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Vaccines for preventing cholera: killed whole cell or other subunit vaccines (injected)

  1. Patricia M Graves1,*,
  2. Jonathan J Deeks2,
  3. Vittorio Demicheli3,
  4. Tom Jefferson4

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 7 AUG 2010

Assessed as up-to-date: 22 FEB 2009

DOI: 10.1002/14651858.CD000974.pub2


How to Cite

Graves PM, Deeks JJ, Demicheli V, Jefferson T. Vaccines for preventing cholera: killed whole cell or other subunit vaccines (injected). Cochrane Database of Systematic Reviews 2010, Issue 8. Art. No.: CD000974. DOI: 10.1002/14651858.CD000974.pub2.

Author Information

  1. 1

    The Carter Center, Atlanta, Georgia, USA

  2. 2

    University of Birmingham, Public Health, Epidemiology and Biostatistics, Birmingham, UK

  3. 3

    Regione Piemonte - Azienda Sanitaria Locale ASL AL, Health Councillorship - Servizio Regionale di Riferimento per l'Epidemiologia, SSEpi-SeREMI - Cochrane Vaccines Field, Torino, Piemonte, Italy

  4. 4

    The Cochrane Collaboration, Vaccines Field, Roma, Italy

*Patricia M Graves, The Carter Center, 453 Freedom Parkway, Atlanta, Georgia, GA 30307, USA. patricia.graves@emory.edu. pgraves.work@gmail.com.

