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Iron therapy for improving psychomotor development and cognitive function in children under the age of three with iron deficiency anaemia

  1. Bo Wang1,
  2. Siyan Zhan2,
  3. Ting Gong3,
  4. Liming Lee3,*

Editorial Group: Cochrane Developmental, Psychosocial and Learning Problems Group

Published Online: 6 JUN 2013

Assessed as up-to-date: 31 MAY 2013

DOI: 10.1002/14651858.CD001444.pub2


How to Cite

Wang B, Zhan S, Gong T, Lee L. Iron therapy for improving psychomotor development and cognitive function in children under the age of three with iron deficiency anaemia. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD001444. DOI: 10.1002/14651858.CD001444.pub2.

Author Information

  1. 1

    Chinese Academy of Medical Sciences, Health Science Popularization Research Center, Beijing, Beijing, China

  2. 2

    School of Public Health, Peking University, Centre for Evidence Based Medicine and Clinical Research, Department of Epidemiology and Biostatistics, Beijing, China

  3. 3

    School of Public Health, Peking University, Department of Epidemiology and Biostatistics, Beijing, Beijing, China

*Liming Lee, Department of Epidemiology and Biostatistics, School of Public Health, Peking University, 36 Xueyuan Road, Haidian District, Beijing, Beijing, 100191, China. lmlee@vip.163.com.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 6 JUN 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Aukett 1986 {published data only}
Driva 1985 {published data only}
  • Driva A, Kafatos A, Solman M. Iron deficiency and the cognitive and psychomotor development of children: a pilot study with institutionalised children. Early Child Development and Care 1985;22(1):73-82.
Honig 1978 {published data only}
  • Honig AS, Oski FA. Developmental scores of iron deficient infants and the effects of therapy. Infant Behavior and Development 1978;1:168-76.
  • Oski FA, Honig AS. The effects of therapy on the developmental scores of iron-deficient infants. Journal of Pediatrics 1978;92(1):21-5.
Idjradinata 1993 {published data only}
Kimmons [pers comm] {unpublished data only}
  • Kimmons G, Moffatt MEK, Lonstaffe S, Whalen-Besant J (University of Manitoba, Winnipeg, Canada). Short term effects of intramuscular iron on the behaviour of iron-deficient children: a clinical trial [personal communication]. Letter to: Susana Martins (Federal University of São Paulo, São Paulo, Brazil) 30 November 2000.
Lozoff 1982 {published data only}
  • Lozoff B, Brittenham GM, Viteri FE, Abraham WW, Urrutia JJ. The effects of short-term oral iron therapy on developmental deficits in iron-deficient anemic infants. Journal of Pediatrics 1982;100(3):351-7.
Lozoff 1987 {published data only}
  • Lozoff B, Brittenham GM, Wolf AW, McClish DK, Kuhnert PM, Jimenez R, et al. Iron deficiency anemia and iron therapy effects on infant developmental test performance. Pediatrics 1987;79(6):981-95.
Walter 1989 {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Deinard 1986 {published data only}
Linos 1990 {published data only}
  • Gonzalez de Aledo Linos A, Rollán Rollán A, Bonilla Miera C. Prospective study of the prevalence of iron deficiency in breast fed infants in Cantabria, its relation to the introduction of cows milk and psychomotor development [Estudio prospectivo sobre la prevalencia de ferropenia en lactantes de Cantabria, su relacion con la introduccion de la leche de vaca el desarrollo psicomotor]. Anales Españoles de Pediatría 1990;32(1):24-7.
Lozoff 1996 {published data only}
Lozoff 2003 {published data only}
  • Lozoff B, De Andraca I, Castillo M, Smith JB, Walter T, Pino P. Behavioral and developmental effects of preventing iron-deficiency anemia in healthy full-term infants. Pediatrics 2003;112(4):846-54.
Moffatt 1994 {published data only}
  • Moffatt MEK, Longstaffe S, Besant J, Dureski C. Prevention of iron deficiency and psychomotor decline in high risk infants through use of iron fortified infant formula: a randomised clinical trial. Journal of Pediatrics 1994;125(4):527–34.
Oski 1983 {published data only}
Stoltzfus 2001 {published data only}
  • Stoltzfus RJ, Kvalsvig JD, Chwaya HM, Montresor A, Albonico M, Tielsch JM, et al. Effects of iron supplementation and anthelmintic treatment on motor and language development of preschool children in Zanzibar: double blind, placebo controlled study. BMJ 2001;323(7326):1389-93.
Walter 1983 {published data only}

