Isoniazid for preventing tuberculosis in non‐HIV infected persons

doi:10.1002/14651858.CD001363

Intervention Review

You have free access to this content

Isoniazid for preventing tuberculosis in non-HIV infected persons

Marek Smieja^1,*,
Catherine Marchetti²,
Deborah Cook³,
Fiona M Smaill⁴

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 20 JAN 2010

Assessed as up-to-date: 5 MAY 2003

DOI: 10.1002/14651858.CD001363

Database Title

The Cochrane Library

Additional Information

How to Cite

Smieja M, Marchetti C, Cook D, Smaill FM. Isoniazid for preventing tuberculosis in non-HIV infected persons. Cochrane Database of Systematic Reviews 1999, Issue 1. Art. No.: CD001363. DOI: 10.1002/14651858.CD001363.

Author Information

¹
McMaster University, Pathology and Molecular Medicine, Hamilton, Ontario, Canada
²
Missisauga, Ontario, Canada
³
McMaster University, Dept. of Clinical Epidemiology & Biostatistics, Hamilton, Ontario, Canada
⁴
McMaster University, Department of Pathology and Molecular Medicine, Faculty of Health Sciences, Hamilton, Ontario, Canada

^*Marek Smieja, Pathology and Molecular Medicine, McMaster University, L-424, St. Luke's Wing, St. Joseph's Healthcare, Hamilton, Ontario, L8N 4A6, Canada. smiejam@mcmaster.ca.

Publication History

Publication Status: Stable (no update expected for reasons given in 'What's new')
Published Online: 20 JAN 2010

ARTICLE TOOLS

View Full Article (HTML) Summary (58K)Standard (272K)Full (318K)

References

References to studies included in this review

References to studies included in this review
References to studies excluded from this review
Additional references

Comstock 1962 {published data only}

Comstock GW. Isoniazid prophylaxis in an undeveloped area. Am Rev Resp Dis 1962;86:810-22.
Comstock GW, Baum C, Snider DE Jr. Isoniazid prophylaxis among Alaskan Eskimos: a final report of the Bethel isoniazid studies. Am Rev Resp Dis 1979;119:827-30.
Comstock GW, Ferebee SH, Hammes LM. A controlled trial of community-wide isoniazid prophylaxis in Alaska. Am Rev Resp Dis 1967;95:935-43.
Comstock GW, Woolpert SF, Baum C. Isoniazid prophylaxis among Alaskan Eskimos: a progress report. Am Rev Resp Dis 1974;110:195-7.

Del Castillo 1965 {published data only}

Del Castillo H, Bautista LD, Jacinto CP, Lorenzo CE, Lapuz S, Legaspi B. Chemoprophylaxis in the Philippines. A controlled pilot study among household contacts of tuberculosis cases. Bull Quezon Institute 1965;7:277-90.

Egsmose 1965 {published data only}

Egsmose T, Ang'awa JOW, Poti SJ. The use of isoniazid among household contacts of open cases of pulmonary tuberculosis. Bull Wld Hlth Org 1965;33:419-33.

Falk 1978 {published data only}

Falk A, Fuchs GF. Prophylaxis with isoniazid in inactive tuberculosis. A veterans administration cooperative study XII. Chest 1978;73:44-48.

Ferebee 1962 {published data only}

Ferebee SH, Mount FW. Tuberculosis morbidity in a controlled trial of the prophylactic use of isoniazid among household contacts. Am Rev Resp Dis 1962;85:490-510.

Ferebee 1963 {published data only}

Ferebee SH, Mount FW, Murray FJ, Livesay VT. A controlled trial of isoniazid prophylaxis in mental institutions. Am Rev Resp Dis 1963;88:161-75.

Girling 1992 {published data only}

Girling DJ, Chan SL, Hong Kong Chest Service/Tuberculosis Research Centre, Madras/British Medical Research Council. A double-blind placebo-controlled clinical trial of three antituberculosis chemoprophylaxis regimens in patients with silicosis in Hong Kong. Am Rev Respir Dis 1992;145:36-41.
- PubMed,
- Web of Science® Times Cited: 115

John 1994 {published data only}

John GT, Thomas PP, Thomas M, Jeyaseelan L, Jacob CK, Shastry JCM. A double-blind randomized controlled trial of primary isoniazid prophylaxis in dialysis and transplant patients. Transplantation 1994;57:1683-4.

