Intervention Review

Piracetam for fetal distress in labour

  1. G Justus Hofmeyr1,*,
  2. Regina Kulier2

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 7 OCT 2009

Assessed as up-to-date: 23 JUN 2009

DOI: 10.1002/14651858.CD001064

Database Title

Additional Information

How to Cite

Hofmeyr GJ, Kulier R. Piracetam for fetal distress in labour. Cochrane Database of Systematic Reviews 1998, Issue 2. Art. No.: CD001064. DOI: 10.1002/14651858.CD001064.

Author Information

  1. 1

    University of the Witwatersrand, University of Fort Hare, Eastern Cape Department of Health, Department of Obstetrics and Gynaecology, East London Hospital Complex, East London, Eastern Cape, South Africa

  2. 2

    Geneva Foundation for Medical Education and Research, Geneva, Switzerland

*G Justus Hofmeyr, Department of Obstetrics and Gynaecology, East London Hospital Complex, University of the Witwatersrand, University of Fort Hare, Eastern Cape Department of Health, Frere and Cecilia Makiwane Hospitals, Private Bag X 9047, East London, Eastern Cape, 5200, South Africa. justhof@gmail.com.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 7 OCT 2009

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Abstract

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

Background

Piracetam is thought to promote the metabolism of brain cells when they are hypoxic. It has been used to prevent adverse effects of fetal distress.

Objectives

The objective of this review was to assess the effects of piracetam for suspected fetal distress in labour on method of delivery and perinatal morbidity.

Search methods

We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (June 2009).

Selection criteria

Randomised trials of piracetam compared with placebo or no treatment for suspected fetal distress in labour.

Data collection and analysis

Both review authors assessed eligibility and trial quality.

Main results

One study of 96 women was included. Piracetam compared with placebo was associated with a trend to reduced need for caesarean section (risk ratio 0.57, 95% confidence interval 0.32 to 1.03). There were no statistically significant differences between the piracetam and placebo group for neonatal morbidity (measured by neonatal respiratory distress) or Apgar score.

Authors' conclusions

There is not enough evidence to evaluate the use of piracetam for fetal distress in labour.

 

Plain language summary

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

Piracetam for fetal distress in labour

Piracetam is thought to support the metabolism of brain cells when they have an insufficient oxygen supply (hypoxia). It may, therefore, prevent any adverse effects for an infant with persistent fetal distress during labour.

This review set out to assess the effects of piracetam for suspected fetal distress in labour on method of delivery and newborn ill effects (morbidity). Only one controlled trial was identified. The trial randomised 96 women to receive either piracetam or a placebo. Piracetam treatment was associated with a trend toward reduced need for a caesarean section as the method of delivery and an improved outcome for the newborn as determined by respiratory problems and signs of hypoxia. The trial did not provide information about any side effects experienced by the mother. This evidence is insufficient for meaningful conclusions.

 

摘要

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

背景

針對分娩中的胎兒窘迫所用的piracetam

piracetam被認為可以在腦部細胞缺氧的時候促進它們的代謝。這個藥物已經被用來預防胎兒窘迫所產生的副作用。

目標

在分娩的時候，會發生可能性的胎兒窘迫，本篇回顧的目的，是要評估piracetam對於這種情況在生產方式與周產期死亡率的影響。

搜尋策略

我們搜尋了the Cochrane Pregnancy and Childbirth Group trials register(2004年十月25日)。

選擇標準

針對分娩時所發生可能性的胎兒窘迫，這些隨機的試驗將piracetam與安慰劑或是不採取治療進行了比較。

資料收集與分析

2位回顧者都評估了合格程度與試驗品質。

主要結論

其中包含了1份96名婦女的研究。跟安慰劑比較起來，piracetam具有降低剖腹產需求的趨勢(relative risk 0.57, 95% confidence interval 0.32 to 1.03)。針對新生兒的死亡率(由新生兒的呼吸窘迫來測量)或是Apgar評分法(Apgar score)，piracetam與安慰劑組之間的相對風險，並沒有統計學上的明顯差異。

作者結論

針對分娩時所發生的胎兒窘迫，並沒有足夠的證據可以評估使用piracetam的結果。

翻譯人

此翻譯計畫由臺灣國家衛生研究院(National Health Research Institutes, Taiwan)統籌。

總結

尚待摘要出現。

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