Intervention Review

You have free access to this content

Surgery for cervical intraepithelial neoplasia

  1. Pierre PL Martin-Hirsch1,*,
  2. Evangelos Paraskevaidis2,
  3. Andrew Bryant3,
  4. Heather O Dickinson3

Editorial Group: Cochrane Gynaecological, Neuro-oncology and Orphan Cancer Group

Published Online: 4 DEC 2013

Assessed as up-to-date: 23 NOV 2012

DOI: 10.1002/14651858.CD001318.pub3


How to Cite

Martin-Hirsch PPL, Paraskevaidis E, Bryant A, Dickinson HO. Surgery for cervical intraepithelial neoplasia. Cochrane Database of Systematic Reviews 2013, Issue 12. Art. No.: CD001318. DOI: 10.1002/14651858.CD001318.pub3.

Author Information

  1. 1

    Royal Preston Hospital, Lancashire Teaching Hospital NHS Trust, Gynaecological Oncology Unit, Preston, Lancashire, UK

  2. 2

    Ioannina University Hospital, Department of Obstetrics and Gynaecology, Ioannina, Greece

  3. 3

    Newcastle University, Institute of Health & Society, Newcastle upon Tyne, UK

*Pierre PL Martin-Hirsch, Gynaecological Oncology Unit, Royal Preston Hospital, Lancashire Teaching Hospital NHS Trust, Sharoe Green Lane, Fullwood, Preston, Lancashire, PR2 9HT, UK. martin.hirsch@me.com.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 4 DEC 2013