Mount 1962 {published data only}

Mount FW, Ferebee SH. The effect of isoniazid prophylaxis on tuberculosis morbidity among household contacts of previously known cases of tuberculosis. Am Rev Resp Dis 1962;85:821-7.

Thompson 1982 {published data only}

Krebs A. The IUAT trial on isoniazid preventive treatment in persons with fibrotic lung lesions. Bull Int Un Tuberc 1976;51(1):193-201.
- PubMed,
- CAS
Thompson NJ, International Uniton Against Tuberculosis Committee on Prophylaxis. Efficacy of various durations of isoniazid preventive therapy for tuberculosis: five years of follow-up in the IUAT trial. Bull WHO 1982;60:555-64.
- PubMed,
- Web of Science® Times Cited: 224

Veening 1968 {published data only}

Veening GJJ. Long term isoniazid prophylaxis. Controlled trial on INH prophylaxis after recent tuberculin conversion in young adults. Bull Int Un Against Tuber 1968;41:169-71.
- PubMed,
- CAS

References to studies excluded from this review

References to studies included in this review
References to studies excluded from this review
Additional references

Bush 1961 {published data only}

Bush OB Jr, Brown FA Jr. Prophylactic treatment of tuberculous contacts. A preliminary report. Am Rev Resp Dis 1961;84:95-7.
- PubMed,
- Web of Science® Times Cited: 4
Bush OV Jr, Sugimoto M, Fujii Y, Brown FA Jr. Isoniazid prophylaxis in contacts of persons with known tuberculosis. Second report. Am Rev Resp Dis 1965;92:732-40.
- PubMed,
- Web of Science® Times Cited: 13

Chiba 1963 {published data only}

Chiba Y, Takahara T, Kondo K, Nagashima A. Chemoprophylaxis of tuberculosis for adults in Japan. Bull Int Un Tuberc 1963;35:91-3.

Clayson 1963 {published data only}

Clayson C, Scottish Thoracic Society. A controlled trial of chemotherapy in pulmonary tuberculosis of doubtful activity: five year follow-up. Tubercle 1963;44:39-46.
- CrossRef

Comstock 1969 {published data only}

Comstock GW, Hammes LM, Pio A. Isoniazid prophylaxis in Alaskan boarding schools. A comparison of two doses. Am Rev Resp Dis 1969;100:773-9.

Comstock 1972 {published data only}

Comstock GW, Ferebee SH, Woolpert S. Preventive treatment of untreated, nonactive tuberculosis in an Eskimo population. Arch Environ Health 1972;25:333-7.

Curry 1967 {published data only}

Curry FJ. Prophylactic effect of isoniazid in young tuberculin reactors. N Engl J Med 1967;277:528-33.
- CrossRef,
- Web of Science® Times Cited: 34

Dahlstrom 1960 {published data only}

Dahlstrom AW, Wilson JL, Sedlacek BB. The immediate effectiveness of isoniazid chemoprophylaxis as determined by the tuberculin test. A five-year study including 5,555 Navajo and Pueblo children from birth to 15 years of age and the use of isonicotinic acid hydrazide in the prevention of tuberculosis. Am Rev Resp Dis 1960;38:599-603.

Debre 1973 {published data only}

Debre R, Perdrizet S, Lotte A, Naveau M, Lert F. Isoniazid chemoprophylaxis of latent primary tuberculosis: in five trial centres in France from 1959 to 1969. Int J Epid 1973;2:153-60.

Dimond 1968 {published data only}

Dimond AH. The chemoprophylaxis of tuberculosis in Gurkha soldiers. Tubercle 1968;49:79-83.
- CrossRef,
- PubMed,
- CAS

Dorken 1984 {published data only}

Dorken E, Grzybowski S, Enarson DA. Ten year evaluation of a trial of chemoprophylaxis against tuberculosis in Frobisher Bay, Canada. Tubercle 1984;65:93-9.

