therapy for pulmonary and extrapulmonary tuberculosis: a twice-weekly, directly observed and cost-effective regimen. Annals of Internal Medicine 1990;112:407-15.
Crowle 1986
  • Crowle AJ, Sbarbaro JA, May MH. Inhibition by pyrazinamide of tubercle bacilli within cultured human macrophages. American Review of Respiratory Disease 1986;134:1052-5.
Davies 1999
  • Davies GR, Connolly C, Sturm AW, McAdam KP, Wilkinson D. Twice-weekly, directly observed treatment for HIV-infected and uninfected tuberculosis patients: cohort study in rural South Africa. AIDS 1999;13(7):811-7.
Dolin 1994
Dutt 1979
E&C Africa 1983
  • East & Central African/British Medical Research Councils' Fifth Collaborative Study. Controlled clinical trial of 4 short-course regimens of chemotherapy (three 6-month and one 8-month) for pulmonary tuberculosis. Tubercle 1983;64:153-66.
Enarson 1996
  • Enarson DA, Rieder HL, Arnadottir T, Trebucq A. Tuberculosis guide for low income countries. 4th Edition. Frankfurt: pmi Verlagsgruppe, 1996.
Grzybowski 1975
  • Grzybowski S, Barnett GD, Styblo K. Contacts of cases of active pulmonary tuberculosis. Bulletin of the International Union Against Tuberculosis 1975;50:90-106.
Harries 1996
  • Harries AD, Nyong'Onya Mbewe L, Salaniponi FM, Nyangulu DS, Veen J, Ringdal T, et al. Tuberculosis programme changes and treatment outcomes in patients with smear-positive pulmonary tuberculosis in Blantyre, Malawi. Lancet 1996;347:807-9.
Hong Kong 1991a
  • HongKong Chest Service / British Medical Research Council. Controlled trial of 2, 4, and 6 months of pyrazinamide in 6-month, three-times-weekly regimens for smear-positive pulmonary tuberculosis, including an assessment of a combined preparation of isoniazid, rifampin, and pyrazinamide. Am Rev Respir Dis 1991;143:700-6.
Hong Kong 1991b
  • Hong Kong Chest Service / Tuberculosis Research Centre, Madras / British Medical Research Council. A controlled clinical comparison of 6 and 8 months of antituberculosis chemotherapy in the treatment of patients with silicotuberculosis in Hong Kong. American Review of Respiratory Disease 1991;143:262-7.
Manalo 1990
  • Manalo F, Tan F, Sbarbaro JA, Iseman MD. Community-based short-course treatment of pulmonary tuberculosis in a developing nation. Initial report of an eight-month, largely intermittent regimen in a population with a high prevalence of drug resistance. American Review of Respiratory Disease 1990;142:1301-5.
Neher 1996
Roumania 1977
  • Tuberculosis Research Institute, Bucharest. Trial of two intermittent short-course regimens (78 doses) in the initial treatment of pulmonary tuberculosis. Tubercle 1977;58:1-8.
Sedlaczek 1995
  • Sedlaczek AM, Serwatowski P, Spiewak W. Evaluation of the efficacy of treatment for smear-positive pulmonary tuberculosis with early introduction of the interrupting method - preliminary report. Pneumonologia i Alergologia Polska 1995;63:293-7.
Singapore 1981
  • Singapore Tuberculosis Service/British Medical Research Council. Clinical trial of six-month and four-month regimens of chemotherapy in the treatment of pulmonary tuberculosis: the results up to 30 months. Tubercle 1981;62:95-102.
Weis 1994
  • Weis SE, Slocum PC, Blais FX, King B, Nunn M, Matney GB, et al. The effect of directly observed therapy on the rates of drug resistance and relapse in tuberculosis. New England Journal of Medicine 1994;330:1179-84.
WHO 1996
  • Global Tuberculosis Programme. Tuberculosis notification update. World Health Organization Weekly Epidemiological Record 1996;71(9):65-72.
Wilkinson 1997a
  • Wilkinson D, Floyd K, Gilks CF. Cost and cost-effectiveness of alternative tuberculosis management strategies in South Africa--implications for policy. South African Medical Journal 1997;87:451-5.
Wilkinson 1997b
  • Wilkinson D, Davies GR. Coping with Africa's increasing tuberculosis burden: are community supervisors an essential component of the DOT strategy?. Tropical Medicine and International Health 1997;2(7):700-4.
    Direct Link:
Wilkinson 1997c
  • Wilkinson D, Anderson E, Davies GR, Sturm AW, McAdam KP. Efficacy of twice weekly treatment for tuberculosis given under direct observation in Africa. Transactions of the Royal Society of Tropical Medicine and Hygiene 1997;91(1):87-9.
View Full Article (HTML) Summary (55K)Standard (170K)Full (209K)