Intervention Review

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Interventions for preventing blood loss during the treatment of cervical intraepithelial neoplasia

  1. Pierre PL Martin-Hirsch1,*,
  2. Andrew Bryant2

Editorial Group: Cochrane Gynaecological, Neuro-oncology and Orphan Cancer Group

Published Online: 4 DEC 2013

Assessed as up-to-date: 26 NOV 2012

DOI: 10.1002/14651858.CD001421.pub3


How to Cite

Martin-Hirsch PPL, Bryant A. Interventions for preventing blood loss during the treatment of cervical intraepithelial neoplasia. Cochrane Database of Systematic Reviews 2013, Issue 12. Art. No.: CD001421. DOI: 10.1002/14651858.CD001421.pub3.

Author Information

  1. 1

    Royal Preston Hospital, Lancashire Teaching Hospital NHS Trust, Gynaecological Oncology Unit, Preston, Lancashire, UK

  2. 2

    Newcastle University, Institute of Health & Society, Newcastle upon Tyne, UK

*Pierre PL Martin-Hirsch, Gynaecological Oncology Unit, Royal Preston Hospital, Lancashire Teaching Hospital NHS Trust, Sharoe Green Lane, Fullwood, Preston, Lancashire, PR2 9HT, UK. martin.hirsch@me.com.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 4 DEC 2013

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[Figure 1]
Figure 1. Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies.
[Figure 2]
Figure 2. Methodological quality summary: review authors' judgements about each methodological quality item for each included study.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Vasopressin versus placebo, Outcome 1 Measured blood loss (ml).
[Analysis 1.2]
Analysis 1.2. Comparison 1 Vasopressin versus placebo, Outcome 2 Subjective troublesome bleeding.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Vasopressin versus placebo, Outcome 3 Bleeding requiring haemostatic sutures, Vasopressin.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Vasopressin versus placebo, Outcome 4 Cervical stenosis.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Tranexamic acid versus control, Outcome 1 Postoperative blood loss.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Tranexamic acid versus control, Outcome 2 Primary haemorrhage.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Tranexamic acid versus control, Outcome 3 Secondary haemorrhage.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Pack versus haemostatic suture, Outcome 1 Perioperative blood loss (ml).
[Analysis 3.2]
Analysis 3.2. Comparison 3 Pack versus haemostatic suture, Outcome 2 Primary haemorrhage.
[Analysis 3.3]
Analysis 3.3. Comparison 3 Pack versus haemostatic suture, Outcome 3 Secondary haemorrhage.
[Analysis 3.4]
Analysis 3.4. Comparison 3 Pack versus haemostatic suture, Outcome 4 Amenorrhoea.
[Analysis 3.5]
Analysis 3.5. Comparison 3 Pack versus haemostatic suture, Outcome 5 Dysmenorrhoea.
[Analysis 3.6]
Analysis 3.6. Comparison 3 Pack versus haemostatic suture, Outcome 6 Transformation zone not visible at colposcopy.
[Analysis 3.7]
Analysis 3.7. Comparison 3 Pack versus haemostatic suture, Outcome 7 Cervical stenosis.
[Analysis 4.1]
Analysis 4.1. Comparison 4 Cerclage suture versus electrical coagulation, Outcome 1 Duration of procedure.
[Analysis 4.2]
Analysis 4.2. Comparison 4 Cerclage suture versus electrical coagulation, Outcome 2 Primary haemorrhage.
[Analysis 4.3]
Analysis 4.3. Comparison 4 Cerclage suture versus electrical coagulation, Outcome 3 Secondary haemorrhage.
[Analysis 4.4]
Analysis 4.4. Comparison 4 Cerclage suture versus electrical coagulation, Outcome 4 Dysmenorrhoea.
[Analysis 4.5]
Analysis 4.5. Comparison 4 Cerclage suture versus electrical coagulation, Outcome 5 Unsatisfactory colposcopy.
[Analysis 5.1]
Analysis 5.1. Comparison 5 Vaginal Amino-Cerv versus routine treatment, Outcome 1 Secondary haemorrhage.
[Analysis 5.2]
Analysis 5.2. Comparison 5 Vaginal Amino-Cerv versus routine treatment, Outcome 2 Vaginal discharge at 2 weeks.
[Analysis 5.3]
Analysis 5.3. Comparison 5 Vaginal Amino-Cerv versus routine treatment, Outcome 3 Vaginal discharge at 4 weeks.
[Analysis 6.1]
Analysis 6.1. Comparison 6 Prilocaine with felypressin versus lignocaine with adrenaline in LLETZ, Outcome 1 Duration of procedure.
[Analysis 7.1]
Analysis 7.1. Comparison 7 Ball electrode versus Monsel’s paste for haemostasis after LEEP, Outcome 1 Blood loss.