This is not the most recent version of the article. View current version (30 APR 2015)

Intervention Review

You have free access to this content

Zinc for the common cold

  1. Meenu Singh1,*,
  2. Rashmi R Das2

Editorial Group: Cochrane Acute Respiratory Infections Group

Published Online: 18 JUN 2013

Assessed as up-to-date: 18 JAN 2013

DOI: 10.1002/14651858.CD001364.pub4


How to Cite

Singh M, Das RR. Zinc for the common cold. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD001364. DOI: 10.1002/14651858.CD001364.pub4.

Author Information

  1. 1

    Post Graduate Institute of Medical Education and Research, Department of Pediatrics, Chandigarh, India

  2. 2

    All India Institute of Medical Sciences (AIIMS), Department of Pediatrics, Bhubaneswar, Odisha, India

*Meenu Singh, Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India. meenusingh4@gmail.com. meenusingh@rediffmail.com.

Publication History

  1. Publication Status: Edited (no change to conclusions), comment added to review
  2. Published Online: 18 JUN 2013

SEARCH

This is not the most recent version of the article. View current version (30 APR 2015)

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Al-Nakib 1987 {published data only}
Douglas 1987 {published data only}
  • Douglas R, Miles H, Moore B, Ryan P, Pinnock C. Failure of effervescent zinc acetate lozenges to alter the course of upper respiratory tract infections in Australian adults. Antimicrobial Agents and Chemotherapy 1987;31(8):1263-5.
Farr 1987a {published data only}
  • Farr B, Conner E, Betts R, Oleski J, Minnefor A, Gwaltney J. Two randomised controlled trials of zinc gluconate lozenge therapy of experimentally induced rhinovirus colds. Antimicrobial Agents and Chemotherapy 1987;31(8):1183-7.
Godfrey 1992 {published data only}
  • Godfrey JC, Sloanne BB, Smith D, Turco JH, Mercer N, Godfrey NJ. Zinc gluconate and the common cold: a controlled clinical study. Journal of International Medical Research 1992;20(3):234-46.
Kurugol 2006a {published data only}
Kurugol 2006b {published data only}
Kurugol 2007 {published data only}
Macknin 1998 {published data only}
Mossad 1996 {published data only}
Petrus 1998 {published data only}
  • Petrus EJ, Lawson KA, Bucci LR, Blum K. Randomized, double-masked, placebo-controlled clinical study of the effectiveness of zinc acetate lozenges on common cold symptoms in allergy-tested subjects. Current Therapeutic Research 1998;59(9):595-607.
Prasad 2000 {published data only}
  • Prasad AS, Fitzgerald JT, Bao B, Beck FWJ, Chandrasekar PH. Duration of symptoms and plasma cytokine levels in patients with the common cold treated with zinc acetate. Annals of Internal Medicine 2000;133(4):245-52.
Prasad 2008 {published data only}
  • Prasad AS, Beck FWJ, Bao B, Snell D, Fitzgerald JT. Duration and severity of symptoms and levels of plasma interleukin-1 receptor antagonist, soluble tumor necrosis factor receptor, and adhesion molecules in patients with common cold treated with zinc acetate. Journal of Infectious Diseases 2008;197(15):795-802.
Smith 1989 {published data only}
  • Smith DS, Helner EC, Nutall CE, Collins M, Rofman B, Ginsberg D, et al. Failure of zinc gluconate in treatment of acute upper respiratory tract infections. Antimicrobial Agents and Chemotherapy 1989;33(5):646-8.
Turner 2000a {published data only}
Turner 2000b {published data only}
Turner 2000c {published data only}
Vakili 2009 {published data only}
  • Vakili R, Vahedian M, Khodaei GH, Mahmoudi M. Effects of zinc supplementation in occurrence and duration of common cold in school aged children during cold season: a double-blind placebo-controlled trial. Iranian Journal of Pediatrics 2009;19(4):376-80.
Weismann 1990 {published data only}
  • Weismann K, Jakobsen J, Weismann JE, Hammer UM, Nyholm SM, Hansen B, et al. Zinc gluconate lozenges for common cold. Danish Medical Journal 1990;37:279-81.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Eby 1984 {published data only}
Eby 2006 {published data only}
  • Eby GA, Halcomb WW. Ineffectiveness of zinc gluconate nasal spray and zinc orotate lozenges in common-cold treatment: a double-blind, placebo-controlled clinical trial. Alternative Therapies In Health And Medicine 2006;12(1):34-8.
Kartasurya 2012 {published data only}
