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Buflomedil for intermittent claudication

  1. Tine LM de Backer1,2,*,
  2. Robert Vander Stichele2

Editorial Group: Cochrane Vascular Group

Published Online: 28 MAR 2013

Assessed as up-to-date: 8 JAN 2013

DOI: 10.1002/14651858.CD000988.pub4


How to Cite

de Backer TLM, Vander Stichele R. Buflomedil for intermittent claudication. Cochrane Database of Systematic Reviews 2013, Issue 3. Art. No.: CD000988. DOI: 10.1002/14651858.CD000988.pub4.

Author Information

  1. 1

    Heart Center, Ghent University Hospital, Ghent, Belgium

  2. 2

    Ghent University, Heymans Institute of Pharmacology, Ghent, Belgium

*Tine LM de Backer, Heart Center, Ghent University Hospital, De Pintelaan 185, Ghent, B-9000, Belgium. tine.debacker@ugent.be. t_de_backer@hotmail.com.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 28 MAR 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Diamantopoulos 2001 {published data only}
  • Diamantopoulos EJ, Grigoriadou M, Ifanti G, Raptis SA. Clinical and hemorheological effects of buflomedil in diabetic subjects with intermittent claudication. International Angiology 2001;20(4):337-44.
  • Diamantopoulos EJ, Raptis SA, Christodoulou-Peters M, Moulopoulos SD. Controlled trial of buflomedil in diabetic peripheral occlusive disease. Ischaemic Diseases and the Microcirculation. New Results. International Symposium. Frankfurt, January 1989:80-4.
Trübestein 1984 {published data only}
  • Trubestein G, Balzer K, Bisler H, Kluken N, Mahfoud Y, Muller-Wiefel H, et al. Buflomedil in obstructive arterial disease: Results of a controlled trial [Buflomedil bei arterieller Verschlusskrankheit: Ergebnissse einer kontrollierten Studie]. Deutsche Medizinische Wochenschrift 1982;107(51-52):1957-61.
  • Trübestein G, Balzer K, Bisler H, Klüken N, Muller-Wiefel H, Unkel B, et al. Buflomedil in arterial occlusive disease: results of a controlled multicenter study. Angiology 1984;35(8):500-5.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Bisler 1983 {published data only}
  • Bisler H. Clinical response to buflomedil in arterial occlusive disease. Therapiewoche 1983;33:2204-10.
Fonseca 1988 {published data only}
  • Fonseca V, Mikhaildis DP, Barradas MA, Jeremy JY, Gracey L, Dandona P. Double-blind placebo-controlled trial of buflomedil in intermittent claudication. International Journal of Clinical Pharmacology Research 1988;8(5):377-81.
Levien 1983 {published data only (unpublished sought but not used)}
  • Levien. [Unpublished study] W80-BU-004LJL. S-Africa, 1983. Mentioned in: Walker GA, Mac Hannaford JC. A meta-analysis of randomized, double-blind, placebo-controlled studies of the effect of buflomedil on intermittent claudication. Fundamental and Clinical Pharmacology 1995;9(4):387-94.
Limbs 2008 {published data only}
  • Leizorovicz A. Buflomedil reduces amputations in patients with peripheral arterial occlusive disease. American College of Cardiology, 54th Annual Scientific Session, Late-Breaking Clinical Trials; 2005 Mar 6-9; Orlando, Florida 2005.
  • Limbs International Medicinal Buflomedil (LIMB) Study Group, Leizorovicz, A, Becker F. Oral buflomedil in the prevention of cardiovascular events in patients with peripheral arterial obstructive disease: a randomized, placebo-controlled, 4-year study.[see comment]. Circulation 2008;117(6):816-22.
Lowe 1987 {unpublished data only}
  • Lowe GDO, Dandona P, Horrocks M, Cotton LT. [Unpublished study] Evaluation of the clinical efficacy and safety of oral buflomedil hydrochloride in the treatment of intermittent claudication. Study QL/UK.83/2-5. UK, 1987. Mentioned in: Walker GA, Mac Hannaford JC. A meta-analysis of randomized, double-blind, placebo-controlled studies of the effect of buflomedil on intermittent claudication. Fundamental and Clinical Pharmacology 1995;9(4):387-94 (Available from the authors).
Lund 1988 {published data only (unpublished sought but not used)}
  • Lund, et al. [Unpublished study] AB-8603. US, 1988. Mentioned in: Walker GA, Mac Hannaford JC. A meta-analysis of randomized, double-blind, placebo-controlled studies of the effect of buflomedil on intermittent claudication. Fundamental and Clinical Pharmacology 1995;9(4):387-94.
Olsson 1986 {published data only (unpublished sought but not used)}
  • Olsson. [Unpublished study] Sweden, 1986. Mentioned in: Walker GA, Mac Hannaford JC. A meta-analysis of randomized, double-blind, placebo-controlled studies of the effect of buflomedil on intermittent claudication. Fundamental and Clinical Pharmacology 1995;9(4):387-94.
Raithel 1985 {published data only (unpublished sought but not used)}
  • Raithel, et al. [Unpublished study] BU-3-P05. Germany, 1985. Mentioned in: Walker GA, Mac Hannaford JC. A meta-analysis of randomized, double-blind, placebo-controlled studies of the effect of buflomedil on intermittent claudication. Fundamental and Clinical Pharmacology 1995;9(4):387-94.