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Alvarez 1994 {published data only}
  • Alvarez R, Helm W, Edwards P, Naumann W, Partridge E, Shingleton H, et al. Prospective randomised trial of LLETZ versus laser ablation in patients with cervical intra-epithelial neoplasia. Gynecologic Oncology 1994;52:175-9.
Berget 1987 {published data only}
Bostofte 1986 {published data only}
Cherchi 2002 {published data only}
  • Cherchi P L, Capobianco G, Ambrosini G, Fadda GM, Piga MD, Canetto AM, et al. Utility of bipolar electrocautery scissors for cervical conization. European Journal of Gynaecological Oncology 2002; Vol. 23, issue 2:154-6.
Chirenje 2001 {published data only}
  • Chirenje ZM, Rusakaniko S, Akino V, Mlingo M. A randomised clinical trial of loop electrosurgical excision procedure (LEEP) versus cryotherapy in the treatment of cervical intraepithelial neoplasia. Journal of Obstetrics and Gynaecology 2001; Vol. 21, issue 6:617-21.
Crompton 1994 {published data only}
Dey 2002 {published data only}
Duggan 1999 {published data only}
  • Duggan B, Felix J, Muderspach L, Gebhardt J, Groshen S, Morrow P, et al. Cold-Knife conization versus conization by loop electrosurgical excision procedure: a randomized, prospective study. American Journal of Obstetrics and Gynecology 1999;180:276-82.
Giacalone 1999 {published data only}
  • Giacalone PL, Laffargue F, Aligier N, Roger P, Combecal J, Daures JP. Randomized study comparing two techniques of conization: cold knife versus loop excision. Gynecologic Oncology 1999;75(3):356-60.
Gilbert 1989 {published data only}
  • Gilbert L, Sunders N, Stringer R, Sharp F. Hemostasis and cold knife cone biopsy: a prospective randomized trial comparing a suture versus non-suturing technique. Obstetrics and Gynecology 1989;74:640-3.
Healey 1996 {published data only}
Jobson 1984 {published data only}
  • Jobson V, Homesley H. Comparison of cryosurgery and carbon dioxide laser ablation for the treatment of CIN. Colposcopy and Gynecologic Laser Surgery 1984;1:173-80.
Kirwan 1985 {published data only}
Kristensen 1990 {published data only}
  • Kristensen G, Jensen L, Holund B. A randomised trial comparing two methods of cold knife conisation with laser conisation. Obstetrics and Gynecology 1990;76:1009-13.
Kwikkel 1985 {published data only}
  • Kwikkel H, Helmerhorst T, Bezemer P, Quaak M, Stolk J. Laser or cryotherapy for cervical intra-epithelial neoplasia: a randomised study to compare efficacy and side effects. Gynecologic Oncology 1985;22:23-31.
Larsson 1982 {published data only}
Mathevet 1994 {published data only}
  • Mathevet P, Chemali E, Roy M, Dargent D. Long-term outcome of a randomized study comparing three techniques of conization: cold knife, laser, and LEEP. European Journal of Obstetrics, Gynecology, and Reproductive Biology 2003; Vol. 106, issue 2:214-8.
  • Mathevet P, Dargent D, Roy M, Beau G. A randomised prospective study comparing three techniques of conisation: cold knife, laser, and LEEP. Gynecologic Oncology 1994;54:175-9.
Mitchell 1998 {published data only}
  • Mitchell M, Tortolero-Luna G, Cook E, Whittaker L, Rhodes-Morris H, Silva E. A randomized clinical trial of cryotherapy, laser vaporization and loop electrosurgical excision for the treatment of squamous intra-epithelial lesions of the cervix. Obstetrics and Gynaecology 1998;92:737-44.
Nagar 2004 {published data only}
  • Nagar HA, Dobbs SP, McClelland HR, Price JH, McClean G, McCluggage WG. The large loop excision of the transformation zone cut or blend thermal artefact study: a randomized controlled trial. International Journal of Gynecological Cancer 2004; Vol. 14, issue 6:1108-11.
Oyesanya 1993 {published data only}
  • Oyesanya O, Amersinghe C, Manning E. Out patient excisional management of cervical Intra-epithelial neoplasia: A prospective randomized comparison between loop diathermy excision and laser excisional conisation. American Journal of Obstetrics and Gynecology 1993;168:485-8.
Panoskaltsis 2004a {published data only}
  • Panoskaltsis T, Ind TE, Perryman K, Dina R, Abrahams Y, Soutter WP. Needle versus loop diathermy excision of the transformation zone for the treatment of cervical intraepithelial neoplasia: a randomised controlled trial. BJOG 2004; Vol. 111, issue 7:748-53.
Paraskevaidis 1994 {published data only}
  • Paraskevaidis E, Kichener H, Malamou-Mitsi V, Agnanti N, Lois D. Thermal tissue damage following laser and large loop conisation of the cervix. Obstetrics and Gynecology 1994;84:752-4.
Partington 1989 {published data only}
  • Partington C, Turner M, Soutter W, Griffiths, Krausz T. Laser vaporization versus laser excision conisation in the treatment of cervical intraepithelial neoplasia. Obstetrics and Gynecology 1989;73:775-9.
Sadek 2000 {published data only}
  • Sadek A L, Istre O Trolle G B. A randomized prospective study of cold knife, large loop excision and needle excision of the transformation zone for treatment of cervical intraepithelial neoplasia. 26th FIGO World Congress of Obstetrics and Gynecology; Sept 3-8 2000; Washington DC 2000; Vol. Book 3:60, Abstract FC3.23.06.
Santos 1996 {published data only}
  • Santos C, Galdos R, Alvarez M, Velarde C, Barriga O, Dyer R, et al. One-session management of cervical intraepithelial neoplasia: A solution for developing countries. Gynecologic Oncology 1996;61:11-5.
Schantz 1984 {published data only}
Takac 1999 {published data only}
Townsend 1983 {published data only}
Vejerslev 1999 {published data only}
