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Iron-chelating agents for treating malaria

  1. Helen J Smith1,*,
  2. Martin M Meremikwu2

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 20 JAN 2010

Assessed as up-to-date: 16 FEB 2003

DOI: 10.1002/14651858.CD001474

Database Title

Additional Information

How to Cite

Smith HJ, Meremikwu MM. Iron-chelating agents for treating malaria. Cochrane Database of Systematic Reviews 2003, Issue 2. Art. No.: CD001474. DOI: 10.1002/14651858.CD001474.

Author Information

  1. 1

    Liverpool School of Tropical Medicine, International Health Group, Liverpool, Merseyside, UK

  2. 2

    University of Calabar Teaching Hospital, Department of Paediatrics, Calabar, Cross River State, Nigeria

*Helen J Smith, International Health Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, Merseyside, L3 5QA, UK. cjdhel@liv.ac.uk.

Publication History

  1. Publication Status: Stable (no update expected for reasons given in 'What's new')
  2. Published Online: 20 JAN 2010

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Gordeuk 1992a {published data only}
  • Gordeuk VR, Thuma PE, Brittenham GM, Zulu S, Simwanza G, Mhangu A, et al. Iron chelation with desferrioxamine B in adults with asymptomatic Plasmodium falciparum parasitaemia. Blood 1992;79(2):308-12.
Gordeuk 1992b {published data only}
  • Gordeuk VR, Thuma PE, Brittenham G, McLaren C, Parry D, Backenstose A, et al. Effect of iron chelation therapy on recovery from deep coma in children with cerebral malaria. New England Journal of Medicine 1992;327(21):1473-7.
  • Hershko C, Gordeuk VR, Thuma PE, Theanacho EN, Spira DT, Hider RC, et al. The antimalarial effect of iron chelators: studies in animal models and in humans with mild falciparum malaria. Journal of Inorganic Biochemistry 1992;47(3-4):267-77.
Gordeuk 1993 {published data only}
  • Gordeuk VR, Thuma PE, Brittenham GM, Biemba G, Zulu S, Simwanza G, et al. Iron chelation as a chemotherapeutic strategy for falciparum malaria. American Journal of Tropical Medicine and Hygiene 1993;48(2):193-7.
Mohanty 2002 {published data only}
  • Mohanty D, Ghosh K, Pathare AV, Karnad D. Deferiprone (L1) as an adjuvant therapy for Plasmodium falciparum malaria. Indian Journal of Medical Research 2002;115:17-21.
Thuma 1998a {published data only}
  • Thuma PE, Mabeza GF, Biemba G, Bhat GJ, McLaren CE, Moyo VM, et al. Effect of iron chelation therapy on mortality in Zambian children with cerebral malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 1998;92(2):214-8.
Thuma 1998b-i {published data only}
  • Thuma PE, Olivieri NF, Mabeza GF, Biemba G, Parry D, Zulu S, et al. Assessment of the effect of the oral iron chelator deferiprone on asymptomatic Plasmodium falciparum parasitemia in humans. American Journal of Tropical Medicine and Hygiene 1998;58(3):358-64.
Thuma 1998b-ii {published data only}
  • Thuma PE, Olivieri NF, Mabeza GF, Biemba G, Parry D, Zulu S, et al. Assessment of the effect of the oral iron chelator deferiprone on asymptomatic Plasmodium falciparum parasitemia in humans. American Journal of Tropical Medicine and Hygiene 1998;58(3):358-64.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Bunnag 1992 {published data only}
  • Bunnang D, Poltera AA, Viraan C, Looareesuwan S, Harinasuta KT, Schindlery C, et al. Plasmodicidal effect of desferrioxamine B in human vivax or falciparum malaria from Thailand. Acta Tropica 1992;52(1):59-67.
Gordeuk 1990 {published data only}
  • Gordeuk VR, Thuma PE, Brittenham GM, Backenstose AR, Vargas L, McKinley E, et al. Reduced duration of coma in children receiving adjunctive desferrioxamine for cerebral malaria (Abstract). Clinical Research 1990;38(3):866.
Looareesuwan 1996 {published data only}
  • Looareesuwan S, Wilairatana P, Vannaphan S, Gordeuk VR, Taylor TE, Meshnick SR, et al. Co-administration of desferrioxamine B with artesunate in malaria: an assessment of safety and tolerance. Annals of Tropical Medicine and Parasitology 1996;90(5):551-4.
Traore 1991 {published data only}
  • Traore O, Carnevale P, Kaptue-Noche L, M'Bede J, Desfontaine M, Elion J, et al. Preliminary report on the use of desferrioxamine in the treatment of Plasmodium falciparum malaria. American Journal of Hematology 1991;37(3):206-8.
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Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Berdoukas 1993
Hershko 1994
Hider 1994
  • Hider RC, Epemolu O, Singh S, Porter JB. Iron chelator design. Advances in Experimental Medicine and Biology 1994;356:343-9.
Higgins 2006
  • Higgins J, Green S, editors. Highly sensitive search strategies for identifying reports of randomized controlled trials in MEDLINE. Cochrane Handbook for Systematic Reviews of Interventions 4.2.6 [updated September 2006]; Appendix 5b. www.cochrane.org/resources/handbook/hbook.htm (accessed 1 May 2007).
Jüni 2001
Lytton 1994
  • Lytton SD, Mester B, Libman J, Shanzer A, Cabantchik ZI. Mode of action of iron (III) chelators as antimalarials: Evidence for differential effects on parasite iron-dependent nulceic acid synthesis. Blood 1994;84(3):910-5.
Mabeza 1996
Meshnick 1993
  • Meshnick SR, Yang YZ, Lima V, Kuypers F, Kamchonwongpaisan S, Yuthavong Y. Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu). Antimicrobial Agents and Chemotherapy 1993;37(5):1108-14.
Murray 1975
Murray 1978
Olivieri 1996
  • Olivieri NF, Buncic JR, Chew E, Gallant T, Harrison RV, Keenan N, et al. Visual and auditory neurotoxicity in patients receiving subcutaneous deferoxamine infusions. New England Journal of Medicine 1996;314(14):869-73.
Oppenheimer 1984
Raventos 1982
  • Raventos-Suarez C, Pollack S, Nagel RL. Plasmodium falciparum: inhibition of in vitro growth by desferrioxamine. American Journal of Tropical Medicine and Hygiene 1982;31(5):919-22.
Review Manager 5
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.0. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2008.
Schulz 1995
  • Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias: Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 1995;273(5):408-12.
WHO 2000
  • Severe falciparum malaria. World Health Organization, Communicable Diseases Cluster. Transactions of the Royal Society of Tropical Medicine and Hygiene 2000;94(Suppl 1):1-90.
Wyler 1992

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Smith 2000
  • Smith HJ, Meremikwu M. Iron chelating agents for treating malaria. Cochrane Database of Systematic Reviews 2000, Issue 2. [DOI: ]
Smith 2003
  • Smith HJ, Meremikwu M. Iron chelating agents for treating malaria. Cochrane Database of Systematic Reviews 2003, Issue 2. [DOI: ]
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