Publication History

  1. Publication Status: Stable (no update expected for reasons given in 'What's new')
  2. Published Online: 7 AUG 2010

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Azurin 1965i {published data only}
  • Azurin JC. A controlled field trial on the effectiveness of cholera and cholera el Tor vaccines in the Phillipines. Proceedings of the Cholera Research Symposium. 1965:369-73.
  • Azurin JC, Alvero M. Cholera incidence in a population offered cholera vaccination: comparison of cooperative and uncooperative groups. Bulletin of the World Health Organization 1971;44(6):815-9.
  • Azurin JC, Cruz A, Pesigan TP, Alvero M, Camena T, Suplido R, Ledesma L, Gomez CZ. A controlled field trial of the effectiveness of cholera and cholera el Tor vaccines in the Phillipines. Bulletin of the World Health Organization 1967;37(5):703-27.
  • [No authors listed]. A controlled field trial of the effectiveness of cholera and cholera el Tor vaccines in the Phillipines. Preliminary report; Phillipines Cholera Committee. Bulletin of the World Health Organization 1965;32(5):603-25.
Azurin 1965ii {published data only}
  • See Azurin 1965i.
Azurin 1965iii {published data only}
  • See Azurin 1965i.
Benenson 1968a {published data only}
  • Benenson AS, Joseph PR, Oseasohn RO. Cholera vaccine field trials in East Pakistan. 1. Reaction and antigenicity studies. Bulletin of the World Health Organization 1968;38(3):347-57.
Benenson 1968b-i {published data only}
  • Benenson A, Mosley WH, Fahimuddin M, Oseasohn RO. Cholera vaccine field trials in East Pakistan. 2. Effectiveness in the field. Bulletin of the World Health Organization 1968;38(3):359-72.
  • Mosley WH, Benenson AS, Barui R. A serological survey for cholera antibodies in rural east Pakistan 2. A comparison of antibody titres in the immunized and control populations of a cholera-vaccine field trial area and the relation of antibody titre to cholera case rate. Bulletin of the World Health Organization 1968;38(3):335-46.
Benenson 1968b-ii {published data only}
  • See Benenson 1968-i.
Burgasov 1976 {published data only}
  • Burgasov PN, Sumarokov AA, Lelikov VL, Marcuk LM, Fedenev VG, Dzaparidze MN, et al. Comparative study of reactions and serological response to cholera vaccines in a controlled field trial conducted in the USSR. Bulletin of the World Health Organization 1976;54(2):163-70.
Curlin 1975 {unpublished data only}
  • Curlin G, Levine M, Aziz KMA, Mizanur Rahman ASM, Verwey WF. Field trial of cholera toxoid. Proceedings of the eleventh joint conference on cholera. New Orleans: US-Japan Cooperative Medical Science Program, 1975 Nov:314-29.
  • Curlin GT, Levine RJ, Ahmed A, Aziz KMA, Mizanur Rahman ASM, Verwey WF. Immunological aspects of a cholera toxoid field trial in Bangladesh. Dacca: Cholera Research Laboratory, 1978 March. Scientific Report No. 8.
das Gupta 1965a {published data only}
  • das Gupta A, Sinha R, Shrivastava DL, De SP, Taneja BL, Rao MS, et al. Controlled field trial of the effectiveness of cholera and cholera el tor vaccines in Calcutta. Bulletin of the World Health Organization 1967;37(5):371-85.
das Gupta 1965b-i {published data only}
  • das Gupta A, Sinha R, Shrivastava DL, De SP, Taneja BL, Rao MS, et al. Controlled field trial of the effectiveness of cholera and cholera El Tor vaccines in Calcutta. Bulletin of the World Health Organization 1967;37(5):371-85.
das Gupta 1965b-ii {published data only}
  • See das Gupta A 1965b-i.
McCormack 1969 {published data only}
  • McCormack WM, Rahman ASMM, Chowdhury AKMA, Mosley WH, Phillips RA. Report of the 1966-67 cholera vaccine trial in rural East Pakistan 3. The lack of effect of prior vaccination or circulating vibriocidal antibody on the severity of clinical cholera. Bulletin of the World Health Organization 1969;40(2):199-204.
  • Mosley WH, Aziz KMA, Rahman ASMM, Chowdhury AKMA, Ahmed A, Fahimuddin M. Report of the 1966-67 cholera vaccine trial in rural East Pakistan. 4. Five years of observation with a practical assessment of the role of a cholera vaccine in cholera control programmes. Bulletin of the World Health Organization 1972;47(2):229-38.
  • Mosley WH, McCormack WM, Ahmed A, Chowdhury AKMA, Barui RK. Report of the 1966-67 cholera vaccine field trial in rural East Pakistan. 2. Results of the serological surveys in the study population--the relationship of case rate to antibody titre and an estimate of the inapparent infection rate with Vibrio cholerae. Bulletin of the World Health Organization 1969;40(2):187-97.
  • Mosley WH, McCormack WM, Fahimuddin M, Aziz KM, Rahman AS, Chowdhury AK, et al. Report of the 1966-67 cholera vaccine field trial in rural East Pakistan. I. Study design and results of the first year of observation. Bulletin of the World Health Organization 1969;40(2):177-85.
Mosley 1970-i {published data only}
  • Mosley WH, Aziz KM, Rahman AS, Chowdhury AK, Ahmed A. Field trials of monovalent Ogawa and Inaba cholera vaccines in rural Bangladesh--three years of observation. Bulletin of the World Health Organization 1973;49(4):381-7.
  • Mosley WH, Woodward WE, Aziz KM, Rahman AS, Chowdhury AK, Ahmed A, et al. The 1968-1969 cholera-vaccine field trial in rural East Pakistan. Effectiveness of monovalent Ogawa and Inaba vaccines and a purified Inaba antigen, with comparative results of serological and animal protection tests. Journal of Infectious Diseases 1970;121 Suppl:1-9.
Mosley 1970-ii {published data only}
  • See Mosley 1970-i.
Mosley 1970-iii {published data only}
  • See Mosley 1970-i.
Oseasohn 1965 {published data only}
  • Benenson A, Mosley WH, Fahimuddin M, Oseasohn RO. Cholera vaccine field trials in East Pakistan. 2. Effectiveness in the field. Bulletin of the World Health Organization 1968;38(3):359-72.
