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Vitamin A for treating measles in children

  1. Hui Ming Yang*,
  2. Meng Mao,
  3. Chaomin Wan

Editorial Group: Cochrane Acute Respiratory Infections Group

Published Online: 8 JUL 2009

Assessed as up-to-date: 28 FEB 2011

DOI: 10.1002/14651858.CD001479.pub3

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How to Cite

Yang HM, Mao M, Wan C. Vitamin A for treating measles in children. Cochrane Database of Systematic Reviews 2005, Issue 4. Art. No.: CD001479. DOI: 10.1002/14651858.CD001479.pub3.

Author Information

  1. West China Second University Hospital, West China Women's and Children's Hospital, Department of Pediatrics, Chengdu, Sichuan, China

*Hui Ming Yang, Department of Pediatrics, West China Second University Hospital, West China Women's and Children's Hospital, No. 17, Section Three, Ren Min Nan Lu Avenue, Chengdu, Sichuan, 610041, China. yanghuiming03@163.com. yang_huiming@hotmail.com.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 8 JUL 2009

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Barclay 1987 {published data only}
  • Barclay AJG, Foster A, Sommer A. Vitamin A supplements and mortality related to measles: a randomised clinical trial. British Medical Journal 1987;282:294-6. [MEDLINE: 1987129562]
Coutsoudis 1991 {published data only}
  • Coutsoudis A, Broughton M, Coovadia HM. Vitamin A supplementation reduces measles morbidity in young African children: a randomized, placebo controlled, double blind trial. American Journal of Clinical Nutrition 1991;54:890-5. [MEDLINE: 1992058799]
  • Coutsoudis A, Coovadia HM, Broughton M, Salisbury RT, Elson I. Micronutrient utilisation during measles treated with vitamin A or placebo. International Journal for Vitamin and Nutrition Research 1991;61:199-204.
  • Coutsoudis A, Kiepiela P, Coovadia HM, Broughton M. Vitamin A supplementation enhances specific IgG antibody levels and total lymphocyte numbers while improving morbidity in measles. Pediatic Infectious Disease Journal 1992;11:203-9.
Dollimore 1997 {published data only}
  • Dolllimore N, Cutts F, Newton Binka F, Ross DA, Sutkover Morris S. Measles incidence, case fatality, and delayed mortality in children with or without vitamin A supplementation in rural Ghana. American Journal of Epidemiology 1997;146(8):646-54.
Ellison 1932 {published data only}
  • Ellison JB. Intensive vitamin therapy in measles. British Medical Journal 1932;ii:708-11.
Hussey 1990 {published and unpublished data}
Kawasaki 1999 {published data only}
  • Kawasaki Y, Hosoya M, Katayose M, Suzuki H. The efficacy of oral vitamin A supplementation for measles and respiratory syncytial virus (RSV) infection. Kansenshogaku Zasshi 1999;73(2):104-9. [MEDLINE: 99230601]
Ogaro 1993 {published data only}
Rosales 1996 {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Chowdhury 2002 {published data only}
  • Chowdhury S, Kumar R, Ganguly NK, Kumar L, Walia BNS. Effect of Vitamin A supplementation on childhood morbidity and mortality. Indian Journal of Medical Sciences 2002;56(6):259-62.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Aaby 1984
Anonymous 1987
Beaton 1993
  • Beaton GH, Martorell R, Aronson KJ, Edmoinston B, McCabe G, Ross AC, et al. Effectiveness of vitamin A supplementation in the control of young child morbidity and mortality in developing countries. ACC/SCN State-of-the-art Series 1993; Vol. Nutrition Policy Discussion Paper no 13.
Bhaskaram 1975
Bloem 1990
  • Bloem MW, Wedel M, Egger RJ, Speek AJ, Schrijver J, Saowakontha S, et al. Mild vitamin A deficiency and risk of respiratory tract diseases and diarrhea in preschool and school children in northeastern Thailand. American Journal of Epidemiology 1990;131(2):332-9.
Butler 1993
  • Butler JC, Havens PL, Sowell AL, Huff DL, Peterson DE, Day SE, et al. Measles severity and serum retinol (vitamin A) concentration among children in the United States. Pediatrics 1993;91:1176-81. [MEDLINE: 1993275705]
Cervinskas 1996
  • Cervinskas J, Lotfi M. Vitamin A deficiency: key resources in its prevention and elimination. The Micronutrient Initiative Information Paper 1996; Vol. Second edition.
Chan 1990
Cochrane 1999
  • Cochrane Acute Respiratory Infections Group. Search strategy for specialised register. The Cochrane Library 1999, issue 4.
D'Souza 1999
  • D'Souza RM, D'Souza R, Fawzi W. Vitamin A for measles in children. Cochrane Database of Systematic Reviews 1999, Issue 4. [DOI: ]
Daulaire 1992
Egger 1997
Fawzi 1993
Frieden 1992
Glasziou 1993
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org .
Hussey 1997
Inua 1983
