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Selective serotonin reuptake inhibitors for premenstrual syndrome

  1. Jane Marjoribanks1,
  2. Julie Brown1,*,
  3. Patrick Michael Shaughn O'Brien2,
  4. Katrina Wyatt3

Editorial Group: Cochrane Gynaecology and Fertility Group

Published Online: 7 JUN 2013

Assessed as up-to-date: 11 FEB 2013

DOI: 10.1002/14651858.CD001396.pub3


How to Cite

Marjoribanks J, Brown J, O'Brien PMS, Wyatt K. Selective serotonin reuptake inhibitors for premenstrual syndrome. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD001396. DOI: 10.1002/14651858.CD001396.pub3.

Author Information

  1. 1

    University of Auckland, Obstetrics and Gynaecology, Auckland, New Zealand

  2. 2

    Keele University Medical School, Academic Department of Obstetrics and Gynaecology, Stoke-on-Trent, Staffordshire, UK

  3. 3

    Peninsula College of Medicine and Dentistry, Institute of Health Service Research, Exeter, UK

*Julie Brown, Obstetrics and Gynaecology, University of Auckland, Park Rd, Grafton, Auckland, 1003, New Zealand. j.brown@auckland.ac.nz.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 7 JUN 2013

SEARCH

[Figure 1]
Figure 1. Study flow diagram.
[Figure 2]
Figure 2. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 3]
Figure 3. Risk of bias summary: review authors' judgments about each risk of bias item for each included study.
[Figure 4]
Figure 4. Forest plot of comparison: 1 SSRIs versus placebo - all symptoms (end scores), outcome: 1.2 Moderate dose SSRI.
[Figure 5]
Figure 5. Forest plot of comparison: 2 SSRIs versus placebo - all symptoms (change scores), outcome: 2.2 Moderate dose SSRI.
[Figure 6]
Figure 6. Forest plot of comparison: 4 SSRIs versus placebo: withdrawal due to adverse events, outcome: 4.2 Mod dose.
[Figure 7]
Figure 7. Funnel plot of comparison: 1 SSRIs versus placebo - all symptoms (end scores), outcome: 1.2 Moderate dose SSRI.
[Analysis 1.1]
Analysis 1.1. Comparison 1 SSRIs versus placebo - all symptoms (end scores), Outcome 1 Low dose SSRI.
[Analysis 1.2]
Analysis 1.2. Comparison 1 SSRIs versus placebo - all symptoms (end scores), Outcome 2 Moderate dose SSRI.
[Analysis 1.3]
Analysis 1.3. Comparison 1 SSRIs versus placebo - all symptoms (end scores), Outcome 3 High dose SSRI.
[Analysis 2.1]
Analysis 2.1. Comparison 2 SSRIs versus placebo - all symptoms (change scores), Outcome 1 Low dose SSRI.
[Analysis 2.2]
Analysis 2.2. Comparison 2 SSRIs versus placebo - all symptoms (change scores), Outcome 2 Moderate dose SSRI.
[Analysis 3.1]
Analysis 3.1. Comparison 3 SSRIs versus placebo: withdrawal due to adverse effects, Outcome 1 Low dose.
[Analysis 3.2]
Analysis 3.2. Comparison 3 SSRIs versus placebo: withdrawal due to adverse effects, Outcome 2 Mod dose.
[Analysis 3.3]
Analysis 3.3. Comparison 3 SSRIs versus placebo: withdrawal due to adverse effects, Outcome 3 High dose.
[Analysis 4.1]
Analysis 4.1. Comparison 4 SSRIs versus placebo: adverse events, Outcome 1 Nausea.
[Analysis 4.2]
Analysis 4.2. Comparison 4 SSRIs versus placebo: adverse events, Outcome 2 Insomnia or sleep disturbance.
[Analysis 4.3]
Analysis 4.3. Comparison 4 SSRIs versus placebo: adverse events, Outcome 3 Sexual dysfunction or decreased libido.
[Analysis 4.4]
Analysis 4.4. Comparison 4 SSRIs versus placebo: adverse events, Outcome 4 Fatigue or sedation.
[Analysis 4.5]
Analysis 4.5. Comparison 4 SSRIs versus placebo: adverse events, Outcome 5 Dizziness or vertigo.
[Analysis 4.6]
Analysis 4.6. Comparison 4 SSRIs versus placebo: adverse events, Outcome 6 Tremor.
[Analysis 4.7]
Analysis 4.7. Comparison 4 SSRIs versus placebo: adverse events, Outcome 7 Somnolence/decreased concentration.
[Analysis 4.8]
Analysis 4.8. Comparison 4 SSRIs versus placebo: adverse events, Outcome 8 Sweating.
[Analysis 4.9]
Analysis 4.9. Comparison 4 SSRIs versus placebo: adverse events, Outcome 9 Dry mouth.
[Analysis 4.10]
Analysis 4.10. Comparison 4 SSRIs versus placebo: adverse events, Outcome 10 Yawning.
[Analysis 4.11]
Analysis 4.11. Comparison 4 SSRIs versus placebo: adverse events, Outcome 11 Asthenia/decreased energy.
[Analysis 4.12]
Analysis 4.12. Comparison 4 SSRIs versus placebo: adverse events, Outcome 12 Diarrhoea.
[Analysis 4.13]
