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Zonisamide add-on for drug-resistant partial epilepsy

  1. Katie Carmichael1,*,
  2. Jennifer Pulman1,
  3. Shaheen Emmanuel Lakhan2,
  4. Prachi Parikh3,
  5. Anthony G Marson1

Editorial Group: Cochrane Epilepsy Group

Published Online: 19 DEC 2013

Assessed as up-to-date: 12 FEB 2013

DOI: 10.1002/14651858.CD001416.pub3


How to Cite

Carmichael K, Pulman J, Lakhan SE, Parikh P, Marson AG. Zonisamide add-on for drug-resistant partial epilepsy. Cochrane Database of Systematic Reviews 2013, Issue 12. Art. No.: CD001416. DOI: 10.1002/14651858.CD001416.pub3.

Author Information

  1. 1

    Institute of Translational Medicine, University of Liverpool, Department of Molecular and Clinical Pharmacology, Liverpool, UK

  2. 2

    Global Neuroscience Initiative Foundation, Beverly Hills, CA, USA

  3. 3

    Cleveland Clinic, Department of Neurology, Cleveland, Ohio, USA

*Katie Carmichael, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Clinical Sciences Centre for Research and Education, Lower Lane, Fazakerley, Liverpool, L9 7LJ, UK. katie_carmichael@hotmail.com.

Publication History

  1. Publication Status: New search for studies and content updated (conclusions changed)
  2. Published Online: 19 DEC 2013

SEARCH

[Figure 1]
Figure 1. Study flow diagram.
[Figure 2]
Figure 2. 'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Zonisamide versus placebo, Outcome 1 50% responder rate - whole treatment period.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Zonisamide versus placebo, Outcome 2 50% responder rate - best-case.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Zonisamide versus placebo, Outcome 3 50% responder rate - worst-case.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Zonisamide versus placebo, Outcome 4 50% responder rate - dose effect Brodie 2005.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Zonisamide versus placebo, Outcome 5 50% responder rate - dose effect Faught 2001.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Zonisamide versus placebo, Outcome 6 Withdrawal rates.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Zonisamide versus placebo, Outcome 7 Adverse effects.