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Late (> 7 days) postnatal corticosteroids for chronic lung disease in preterm infants

  1. Lex W Doyle1,*,
  2. Richard A Ehrenkranz2,
  3. Henry L Halliday3

Editorial Group: Cochrane Neonatal Group

Published Online: 13 MAY 2014

Assessed as up-to-date: 18 FEB 2014

DOI: 10.1002/14651858.CD001145.pub3


How to Cite

Doyle LW, Ehrenkranz RA, Halliday HL. Late (> 7 days) postnatal corticosteroids for chronic lung disease in preterm infants. Cochrane Database of Systematic Reviews 2014, Issue 5. Art. No.: CD001145. DOI: 10.1002/14651858.CD001145.pub3.

Author Information

  1. 1

    The University of Melbourne, Department of Obstetrics and Gynaecology, Parkville, Victoria, Australia

  2. 2

    Yale University, Department of Pediatrics, New Haven, Connecticut, USA

  3. 3

    Honorary Professor of Child Health, Queen's University (Retired), Belfast, Northern Ireland, UK

*Lex W Doyle, Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, Victoria, 3052, Australia. lwd@unimelb.edu.au.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 13 MAY 2014

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Ariagno 1987 {published data only}
  • Ariagno RL. Personal communication. email 2000.
  • Ariagno RL, Sweeney TE, Baldwin RB, Inguillo D, Martin D. Controlled trial of dexamethasone in preterm infants at risk for bronchopulmonary dysplasia: lung function, clinical course and outcome at three years. Unpublished manuscript supplied by authors 2000.
  • Ariagno RL, Sweeney TJ, Baldwin RB, Inguillo D, Martin D. Dexamethasone effects on lung function and risks in 3 week old ventilatory dependent preterm infants. American Reviews of Respiratory Disease 1987;135:A125.
Avery 1985 {published data only}
  • Avery GB, Fletcher AB, Caplan M, Brudno DS. Control trial of dexamethasone in respirator-dependent infants with bronchopulmonary dysplasia. Pediatrics 1985;75:106-11.
Brozanski 1995 {published data only}
  • Brozanski BS, Jones JG, Gilmore CH, et al. Effect of pulse dexamethasone therapy on the incidence and severity of chronic lung disease in the very low birthweight infant. Journal of Pediatrics 1995;126:769-76.
  • Gilmour CH, Sentipal-Walerius JM, Jones JG, Doyle JM, Brozanski BS, Balsan MJ, et al. Pulse dexamethasone does not impair growth and body composition of very low birth weight infants. Journal of the American College of Nutrition 1995;14:455-62.
  • Hofkosh D, Brozanski BS, Edwards MD, et al. One year outcome of infants treated with pulse dexamethasone for prevention of BPD. Pediatric Research 1995;37:259A.
CDTG 1991 {published data only}
  • Collaborative Dexamethasone Trial Group. Dexamethasone therapy in neonatal chronic lung disease: an international placebo-controlled trial. Pediatrics 1991;88:421-7.
  • Jones R, Wincott E, Elbourne D, Grant A. Controlled trial of dexamethasone in neonatal chronic lung disease: a 3 year follow-up. Pediatrics 1995;96:897-906.
  • Jones RA. Randomized, controlled trial of dexamethasone in neonatal chronic lung disease: 13- to 17-year follow-up study: I. Neurologic, psychological, and educational outcomes. Pediatrics 2005;116:370-8.
  • Jones RA. Randomized, controlled trial of dexamethasone in neonatal chronic lung disease: 13- to 17-year follow-up study: II. Respiratory status, growth, and blood pressure. Pediatrics 2005;116:379-84.
Cummings 1989 {published data only}
  • Cummings JJ. Personal communication. email 2002.
  • Cummings JJ, D'Eugenio DB, Gross SJ. A controlled trial of dexamethasone in preterm infants at high risk for bronchopulmonary dysplasia. New England Journal of Medicine 1989;320:1505-10.
  • Gross SJ, Anbar RD, Mettelman BB. Follow-up at 15 years of preterm infants from a controlled trial of moderately early dexamethasone for the prevention of chronic lung disease. Pediatrics 2005;115:681-7.
Doyle 2006 {published data only}
  • Doyle LW, Davis PG, Morley CJ, McPhee A, Carlin JB. Outcome at 2 years of age of infants from the DART study: a multicenter, international, randomized, controlled trial of low-dose dexamethasone. Pediatrics 2007;119:716-721.
  • Doyle LW, Davis PG, Morley CJ, McPhee A, Carlin JB, DART Study Investigators. Low-dose dexamethasone facilitates extubation among chronically ventilator-dependent infants: a multicenter international randomized controlled trial. Pediatrics 2006;117:75-83.
