Fibrinolytic agents for acute arterial occlusion

  • Protocol
  • Intervention



This is the protocol for a review and there is no abstract. The objectives are as follows:

The objective of this review is to determine which is the most effective fibrinolytic agent in peripheral arterial thrombolysis. Outcome measures will include limb salvage, amputation, death, vessel patency, time to lysis, and complications, specifically the risk of major haemorrhage and stroke. The logistics of the various techniques will also be discussed. The specific hypotheses to be tested are:

1) There is no overall additional benefit from any of the different fibrinolytic agents available to the majority of patients suitable for peripheral arterial thrombolysis.

2) Complication rates may be higher with certain fibrinolytic agents.