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Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems

  1. G Justus Hofmeyr1,*,
  2. Theresa A Lawrie2,
  3. Álvaro N Atallah3,
  4. Lelia Duley4

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 4 AUG 2010

DOI: 10.1002/14651858.CD001059.pub3


How to Cite

Hofmeyr GJ, Lawrie TA, Atallah ÁN, Duley L. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database of Systematic Reviews 2010, Issue 8. Art. No.: CD001059. DOI: 10.1002/14651858.CD001059.pub3.

Author Information

  1. 1

    University of the Witwatersrand, University of Fort Hare, Eastern Cape Department of Health, Department of Obstetrics and Gynaecology, East London Hospital Complex, East London, Eastern Cape, South Africa

  2. 2

    University of the Witwatersrand/University of Fort Hare/East London Hospital Complex, Effective Care Research Unit, East London, South Africa

  3. 3

    Universidade Federal de São Paulo / Escola Paulista de Medicina, Brazilian Cochrane Centre, São Paulo, SP, Brazil

  4. 4

    University of Leeds, Centre for Epidemiology and Biostatistics, Bradford, West Yorkshire, UK

*G Justus Hofmeyr, Department of Obstetrics and Gynaecology, East London Hospital Complex, University of the Witwatersrand, University of Fort Hare, Eastern Cape Department of Health, Frere and Cecilia Makiwane Hospitals, Private Bag X 9047, East London, Eastern Cape, 5200, South Africa. justhof@gmail.com.

