Intervention Review

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Phytoestrogens for menopausal vasomotor symptoms

  1. Anne Lethaby1,*,
  2. Jane Marjoribanks1,
  3. Fredi Kronenberg2,
  4. Helen Roberts1,
  5. John Eden3,
  6. Julie Brown4

Editorial Group: Cochrane Menstrual Disorders and Subfertility Group

Published Online: 10 DEC 2013

Assessed as up-to-date: 30 JUL 2013

DOI: 10.1002/14651858.CD001395.pub4


How to Cite

Lethaby A, Marjoribanks J, Kronenberg F, Roberts H, Eden J, Brown J. Phytoestrogens for menopausal vasomotor symptoms. Cochrane Database of Systematic Reviews 2013, Issue 12. Art. No.: CD001395. DOI: 10.1002/14651858.CD001395.pub4.

Author Information

  1. 1

    University of Auckland, Department of Obstetrics and Gynaecology, Auckland, New Zealand

  2. 2

    College of Physicians & Surgeons, Columbia University in the City of New York, Department of Rehabilitation Medicine, New York, USA

  3. 3

    Royal Hospital for Women, Sydney Menopause Centre & Natural Therapies Unit, Randwick, NSW, Australia

  4. 4

    University of Auckland, The Liggins Institute and Department of Obstetrics and Gynaecology, Auckland, New Zealand

*Anne Lethaby, Department of Obstetrics and Gynaecology, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand. a.lethaby@auckland.ac.nz.

Publication History

  1. Publication Status: New search for studies and content updated (conclusions changed)
  2. Published Online: 10 DEC 2013

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[Figure 1]
Figure 1. Study flow diagram.
[Figure 2]
Figure 2. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 3]
Figure 3. Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
[Figure 4]
Figure 4. Forest plot of comparison: 1 Promensil versus placebo, outcome: 1.1 Incidence of hot flushes (number/d).
[Analysis 1.1]
Analysis 1.1. Comparison 1 Promensil versus placebo, Outcome 1 Incidence of hot flushes (number/d).
[Analysis 1.2]
Analysis 1.2. Comparison 1 Promensil versus placebo, Outcome 2 Change in frequency of hot flushes (% reduction).
[Analysis 1.3]
Analysis 1.3. Comparison 1 Promensil versus placebo, Outcome 3 Improvement in hot flush severity rate.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Promensil versus placebo, Outcome 4 Change in vasomotor score from baseline to end of study/vasomotor severity—Kupperman subscale.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Promensil versus placebo, Outcome 5 Endometrial thickness (mm) after treatment.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Promensil versus placebo, Outcome 6 Adverse event rates.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Promensil versus placebo, Outcome 7 Incidence of specific adverse events.