This is not the most recent version of the article. View current version (9 NOV 2011)

Intervention Review

You have free access to this content

Human albumin solution for resuscitation and volume expansion in critically ill patients

  1. The Albumin Reviewers (Alderson P, Bunn F, Li Wan Po A, Li L, Pearson M, Roberts I, Schierhout G)

Editorial Group: Cochrane Injuries Group

Published Online: 18 OCT 2004

Assessed as up-to-date: 15 JUN 2008

DOI: 10.1002/14651858.CD001208.pub2


How to Cite

The Albumin Reviewers (Alderson P, Bunn F, Li Wan Po A, Li L, Pearson M, Roberts I, Schierhout G). Human albumin solution for resuscitation and volume expansion in critically ill patients. Cochrane Database of Systematic Reviews 2004, Issue 4. Art. No.: CD001208. DOI: 10.1002/14651858.CD001208.pub2.

Author Information

  1. London School of Hygiene & Tropical Medicine, Cochrane Injuries Group, London, UK

*Ian Roberts, Cochrane Injuries Group, London School of Hygiene & Tropical Medicine, North Courtyard, Keppel Street, London, WC1E 7HT, UK. ian.roberts@lshtm.ac.uk.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 18 OCT 2004

SEARCH

This is not the most recent version of the article. View current version (09 NOV 2011)

