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Mannitol for acute traumatic brain injury

  1. Abel Wakai1,*,
  2. Ian G Roberts2,
  3. Gillian Schierhout3

Editorial Group: Cochrane Injuries Group

Published Online: 8 OCT 2008

Assessed as up-to-date: 28 FEB 2006

DOI: 10.1002/14651858.CD001049.pub4

Database Title

Additional Information

How to Cite

Wakai A, Roberts IG, Schierhout G. Mannitol for acute traumatic brain injury. Cochrane Database of Systematic Reviews 2007, Issue 1. Art. No.: CD001049. DOI: 10.1002/14651858.CD001049.pub4.

Author Information

  1. 1

    Sunnybrook Health Sciences Centre, Division of Emergency Medicine, Toronto, Ontario, Canada

  2. 2

    London School of Hygiene & Tropical Medicine, Cochrane Injuries Group, London, UK

  3. 3

    London School of Hygiene & Tropical Medicine, c/o Cochrane Injuries Group, London, UK

*Abel Wakai, Division of Emergency Medicine, Sunnybrook Health Sciences Centre, Suite C7-16, Toronto, Ontario, M4N 3M5, Canada. abelwakai@gmail.com.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 8 OCT 2008

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Sayre 1996 {published data only}
  • Sayre MR, Daily SW, Stern SA, Storer DL, van Loveren HR, Hurst JD. Out-of-hospital administration of mannitol does not change systolic blood pressure. Academic Emergency Medicine 1996;3(9):840-8. [MEDLINE: 1997024527]
    Direct Link:
Schwartz 1984 {published data only}
  • Schwartz ML, Tator CH, Rowed DW, Reid SR, Meguro K, Andrews DF. The University of Toronto head injury treatment study: a prospective, randomized comparison of pentobarbital and mannitol. Canadian Journal of Neurological Sciences 1984;11(4):434-40. [MEDLINE: 1985098889]
Smith 1986 {published data only}
Vialet 2003 {published data only}
  • Vialet R, Albanese J, Thomachot L, Antonini F, Bourgouin A, Alliez B, et al. Isovolume hypertonic solutes (sodium chloride or mannitol) in the treatment of refractory posttraumatic intracranial hypertension: 2 mL/kg 7.5% saline is more effective than 2 mL/kg 20% mannitol. Critical Care Medicine 2003;31(6):1683-7. [MEDLINE: 12794404]

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Battison 2005 {published data only}
  • Battison C, Andrews PJ, Graham C, Petty T. Randomized, controlled trial of the effect of a 20% mannitol solution and a 7.5% saline/6% dextran solution on increased intracranial pressure after brain injury. Critical Care Medicine 2005;33(1):196-202. [MEDLINE: 15644669]
Cruz 2001 {published data only}
  • Cruz C, Minoja G, Okuchi K. Improving clinical outcomes from acute subdural hematomas with emergency preoperative administration of high doses of mannitol: a randomized trial. Neurosurgery 2001;49(4):864-71.
Cruz 2002 {published data only}
  • Cruz C, Minoja G, Okuchi K. Major clinical and physiological benefits of early high doses of mannitol for intraparenchymal temporal lobe hemorrhages with abnormal pupilary widening. Neurosurgery 2002;51(3):628-38.
Cruz 2004 {published data only}
  • Cruz J, Minoja G, Okuchi K, Facco E. Successful use of the new high-dose mannitol treatment in patients with Glasgow Coma Scores of 3 and bilateral abnormal pupillary widening: a randomized trial. Journal of Neurosurgery 2004;100(3):376-83. [MEDLINE: 15035271]
Fortune 1995 {published data only}
  • Fortune JB, Feustel PJ, Graca I, Hasselbarth J, Kuehler DH. Effect of hyperventilation, mannitol, and ventriculostomy drainage on cerebral blood-flow after head-injury. Journal of Trauma-Injury Infection and Critical Care 1995;39(6):1091-9.
Gaab 1989 {published data only}
  • Gaab MR, Seegers K, Goetz C. THAM (Tromethamine, "Tris-Buffer"): Effective therapy of traumatic brain swelling?. In: Hoff JT, Betz AL editor(s). Intracranial Pressure VII. Berlin Heidelberg: Springer-Verlag, 1989:616-9.
Levin 1979 {published data only}
Midgely 1993 {published data only}
  • Midgley S. CPP and SJO2 with ICP Reduction Therapy After Severe Head Injury. Intracranial Pressure. New York: Springer-Verlag, 1993:558-63.
Smedema 1993 {published data only}
  • Smedema RJA. Comparison Study Between Mannitol and Glycerol Therapy in Reducing Intracranial Pressure. Intracranial Pressure. Vol. 8, New York: Springer-Verlag, 1993:605-8.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Ghajar 1995
Jeevaratnam 1996
  • Jeevaratnam DR, Menon DK. Survey of intensive care of severely head injured patients in the United Kingdom. BMJ 1996;312:994-7.
Matta 1996
  • Matta B, Menon D. Severe head injury in the United Kingdom and Ireland: a survey of practice and implications for management. Critical Care Medicine 1996; 24;10:1743-8.
Task Force 1995
  • Task force of the American Association of Neurological Surgeons and Joint Section in Neurotrauma and Critical Care. Guidelines for the management of severe head injury. Brain Trauma Foundation, 1995.
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