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Intervention Review

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Mannitol for acute traumatic brain injury

  1. Abel Wakai1,*,
  2. Ian G Roberts2,
  3. Gillian Schierhout3

Editorial Group: Cochrane Injuries Group

Published Online: 24 JAN 2007

Assessed as up-to-date: 28 FEB 2006

DOI: 10.1002/14651858.CD001049.pub4


How to Cite

Wakai A, Roberts IG, Schierhout G. Mannitol for acute traumatic brain injury. Cochrane Database of Systematic Reviews 2007, Issue 1. Art. No.: CD001049. DOI: 10.1002/14651858.CD001049.pub4.

Author Information

  1. 1

    Sunnybrook Health Sciences Centre, Division of Emergency Medicine, Toronto, Ontario, Canada

  2. 2

    London School of Hygiene & Tropical Medicine, Cochrane Injuries Group, London, UK

  3. 3

    London School of Hygiene & Tropical Medicine, c/o Cochrane Injuries Group, London, UK

*Abel Wakai, Division of Emergency Medicine, Sunnybrook Health Sciences Centre, Suite C7-16, Toronto, Ontario, M4N 3M5, Canada. abelwakai@gmail.com.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 24 JAN 2007

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This is not the most recent version of the article. View current version (05 AUG 2013)

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Sayre 1996 {published data only}
Schwartz 1984 {published data only}
  • Schwartz ML, Tator CH, Rowed DW, Reid SR, Meguro K, Andrews DF. The University of Toronto head injury treatment study: a prospective, randomized comparison of pentobarbital and mannitol. Canadian Journal of Neurological Sciences 1984;11(4):434-40. [MEDLINE: 1985098889]
Smith 1986 {published data only}
Vialet 2003 {published data only}
  • Vialet R, Albanese J, Thomachot L, Antonini F, Bourgouin A, Alliez B, et al. Isovolume hypertonic solutes (sodium chloride or mannitol) in the treatment of refractory posttraumatic intracranial hypertension: 2 mL/kg 7.5% saline is more effective than 2 mL/kg 20% mannitol. Critical Care Medicine 2003;31(6):1683-7. [MEDLINE: 12794404]

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Battison 2005 {published data only}
  • Battison C, Andrews PJ, Graham C, Petty T. Randomized, controlled trial of the effect of a 20% mannitol solution and a 7.5% saline/6% dextran solution on increased intracranial pressure after brain injury. Critical Care Medicine 2005;33(1):196-202. [MEDLINE: 15644669]
Cruz 2001 {published data only}
  • Cruz C, Minoja G, Okuchi K. Improving clinical outcomes from acute subdural hematomas with emergency preoperative administration of high doses of mannitol: a randomized trial. Neurosurgery 2001;49(4):864-71.
Cruz 2002 {published data only}
  • Cruz C, Minoja G, Okuchi K. Major clinical and physiological benefits of early high doses of mannitol for intraparenchymal temporal lobe hemorrhages with abnormal pupilary widening. Neurosurgery 2002;51(3):628-38.
Cruz 2004 {published data only}
  • Cruz J, Minoja G, Okuchi K, Facco E. Successful use of the new high-dose mannitol treatment in patients with Glasgow Coma Scores of 3 and bilateral abnormal pupillary widening: a randomized trial. Journal of Neurosurgery 2004;100(3):376-83. [MEDLINE: 15035271]
Fortune 1995 {published data only}
  • Fortune JB, Feustel PJ, Graca I, Hasselbarth J, Kuehler DH. Effect of hyperventilation, mannitol, and ventriculostomy drainage on cerebral blood-flow after head-injury. Journal of Trauma-Injury Infection and Critical Care 1995;39(6):1091-9.
Gaab 1989 {published data only}
  • Gaab MR, Seegers K, Goetz C. THAM (Tromethamine, "Tris-Buffer"): Effective therapy of traumatic brain swelling?. In: Hoff JT, Betz AL editor(s). Intracranial Pressure VII. Berlin Heidelberg: Springer-Verlag, 1989:616-9.
Levin 1979 {published data only}
Midgely 1993 {published data only}
  • Midgley S. CPP and SJO2 with ICP Reduction Therapy After Severe Head Injury. Intracranial Pressure. New York: Springer-Verlag, 1993:558-63.
Smedema 1993 {published data only}
  • Smedema RJA. Comparison Study Between Mannitol and Glycerol Therapy in Reducing Intracranial Pressure. Intracranial Pressure. Vol. 8, New York: Springer-Verlag, 1993:605-8.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Ghajar 1995
Jeevaratnam 1996
  • Jeevaratnam DR, Menon DK. Survey of intensive care of severely head injured patients in the United Kingdom. BMJ 1996;312:994-7.
Matta 1996
  • Matta B, Menon D. Severe head injury in the United Kingdom and Ireland: a survey of practice and implications for management. Critical Care Medicine 1996; 24;10:1743-8.
Task Force 1995
  • Task force of the American Association of Neurological Surgeons and Joint Section in Neurotrauma and Critical Care. Guidelines for the management of severe head injury. Brain Trauma Foundation, 1995.