Corticosteroids are widely used in inflammatory conditions as an immunosuppressive agent. Diseases treated with corticosteroids include connective tissue diseases, asthma, inflammatory bowel disease and organ transplantation. Bone loss is a serious side effect of this therapy. Several studies have examined the use of bisphosphonates as a treatment for corticosteroid-induced osteoporosis and have reported varying magnitudes of effect. The best estimate of the magnitude of efficacy regarding bisphosphonate prevention of corticosteroid-induced bone loss is needed, before their use is advocated.