Durand 1995 {published data only}
  • Durand M. Personal communication. email 2012.
  • Durand M, Sardesi S, McEvoy C. Effect of early dexamethasone therapy on pulmonary mechanics and chronic lung disease in very low birth weight infants: a randomized controlled trial. Pediatrics 1995;95:584-90.
Harkavy 1989 {published data only}
  • Harkavy KL. Personal communication. email 2002.
  • Harkavy KL, Scanlow JW, Chowdhry PK, Grylack LJ. Dexamethasone therapy for chronic lung disease in ventilator-and oxygen-dependent infants. A controlled trial. Journal of Pediatrics 1989;115:979-83.
Kari 1993 {published data only}
Kazzi 1990 {published data only}
  • Kazzi NJ, Brans YW, Poland RL. Dexamethasone effects on the hospital course of infants with bronchopulmonary dysplasia who are dependent on artificial ventilation. Pediatrics 1990;86:722-7.
Kothadia 1999 {published data only}
  • Bensky AS, Kothadia JM, Covitz W. Cardiac effects of dexamethasone in very low birth weight infants. Pediatrics 1996;97:818-21.
  • Goldstein DJ, Waldrep EL, VanPelt JC, O'Shea TM. Developmental outcome at 5 years following dexamethasone use for very low birth weight infants. Pediatric Research 2000;47:310A (Abstract 1832).
  • Kothadia JM, O'Shea TM, Roberts D, Auringer ST, Weaver RG, Dillard RG. Randomized placebo-controlled trial of a 42-day tapering course of dexamethasone to reduce the duration of ventilator dependency in very low birthweight infants. Pediatrics 1999;104:22-7.
  • Nixon PA, Washburn LK, Schechter MS, O'Shea TM. Follow-up study of a randomized controlled trial of postnatal dexamethasone therapy in very low birth weight infants: effects on pulmonary outcomes at age 8 to 11 years. Journal of Pediatrics 2007;150:345-50.
  • O'Shea TM, Goldstein DJ, Jackson BG, Kothadia JM, Dillard RG. Randomized trial of a 42-day tapering course of dexamethasone in very low birth weight infants: neurological, medical and functional outcome at 5 years of age. Pediatric Research 2000;47:319A (abstract 1883).
  • O'Shea TM, Kothadia JM, Klinepeter KL, Goldstein DJ, Jackson BG, Weaver RG, et al. Randomized placebo-controlled trial of a 42-day tapering course of dexamethasone to reduce the duration of ventilator dependency in very low birth weight infants: outcome of study participants at 1-year adjusted age. Pediatrics 1999;104:15-21.
  • Washburn LK, Nixon PA, O'Shea TM. Follow-up of a randomized, placebo-controlled trial of postnatal dexamethasone: blood pressure and anthropometric measurements at school age. Pediatrics 2006;118:1592-9.
Kovacs 1998 {published data only}
Noble-Jamieson 1989 {published data only}
Ohlsson 1992 {published data only}
  • Ohlsson A. MSc Thesis. A randomized controlled trial of dexamethasone treatment in very low birthweight infants with ventilator dependent chronic lung disease.. McMaster University 1990.
  • Ohlsson A, Calvert SA, Hosking M, Shennan AT. Randomized controlled trial of dexamethasone treatment in very-low-birth-weight infants with ventilator-dependent chronic lung disease. Acta Paediatrica 1992;81:751-6.
Papile 1998 {published data only}
  • Papile LA, Tyson JE, Stoll BJ, Wright LL, Donovan EF, Bauer CR, et al. A multicenter trial of two dexamethasone regimens in ventilator-dependent premature infants. New England Journal of Medicine 1998;338:1112-8.
  • Stoll BJ, Temprosa M, Tyson JE, Papile LA, Wright LL, Bauer CR, et al. Dexamethasone therapy increases infection in low birth weight infants. Pediatrics 1999;104:e63.
Parikh 2013 {published data only}
  • Parikh NA, Kennedy KA, Lasky RE, McDavid GE, Tyson JE. Pilot randomized trial of hydrocortisone in ventilator-dependent extremely preterm infants: effects on regional brain volumes. Journal of Pediatrics 2013;162(4):685-90.
Romagnoli 1998 {published data only}
  • Romagnoli C, Vento G, Tortorolo L, et al. Dexamethasone for the prevention of chronic lung disease in preterm neonates: a prospective randomized study [II desametazone nella prevenzione della patologia polmonare cronica del neonato pretermine: studio prospettico randomizzato]. Riv Italiano Pediatrics 1998;24:283-8.
