1 Amenorrhoea rate | 3 | | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only |

1.1 At 6 months follow up | 2 | 179 | Risk Ratio (M-H, Fixed, 95% CI) | 4.39 [2.00, 9.66] |

1.2 At 12 months follow up | 3 | 231 | Risk Ratio (M-H, Fixed, 95% CI) | 3.78 [2.07, 6.91] |

1.3 At 2 to 5 years follow up | 1 | 120 | Risk Ratio (M-H, Fixed, 95% CI) | 1.56 [0.93, 2.64] |

2 PBAC score after treatment | | | Other data | No numeric data |

2.1 At 12 months follow up | | | Other data | No numeric data |

3 Satisfaction rate | 3 | | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only |

3.1 At 6 months follow up | 2 | 181 | Risk Ratio (M-H, Fixed, 95% CI) | 1.08 [0.94, 1.24] |

3.2 At 12 months follow up | 3 | 230 | Risk Ratio (M-H, Fixed, 95% CI) | 1.10 [0.99, 1.22] |

4 Duration of operation | | | Other data | No numeric data |

5 Operative difficulties | 1 | | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only |

5.1 Technical complication rate | 1 | 55 | Risk Ratio (M-H, Fixed, 95% CI) | 0.73 [0.13, 3.99] |

6 Completion of procedure | 1 | 81 | Risk Ratio (M-H, Fixed, 95% CI) | 1.05 [0.97, 1.15] |

7 SF12 physical score | 1 | 55 | Mean Difference (IV, Fixed, 95% CI) | 1.60 [-4.27, 7.47] |

7.1 At 12 months follow up | 1 | 55 | Mean Difference (IV, Fixed, 95% CI) | 1.60 [-4.27, 7.47] |

8 SF12 mental score | 1 | 55 | Mean Difference (IV, Fixed, 95% CI) | 7.5 [-0.52, 15.52] |

8.1 At 12 months follow up | 1 | 55 | Mean Difference (IV, Fixed, 95% CI) | 7.5 [-0.52, 15.52] |

9 SF-36 Physical function score | 1 | | Mean Difference (IV, Fixed, 95% CI) | Subtotals only |

9.1 At 6 months follow up | 1 | 90 | Mean Difference (IV, Fixed, 95% CI) | 2.0 [-6.55, 10.55] |

9.2 At 12 months follow up | 1 | 78 | Mean Difference (IV, Fixed, 95% CI) | 3.0 [-6.44, 12.44] |

9.3 At 2 to 5 years follow up | 1 | 98 | Mean Difference (IV, Fixed, 95% CI) | 2.0 [-8.26, 12.26] |

10 SF-36 Role physical | 1 | | Mean Difference (IV, Fixed, 95% CI) | Subtotals only |

10.1 At 6 months follow up | 1 | 90 | Mean Difference (IV, Fixed, 95% CI) | 5.0 [-7.67, 17.67] |

10.2 At 12 months follow up | 1 | 78 | Mean Difference (IV, Fixed, 95% CI) | 5.0 [-6.96, 16.96] |

10.3 At 2 to 5 years follow up | 1 | 98 | Mean Difference (IV, Fixed, 95% CI) | 8.0 [-2.66, 18.66] |

11 SF-36 Role emotional | 1 | | Mean Difference (IV, Fixed, 95% CI) | Subtotals only |

11.1 At 6 months follow up | 1 | 90 | Mean Difference (IV, Fixed, 95% CI) | -6.0 [-18.64, 6.64] |

11.2 At 12 months follow up | 1 | 78 | Mean Difference (IV, Fixed, 95% CI) | 4.0 [-1.92, 9.92] |

11.3 At 2 to 5 years follow up | 1 | 98 | Mean Difference (IV, Fixed, 95% CI) | -9.0 [-14.45, -3.55] |

12 SF-36 Social functioning | 1 | | Mean Difference (IV, Fixed, 95% CI) | Subtotals only |