  • Vejerslev LO, Schouenborg L, Sørensen F, Nielsen D, Sørensen SS, Juhl BR, et al. Loop diathermy or laser excisional conization for cervical intraepithelial neoplasia. Acta Obstetricia et Gynecologica Scandinavica 1999; Vol. 78, issue 10:900-5.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Bar-AM 2000 {published data only}
  • Bar-Am A, Daniel Y, Ron IG, Niv J, Kupferminc MJ, Bornstein J, Lessing JB. Combined colposcopy, loop conization, and laser vaporization reduces recurrent abnormal cytology and residual disease in cervical dysplasia. Gynecologic Oncology 2000;78(1):47-51.
Boardman 2004 {published data only}
  • Boardman LA, Steinhoff MM, Shackelton R, Weitzen S, Crowthers L. A randomized trial of the Fischer cone biopsy excisor and loop electrosurgical excision procedure. Obstetrics and Gynecology 2004;104(4):745-50.
Ferenczy 1985 {published data only}
Gentile 2001 {published data only}
  • Gentile G, Tallarini A. Ablative techniques in the treatment of cervical lesions. Tumori 2001;87 Suppl(5):12.
Girardi 1994 {published data only}
  • Girardi F, Heydarfadai M, Koroschetz F, Pickel H, Winter R. Cold-knife conisation versus loop excision: histolopathologic and clinical results of a randomised trial. Gynecologic Oncology 1994;55:368-70.
Gunasekera 1990 {published data only}
Lisowski 1999 {published data only}
  • Lisowski-P, Knapp-P, Zbroch-T, Kobylec-M, Knapp-P. The effectiveness of conservative treatment of cervical lesions using the LLETZ and CO2 laser. Przeglad Lekarski 1999;56:72-5.
O'Shea 1986 {published data only}
  • O'Shea R, Need J, Pomeroy G. Cryotherapy versus electrocoagulation diathermy for cervical intraepithelial neoplasia- a prospective randomised trial. Colposcopy and Gynecologic Laser Surgery 1986;2(3):159-61.
Panoskaltsis 2004b {published data only}
Singh 1988 {published data only}
  • Singh P, Loke K, Hii J, Sabaratnam A, Lim-Tan S, Kitchener H, et al. Cold coagulation versus cryotherapy for treatment of cervical intraepithelial neoplasia: results of a prospective randomized trial. Colposcopy and Gynecologic Laser Surgery 1988;4(4):211-21.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Anderson 1986
  • Anderson M. Are we vaporizing microinvasive lesions?. RCOG Perinatology Press 1986;1:127-31.
Benedet 1981
  • Benedet J, Nickerson K, White G. Laser therapy for cervical intraepithelial neoplasia. Obstetrics and Gynecology 1981;57:188.
Bigrigg 1990
  • Bigrigg MA, Codling BW, Pearson P, Read MD, Swingler GR. Colposcopic diagnosis and treatment of cervical dysplasia at a single visit. Experience of low-voltage diathermy loop in 1000 patients. Lancet 1990;336(8709):229-31.
Chappatte 1991
  • Chappatte O, Byrne D, Raju K, Nayagam M, Kenney A. Histological differences between colposcopic-directed biopsy and loop excision of the transformation zone: a cause for concern. Gynecologic Oncology 1991;43:46-50.
Cirisano 1999
Creasman 1984
  • Creasman W, Hinshaw W, Clarke-Pearson D. Cyrosurgery in the management of cervical intraepithelial neoplasia. Obstetrics and Gynecology 1984;63:145.
CTCAE 2006
  • CTCAE. Common Terminology Criteria for Adverse Events. (http://ctep.cancer.gov/forms/CTCAEv3.pdf) 9th August 2006; Vol. v3.0 (CTCAE).
Deeks 2001
  • Deeks JJ, Altman DG, Bradburn MJ. Statistical methods for examining heterogeneity and combining results from several studies in meta-analysis. In: Egger M, Davey Smith G, Altman DG editor(s). Systematic Reviews in Health Care: Meta-Analysis in Context. 2nd Edition. London: BMJ Publication Group, 2001.
DerSimonian 1986
EUROCARE 2003
  • Sant M, Aareleid T, Berrino F, Bielska Lasota M, Carli PM, Faivre J, et al. and the EUROCARE Working Group. EUROCARE-3: Survival of cancer patients diagnosed 1990-94 - Results and commentary. Annals of Oncology 2003;14 Suppl 5:v61-v118.
GLOBOCAN 2009
  • Ferlay J, Bray F, Pisani P, Parkin DM. GLOBOCAN 2009.  Cancer Incidence, Mortality and Prevalence Worldwide. IARC CancerBase No. 5, version 2.0.  IARCPress, Lyon 2009.
Hatch 1981
Higgins 2003
IARC 2002
  • Parkin DM, Whelan SL, Ferlay J, Teppo L, Thomas DB. Cancer Incidence in Five Continents. IARC Scientific Publication No. 155, Lyon 2002; Vol. Volume VIII.
Jordan 1984
  • Jordan J. Symposia on cervical neoplsaia, excisional methods. Colposcopy and Gynecologic Laser Surgery 1984;1:271.
Jordan 1985
Kaufman 1978
Kyrgiou 2004
  • Kyrgiou M, Koliopoulos G, Martin-Hirsch P, Arbyn M, Prendiville W, Paraskevaidis E. Obstetric outcomes after conservative treatment for intraepithelial or early invasive cervical lesions: systematic review and meta-analysis. Lancet 2004;367(9509):489-98.
Larson 1983
  • Larson G. Conisation for preinvasive and invasive carcinoma. Acta Obstetricia et Gynecologica Scandinavica 1983;114 Suppl:1-40.
Leiman 1980
  • Leiman G, Harrison N, Rubin A. Pregnancy following conisation of the cervix: complications related to cone biopsy. American Journal of Obstetrics and Gynecology 1980;136:14-8.
Luesley 1985
Luesley 1990
Murdoch 1992
Nuovo 2000
Ostergard 1980
  • Ostergard D. Cryosurgical treatment of cervical intraepithelial neoplasia. Obstetrics and Gynecology 1980;56:233.
Ostor 1993
Peto 2004
Popkin et al 1978
  • Popkin D, Scali V, Ahmed M. Cryosurgery for the treatment of cervical intraepithelial neoplasia. American Journal of Obstetrics and Gynecology 1978;130:551.
Prendeville 1989
Sargent 2008
  • Sargent A, Bailey A, Almonte M, Turner A, Thomson C, Peto J, et al. Prevalence of type-specific HPV infection by age and grade of cervical cytology: data from the ARTISTIC trial. British Journal of Cancer 2008;98(10):1704-9.
Tabor 1990
Whiteley 1990
Wright TC 1992
  • Wright TC Jr, Gagnon S, Richart RM, Ferenczy A. Treatment of cervical intraepithelial neoplasia using the loop electrosurgical excision procedure. Obstetrics and Gynecology 1992;79(2):173-8.