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
AHRQ 2006
  • Agency for Healthcare Research and Quality. Screening for iron deficiency anemia in childhood and pregnancy. Publication No. AHRQ 06-0590.
Bayley 1993
  • Bayley N. Bayley Scales of Infant Development. 2nd Edition. San Antonio: The Psychological Corporation, 1993.
Dallman 1975
De Maeyer 1985
  • De Maeyer E, Adiels-Tegman M. The prevalence of anaemia in the world. World Health Statistics Quarterly 1985;38(3):302-16.
Felt 1996
  • Felt BT, Lozoff B. Brain iron and behaviour of rats are not normalised by treatment of iron deficiency anaemia during early development. Journal of Nutrition 1996;126(3):693-701.
Follmann 1992
Goddard 2011
Higgins 2003
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Lansdown 1995
  • Lansdown R, Wharton BA. Iron and mental and motor behaviour in children. Iron, Nutrition and Physiological Significance: Report of the British Nutrition Foundation Task Force. London: Chapman and Hall, 1995:65-78.
Larkin 1990
  • Larkin EC, Rao GA. Importance of fetal and neonatal iron: adequacy for normal development of the central nervous system. In: Dobbing J editor(s). Brain, Behaviour and Iron in the Infant Diet. London: Springer-Verlag, 1990:43-62.
Lee 1993
  • Lee GR. Wintrobe's Clinical Hematology. 9th Edition. Vol. 1, Philadelphia, PA: Lea & Febiger, 1993.
Logan 1997
  • Logan S. Commentary on Booth IW, Aukett MA: Iron deficiency anaemia in infancy and early childhood. Archives of Disease in Childhood 1997;76:549-54 [commentary pp 553-4].
Lozoff 1986
  • Lozoff B, Brittenham GM. Behavioural aspects of iron deficiency. Progress in Haematology 1986;XIV:23-53.
Martin 2001
  • Martin S, Logan S, Gilbert R. Iron therapy for improving psychomotor development and cognitive function in children under the age of three with iron deficiency anaemia. Cochrane Database of Systematic Reviews 2001, Issue 2. [DOI: 10.1002/14651858.CD001444]
RevMan 2011 [Computer program]
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2011.
Roncagliolo 1998
  • Roncagliolo M, Garrido M, Walter T, Peirano P, Lozoff B. Evidence of altered central nervous system development in infants with iron deficiency anaemia at 6 months: delayed maturation of auditory brainstem responses. The American Journal of Clinical Nutrition 1998;68(3):683-90.
Sachdev 2004
  • Sachdev HPS, Gera T, Nestel P. Effect of iron supplementation on mental and motor development in children: systematic review of randomised controlled trials. Public Health Nutrition 2004;8(2):117-32.
Szajewska 2010
  • Szajewska H, Ruszczynski M, Chmielewska A. Effects of iron supplementation in nonanemic pregnant women, infants, and young children on the mental performance and psychomotor development of children: a systematic review of randomized controlled trials. The American Journal of Clinical Nutrition 2010;91(6):1684-90.
Walter 1994
  • Walter T. Effect of iron-deficiency anaemia on cognitive skills in infancy and childhood. Bailliere's Clinical Haematology 1994;7(4):815-27.