  • Mosley WH, Benenson AS, Barui R. A serological survey for cholera antibodies in rural east Pakistan. 2. A comparison of antibody titres in the immunized and control population of a cholera-vaccine field-trial area and the relation of antibody titre to cholera case rate. Bulletin of the World Health Organization 1968;38(3):335-46.
  • Oseasohn RO, Benenson AS, Fahimuddin M. Cholera vaccine field trial in rural East Pakistan (first year of observation). Proceedings of the Cholera Research Symposium; 1965; Honolulu. 1965:362-6.
Pal 1980 {published data only}
  • Pal SC, Deb BC, Sen Gupta PG, De SP, Sircar BK, Sen D, et al. A controlled field trial of an aluminium phosphate-adsorbed cholera vaccine in Calcutta. Bulletin of the World Health Organization 1980;58(5):741-5.
PCC 1968 {published data only}
  • Philippines Cholera Committee. A controlled field trial of the effectiveness of various doses of cholera el Tor vaccine in the Philippines. Bulletin of the World Health Organization 1968;38(6):917-23.
PCC 1973a-i {published data only}
  • Philippines Cholera Committee. A controlled field trial of the effectiveness of monovalent classical and el tor cholera vaccines in the Philippines. Bulletin of the World Health Organization 1973;49(1):13-9.
PCC 1973a-ii {published data only}
  • See PCC 1973b-i.
PCC 1973a-iii {published data only}
  • See PCC 1973b-i.
PCC 1973a-iv {published data only}
  • See PCC 1973b-i.
PCC 1973b {published data only}
  • Philippines Cholera Committee. A controlled field trial on the effectiveness of the intradermal and subcutaneous administration of cholera vaccine in the Philippines. Bulletin of the World Health Organization 1973;49(4):389-94.
Saroso 1978i {published data only}
  • Saroso JS, Bahrawi W, Witjaksono H, Budiarso RL, Brotowasisto, Bencić Z, et al. A controlled field trial of plain and aluminium hydroxide-adsorbed cholera vaccines in Surabaya, Indonesia, during 1973--75. Bulletin of the World Health Organization 1978;56(4):619-27.
Saroso 1978ii {published data only}
  • See Saroso 1978i.
Taneja 1965 {published data only}
  • Taneja BL. Controlled field trials of cholera vaccines in Calcutta. Proceedings of the Cholera Research Symposium. 1965:373-379.
  • das Gupta A, Sinha R, Shrivastava DL, De SP, Taneja BL, Rao MS, Abou-Gareeb AH. Controlled field trial of the effectiveness of cholera and cholera el tor vaccines in Calcutta. Bulletin of the World Health Organization 1967;37(5):371-385.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Beran 1964 {published data only}
  • Beran GW, Elvina O, Florendo FN Jr. Studies on the role of active immunization in the prevention of cholera El Tor. Journal of the Philippine Medical Association 1964;40(2):122-35.
Beran 1965 {published data only}
  • Beran GW, Elviña O, Florendo FN Jr. Human volunteer studies using el tor cholera vaccines. I. Post-vaccinal reactions. Journal of the Philippine Medical Association 1965;41(3):183-90.
Black 1979 {published data only}
  • Black RE, Yunus MD, Eusof A, Ahmed A, Khan MR, Sack DA. Report on reactogenicity and immunogenicity of Wellcome cholera toxoids in Bangladeshi volunteers. Dacca, Bangladesh: International Centre for Diarrhoeal Disease Research, 1979 July. Scientific Report No. 29.
Cabrera 2005 {published data only}
  • Cabrera O, Martínez ME, Cuello M, Soto CR, Valmaseda T, Cedré B, et al. Preparation and evaluation of vibrio cholerae O1 EL Tor Ogawa lipopolysaccharide-tetanus toxoid conjugates. Vaccine 2006;2006(24 Suppl 2):74-5.
Chandra Sekar 1947 {published data only}
  • Chandra Sekar C. Statistical assessment if the efficacy of anticholera inoculation from the data of 63 cheris in South Arcot district. Indian Journal of Medical Research 1947;35(3):153-76.
Clasener 1968 {published data only}
  • Clasener HA, Beunders BJ. Immunization of man with typhoid and cholera vaccine. Agglutinating antibodies after intracutaneous and subcutaneous injection. Acta Leidensia 1968;36:78-85.
Ganguly 1975 {published data only}
  • Ganguly R, Clem LW, Bencic Z, Sinha R, Sakazaki R, Waldman RH. Antibody response in the intestinal secretions of volunteers immunized with various cholera vaccines. Bulletin of the World Health Organization 1975;52(3):323-30.
Gateff 1975 {published data only}
  • Gateff C, Dodin A, Wiart J. A comparison of the serological effects of classical cholera vaccine and of purified fraction vaccine, with or without simultaneous yellow fever vaccine (author's transl). Annales de Microbiologie 1975;126(2):231-46.
Gupta 1998 {published data only}
  • Gupta RK, Taylor DN, Bryla DA, Robbins JB, Szu SC. Phase 1 evaluation of Vibrio cholerae 01, serotype Inaba, polysaccharide-cholera toxin conjugates in adult volunteers. Infection and Immunity 1998;66(7):3095-9.
McBean 1972 {published data only}
Mosley 1968 {published data only}
  • Mosley WH, Benenson AS, Barui R. A serological survey for cholera antibodies in rural east Pakistan. 1. The distribution of antibody in the control population of a cholera-vaccine field-trial area and the relation of antibody titre to the pattern of endemic cholera. Bulletin of the World Health Organization 1968;38(3):327-34.
Nimbkar 1975 {published data only}
  • Nimbkar YS, Karbhari RS, Cherian S, Chanderkar NG, Bhamaria RP, Ranadive PS, et al. Antibody response to two cholera vaccines in volunteers. Progress in Drug Research 1975;19:544-62.
Peltola 1977 {published data only}
  • Peltola H, Ruutu P, Palomäki H, Kaukinen K, Aho K. Intracutaneous vaccination technic with less side effects against typhoid and cholera. Duodecim 1977;93(7):431-8.
Russell 1927 {published data only}
  • Russell AJH. Bezredka's cholera bilivaccin versus anti-cholera vaccine: a comparative field test. Transactions of the seventh congress of the Far East Association of Tropical Medicine 1927;1:523-34.
Sommer 1973a {published data only}