  • Romagnoli C, Zecca E, Luciano R, Torrioli G, Tortorolo G. A three year follow-up of preterm infants after moderately early treatment with dexamethasone. Archives of Disease of Childhood Fetal and Neonatal Edition 2002;87:F55-8.
  • Romagnoli C, Zecca E, Vento G, Maggio L, Papacci P, Tortorolo G. Effect on growth of two different dexamethasone courses for preterm infants at risk of chronic lung disease. Pharmacology 1999;59:266-74.
Scott 1997 {published data only}
  • Scott SM, Backstrom C, Bessman S. Effect of five days of dexamethasone therapy on ventilator dependence and adrenocorticotropic hormone-stimulated cortisol concentrations. Journal of Perinatology 1997;17(1):24-8.
Vento 2004 {published data only}
  • Vento G. Personal communication. email 2012.
  • Vento G, Matassa PG, Zecca E, Tortorolo L, Martelli M, De Carolis MP, et al. Effect of dexamethasone on tracheobronchial aspirate fluid cytology and pulmonary mechanics in preterm infants. Pharmacology 2004;71:113-9.
Vincer 1998 {published data only}
  • Vincer MJ. Personal communication. email 2002.
  • Vincer MJ, Allen AC. Double blind randomized controlled trial of 6-day pulse of dexamethasone for very low birth weight infants (VLBW <1500 grams) who are ventilator dependent at 4 weeks of age. Pediatric Research 1998;43:201A.
Walther 2003 {published data only}
  • Walther F. Personal communication. email 2012.
  • Walther FJ, Findlay RD, Durand M. Adrenal suppression and extubation rate after moderately early low-dose dexamethasone therapy in very preterm infants. Early Human Development 2003;74:37-45.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Anttila 2005 {published data only}
  • Anttila E, Peltoniemi O, Haumont D, Herting E, ter Horst H, Heinonen K, et al. Early neonatal dexamethasone treatment for prevention of bronchopulmonary dysplasia. Randomised trial and meta-analysis evaluating the duration of dexamethasone therapy. European Journal of Pediatrics 2005;164(8):472-81. [PUBMED: 15864643]
Armstrong 2002 {published data only}
  • Armstrong DL, Penrice J, Bloomfield FH, Knight DB, Dezoete JA, Harding JE. Follow up of a randomised trial of two different courses of dexamethasone for preterm babies at risk of chronic lung disease. Archives of Disease of Childhood. Fetal and Neonatal Edition 2002;86:F102-7.
Ashton 1994 {published data only}
  • Ashton MR, Postle AD, Smith DE, Hall MA. Surfactant phosphadidylcholine composition during dexamethasone treatment in chronic lung disease. Archives of Disease of Childhood. Fetal and Neonatal Edition 1994;71:F114-7.
Baden 1972 {published data only}
  • Baden M, Bauer CR, Colle E, Klein G, Taeusch HW Jr, Stern L. A controlled trial of hydrocortisone therapy in infants with respiratory distress syndrome. Pediatrics 1972;50(4):526-34. [PUBMED: 4561296]
  • Fitzhardinge PM, Eisen A, Lejtenyi C, Metrakos K, Ramsay M. Sequelae of early steroid administration to the newborn infant. Pediatrics 1974;53(6):877-83.
Batton 2012 {published data only}
  • Batton BJ, Li L, Newman NS, Das A, Watterberg KL, Yoder BA, et al. Feasibility study of early blood pressure management in extremely preterm infants. Journal of Pediatrics 2012;161(1):65-9.e1. [PUBMED: 22336574]
Biswas 2003 {published data only}
  • Biswas S, Buffery J, Enoch H, Bland M, Markiewicz M, Walters D. Pulmonary effects of triiodothyronine (T3) and hydrocortisone (HC) supplementation in preterm infants less than 30 weeks gestation: results of the THORN trial--thyroid hormone replacement in neonates. Pediatric Research 2003;53(1):48-56. [PUBMED: 12508081]
Bloomfield 1998 {published data only}
  • Bloomfield FH, Knight DB, Harding JE. Side effects of 2 different dexamethasone courses for preterm infants at risk of chronic lung disease: a randomized trial. Journal of Pediatrics 1998;133:395-400.
Bonsante 2007 {published data only}
  • Bonsante F, Latorre G, Iacobelli S, Forziati V, Laforgia N, Esposito L, et al. Early low-dose hydrocortisone in very preterm infants: a randomized, placebo-controlled trial. Neonatology 2007;91(4):217-21. [PUBMED: 17568152]
Couser 1992 {published data only}
  • Couser RJ, Ferrara TB, Falde B, Johnson K, Schilling CG, Hoekstra RE. Effectiveness of dexamethasone in preventing extubation failure in preterm infants at increased risk for airway edema. Journal of Pediatrics 1992;121:591-6.