  • Inua M, Duggan MB, West CE, Whittle HC, Kogbe OI, Sandford-Smith JH, et al. Post-measles corneal ulceration in children in northern Nigeria: the role of vitamin A, malnutrition and measles. Annals of Tropical Paediatrics 1983;3(4):181-91. [MEDLINE: 1984152596]
Lefebvre 2011
  • Lefebvre C, Manheimer E, Glanville J. Chapter 6: Searching for studies. In: Higgins JPT, Green S editor(s). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 (updated March 2011). The Cochrane Collaboration. Available from www.cochrane-handbook.org. Chichester, UK: Wiley-Blackwell, 2011.
Markowitz 1989
  • Markowitz LE, Nzilambi N, Driskell WJ, Sension MG, Rovira EZ, Nieburg P, et al. Vitamin A levels and mortality among hospitalized measles patients, Kinshasa, Zaire. Journal of Tropical Pediatrics 1989;35(3):109-12.
Milton 1987
MMWR 1998
  • CDC. Advances in Global Measles Control and Elimination: Summary of the 1997 International Meeting. MMWR 1998;47(RR-11):2.
Morley 1969a
Muhilal 1988
  • Muhilal, Permeisih D, Idjradinata YR, Muherdiyantiningsih BS, Karyadi D. Vitamin A-fortified monosodium glutamate and health, growth, and survival of children: a controlled field trial. American Journal of Clinical Nutrition 1988;48(5):1271-6. [MEDLINE: 1989047246]
Pediatrics 1993
  • American Academy of Pediatrics. Vitamin A treatment of measles. Pediatrics 1993;91(5):1014-5.
Rahmathullah 1990
  • Rahmathullah L, Underwood BA, Thulasiraj RD, Milton RC, Ramaswamy K, Rahmathullah R. Reduced mortality among children in South India receiving a small weekly dose of vitamin A. New England Journal of Medicine 1990;323(14):929-35.
Rahmathullah 1991
  • Rahmathullah L, Underwood BA, Thulasiraj RD, Milton RC. Diarrhea, respiratory infections, and growth are not affected by a weekly low-dose vitamin A supplement: a masked, controlled field trial in children in southern India. American Journal of Clinical Nutrition 1991;54:568-77.
Reddy 1986
  • Reddy V, Bhaskaram P, Raghuramulu N, Milton RC, Rao V, Madhusudan J, et al. Relationship between measles, malnutrition, and blindness: a prospective study in Indian children. American Journal of Clinical Nutrition 1986;44(6):924-30.
RevMan 2011
Sheldon 2000
Sommer 1983
Sommer 1984
  • Sommer A, Katz J, Tarwotjo I. Increased risk of respiratory disease and diarrhea in children with preexisting mild vitamin A deficiency. American Journal of Clinical Nutrition 1984;40(5):1090-5.
Sommer 1986
  • Sommer A, Tarwotjo I, Djunaedi E, West KP Jr, Loeden AA, Tilden R, et al. Impact of vitamin A supplementation on childhood mortality. A randomised controlled community trial. Lancet 1986;1(8491):1169-73.
Sommer 1996
  • Sommer A, West K. Vitamin A deficiency: health, survival and vision. New York: Oxford University Press, 1996.
Sommer 1997
Tielsch 1984
VAST Study 1993
Vijayaraghavan 1990
West 1991
Whittle 1979
  • Whittle HC, Smith JS, Kogbe OI, Dossetor J, Duggan M. Severe ulcerative herpes of mouth and eye following measles. Transactions of the Royal Society of Tropical Medicine and Hygiene 1979;73(1):66-9.
WHO 1987
  • World Health Organization. Expanded programme on immunization: programme for the prevention of blindness. WHO Weekly Epidemiology Record 1987;62:133-4.
WHO 1988
  • World Health Organization. Joint WHO/UNICEF statement on vitamin A for measles. International Nursing Review 1988;35:21. [MEDLINE: 1988138612]
WHO 1993
  • World Health Organization. EPI Program Report. Geneva 1993.
WHO 1997
  • World Health Organization. A guide to the treatment and prevention of vitamin A deficiency and xerophthalmia. Second Edition. Geneva: WHO, 1997. [: ISBN 92 4 154506 2]
    Direct Link:
WHO 1998
  • World Health Organization. Using national immunization days to deliver vitamin A. EPI Update 1993; Vol. 33, issue 3.
Wolbach 1925
  • Wolbach SB, Howe PR. Tissue changes following deprivation of fat-soluble A vitamin. Journal of Experimental Medicine 1925;42:753-77.
World Bank 1993
  • World Bank. World Development Report 1993: Investing in Health. New York: Oxford University Press, 1993.

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
D'Souza 2001
  • D'Souza RM, D'Souza R. Vitamin A for treating measles in children. Cochrane Database of Systematic Reviews 2001, Issue 2. [DOI: ]
Harbord 2006
  • Harbord RM, Egger M, Sterne JA. A modified test for small study effects in meta-analyses of controlled trials with binary endpoints. Statistics in Medicine 2006;25(20):3443-57.
    Direct Link:
Huiming 2005
Huiming 2007
  • Huiming Y, Chaomin W, Meng M. Vitamin A for treating measles in children. Cochrane Database of Systematic Reviews 2007, Issue 4. [DOI: ]
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