Dormer 1959 {published data only}

Dormer BA, Harrison I, Swart JA, Vidor SR. Prophylactic isoniazid. Protection of infants in a tuberculosis hospital. Lancet 1959;274:902-3.
- CrossRef

Dormer 1960 {published data only}

Dormer BA, Wood MM. Prophylactic isoniazid in nurses in a tuberculosis hospital. Lancet 1960;ii:837-40.
- CrossRef

Ferebee 1957 {published data only}

Ferebee SH, Mount FW, Anastasiades AA. Prophylactic effects of isoniazid on primary tuberculosis in children. A preliminary report. Am Rev Resp Dis 1957;76:942-63.

Gordin HIV 1997 {published data only}

Gordin FM, Matts JP, Miller C, Brown LS, Hafner R, John Sl, et al. A controlled trial of isoniazid in persons with anergy and human immunodeficiency virus infection who are at high risk for tuberculosis. N Engl J Med 1997;337:315-20.

Groth-Peterson 1960 {published data only}

Comstock GW, Baum C, Snider DE Jr. Isoniazid prophylaxis among Alaskan Eskimos: a final report of the Bethel isoniazid studies. Am Rev Resp Dis 1979;119:827-30.
Groth-Petersen E, Gad U, Ostergaard F. Mass chemoprophylaxis of tuberculosis. The acceptability and untoward side effects of isoniazid in a control study in Greenland. Amer Rev Resp Dis 1960;81:643-52.
Horwitz O. Long-term results of the chemoprophylactic trial in Greenland. Bull Int Union Tuberc 1968;41:167-71.
- PubMed,
- CAS
Horwitz O, Payne PG, Wilbek E. Epidemiological basis of tuberculosis eradication. 4. The isoniazid trial in Greenland. Bull Wld Hlth Org 1966;5:509-26.

Grzybowski 1972 {published data only}

Grzybowski S, Ashley MJ, Pinkus G. Chemoprophylaxis in inactive tuberculosis: long-term evaluation of a Canadian trial. Can Med Ass J 1976;114:607-11.
Grzybowski S, Galbraith JD, Styblo K, Chan-Yeung M, Dorken E, Brown A. Tuberculosis in Canadian Eskimos. Arch Environ Health 1972;25:329-32.

Hawken HIV 1997 {published data only}

Hawken MP, Meme HK, Elliott LC, Chakaya JM, Morris JS, Githui WA, et al. Isoniazid preventive therapy for tuberculosis in HIV-1 infected adults. Results of a randomized controlled trial. AIDS 1997;11:875-82.

Hsu 1974 {published data only}

Hsu KHK. Isoniazid in the prevention and treatment of tuberculosis. A 20-year study of the effectiveness in children. JAMA 1974;229:528-33.
Hsu KHK. Thirty years after isoniazid. Its impact on tuberculosis in children and adolescents. JAMA 1984;251:1283-5.

Katz 1962 {published data only}

Katz J, Kunofsky S, Damijonaitis V, Lafleur A, Caron T. Effect of isoniazid upon the reactivation of inactive tuberculosis. Preliminary report. Amer Rev Resp Dis 1962;86:8-15.

Katz 1965 {published data only}

Katz J, Kunofsky S, Damijonaitis V, Lafleur A, Caron T. Effect of isoniazid upon the reactivation of inactive tuberculosis; final report. Am Rev Respir Dis 1965;91:345-50.

Khoury 1969 {published data only}

Khoury SA, Theodore A, Platte VJ. Isoniazid prophylaxis in a slum area. Am Rev Resp Dis 1969;99:345-53.

Lotte 1964 {published data only}

Lotte A, Hatton F, Perdrizet S, Rouillon A. Chemoprophylaxis of primary tuberculosis in children and adolescents in France: an epidemiological study of cases recruited from 1948 to 1958 and followed up to 1963 [Chimioprophylaxie des tuberculoses primaires de l'enfant et de l'adolescent en France. Etude epidemiologique des cas recrutes de 1948 a 1958 et suivis jusqu'en 1963]. Bull WHO 1964;31:223-245.