Cranefield 2004 {published data only}
  • Cranefield DJ, Odd DE, Harding JE, et al. High incidence of nephrocalcinosis in extremely preterm infants treated with dexamethasone. Pediatric Radiology 2004;34:1090-7.
Durand 2002 {published data only}
  • Durand M, Mendoza MW, Tantivit P, Kugelman A, McEvoy C. A randomized trial of moderately early low-dose dexamethasone therapy in very low birth weight infants: dynamic pulmonary mechanics, oxygenation, and ventilation. Pediatrics 2002;109:262-8.
Efird 2005 {published data only}
  • Efird MM, Heerens AT, Gordon PV, Bose CL, Young DA. A randomized-controlled trial of prophylactic hydrocortisone supplementation for the prevention of hypotension in extremely low birth weight infants. Journal of Perinatology 2005;25(2):119-24. [PUBMED: 15329742]
Ferrara 1990 {published data only}
  • Ferrara TB, Georgieff MK, Ebert TJ, Fisher JB. Routine use of dexamethasone for the prevention of post-extubation respiratory distress. Journal of Perinatology 1989;9:287-90.
Garland 1999 {published data only}
  • Garland JS, Alex CP, Pauly TH, Whitehead VL, Brand J, Winston JF, et al. A three-day course of dexamethasone therapy to prevent chronic lung disease in ventilated neonates: a randomized trial. Pediatrics 1999;104(1 Pt 1):91-9. [PUBMED: 10390266]
Groneck 1993 {published data only}
  • Groneck P, Reuss D, Gotze-Speer B, Speer CP. Effects of dexamethasone on chemotactic activity and inflammatory mediators in tracheobronchial aspirates of preterm infants at risk for chronic lung disease. Journal of Pediatrics 1993;122:938-44.
Halac 1990 {published data only}
  • Halac E, Halac J, Begue EF, Casanas JM, Indiveri DR, Petit JF, et al. Prenatal and postnatal corticosteroid therapy to prevent neonatal necrotizing enterocolitis: a controlled trial. Journal of Pediatrics 1990;117(1 Pt 1):132-8. [PUBMED: 2196355]
Kopelman 1999 {published data only}
  • Kopelman AE, Moise AA, Holbert D, Hegemier SE. A single very early dexamethasone dose improves respiratory and cardiovascular adaptation in preterm infants. Journal of Pediatrics 1999;135(3):345-50. [PUBMED: 10484801]
Lin 1999 {published data only}
Mammel 1983 {published data only}
  • Mammel MC, Green TP, Johnson TR. Controlled trial of dexamethasone therapy in infants with bronchopulmonary dysplasia. Lancet 1983;i:1356-8.
Merz 1999 {published data only}
  • Merz U, Peschgens T, Kusenbach G, Hörnchen H. Early versus late dexamethasone treatment in preterm infants at risk for chronic lung disease: a randomized pilot study. European Journal of Pediatrics 1999;158:318-22.
Mukhopadhyay 1998 {published data only}
  • Mukhopadhyay K, Kumar P, Narang A. Role of early postnatal dexamethasone in respiratory distress syndrome. Indian Pediatrics 1998;35(2):117-22. [PUBMED: 9707853]
Ng 2006 {published data only}
  • Ng PC, Lee CH, Bnur FL, Chan IH, Lee AW, Wong E, et al. A double-blind, randomized, controlled study of a "stress dose" of hydrocortisone for rescue treatment of refractory hypotension in preterm infants. Pediatrics 2006;117(2):367-75. [PUBMED: 16452355]
Odd 2004 {published data only}
Peltoniemi 2005 {published data only}
  • Peltoniemi O, Kari MA, Heinonen K, Saarela T, Nikolajev K, Andersson S, et al. Pretreatment cortisol values may predict responses to hydrocortisone administration for the prevention of bronchopulmonary dysplasia in high-risk infants. Journal of Pediatrics 2005;146(5):632-7. [PUBMED: 15870666]
  • Peltoniemi OM, Lano A, Puosi R, Yliherva A, Bonsante F, Kari MA, et al. Trial of early neonatal hydrocortisone: two-year follow-up. Neonatology 2009;95(3):240-7.
Rastogi 1996 {published data only}
  • Morales P, Rastogi A, Bez ML, Akintorin SM, Pyati S, Andes SM, et al. Effect of dexamethasone therapy on the neonatal ductus arteriosus. Pediatric Cardiology 1998;19(3):225-9.
  • Rastogi A, Akintorin SM, Bez ML, Morales P, Pildes RS. A controlled trial of dexamethasone to prevent bronchopulmonary dysplasia in surfactant-treated infants. Pediatrics 1996;98(2 Pt 1):204-10. [PUBMED: 8692619]
Romagnoli 1999 {published data only}
  • Romagnoli C, Zecca E, Luciano R, Torrioli G, Tortorolo G. Controlled trial of early dexamethasone treatment for the prevention of chronic lung disease in preterm infants: a 3-year follow-up. Pediatrics 2002;109(6):e85.