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Bland 1973 {published data only}
  • Bland RD, Clarke TL, Harden LB, Meyer JL, Ries JP, Madden WA, Crast FW, Coyer WF, Bass JW. Early albumin infusion to infants at risk for respiratory distress. Archives of Disease in Childhood 1973;48:800-5.
Bland 1976 {published data only}
  • Bland RD, Clarke TL, Harden LB. Rapid infusion of sodium bicarbonate and albumin into high-risk premature infants soon after birth: A controlled, prospective trial. American Journal of Obstetrics and Gynecology 1976;124:263-7. [MEDLINE: 1976109310]
Boldt 1993 {published data only}
  • Boldt J, Knothe C, Zickmann B, Andres P, Dapper F, Hempelmann G. Influence of different intravascular volume therapies on platelet function in patients undergoing cardiopulmonary bypass. Anesthesia and Analgesia 1993;76:1185-90. [MEDLINE: 1993270221]
Boutros 1979 {published data only}
  • Boutros AR, Ruess R, Olson L, Hoyt JL, Baker WH. Comparison of hemodynamic, pulmonary, and renal effects of use of three types of fluids after major surgical procedures on the abdominal aorta. Critical Care Medicine 1979;7(1):9-13. [MEDLINE: 1979106434]
Brown 1988 {published data only}
Cooper 2006 {published data only}
Dubois 2006 {published data only}
  • Dubois M J, Orellana-Jimenez C, Melot C, De Backer D, Berre J, Leeman M, et al. Albumin administration improves organ function in critically ill hypoalbuminemic patients: A prospective, randomized, controlled, pilot study.[see comment]. Critical Care Medicine 2006;34(10):2536-40.
Ernest 1999 {published data only}
Ernest 2001 {published data only}
Foley 1990 {published data only}
Gallagher 1985 {published data only}
  • Gallagher JD, Moore RA, Kerns D, Jose AB, Botros SB, Flicker S, Naidech H, Clark DL. Effects of colloid or crystalloid administration on pulmonary extravascular water in the postoperative period after coronary artery bypass grafting. Anesthesia and Analgesia 1985;64:753-8. [MEDLINE: 1985249399]
Golub 1994 {published data only}
Goodwin 1983 {published data only}
Greenhalgh 1995 {published data only}
  • Greenhalgh DG, Housinger TA, Kagan RJ, et al. Maintenance of serum albumin levels in pediatric burn patients: a prospective, randomized trial. Journal of Trauma 1995;39(1):67-73; discussion 73-4. [MEDLINE: 1995363875]
Greenough 1993 {published and unpublished data}
Grundmann 1982 {published data only}
Jelenko 1978 {published data only}
  • Jelenko C 3rd. Fluid therapy and the HALFD method. Journal of Trauma 1979;19(11 Suppl):866-7. [MEDLINE: 1980029813]
  • Jelenko C 3rd, Solenberger RI, Wheeler ML, Callaway BD. Shock and resuscitation. III. Accurate refractometric COP determinations in hypovolemia treated with HALFD. Journal of the American College of Emergency Physicians 1979;8(7):253-6. [MEDLINE: 1979197471]
  • Jelenko C 3rd, Wheeler ML, Callaway BD, Divilio LT, Bucklen KR, Holdredge TD. Shock and resuscitation. II: volume repletion with minimal edema using the "HALFD"(Hypertonic Albuminated Fluid Demand) regimen. Journal of the American College of Emergency Physicians 1978;7(9):326-33. [MEDLINE: 1994194739]
  • Jelenko C 3rd, Williams JB, Wheeler ML, et al. Studies in shock and resuscitation, I: use of a hypertonic, albumin-containing, fluid demand regimen (HALFD) in resuscitation. Critical Care Medicine 1979;7(4):157-67. [MEDLINE: 1979190564]
Kanarek 1992 {published data only}
Lowe 1977 {published data only}
  • Lowe RJ, Moss GS, Jilek J, Levine HD. Crystalloid versus colloid in the etiology of pulmonary failure after trauma - a randomized trial in man. Critical Care Medicine 1979;7(3):107-12. [MEDLINE: 1979168390]
  • Lowe RJ, Moss GS, Jilek J, Levine HD. Crystalloid vs colloid in the etiology of pulmonary failure after trauma: a randomized trial in man. Surgery 1977;1(6):676-83. [MEDLINE: 1977175168]
  • Moss GS, Lowe RJ, Jilek J, Levine HD. Colloid or crystalloid in the resuscitation of hemorrhagic shock: a controlled clinical trial. Surgery 1981;89(4):434-8. [MEDLINE: 1981153604]
Lucas 1978 {published data only}
Maitland 2005 {published data only}
McNulty 1993 {published data only}
  • McNulty SE, Sharkey SJ, Asam B, Lee JH. Evaluation of STAT-CRIT Hematocrit Determination in comparison to Coulter and Centrifuge: the effects of isotonic hemodilution and albumin administration. Anesthesia and Analgesia 1993;76:830-4. [MEDLINE: 1993220903]
Myburgh 2007 {published data only}