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Abba (in progress)
  • Abba K, Qadri F, Graves PM, Zaman K. Oral vaccines for preventing cholera. Cochrane Database of Systematic Reviews In progress.
Bhadra 1994
Calain 2004
Clemens 1994
  • Clemens J, Spriggs D, Sack D. Public health considerations for the use of cholera vaccines in cholera control programes. In: Wachsmuth K, Blake PA, Olvik O editor(s). Vibrio cholerae and cholera: molecular to global perspectives. Washington: American Society for Microbiology, 1994:25-40.
Clemens 1996
Cvjetanović 1978a
  • Cvjetanović B, Grab B, Uemura K. Dynamics of acute bacterial diseases. Epidemiological models and their application in public health. Part I. Theory and practice of epidemiological models. Bulletin of the World Health Organization 1978;56 Suppl 1:9-23.
Cvjetanović 1978b
  • Cvjetanović B, Grab B, Uemura K. Dynamics of acute bacterial diseases. Epidemiological models and their application in public health. Part II. Epidemiological models of acute bacterial diseases. Bulletin of the World Health Organization 1978;56 Suppl 1:25-143.
Davis 1995
  • Davis R, Spencer CM. Live oral cholera vaccine: A preliminary review of its pharmacology and clinical potential in providing protective immunity against cholera. Clinical Immunotherapeutics 1995;4(3):235-47.
Feeley 1978
  • Feeley JC, Gangarosa EJ. Field trials of Cholera vaccine [Cholera and related diarrheas]. 43rd Nobel symposium; 1978; Stockholm, Sweden. Basel: Karger, 1980:204-10.
Graves 2001
Jefferson 1996
Jefferson 1998
Joo 1974
  • Joo I. Cholera vaccines. In: Barua D, Burrows W editor(s). Cholera. Philadelphia: Saunders, 1974:333-5.
Lefebvre 2008
  • Lefebvre C, Manheimer E, Glanville J. Chapter 6: Searching for studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.0 (updated February 2008). The Cochrane Collaboration, 2008. Available from www.cochrane-handbook.org (accessed 1 September 2008).
Sommer 1973b
  • Sommer A, Mosley WH. Ineffectiveness of cholera vaccination as an epidemic control measure. Lancet 1973;814:1232-5.
Sánchez 1997
WHO 2006a
  • WHO. Cholera, 2005. Weekly Epidemiological Record 2006;81:297-308.
WHO 2006b
  • World Health Organization, Global Task Force on Cholera Control. Oral cholera vaccine use in complex emergencies: what next? Report of a WHO meeting, 14-16 December 2005, Cairo, Egypt [WHO/CDS/NTD/IDM/2006.2]. Geneva: World Health Organization, 2006.