  • Romagnoli C, Zecca E, Vento G, De Carolis MP, Papacci P, Tortorolo G. Early postnatal dexamethasone for the prevention of chronic lung disease in high-risk preterm infants. Intensive Care Medicine 1999;25(7):717-21. [PUBMED: 10470576]
  • Romagnoli C, Zecca E, Vento G, Maggio L, Papacci P, Tortorolo G. Effect on growth of two different dexamethasone courses for preterm infants at risk of chronic lung disease. Pharmacology 1999;59:266-74.
Sanders 1994 {published data only}
  • Sanders RJ, Cox C, Phelps DL, Sinkin RA. Two doses of early intravenous dexamethasone for the prevention of bronchopulmonary dysplasia in babies with respiratory distress syndrome. Pediatric Research 1994;36(1 Pt 1):122-8. [PUBMED: 7936832]
Shinwell 1996 {published data only}
  • Shinwell ES, Karplus M, Reich D, Weintraub Z, Blazer S, Bader D, et al. Early postnatal dexamethasone treatment and increased incidence of cerebral palsy. Archives of Disease in Childhood. Fetal and Neonatal Edition 2000;83(3):F177-81.
  • Shinwell ES, Karplus M, Reich D, et al. Early dexamethasone therapy is associated with increased incidence of cerebral palsy. Hot Topics in Neonatology. Ross Laboratories, 1999:240-54.
  • Shinwell ES, Karplus M, Zmora E, Reich D, Rothschild A, Blazer S, et al. Failure of early postnatal dexamethasone to prevent chronic lung disease in infants with respiratory distress syndrome. Archives of Disease in Childhood. Fetal and Neonatal Edition 1996;74(1):F33-7. [PUBMED: 8653433]
Sinkin 2000 {published data only}
  • D'Angio CT, Maniscalco WM, Ryan RM, Avissar NE, Basavegowda K, Sinkin RA. Vascular endothelial growth factor in pulmonary lavage fluid from premature infants: effects of age and postnatal dexamethasone. Biology of the Neonate 1999;76(5):266-73.
  • Sinkin RA, Dweck HS, Horgan MJ, Gallaher KJ, Cox C, Maniscalco WM, et al. Early dexamethasone-attempting to prevent chronic lung disease. Pediatrics 2000;105(3 Pt 1):542-8. [PUBMED: 10699107]
Soll 1999 {published data only}
  • Soll RF for the Vermont Oxford Network Steroid Study Group. Early postnatal dexamethasone therapy for the prevention of chronic lung disease. Pediatric Research 1999;45:226A.
  • The Vermont Oxford Network Steroid Study Group. Early postnatal dexamethasone therapy for the prevention of chronic lung disease. Pediatrics 2001;108(3):741-8.
Stark 2001 {published data only}
  • Stark AR, Carlo WA, Tyson JE, Papile LA, Wright LL, Shankaran S, et al. Adverse effects of early dexamethasone in extremely-low-birth-weight infants. National Institute of Child Health and Human Development Neonatal Research Network. New England Journal of Medicine 2001;344(2):95-101. [PUBMED: 11150359]
  • Stark AR, Carlo WA, Vohr BR, Papile LA, Saha S, Bauer CR, et al. Death or neurodevelopmental impairment at 18 to 22 months corrected age in a randomized trial of early dexamethasone to prevent death or chronic lung disease in extremely low birth weight infants. Journal of Pediatrics 2013 Aug 27 [Epub ahead of print].
Subhedar 1997 {published data only}
  • Subhedar NV, Bennett AJ, Wardle SP, Shaw NJ. More trials on early treatment with corticosteroids are needed. BMJ (Clinical research ed.) 2000;320(7239):947.
  • Subhedar NV, Ryan SW, Shaw NJ. Open randomised controlled trial of inhaled nitric oxide and early dexamethasone in high risk preterm infants. Archives of Disease in Childhood. Fetal and Neonatal Edition 1997;77(3):F185-90. [PUBMED: 9462187]
Suske 1996 {published data only}
Tapia 1998 {published data only}
  • Tapia JL, Ramirez R, Cifuentes J, Fabres J, Hubner ME, Bancalari A, et al. The effect of early dexamethasone administration on bronchopulmonary dysplasia in preterm infants with respiratory distress syndrome. Journal of Pediatrics 1998;132(1):48-52. [PUBMED: 9469999]
Wang 1996 {published data only}
  • Wang JY, Yeh TF, Lin YC, Miyamura K, Holmskov U, Reid KB. Measurement of pulmonary status and surfactant protein levels during dexamethasone treatment of neonatal respiratory distress syndrome. Thorax 1996;51(9):907-13. [PUBMED: 8984701]
  • Wang JY, Yeh TF, Lin YJ, Chen WY, Lin CH. Early postnatal dexamethasone therapy may lessen lung inflammation in premature infants with respiratory distress syndrome on mechanical ventilation. Pediatrics 1997;23(3):193-7.