  • Myburgh J, Cooper J, Finfer S, Bellomo R, Norton R, Bishop N, et al. Saline or Albumin for Fluid Resuscitation in Patients With Traumatic Brain Injury. New England Journal of Medicine 2007;357(9):874-84.
Nielsen 1985 {published data only}
  • Nielsen OM, Engell HC. Effects of maintaining normal plasma colloid osmotic pressure on renal function and excretion of sodium and water after major surgery: a randomised study. Danish Medical Bulletin 1985;32:182-5. [MEDLINE: 1985256448]
  • Nielsen OM, Engell HC. Extracellular fluid volume and distribution in relation to changes in plasma colloid osmotic pressure after major surgery. A randomised study. Acta Chirurgica Scandinavica 1985;151:221-5. [MEDLINE: 1985247186]
  • Nielsen OM, Thunedborg P, Jorgensen K. Albumin administration and acute phase proteins in abdominal vascular surgery: a randomised study. Danish Medical Bulletin 1989;36:496-9. [MEDLINE: 1990031802]
Nilsson 1980 {published data only}
Oca 1999 {published data only}
  • Oca MJ, Nelson M, Donn SM. Randomized trial of normal saline (NS) versus 5% albumin (ALB) for the treatment of neonatal hypotension. Pediatric Research. 1999; Vol. 45:#1265.
Oca 2003 {published data only}
  • Oca MJ, Nelson M, Donn SM. Randomized trial of normal saline versus 5% albumin for the treatment of neonatal hypotension. Journal of Perinatology 2003;23(6):473-6.
Pockaj 1994 {published data only}
  • Pockaj BA, Yang JC, Lotze MT, et al. A prospective randomized trial evaluating colloid versus crystalloid resuscitation in the treatment of the vascular leak syndrome associated with interleukin-2 therapy. Journal of Immunotherapy 1994;15(1):22-8. [MEDLINE: 1994153877]
Prien 1990 {published data only}
  • Prien T, Backhaus N, Pelster F, Pircher W, Bunte H, Lawin P. Effect of intraoperative fluid administration and colloid osmotic pressure on the formation of intestinal edema during gastrointestinal surgery. Journal Clinical Anesthesia 1990;2:317-23. [MEDLINE: 1991104037]
Quinlan 2004 {published data only}
  • Quinlan GJ, Mumby S, Martin GS, Bernard GR, Gutteridge JM, Evans TW. Albumin influences total plasma antioxidant capacity favorably in patients with acute lung injury. Critical Care Medicine 2004;32(3):755-9.
Rackow 1983 {published data only}
  • Rackow EC, Falk JL, Fein IA, et al. Fluid resuscitation in circulatory shock: a comparison of the cardiorespiratory effects of albumin, hetastarch, and saline solutions in patients with hypovolemic and septic shock. Critical Care Medicine 1983;11(11):839-50. [MEDLINE: 1984027713]
Rubin 1997 {published data only}
SAFE 2004 {published data only}
Shah 1977 {published data only}
Skillman 1975 {published data only}
So 1997 {published data only}
Tollofsrud 1995 {published data only}
Virgilio 1979 {published data only}
Woittiez 1998 {unpublished data only}
  • Timmer B, Hondebrink Y, Oude Nijhuis J, Woittiez AJJ. Restoration of colloid osmotic pressure in hypoalbuminaemic patients. Netherlands Journal of Medicine 1998;52:A42.
  • Woittiez AJ. Restoration of colloid osmotic pressure in post operative intensive care patients. A randomised placebo controlled trial with albumin 20% and hydroxy-ethyl starch. In: Medical Editors' Trial Amnesty. In: The Cochrane Controlled Trials Register In: The Cochrane Library, Issue 2, 1998. Oxford: Update Software.
Wojtysiak 1992 {published data only}
  • Binkley JF, Brown RO, Wojtysiak SL, Powers DA, Kudsk KA. Effects of human albumin administration on visceral protein markers in patients receiving parenteral nutrition. Clinical Pharmacy 1993;Vol 12:377-9.
  • Wojtysiak SL, Brown RO, Roberson D, Powers DA, Kudsk KA. Effect of hypoalbuminaemia and parenteral nutrition on free water excretion and electrolyte-free water resorption. Critical Care Medicine 1992;20:164-9. [MEDLINE: 1992146052]
Woods 1993 {published data only}
Zetterstrom 1981a {published data only}
  • Zetterstrom H, Hedstrand U. Albumin treatment following major surgery. I. Effects on plasma oncotic pressure, renal function and peripheral oedema. Acta Anaesthsiologica Scandinavica 1981;25:125-32. [MEDLINE: 1982109921]
Zetterstrom 1981b {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Artru 1989 {published data only}
  • Artru F, Philippon B, Flachaire E, et al. A controlled study of Dextran 40: effect on cerebral blood flow and metabolic rates in acute head trauma. Intensive Care Medicine 1989;15(8):499-504.
Bellomo 2006 {published data only}
  • Bellomo R, Morimatsu H, French C, Cole L, Story D, Uchino S, et al. The Effects of Saline or Albumin Resuscitation on Acid-Base Status and Serum Electrolytes. Critical Care Medicine 2006;34(12):2891-7.