Zinnagl 1986 {published data only}
  • Zinnagl N. A double blind study of the effects of buflomedil in 40 patients with arterial occlusive disease in Stage IIB [Doppelblindstudie über die Wirksamkeit von Buflomedil an 40 Patienten mit arterieller Verschlusskrankheit im Stadium IIB]. International Symposium on Conservative Therapy of Arterial Occlusive Disease. Bonn, May 23-25. New York: Georg Thieme Verlag, 1986.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Baitsch 1983
  • Baitsch R. [Unpublished study]. BU-2-DO2. Germany, 1983. Mentioned in: Walker GA, Mac Hannaford JC. A meta-analysis of randomized, double-blind, placebo-controlled studies of the effect of buflomedil on intermittent claudication. Fundamental and Clinical Pharmacology 1995; Vol. 9, issue 4:387-94.
Bevan 1992
Cameron 1988
Diamantopoulos 1989
  • Diamantopoulos EJ, Raptis SA, Christodoulou-Peters M, Moulopoulos SD. Controlled trial of buflomedil in diabetic peripheral occlusive disease. Ischaemic diseases and the microcirculation. New results. International Symposium. Frankfurt, January 1989:80-4.
Dickersin 1994
Fontaine 1954
  • Fontaine VR, Kim M, Kieny R. Surgical treatment for peripheral vascular disease [Die chirurgische Behandlung der peripheren Durchblutungsstorungen]. Helvetica Chirurgica Acta 1954;5/6:499-533.
Gardner 1989a
  • Gardner MJ, Altman DG. Estimating with confidence. In: Gardner MJ, Altman DG editor(s). Statistics with confidence: confidence intervals and statistical guidelines. London: BMJ Publishing Group, 1989:3-5.
Gardner 1989b
  • Gardner MJ, Altman DG. Estimation rather than hypothesis testing: confidence intervals rather than P values. In: Gardner MJ, Altman DG editor(s). Statistics with confidence: confidence intervals and statistical guidelines. London: BMJ Publishing Group, 1989:6-19.
Gardner 1989c
  • Altman DG, Gardner MJ. Calculating confidence intervals for means and their differences. In: Gardner MJ, Altman DG editor(s). Statistics with confidence: confidence intervals and statistical guidelines. London: BMJ Publishing Group, 1989:20-7.
Gardner 1989d
  • Gardner MJ, Altman DG. Tables for calculation of confidence intervals. In: Gardner MJ, Altman DG editor(s). Statistics with confidence: confidence intervals and statistical guidelines. London: BMJ Publishing Group, 1989:111-29.
Jadad 1996
  • Jadad RJ, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Controlled Clinical Trials 1996;17:1-12.
Jepson 1997
  • Jepson RG, Kleijnen J, Leng GC. Garlic for peripheral arterial occlusive disease. Cochrane Database of Systematic Reviews 2006, Issue 2. [DOI: 10.1002/14651858.CD000095]
Kleijnen 1998
Leng 2000
  • Leng GC, Fowler B, Ernst E. Exercise for intermittent claudication. Cochrane Database of Systematic Reviews 2000, Issue 2. [DOI: 10.1002/14651858.CD000990]
Liard 1997
  • Liard F, Benichou AC, Gamand S, Lehert P. The effects of naftidrofuryl on quality of life. Disease Management Health Outcomes 1997;2(Suppl 1):71-8.
Marimbert 2006
  • Marimbert J. Lettre aux professionnels de santé: Pharmacovigilance et la sécurité d'emploi du buflomédil [Letter to health professionals: Pharmacovigilance and safety of use of buflomedil]. Agence française de sécurité sanitaire des produits de santé. 13 November 2006.
Mulrow 1999
  • Mulrow CD, Oxman AD. Cochrane Collaboration Handbook (In: The Cochrane Library, Issue 3). Oxford: Update Software, 1999.
Price 2001
  • Price JF, Leng GC. Steroid sex hormones for lower limb atherosclerosis. Cochrane Database of Systematic Reviews 2005, Issue 3. [DOI: 10.1002/14651858.CD000188]
Schulz 1995
  • Schulz KF, Chalmers IC, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. Journal of the American Medical Association 1995;273(5):408-12.
Spengel 1997
  • Spengel A, Brown TM, Dietze S, Kirchberger I, Comte S. The claudication scale (CLAU-S). New disease-specific quality-of-life instrument in intermittent claudication. Disease Management Health Outcomes 1997;2(Suppl 1):65-70.
Verhaeghe 1998
Walker 1995
Wood 2005
  • Wood S. Buflomedil to reduce clinical complications of peripheral artery disease? Maybe, maybe not. www.theheart.org/article/402581.do 11 March 2005, issue accessed 26 April 2007.
Wurzinger 1987
  • Wurzinger LJ, Schmid-Schonbein H. Effect of buflomedil on epinephrine-enhanced platelet aggregation in vitro and ex vivo. Arzneimittel-Forschung 1987;37(10):1113-5.

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
De Backer 2000
  • De Backer TLM, Vander Stichele RH, Bogaert MG. Buflomedil for intermittent claudication. Cochrane Database of Systematic Reviews 2000, Issue 2. [DOI: 10.1002/14651858.CD000988]
De Backer 2007
de Backer 2008
  • de Backer TLM, Bogaert M, Vander Stichele R. Buflomedil for intermittent claudication. Cochrane Database of Systematic Reviews 2008, Issue 1. [DOI: 10.1002/14651858.CD000988.pub3]