Watterberg 2004 {published data only}
  • Watterberg KL, Gerdes JS, Cole CH, Aucott SW, Thilo EH, Mammel MC, et al. Prophylaxis of early adrenal insufficiency to prevent bronchopulmonary dysplasia: a multicenter trial. Pediatrics 2004;114(6):1649-57. [PUBMED: 15574629]
  • Watterberg KL, Shaffer ML, Mishefske MJ, Leach CL, Mammel MC, Couser RJ, et al. Growth and neurodevelopmental outcomes after early low-dose hydrocortisone treatment in extremely low birth weight infants. Pediatrics 2007;120(1):40-8.
Wilson 1988 {published data only}
  • Wilson DM, Baldwin RB, Ariagno RL. A randomized, placebo-controlled trial of effects of dexamethasone on hypothalmic-pituitary-adrenal axis in preterm infants. Journal of Pediatrics 1988;113:764-8.
Yeh 1990 {published data only}
  • Yeh TF, Torre JA, Rastogi A, Anyebuno MA, Pildes RS. Early postnatal dexamethasone therapy in premature infants with severe respiratory distress syndrome: a double-blind, controlled study. Journal of Pediatrics 1990;117(2 Pt 1):273-82. [PUBMED: 2199642]
Yeh 1997 {published data only}
  • Lin YJ, Lin CH, Wu JM, Tsai WH, Yeh TF. The effects of early postnatal dexamethasone therapy on pulmonary outcome in premature infants with respiratory distress syndrome: a two-year follow-up study. Acta Paediatrica 2005;94(3):310-6.
  • Lin YJ, Yeh TF, Lin HC, Wu JM, Lin CH, Yu CY. Effects of early postnatal dexamethasone therapy on calcium homeostasis and bone growth in preterm infants with respiratory distress syndrome. Acta Paediatrica 1998;87(10):1061-5.
  • Peng CT, Lin HC, Lin YJ, Tsai CH, Yeh TF. Early dexamethasone therapy and blood cell count in preterm infants. Pediatrics 1999;104(3 Pt 1):476-81.
  • Yeh TF, Lin IJ, Hsieh WS, et al. Prevention of chronic lung disease (CLD) in premature RDS infants with early and prolonged dexamethasone (D) therapy--A multicenter double-blind controlled study. Pediatric Research 1994;35:262A.
  • Yeh TF, Lin YJ, Hsieh WS, Lin HC, Lin CH, Chen JY, et al. Early postnatal dexamethasone therapy for the prevention of chronic lung disease in preterm infants with respiratory distress syndrome: a multicenter clinical trial. Pediatrics 1997;100(4):E3. [PUBMED: 9310536]
  • Yeh TF, Lin YJ, Huang CC, Chen YJ, Lin CH, Lin HC, et al. Early dexamethasone therapy in preterm infants: a follow-up study. Pediatrics 1998;101(5):E7.
  • Yeh TF, Lin YJ, Lin HC, Huang CC, Hsieh WS, Lin CH, et al. Outcomes at school age after postnatal dexamethasone therapy for lung disease of prematurity. New England Journal of Medicine 2004;350(13):1304-13.
Yoder 1991 {published data only}
  • Yoder MC, Chua R, Tepper R. Effect of dexamethasone on pulmonary inflammation and pulmonary function in ventilator-dependent infants with bronchopulmonary dysplasia. American Reviews of Respiratory Disease 1991;143:1044-8.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Onland 2011 {unpublished data only}
  • Onland W, Offringa M, Cools F, Jaegere AP, Rademaker K, Blom H, et al. Systemic hydrocortisone to prevent bronchopulmonary dysplasia in preterm infants (the SToP-BPD study); a multicenter randomized placebo controlled trial. BMC Paediatrics 2011;11:102.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Anonymous 1991
Ariagno 2000
  • Ariagno RL, Sweeney TE, Baldwin RB, Inguillo D, Martin D. Controlled trial of dexamethasone in preterm infants at risk for bronchopulmonary dysplasia: lung function, clinical course and outcome at three years. Unpublished manuscript supplied by authors 2000.
Arias-Camison 1999
  • Arias-Camison JM, Lau J, Cole CH, Frantz ID. Meta-analysis of dexamethasone therapy started in the first 15 days of life for prevention of chronic lung disease in premature infants. Pediatric Pulmonology 1999;341:1190-6.
Bhuta 1998
  • Bhuta T, Ohlsson A. Systematic review and meta-analysis of early postnatal dexamethasone for prevention of chronic lung disease. Archives of Disease of Childhood. Fetal and Neonatal Edition 1998;79:F26-3.
Doyle 2000
Doyle 2007
  • Doyle LW, Davis PG, Morley CJ, McPhee A, Carlin JB. Outcome at 2 years of age of infants from the DART study: a multicenter, international, randomized, controlled trial of low-dose dexamethasone. Pediatrics 2007;119:716-21.
Doyle 2010a
Doyle 2010b