Analysis 4.13. Comparison 4 SSRIs versus placebo: adverse events, Outcome 13 Constipation.
[Analysis 4.14]
Analysis 4.14. Comparison 4 SSRIs versus placebo: adverse events, Outcome 14 Gastrointestinal irritability or dyspepsia.
[Analysis 4.15]
Analysis 4.15. Comparison 4 SSRIs versus placebo: adverse events, Outcome 15 Headache.
[Analysis 4.16]
Analysis 4.16. Comparison 4 SSRIs versus placebo: adverse events, Outcome 16 Decreased appetite.
[Analysis 4.17]
Analysis 4.17. Comparison 4 SSRIs versus placebo: adverse events, Outcome 17 Increased appetite.
[Analysis 4.18]
Analysis 4.18. Comparison 4 SSRIs versus placebo: adverse events, Outcome 18 Anxiety.
[Analysis 4.19]
Analysis 4.19. Comparison 4 SSRIs versus placebo: adverse events, Outcome 19 Cardiovascular symptoms.
[Analysis 4.20]
Analysis 4.20. Comparison 4 SSRIs versus placebo: adverse events, Outcome 20 Respiratory disorder.
[Analysis 4.21]
Analysis 4.21. Comparison 4 SSRIs versus placebo: adverse events, Outcome 21 Sinusitis.
[Analysis 4.22]
Analysis 4.22. Comparison 4 SSRIs versus placebo: adverse events, Outcome 22 Infection.
[Analysis 5.1]
Analysis 5.1. Comparison 5 SSRIs versus placebo - psychological symptoms (end scores), Outcome 1 Low dose SSRI.
[Analysis 5.2]
Analysis 5.2. Comparison 5 SSRIs versus placebo - psychological symptoms (end scores), Outcome 2 Moderate dose SSRI.
[Analysis 6.1]
Analysis 6.1. Comparison 6 SSRIs versus placebo - psychological symptoms (change scores), Outcome 1 Low dose SSRI.
[Analysis 6.2]
Analysis 6.2. Comparison 6 SSRIs versus placebo - psychological symptoms (change scores), Outcome 2 Moderate dose SSRI.
[Analysis 7.1]
Analysis 7.1. Comparison 7 SSRIs versus placebo - physical symptoms (end scores), Outcome 1 Moderate dose SSRI.
[Analysis 7.2]
Analysis 7.2. Comparison 7 SSRIs versus placebo - physical symptoms (end scores), Outcome 2 High dose SSRI.
[Analysis 8.1]
Analysis 8.1. Comparison 8 SSRIs versus placebo - physical symptoms (change scores), Outcome 1 Low dose SSRI.
[Analysis 8.2]
Analysis 8.2. Comparison 8 SSRIs versus placebo - physical symptoms (change scores), Outcome 2 Moderate dose SSRI.
[Analysis 9.1]
Analysis 9.1. Comparison 9 SSRIs versus placebo - functional symptoms (end scores), Outcome 1 Low dose SSRI.
[Analysis 9.2]
Analysis 9.2. Comparison 9 SSRIs versus placebo - functional symptoms (end scores), Outcome 2 Moderate dose SSRI.
[Analysis 10.1]
Analysis 10.1. Comparison 10 SSRIs versus placebo - functional symptoms (change scores), Outcome 1 Low dose SSRI.
[Analysis 10.2]
Analysis 10.2. Comparison 10 SSRIs versus placebo - functional symptoms (change scores), Outcome 2 Moderate dose SSRI.
[Analysis 11.1]
Analysis 11.1. Comparison 11 SSRIs versus placebo - irritability (end scores), Outcome 1 Low dose SSRI.
[Analysis 11.2]
Analysis 11.2. Comparison 11 SSRIs versus placebo - irritability (end scores), Outcome 2 Moderate dose SSRI.
[Analysis 12.1]
Analysis 12.1. Comparison 12 SSRIs versus placebo - irritability (change scores), Outcome 1 Low dose SSRI.
[Analysis 12.2]
Analysis 12.2. Comparison 12 SSRIs versus placebo - irritability (change scores), Outcome 2 Moderate dose SSRI.
[Analysis 13.1]
Analysis 13.1. Comparison 13 SSRIs versus placebo: response rates, Outcome 1 Low dose SSRI.
[Analysis 13.2]
Analysis 13.2. Comparison 13 SSRIs versus placebo: response rates, Outcome 2 Moderate dose SSRI.
[Analysis 13.3]
Analysis 13.3. Comparison 13 SSRIs versus placebo: response rates, Outcome 3 High dose SSRI.
[Analysis 14.1]
Analysis 14.1. Comparison 14 SSRIs versus placebo: withdrawal for any reason, Outcome 1 Low dose.
[Analysis 14.2]
Analysis 14.2. Comparison 14 SSRIs versus placebo: withdrawal for any reason, Outcome 2 Mod dose.
[Analysis 15.1]
Analysis 15.1. Comparison 15 Luteal SSRI versus continuous SSRI, Outcome 1 All symptoms (end scores).
[Analysis 15.2]
Analysis 15.2. Comparison 15 Luteal SSRI versus continuous SSRI, Outcome 2 Response rate.
[Analysis 15.3]
Analysis 15.3. Comparison 15 Luteal SSRI versus continuous SSRI, Outcome 3 Adverse effects.
[Analysis 16.1]
Analysis 16.1. Comparison 16 Semi-intermittent versus other regimens, Outcome 1 Response rate.
[Analysis 16.2]
Analysis 16.2. Comparison 16 Semi-intermittent versus other regimens, Outcome 2 Withdrawal due to adverse effects.