Publication History

  1. Publication Status: Edited (no change to conclusions), comment added to review
  2. Published Online: 4 AUG 2010

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[Figure 1]
Figure 1. Funnel plot of comparison: 1 Routine calcium supplementation in pregnancy by baseline dietary calcium, outcome: 1.1 High blood pressure (with or without proteinuria).
[Figure 2]
Figure 2. Funnel plot of comparison: 2 Routine calcium supplementation in pregnancy by hypertension risk, outcome: 2.1 High blood pressure (with or without proteinuria).
[Figure 3]
Figure 3. Funnel plot of comparison: 1 Routine calcium supplementation in pregnancy by baseline dietary calcium, outcome: 1.2 Pre-eclampsia.
[Figure 4]
Figure 4. Funnel plot of comparison: 2 Routine calcium supplementation in pregnancy by hypertension risk, outcome: 2.2 Pre-eclampsia.
[Figure 5]
Figure 5. Funnel plot of comparison: 1 Routine calcium supplementation in pregnancy by baseline dietary calcium, outcome: 1.12 Preterm birth.
[Figure 6]
Figure 6. Funnel plot of comparison: 3 Routine calcium supplementation in pregnancy by study sample size, outcome: 3.1 High blood pressure (with or without proteinuria).
[Figure 7]
Figure 7. Funnel plot of comparison: 3 Routine calcium supplementation in pregnancy by study sample size, outcome: 3.3 Preterm birth.
[Figure 8]
Figure 8. Funnel plot of comparison: 4 Routine calcium supplementation in pregnancy by baseline dietary calcium and study sample size, outcome: 4.1 Pre-eclampsia.
[Figure 9]
Figure 9. Funnel plot of comparison: 1 Routine calcium supplementation in pregnancy by baseline dietary calcium, outcome: 1.16 Stillbirth or death before discharge from hospital.
[Figure 10]
Figure 10. Funnel plot of comparison: 2 Routine calcium supplementation in pregnancy by hypertension risk, outcome: 2.5 Stillbirth or death before discharge from hospital.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Routine calcium supplementation in pregnancy by baseline dietary calcium, Outcome 1 High blood pressure (with or without proteinuria).
[Analysis 1.2]
Analysis 1.2. Comparison 1 Routine calcium supplementation in pregnancy by baseline dietary calcium, Outcome 2 Pre-eclampsia.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Routine calcium supplementation in pregnancy by baseline dietary calcium, Outcome 3 Preterm birth.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Routine calcium supplementation in pregnancy by baseline dietary calcium, Outcome 4 Admission to neonatal intensive care unit.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Routine calcium supplementation in pregnancy by baseline dietary calcium, Outcome 5 Stillbirth or death before discharge from hospital.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Routine calcium supplementation in pregnancy by baseline dietary calcium, Outcome 6 Maternal death/serious morbidity.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Routine calcium supplementation in pregnancy by baseline dietary calcium, Outcome 7 Placental abruption.
[Analysis 1.8]
Analysis 1.8. Comparison 1 Routine calcium supplementation in pregnancy by baseline dietary calcium, Outcome 8 Caesarean section.
[Analysis 1.9]
Analysis 1.9. Comparison 1 Routine calcium supplementation in pregnancy by baseline dietary calcium, Outcome 9 Proteinuria (gestational with no proteinuria.
[Analysis 1.10]
Analysis 1.10. Comparison 1 Routine calcium supplementation in pregnancy by baseline dietary calcium, Outcome 10 Severe pre-eclampsia.
[Analysis 1.11]
Analysis 1.11. Comparison 1 Routine calcium supplementation in pregnancy by baseline dietary calcium, Outcome 11 Eclampsia.
[Analysis 1.12]
Analysis 1.12. Comparison 1 Routine calcium supplementation in pregnancy by baseline dietary calcium, Outcome 12 HELLP syndrome.
[Analysis 1.13]
Analysis 1.13. Comparison 1 Routine calcium supplementation in pregnancy by baseline dietary calcium, Outcome 13 Intensive care unit admission.
[Analysis 1.14]
Analysis 1.14. Comparison 1 Routine calcium supplementation in pregnancy by baseline dietary calcium, Outcome 14 Maternal death.
[Analysis 1.15]
Analysis 1.15. Comparison 1 Routine calcium supplementation in pregnancy by baseline dietary calcium, Outcome 15 Birthweight < 2500 g.
[Analysis 1.16]
Analysis 1.16. Comparison 1 Routine calcium supplementation in pregnancy by baseline dietary calcium, Outcome 16 Neonate small-for-gestational age as defined by trial authors.
[Analysis 1.17]
Analysis 1.17. Comparison 1 Routine calcium supplementation in pregnancy by baseline dietary calcium, Outcome 17 Childhood systolic blood pressure > 95th percentile.
[Analysis 1.18]
Analysis 1.18. Comparison 1 Routine calcium supplementation in pregnancy by baseline dietary calcium, Outcome 18 Childhood diastolic blood pressure > 95th percentile.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Routine calcium supplementation in pregnancy by hypertension risk, Outcome 1 High blood pressure (with or without proteinuria).
[Analysis 2.2]
Analysis 2.2. Comparison 2 Routine calcium supplementation in pregnancy by hypertension risk, Outcome 2 Pre-eclampsia.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Routine calcium supplementation in pregnancy by hypertension risk, Outcome 3 Preterm birth.
[Analysis 2.4]
Analysis 2.4. Comparison 2 Routine calcium supplementation in pregnancy by hypertension risk, Outcome 4 Admission to neonatal intensive care unit.
[Analysis 2.5]
Analysis 2.5. Comparison 2 Routine calcium supplementation in pregnancy by hypertension risk, Outcome 5 Stillbirth or death before discharge from hospital.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Routine calcium supplementation in pregnancy by study sample size, Outcome 1 High blood pressure (with or without proteinuria).
[Analysis 3.2]
Analysis 3.2. Comparison 3 Routine calcium supplementation in pregnancy by study sample size, Outcome 2 Pre-eclampsia.
[Analysis 3.3]
Analysis 3.3. Comparison 3 Routine calcium supplementation in pregnancy by study sample size, Outcome 3 Preterm birth.
[Analysis 3.4]
Analysis 3.4. Comparison 3 Routine calcium supplementation in pregnancy by study sample size, Outcome 4 Admission to neonatal intensive care unit.
[Analysis 3.5]
Analysis 3.5. Comparison 3 Routine calcium supplementation in pregnancy by study sample size, Outcome 5 Stillbirth or death before discharge from hospital.
[Analysis 4.1]
Analysis 4.1. Comparison 4 Routine calcium supplementation in pregnancy by baseline dietary calcium and study sample size (not pre-specified), Outcome 1 Pre-eclampsia.
[Analysis 5.1]
Analysis 5.1. Comparison 5 Routine calcium supplementation in pregnancy by other outcomes (not pre-specified), Outcome 1 Uterine artery RI at 32 weeks.
[Analysis 5.2]
Analysis 5.2. Comparison 5 Routine calcium supplementation in pregnancy by other outcomes (not pre-specified), Outcome 2 Umbilical artery RI at 32 weeks.
[Analysis 5.3]
Analysis 5.3. Comparison 5 Routine calcium supplementation in pregnancy by other outcomes (not pre-specified), Outcome 3 Low platelet count at 35 weeks.
[Analysis 5.4]
Analysis 5.4. Comparison 5 Routine calcium supplementation in pregnancy by other outcomes (not pre-specified), Outcome 4 High serum uric acid at 35 weeks.
[Analysis 5.5]
Analysis 5.5. Comparison 5 Routine calcium supplementation in pregnancy by other outcomes (not pre-specified), Outcome 5 High urine protein/creatinine ratio at 35 weeks.
[Analysis 5.6]
Analysis 5.6. Comparison 5 Routine calcium supplementation in pregnancy by other outcomes (not pre-specified), Outcome 6 Ultrasound estimate of fetal growth at 32 weeks: femur length (cm)*.
[Analysis 5.7]
Analysis 5.7. Comparison 5 Routine calcium supplementation in pregnancy by other outcomes (not pre-specified), Outcome 7 Ultrasound estimate of fetal growth at 32 weeks: biparietal diameter (cm)*.
[Analysis 5.8]
Analysis 5.8. Comparison 5 Routine calcium supplementation in pregnancy by other outcomes (not pre-specified), Outcome 8 Ultrasound estimate of fetal growth at 32 weeks: abdominal circumference (cm)*.