Intervention Review

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Fibrinolytic agents for peripheral arterial occlusion

  1. Iain Robertson1,*,
  2. David O Kessel2,
  3. David C Berridge3

Editorial Group: Cochrane Vascular Group

Published Online: 19 DEC 2013

DOI: 10.1002/14651858.CD001099.pub3

How to Cite

Robertson I, Kessel DO, Berridge DC. Fibrinolytic agents for peripheral arterial occlusion. Cochrane Database of Systematic Reviews 2013, Issue 12. Art. No.: CD001099. DOI: 10.1002/14651858.CD001099.pub3.

Author Information

  1. 1

    Gartnavel General Hospital, Department of Radiology, Glasgow, UK

  2. 2

    Leeds Teaching Hospitals Trust, Department of Clinical Radiology, Leeds, West Yorkshire, UK

  3. 3

    Leeds General Infirmary, Leeds Vascular Institute, Leeds, Yorkshire, UK

*Iain Robertson, Department of Radiology, Gartnavel General Hospital, 1053 Great Western Road, Glasgow, G12 0XN, UK.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 19 DEC 2013



References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Berridge 1991 {published data only}
  • Berridge DC, Gregson RHS, Hopkinson BR, Makin GS. Randomized trial of intra-arterial recombinant tissue plasminogen activator, intravenous recombinant tissue plasminogen activator and intra-arterial streptokinase in peripheral arterial thrombolysis. British Journal of Surgery 1991;78:988-95.
Mahler 2001 {published data only}
  • Mahler F, Schneider E, Hess H, Steering Committee, Study on Local Thrombolysis. Recombinant tissue plasminogen activator versus urokinase for local thrombolysis of femoropopliteal occlusions: A prospective, randomized multicenter trial. Journal of Endovascular Therapy 2001;8(6):638-47.
Meyerovitz 1990 {published data only}
  • Meyerovitz MF, Goldhaber SZ, Reagan K, Polak JF, Kandarpa K, Grassi C, et al. Recombinant tissue-type plasminogen versus urokinase in peripheral arterial and graft occlusions: A randomized trial. Radiology 1990;175:75-8.
Ouriel 1999 {published data only}
  • Ouriel K, Kandarpa K, Krishna MD, Scheurr D, Hultquist M, Hodkinson G, et al. Prourokinase vs urokinase for recanalization of peripheral occlusions, safety and efficacy: The PURPOSE trial. Journal of Vascular and Interventional Radiology 1999;10(8):1083-91.
Schweizer 1996 {published data only}
  • Schweizer J, Altmann E, Stoblein F, Florek HJ, Kaulen R. Comparision of tissue plasminogen activator and urokinase in the local infiltration thrombolysis of peripheral arterial occlusions. European Journal of Radiology 1996;22:129-32.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Braithwaite 1997 {published data only}
  • Braithwaite BD, Buckenham TM, Galland RB, Heather BP, Earnshaw JJ. Prospective randomized trial of high-dose bolus versus low-dose tissue plasminogen activator infusion in the management of acute limb ischaemia. British Journal of Surgery 1997;84(5):646-50.
  • Braithwaite BD, Virgo H, Earnshaw JJ. The systematic effects of high dose bolus and low dose intra-arterial thrombolysis with tissue plasminogen activator (t-PA) for acute limb ischaemia. Thrombosis and Haemostasis. 1997; Vol. 503 Abstract No PS-2058, issue Supplement June.
Cina 1999 {published data only}
  • Cina CS, Goh RH, Chan J, Kenny B, Evans G, Rawlinson J, et al. Intraarterial catheter-directed thrombolysis: urokinase versus tissue plasminogen activator. Annals of Vascular Surgery 1999;13(6):571-5.
Dawson 1991 {published data only}
Dawson 1991a {published data only}
  • Dawson KJ, Hehir D, Hamilton G. Low dose intra-arterial streptokinase compared with tissue plasminogen activator in acute lower limb ischaemia. Irish Journal of Medical Science 1991;160:216-7.
Didier 1995 {published data only}