  • Kartasurya MI, Ahmed F, Subagio HW, Rahfiludin MZ, Marks GC. Zinc combined with vitamin A reduces upper respiratory tract infection morbidity in a randomised trial in preschool children in Indonesia. British Journal of Nutrition 2012;108(12):2251-60.
McElroy 2003 {published data only}
  • McElroy BH, Miller SP. An open-label, single-center, phase IV clinical study of the effectiveness of zinc gluconate glycine lozenges (Cold-Eeze) in reducing the duration and symptoms of the common cold in school-aged subjects. American Journal of Therapeutics 2003;10:324-9.
Potter 1993 {published data only}
Veverka 2009 {published data only}
  • Veverka DV, Wilson C, Martinez MA, Wenger R, Tamosuinas A. Use of zinc supplements to reduce upper respiratory infections in United States Air Force Academy Cadets. Complementary Therapies in Clinical Practice 2009;15:91-5.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Caruso 2007
Chandra 1984
Couch 1984
Eby 1995
  • Eby GA. Linearity in dose-response from zinc lozenges in treatment of common colds. Journal of Pharmacy Technology 1995;11:110-12.
Eby 2004
Eby 2010
Eby 2012
  • Eby G. The mouth-nose biologically closed electric circuit in zinc lozenge therapy of common colds as explanation of rapid therapeutic action. Expert Review of Respiratory Medicine 2012;6(3):251-2.
Egger 1997
Farr 1987b
Farr 1988
  • Farr B, Hayden FG, Gwaltney JM. Letter to the Editor. Antimicrobial Agents and Chemotherapy 1988;32:607.
Fendrick 2003
  • Fendrick AM, Monto AS, Nightengale B, Sarnes M. The economic burden of non-influenza-related viral respiratory tract infection in the United States. Archives of Internal Medicine 2003;163(4):487-94.
Garibaldi 1985
Geist 1987
Gwaltney 1966
Harisch 1987
  • Harisch G, Kretschmer M. Some aspects of a non-linear effect of zinc ions on the histamine release from rat peritoneal mast cells. Research Communications in Chemical Pathology and Pharmacology 1987;55:39-48.
Hatch 1987
  • Hatch B, Berthon G. Metal ion-FTS nonapeptide interactions. A quantitative study of zinc(II)-nonapeptide complexes (thymulin) under physiological conditions and assessment of their biological significance. Inorganica Chimica Acta 1987;136:165-71.
Hemilä 2011
  • Hemilä H. Zinc lozenges may shorten the duration of colds: a systematic review. Open Respiratory Medicine Journal 2011;5:51-8.
Higgins 2003
Higgins 2011
  • Higgins J, Altman DG. Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration. Available from www.cochrane-handbook.org. Chichester: Wiley-Blackwell, 2011.
Hulisz 2004
  • Hulisz D. Efficacy of zinc against common cold viruses: an overview. Journal of the American Pharmacists Association 2004;44:594-603.
Jackson 2000
  • Jackson JL, Lesho E, Peterson C. Zinc and the common cold: a meta-analysis revisited. Journal of Nutrition 2000;130(Suppl 5):1512-5.
Kelly 1983
Kirkpatrick 1996
Korant 1976
  • Korant BD, Butterworth BE. Inhibition by zinc of rhinovirus protein cleavage: interaction of zinc with capsid polypeptides. Journal of Virology 1976;18:298-306.
Lau 1997
Lefebvre 2011
  • Lefebvre C, Manheimer E, Glanville J. Chapter 6: Searching for studies. In: Higgins JPT, Green S editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration. Available from www.cochrane-handbook.org. Copenhagen: Wiley-Blackwell, 2011.
Macknin 1999
Marshall 1998
Novick 1996
  • Novick SG, Godfrey JC, Godfrey NJ, Wilder HR. How does zinc modify the common cold? Clinical observations and implications regarding mechanisms of action. Medical Hypotheses 1996;46:295-302.
Pasternak 1987
Pfeiffer 1980
  • Pfeiffer CC, Papaioannou R, Sohler A. Effect of chronic zinc intoxication on copper levels, blood formation and polyamines. Journal of Orthomolecular Psychiatry 1980;9:79-89.
RevMan 2012
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
Rothman 1988
  • Rothman KJ. Causal inference. Epidemiology Resources, Boston: Chestnut Hill 1988.
Science 2012
  • Science M, Johnstone J, Roth DE, Guyatt G, Loeb M. Zinc for the treatment of the common cold: a systematic review and meta-analysis of randomized controlled trials. Canadian Medical Association Journal 2012;184(10):E551-61.
Simasek 2007
Turner 2001
Zarembo 1992

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Marshall 1999
Singh 2011