Mount 1961 {published data only}

Mount FW, Ferebee SH. Preventive effects of isoniazid in the treatment of primary tuberculosis in children. N Engl J Med 1961;26:713-21.
- CrossRef,
- Web of Science® Times Cited: 73

Mysakowska 1964 {published data only}

Mysakowska H, Pietron E, Grodzki S, Srednicka D, Cyganiewicz E, Rozynska M, Smajkiewicz L. An appraisal of the chemoprophylaxis of tuberculosis in the student population of Lublin, Poland, following thirty months' observation. Am Rev Resp Dis 1964;93:628-9.
- PubMed,
- Web of Science® Times Cited: 3

Narain 1970 {published data only}

Narain R, Mayurnath S, Rao MSS, Murthy SS. Feasibility of a chemoprophylaxis trial in India against tuberculosis. A pilot study. Bull Wld Hlth Org 1970;43:41-52.

Nyboe 1963 {unpublished data only}

Nyboe J, Farah AR, Christensen OW. Report on tuberculosis chemotherapy pilot project (Tunisia 9). WHO/ TB/ Techn. 10 April 22, 1963.

Pamra 1971 {published data only}

Pamra SP, Mathur GP. Effects of chemoprophylaxis on minimal pulmonary tuberculosis lesions of doubtful activity. Bull Wld Hlth Org 1971;45:593-602.

Pape HIV 1993 {published data only}

Pape JW, Jean SS, Ho Sl, Hafner A, Johnson WD Jr. Effect of isoniazid prophylaxis on incidence of active tuberculosis and progression of HIV infection. Lancet 1993;342:268-72.

Vandiviere 1973 {published data only}

Vandiviere HM, Dworski M, Melvin IG, Watson KA, Begley J. Efficacy of Bacillus Calmette-Guerin and isoniazid-resistant Bacillus Calmette-Guerin with and without isoniazid chemoprophylaxis from day of vaccination. II. Field trial in man. Am Rev Resp Dis 1973;108:301-13.

Whalen HIV 1997 {published data only}

Whalen CC, Johnson JL, Okwera A, Hom DL, Huebner R, Mugyenyi P, et al. A trial of three regimens to prevent tuberculosis in Ugandan adults infected with the human immunodeficiency virus. N Engl J Med 1997;337:801-8.

Zorini 1958 {published data only}

Zorini AO. Antituberculous chemoprophylaxis with isoniazid preliminary note. Dis Chest 1958;33:1-17.

Zorini 1961 {published data only}

Zorini AO. Chemoprophylaxis by means of isoniazid in tuberculosis. Dis Chest 1961;15:67-72.

Zorini 1963 {published data only}

Zorini AO. Further developments in human and bovine antituberculosis chemoprophylaxis with isoniazid in Italy. Dis Chest 1963;43:131-41.

Additional references

References to studies included in this review
References to studies excluded from this review
Additional references

AAP 1992

American Academy of Pediatrics. Chemotherapy for tuberculosis in infants and children. Pediatrics 1992;89:161-5.
- PubMed

ATS&CDCP 1994

American Thoracic Society and the Centers for Disease Control and Prevention. Treatment of tuberculosis and tuberculosis infection in adults and children. Am Rev Respir Dis 1994;149:1359-74.
- Web of Science® Times Cited: 605

Barnes 1993

Barnes PF, Barrows SA. Tuberculosis in the 1990s. Ann Intern Med 1993;119:400-10.

Cochrane IDG 1998

Garner P, Gelband H, McIntosh H, Olliaro P, Salinas R, Volmink J, Wilkinson D. (eds). Guidelines for quality assessment of randomized controlled trials. 1998.

Ferebee 1970

Ferebee SH. Controlled chemoprophylaxis trials in tuberculosis. A general review. Adv Tuberc Res 1970;17:28-106.
- Web of Science®

Fitzgerald 1990

Fitzgerald JM, Gafni A. A cost-effectiveness analysis of the routine use of isoniazid prophylaxis in patients with a positive Mantoux skin test. Am Rev Respir Dis 1990;142:848-53.

Jordan 1991

Jordan TJ, Lewit EM, Reichman LB. Isoniazid preventive therapy for tuberculosis. Decision analysis considering ethnicity and gender. Am Rev Respir Dis 1991;144:1357-60.

