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Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems

  1. GJ Hofmeyr,
  2. AN Atallah,
  3. L Duley

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 21 JAN 2002

DOI: 10.1002/14651858.CD001059


How to Cite

Hofmeyr GJ, Atallah AN, Duley L. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. The Cochrane Database of Systematic Reviews 2002, Issue 1. Art. No.: CD001059. DOI: 10.1002/14651858.CD001059.

Author Information

*Prof G Justus Hofmeyr, Director/Hon. Professor, Effective Care Research Unit, University of the Witwatersrand, University of Fort Hare, Eastern Cape Department of Health, Frere and Cecilia Makiwane Hospitals, Private Bag X 9047, East London, Eastern Cape, 5200, SOUTH AFRICA. gjh@global.co.za.

Publication History

  1. Published Online: 21 JAN 2002

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This is not the most recent version of the article. View current version (24 JUN 2014)

 
Comparison 01. Routine calcium supplementation in pregnancy by hypertension risk

Outcome titleNo. of studiesNo. of participantsStatistical methodEffect size

 01 High blood pressure (with or without proteinuria)106634Relative Risk (Random) 95% CI0.58 [0.43, 0.79]

 02 Pre-eclampsia116894Relative Risk (Random) 95% CI0.35 [0.20, 0.60]

 03 Maternal death/serious morbidity31420Relative Risk (Fixed) 95% CI0.39 [0.02, 9.20]

 04 Placental abruption31408Relative Risk (Fixed) 95% CI1.52 [0.43, 5.37]

 05 Caesarean section66332Relative Risk (Fixed) 95% CI0.94 [0.84, 1.05]

 07 Preterm delivery96671Relative Risk (Random) 95% CI0.66 [0.43, 1.01]

 08 Birthweight < 2500g76491Relative Risk (Random) 95% CI0.69 [0.47, 1.01]

 09 Neonate small for gestational age as defined by trial authors1190Relative Risk (Fixed) 95% CI0.72 [0.26, 1.99]

 10 Admission to neonatal intensive care unit35497Relative Risk (Fixed) 95% CI1.09 [0.96, 1.24]

 12 Stillbirth or death before discharge from hospital96763Relative Risk (Fixed) 95% CI1.04 [0.65, 1.66]

 15 Childhood systolic blood pressure > 95th percentile1514Relative Risk (Fixed) 95% CI0.59 [0.39, 0.91]

 16 Childhood diastolic blood pressure > 95th percentile1514Relative Risk (Fixed) 95% CI0.81 [0.50, 1.31]

 
Comparison 02. Routine calcium supplementation in pregnancy by baseline dietary calcium

Outcome titleNo. of studiesNo. of participantsStatistical methodEffect size

 01 High blood pressure (with or without proteinuria)96604Relative Risk (Random) 95% CI0.53 [0.37, 0.75]

 02 Pre-eclampsia106864Relative Risk (Random) 95% CI0.37 [0.21, 0.64]

 03 Maternal death/serious morbidity31420Relative Risk (Fixed) 95% CI0.39 [0.02, 9.20]

 04 Placental abruption31408Relative Risk (Fixed) 95% CI1.52 [0.43, 5.37]

 05 Caesarean section66332Relative Risk (Fixed) 95% CI0.94 [0.84, 1.05]

 07 Preterm delivery96670Relative Risk (Random) 95% CI0.66 [0.43, 1.01]

 08 Birthweight < 2500g76491Relative Risk (Random) 95% CI0.69 [0.47, 1.01]

 09 Neonate small for gestational age as defined by trial authors1190Relative Risk (Fixed) 95% CI0.72 [0.26, 1.99]

 10 Admission to neonatal intensive care unit35497Relative Risk (Fixed) 95% CI1.09 [0.96, 1.24]

 12 Stillbirth or death before discharge from hospital96763Relative Risk (Fixed) 95% CI1.04 [0.65, 1.66]

 15 Childhood systolic blood pressure > 95th percentile00Relative Risk (Fixed) 95% CINot estimable

 16 Childhood diastolic blood pressure > 95th percentile00Relative Risk (Fixed) 95% CINot estimable