  • Didier D, Meyerovitz MF, Vogel JJ, Soulier L, Bounameaux H. Thrombolysis versus mechanical recanalisation of chronic peripheral arterial occlusions. Randomized study. Schweizerische Medizinische Wochenschrift 1995;125:11.
Dube 1996 {published data only}
  • Dube M, Soulez G, Therasse E, Cartier P, Blair JF, Roy P, et al. Comparison of streptokinase and urokinase in local thrombolysis of peripheral arterial occlusions for lower limb salvage. Journal of Vascular and Interventional Radiology 1996;7(4):587-93.
Duda 2001 {published data only}
  • Duda S, Tepe G, Luz O, Ouriel K, Dietz K, Hahn U, et al. Peripheral arterial occlusion: treatment with abxcimab plus urokinase versus urokinase alone - a randomised pilot trial (the PROMPT trial). Radiology 2001;221:689-96.
Gryglewski 1995 {published data only}
  • Gryglewski RJ, Szczeklik A, Korbut R, Swies J, Musial J, Krzanowski M, et al. The mechanism of anti-thrombotic, thrombolytic and fibrinolytic actions of camonagrel--a new thromboxane synthase inhibitor. Wiener Klinische Wochenschrift 1995;107:283-9.
Han 2010 {published data only}
  • Han SM, Weaver FA, Comerota AJ, Perler BA, Joing M. Efficacy and safety of alfimeprase in patients with acute peripheral arterial occlusion (PAO). Journal of Vascular Surgery 2010;51(3):600-9.
Hess 1996 {published data only}
  • Hess H, Mietaschk A, von Bilderling P, Neller P. Peripheral arterial occlusions: local low-dose thrombolytic therapy with recombinant tissue-type plasminogen activator (rt-PA). European Journal of Vascular and Endovascular Surgery 1996;12(1):97-104.
Hiatt 2002 {published data only}
  • Hiatt WR. Abciximab added to urokinase increased amputation-free survival in peripheral arterial occlusion of the legs. American College of Physicians Journal Club 2002;137(1):12.
Reichle 1976 {published data only}
Sarif 2005 {published data only}
  • Sarif J, Lindhoff-Last E, Bauersachs R. Rebound after discontinuation of long-term oral anticoagulation (OAC): Effects of a 4 week course of LMWH on VTE recurrences. Journal of Thrombosis and Haemostasis. 2005; Vol. 3, issue 1:Abstract no: P1024.
Schulman 1996 {published data only}
STILE 1994 {published data only}
Tepe 2006 {published data only}
  • Tepe G, Hopfenzitz C, Dietz K, Wiskirchen J, Heller S, Ouriel K, et al. Peripheral Arteries: Treatment with antibodies of platelet receptors and reteplase for thrombolysis-APART trial. Radiology 2006;239(3):892-900.
Vanderschueren 1995 {published data only}
  • Vanderschueren S, Stockx L, Wilms G, Lacroix H, Verhaege R, Vermuylen J, et al. Thrombolytic therapy of peripheral arterial occlusion with recombinant staphylokinase. Circulation 1995;92(8):2050-7.
Wen 2005 {published data only}
  • Wen Y, Rong C, Yu W, Qian Z, Shu-rong L, Ning L, et al. Effect of urokinase injected by volumetric infusion pump on rest pain, intermittent limp and walking distance in aged patients with arteriosclerosis obliterans of the lower limbs. Zhongguo Linchuang Kangfu 2005;9(30):232-3.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Anonymous 1986
  • Ad Hoc Committee on Reporting Standards, Society for Vascular Surgery/North American Chapter International Society for Cardiovascular Surgery. Suggested standards for reports dealing with lower extremity ischaemia. Journal of Vascular Surgery 1986;4(1):80-94.
Anonymous 1991
  • Anonymous. Second European Consensus Document on chronic critical leg ischaemia. Circulation 1991;84 Suppl IV(4):1-26.
Berridge 2013
Fontaine 1954
  • Fontaine VR, Kim M, Kieny R. Die chirurgische Behandlung der peripheren Durchblutungsstorungen [Die chirurgische Behandlung der peripheren Durchblutungsstorungen]. Helvetica Chirurgica Acta 1954;5/6:499-533.
Higgins 2009
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.2 [updated September 2009]. The Cochrane Collaboration, 2009. Available from
Kessel 2004

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Robertson 2010