JTCBTS 1990

Joint Tuberculosis Committee of the British Thoracic Society. Control and prevention of tuberculosis: an updated code of practice, 1990. Br Med J 1990;300:995-8.
- CrossRef,
- Web of Science® Times Cited: 18

JTCBTS 1994

Joint Tuberculosis Committee of the British Thoracic Society. Control and prevention of tuberculosis in the United Kingdom: Code of practice 1994. Thorax 1994;49:1193-1200.

Kochi 1991

Kochi A. The global tuberculosis situation and the new control strategy of the World Health Organization. Tubercle 1991;72:1-6.

Kopanoff 1978

Kopanoff DE, Snider DE Jr, Caras GJ. Isoniazid-Related Hepatitis. A US Public Health Service Cooperative Surveillance Study. Am Rev Resp Dis 1978;117:991-1001.

Laupacis 1988

Laupacis A, Sackett DL, Roberts RS. An assessment of clinically useful measures of the consequences of treatment. N Engl J Med 1988;318:1728-33.

McQuay 1997

McQuay HJ, Moore RA. Using numerical results from systematic reviews in clinical practice. Ann Intern Med 1997;126:712-20.

Miller 1993

Miller B. Preventive therapy for tuberculosis. Med Clin N Amer 1993;77:1263-75.

MMWR 1990

MMWR. The use of preventive therapy for tuberculous infection in the United States: Recommendations of the Advisory Committee for Elimination of Tuberculosis. MMWR 1990;39:9-12.

O'Brien 1998

O'Brien R. Personal communication. 1998.

Ormerod 1990

Ormerod LP for a subcommittee of the Joint Tuberculosis Committee. Chemotherapy and management of tuberculosis in the United Kingdom: recommendations of the Joint Tuberculosis Committee of the British Thoracic Society. Thorax 1990;45:403-8.

Rose 1986

Rose DN, Schechter CB, Silver AL. The age threshold for isoniazid chemoprophylaxis. JAMA 1986;256:2709-13.

Salpeter 1993

Salpeter SR. Fatal isoniazid-induced hepatitis. Its risk during chemoprophylaxis. West J Med 1993;159(5):560-4.

Salpeter 1997

Salpeter SR, Sanders GD, Salpeter EE, Owens DK. Monitored isoniazid prophylaxis for low-risk tuberculin reactors older than 35 years of age: a risk-benefit and cost-effectiveness analysis. Ann Intern Med 1997;127:1051-61.

SC(T)CTS&CLA 1996

Standards Committee (Tuberculosis) of the Canadian Thoracic Society and the Canadian Lung Association. Canadian Tuberculosis Standards. Fourth. Canada: The Lowe-Martin Group Inc, 1996:1996.

Snider 1986

Snider DE Jr, Caras GJ, Koplan JP. Preventive therapy with isoniazid. Cost-effectiveness of different durations of therapy. JAMA 1986;255:1579-83.

Snider 1988

Snider DE Jr. Decision analysis for isoniazid preventive therapy: take it or leave it? [editorial]. Am Rev Respir Dis 1988;137:2-4.
- PubMed,
- Web of Science® Times Cited: 30

Snider 1992

Snider DE Jr, Caras GJ. Isoniazid-associated deaths: A review of available information. Am Rev Respir Dis 1992;145:494-7.
- PubMed,
- Web of Science® Times Cited: 127

Stead 1987

Stead WW, To T, Harrison RW, et al. Benefit-risk considerations in preventive treatment for tuberculosis in elderly persons. Ann Intern Med 1987;107:843-5.

Taylor 1981

Taylor WC, Aronson MD, Delbanco TL. Should young adults with a positive tuberculin test take isoniazid?. Ann Intern Med 1981;94:808-13.

Wilkinson 1998

Wilkinson D. Preventing TB in HIV infected persons. Available in The Cochrane Library [database on disk and CDROM]. In: Garner P, Gelband H, McIntosh H, Olliaro P, Salinas R, Volmink J, Wilkinson D editor(s). Infectious Diseases Module of The Cochrane Database of Systematic Reviews, Issue 1. Oxford: Update Software, 1998.