Brehme 1993 {published data only}
  • Brehme S, Keysser G, Turowski A, Schmidt HH. Hemorheologic effects of hydroxyethyl starch 200/0.5, dextran 40, oxypolygelatine and full electrolyte solution over 48 hours. Z Gesamte Inn Med 1993;48(10):506-10.
Carlon 1979 {published data only}
Fiorica 1991 {published data only}
  • Fiorica JV, Roberts WS, Hoffman MS, Barton DP, Finan MA, Lyman G, Cavanagh D. Concentrated albumin infusion as an aid to postoperative recovery after pelvic exenteration. Gynecologic Oncology 1991;43:265-9.
Goslinga 1992 {published data only}
  • Goslinga H, Eijzenbach V, Heuvelmans JH, van de Nes JC, Kurk RM, Bezemer PD. Individualized hemodilution in acute brain infarct using a 20% albumin solution and physiological saline solution. Ned Tijdschr Geneeskd 1992;136(49):2422-8.
  • Goslinga H, Eijzenbach V, Heuvelmans JH, et al. Custom-tailored hemodilution with albumin and crystalloids in acute ischemic stroke. Stroke 1992;23(2):181-8.
  • Goslinga H, Heuvelmans JH, Schmid Schonbein H. Hemodilution and rehydration in acute ischemic stroke. A preliminary report on the Amsterdam Stroke Study. Acta Medica Austriaca 1991;18 Suppl 1:41-4.
Grundmann 1985 {published data only}
Grundmann 1986 {published data only}
  • Grundmann R, von Lehndorff C. Indications for postoperative human albumin therapy in the intensive care unit: a prospective randomised study. Langenbecks Archiv fur Chirurgie 1986;367:235-46.
Hauser 1980 {published data only}
  • Hauser CJ, Shoemaker WC, Turpin I, Goldberg SJ. Oxygen transport respons to colloids and crystalloids in critically ill surgical patients. Surgery 1980;150(6):811-6.
Lagonidis 1995 {published data only}
  • Lagonidis D, Magder S. Acute volume loading with colloid vs. crystalloid after coronary artery bypass. Intensive Care Medicine 1992;18:(suppl 2):S225.
Lennihan 2000 {published data only}
  • Lennihan L, Mayer SA, Fink ME, Beckford A, Paik MC, Zhang H, Wu Y, Kledanoff LM, Raps EC, Solomon RA. Effect of hypervolemic therapy on cerebral blood flow after subarachnoid hemorrhage. Stroke 2000;31(2):383-91.
Magder 1999 {published data only}
Maitland 2005a {published data only}
  • Maitland K, Pamba A, English M, Peshu N, Marsh K, Newton C, et al. Randomized trial of volume expansion with albumin or saline in children with severe malaria: Preliminary evidence of albumin benefit. Clinical Infectious Diseases 2005;40(4):538-45.
Martin 1999 {published data only}
  • Martin GS, Mangialardi RJ, Wheeler AP, Berhard GR. Albumin and diuertics in acute lung injury/acute respiratory distress syndrome. American Journal of Respiratory Critical Care Medicine 1999;159(3):A376.
Metildi 1984 {published data only}
  • Metildi LA, Shackford SR, Virgilio RW, Peters RM. Crystalloid versus colloid in fluid resuscitation of patients with severe pulmonary insufficiency. Surgical Gynecology and Obstetrics 1984;158(3):207-12.
Steinberg 1989 {published data only}
  • Steinberg B, Kochs E, Bause H, Schulte am Esch J. Effects of low molecular weight hydroxyethyl starch (HES 40) in comparison with Ringer solution on oxygen tension in skeletal muscles of infected patients. Anasthesie Intensivtherapie Notfallmedizin 1989;24(6):377-81.
Tomita 1994 {published data only}
  • Tomita H, Ito U, Tone O, Masaoka H, Tominaga B. High colloid oncotic therapy for contusional brain edema. Acta Neurochirurgica 1994;suppl:547-9.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Martin {unpublished data only}
  • Martin G. Bioimpedance measures of albumin effects in acute lung injury.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
ABPI 1998
  • ABPI Compendium of data sheets and summaries of produce characteristics 1998-99. Association of the British Pharmaceutical Industry, London 1998.
Egger 1997
Fleck 1985
  • Fleck A, Raines G, Hawker F, Trotter J, Wallace P, Ledingham I, Calman KC. Increased vascular permeability: a major cause of hypoalbuminaemia in disease and injury. Lancet 1985;I:781-4.
Goldwasser 1997
McClelland 1990
Oxman 1994
  • Oxman A, Cook D, Guyatt GH for the Evidence-based Medicine Working Group. User’s Guides to the Medical Literature. VI. How to use an overview. Journal of the American Medical Association 1994;272:1367-71.
Schulz 1996
  • Schulz KF, Chalmers I, Hayes RJ, Altman DG. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. Journal of the American Medical Association 1995;273(5):408-12.
Soni 1995

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
CIGAR 1998