  • Doyle LW, Ehrenkranz RA, Halliday HL. Dexamethasone treatment in the first week of life for preventing bronchopulmonary dysplasia in preterm infants: a systematic review. Neonatology 2010;98(3):217-24.
Doyle 2010c
  • Doyle LW, Ehrenkranz RA, Halliday HL. Dexamethasone treatment after the first week of life for bronchopulmonary dysplasia in preterm infants: a systematic review. Neonatology 2010;98(4):289-96.
Doyle 2014
  • Doyle LW, Ehrenkranz RE, Halliday HL. Early (< 8 days) postnatal corticosteroids for preventing chronic lung disease in preterm infants.. Cochrane Database of Systematic Reviews 2014, Issue 5. [DOI: 10.1002/14651858.CD001146.pub4]
Egberts 1997
  • Egberts J, Brand R, Walti H, Bevilacqua G, Breart G, Gardini F. Mortality, severe respiratory distress syndrome and chronic lung disease of the newborn are reduced more after prophylactic than after therapeutic administration of the surfactant Curosurf. Pediatrics 1997;100(1):E4. [http://www.pediatrics.org/egi/content/full/100/1/e4]
Flagel 2002
  • Flagel SB, Vazquez DM, Watson SJ Jr, Neal CR. Effects of tapering neonatal dexamethasone on rat growth, neurodevelopment, and stress response. American Journal of Regulatory Integrative Comparative Physiology 2002;282:R55-66.
Gibson 1993
Giffin 1994
Gramsbergen 1998
Gross 2005
  • Gross SJ, Anbar RD, Mettelman BB. Follow-up at 15 years of preterm infants from a controlled trial of moderately early dexamethasone for the prevention of chronic lung disease. Pediatrics 2005;115:681-7.
Halliday 1997
  • Halliday HL. A review of postnatal corticosteroids for treatment and prevention of chronic lung disease in the preterm infant. Prenatal Neonatal Medicine 1997;2:1-2.
Halliday 1999
Higgins 2011
  • Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Hofkosh 1995
  • Hofkosh D, Brozanski BS, Edwards MD, et al. One year outcome of infants treated with pulse dexamethasone for prevention of BPD. Pediatric Research 1995;37:259A.
Jones 1995
  • Jones R, Wincott E, Elbourne D, Grant A. Controlled trial of dexamethasone in neonatal chronic lung disease: a 3 year follow-up. Pediatrics 1995;96:897-906.
Jones 2005A
  • Jones RA. Randomized, controlled trial of dexamethasone in neonatal chronic lung disease: 13- to 17-year follow-up study: I. Neurologic, psychological, and educational outcomes. Pediatrics 2005;116:370-8.
Jones 2005b
  • Jones RA. Randomized, controlled trial of dexamethasone in neonatal chronic lung disease: 13- to 17-year follow-up study: II. Respiratory status, growth, and blood pressure. Pediatrics 2005;116:379-84.
La Force 1993
Mieskonen 2003
Ng 1993
Nixon 2007
  • Nixon PA, Washburn LK, Schechter MS, O'Shea TM. Follow-up study of a randomized controlled trial of postnatal dexamethasone therapy in very low birth weight infants: effects on pulmonary outcomes at age 8 to 11 years. Journal of Pediatrics 2007;150:345-50.
Northway 1967
Onland 2012
RevMan 2012 [Computer program]
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
Romagnoli 2002
  • Torrioli G, Tortorolo G. A three year follow-up of preterm infants after moderately early treatment with dexamethasone. Archives of Disease of Childhood. Fetal and Neonatal Edition 2002;87:F55-8.
Shah 2003
  • Shah SS, Ohlsson A, Halliday HL, Shah VS. Inhaled versus systemic corticosteroids for preventing chronic lung disease in ventilated very low birth weight preterm neonates. Cochrane Database of Systematic Reviews 2003, Issue 1. [DOI: 10.1002/14651858.CD002058]
Shah 2007a
  • Shah V, Ohlsson A, Halliday H, Dunn MS. Early administration of inhaled corticosteroids for preventing chronic lung disease in ventilated very low birth weight preterm neonates. Cochrane Database of Systematic Reviews 2007, Issue 4. [DOI: 10.1002/14651858.CD001969.pub2]
Shah 2007b
  • Shah SS, Ohlsson A, Halliday HL, Shah VS. Inhaled versus systemic corticosteroids for the treatment of chronic lung disease in ventilated very low birth weight preterm infants. Cochrane Database of Systematic Reviews 2007, Issue 4. [DOI: 10.1002/14651858.CD002057.pub2]
Stanley 1982
Tarnow-Mordi 1999
Tschanz 1995
Washburn 2006
  • Washburn LK, Nixon PA, O'Shea TM. Follow-up of a randomized, placebo-controlled trial of postnatal dexamethasone: blood pressure and anthropometric measurements at school age. Pediatrics 2006;118:1592-9.
Watterberg 1999
Weichsel 1977

