Intervention Review

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Mannitol for acute traumatic brain injury

  1. Abel Wakai1,*,
  2. Aileen McCabe1,
  3. Ian Roberts2,
  4. Gillian Schierhout3

Editorial Group: Cochrane Injuries Group

Published Online: 5 AUG 2013

Assessed as up-to-date: 20 APR 2009

DOI: 10.1002/14651858.CD001049.pub5


How to Cite

Wakai A, McCabe A, Roberts I, Schierhout G. Mannitol for acute traumatic brain injury. Cochrane Database of Systematic Reviews 2013, Issue 8. Art. No.: CD001049. DOI: 10.1002/14651858.CD001049.pub5.

Author Information

  1. 1

    Division of Population Health Sciences (PHS), Royal College of Surgeons in Ireland, Emergency Care Research Unit (ECRU), Dublin 2, Ireland

  2. 2

    London School of Hygiene & Tropical Medicine, Cochrane Injuries Group, London, UK

  3. 3

    London School of Hygiene & Tropical Medicine, c/o Cochrane Injuries Group, London, UK

*Abel Wakai, Emergency Care Research Unit (ECRU), Division of Population Health Sciences (PHS), Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland. awakai@rcsi.ie. abelwakai@gmail.com.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 5 AUG 2013

SEARCH

[Figure 1]
Figure 1. Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
[Figure 2]
Figure 2. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies. Four studies are included in this review.
[Analysis 1.1]
Analysis 1.1. Comparison 1 ICP-directed mannitol ('treatment') compared to mannitol according to neurological signs ('control'), Outcome 1 Death.
[Analysis 1.2]
Analysis 1.2. Comparison 1 ICP-directed mannitol ('treatment') compared to mannitol according to neurological signs ('control'), Outcome 2 Death or severe disability.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Mannitol versus pentobarbital, Outcome 1 Death.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Mannitol versus hypertonic saline, Outcome 1 Death.
[Analysis 4.1]
Analysis 4.1. Comparison 4 Mannitol versus placebo, Outcome 1 Death.