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Halliday 1998
  • Halliday HL. Postnatal corticosteroids in the preterm infants with chronic lung disease: Late treatment (>3 weeks). Cochrane Database of Systematic Reviews 1998, Issue 3. [DOI: 10.1002/14651858.CD001145]
Halliday 2000a
  • Halliday HL, Ehrenkranz RA. Moderately early (7-14 days) postnatal corticosteroids for preventing chronic lung disease in preterm infants. Cochrane Database of Systematic Reviews 2000, Issue 2. [DOI: 10.1002/14651858.CD001144]
Halliday 2000b
  • Halliday HL, Ehrenkranz RA. Delayed (>3 weeks) postnatal corticosteroids for chronic lung disease in preterm infants. Cochrane Database of Systematic Reviews 2000, Issue 4. [DOI: 10.1002/14651858.CD001145]
Halliday 2001a
  • Halliday HL, Ehrenkranz RA. Delayed (>3 weeks) postnatal corticosteroids for chronic lung disease in preterm infants. Cochrane Database of Systematic Reviews 2001, Issue 2. [DOI: 10.1002/14651858.CD001145]
Halliday 2001b
  • Halliday HL, Ehrenkranz RA. Moderately early (7-14 days) postnatal corticosteroids for preventing chronic lung disease in preterm infants. Cochrane Database of Systematic Reviews 2001, Issue 1. [DOI: 10.1002/14651858.CD001144]
Halliday 2003a
  • Halliday HL, Ehrenkranz RA, Doyle LW. Moderately early (7-14 days) postnatal corticosteroids for preventing chronic lung disease in preterm infants. Cochrane Database of Systematic Reviews 2003, Issue 1. [DOI: 10.1002/14651858.CD001144]
Halliday 2003b
  • Halliday HL, Ehrenkranz RA, Doyle LW. Delayed (>3 weeks) postnatal corticosteroids for chronic lung disease in preterm infants. Cochrane Database of Systematic Reviews 2003, Issue 1. [DOI: 10.1002/14651858.CD001145]
Halliday 2009
  • Halliday HL, Ehrenkranz RA, Doyle LW. Late (>7 days) postnatal corticosteroids for chronic lung disease in preterm infants. Cochrane Database of Systematic Reviews 2009, Issue 1. [DOI: 10.1002/14651858.CD001145.pub2]