12.1 At 6 months follow up | 1 | 90 | Mean Difference (IV, Fixed, 95% CI) | -1.0 [-9.98, 7.98] |

12.2 At 12 months follow up | 1 | 78 | Mean Difference (IV, Fixed, 95% CI) | 3.0 [-6.17, 12.17] |

12.3 At 2 to 5 years follow up | 1 | 98 | Mean Difference (IV, Fixed, 95% CI) | 4.0 [-5.60, 13.60] |

13 SF-36 Mental health | 1 | | Mean Difference (IV, Fixed, 95% CI) | Subtotals only |

13.1 At 6 months follow up | 1 | 90 | Mean Difference (IV, Fixed, 95% CI) | -3.0 [-10.84, 4.84] |

13.2 At 12 months follow up | 1 | 78 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [-8.03, 8.03] |

13.3 At 2 to 5 years follow up | 1 | 98 | Mean Difference (IV, Fixed, 95% CI) | -5.0 [-11.39, 1.39] |

14 SF-36 Energy/vitality | 1 | | Mean Difference (IV, Fixed, 95% CI) | Subtotals only |

14.1 At 6 months follow up | 1 | 90 | Mean Difference (IV, Fixed, 95% CI) | -6.0 [-13.54, 1.54] |

14.2 At 12 months follow up | 1 | 78 | Mean Difference (IV, Fixed, 95% CI) | 9.0 [-0.44, 18.44] |

14.3 At 2 to 5 years follow up | 1 | 98 | Mean Difference (IV, Fixed, 95% CI) | -3.0 [-10.39, 4.39] |

15 SF-36 Pain | 1 | | Mean Difference (IV, Fixed, 95% CI) | Subtotals only |

15.1 At 6 months follow up | 1 | 90 | Mean Difference (IV, Fixed, 95% CI) | 2.0 [-6.00, 12.00] |

15.2 At 12 months follow up | 1 | 78 | Mean Difference (IV, Fixed, 95% CI) | -1.0 [-12.61, 10.61] |

15.3 At 2 to 5 years follow up | 1 | 98 | Mean Difference (IV, Fixed, 95% CI) | -5.0 [-14.79, 4.79] |

16 SF-36 General health | 1 | | Mean Difference (IV, Fixed, 95% CI) | Subtotals only |

16.1 At 6 months follow up | 1 | 90 | Mean Difference (IV, Fixed, 95% CI) | -5.0 [-13.30, 3.30] |

16.2 At 12 months follow up | 1 | 78 | Mean Difference (IV, Fixed, 95% CI) | 6.0 [-4.10, 16.10] |

16.3 At 2 to 5 years follow up | 1 | 98 | Mean Difference (IV, Fixed, 95% CI) | 6.0 [-5.72, 17.72] |

17 RSCL Physical symptoms | 1 | | Mean Difference (IV, Fixed, 95% CI) | Subtotals only |

17.1 At 6 months follow up | 1 | 90 | Mean Difference (IV, Fixed, 95% CI) | 1.0 [-3.94, 5.94] |

17.2 At 12 months follow up | 1 | 78 | Mean Difference (IV, Fixed, 95% CI) | -4.0 [-8.56, 0.56] |

18 RSCL Psychological distress | 1 | | Mean Difference (IV, Fixed, 95% CI) | Subtotals only |

18.1 At 6 months follow up | 1 | 90 | Mean Difference (IV, Fixed, 95% CI) | -1.0 [-10.14, 8.14] |

18.2 At 12 months follow up | 1 | 78 | Mean Difference (IV, Fixed, 95% CI) | -1.0 [-7.92, 5.92] |

19 RSCL Activity level | 1 | | Mean Difference (IV, Fixed, 95% CI) | Subtotals only |

19.1 At 6 months follow up | 1 | 90 | Mean Difference (IV, Fixed, 95% CI) | -1.0 [-3.35, 1.35] |

19.2 At 12 months follow up | 1 | 78 | Mean Difference (IV, Fixed, 95% CI) | -2.0 [-4.32, 0.32] |

20 RSCL Overall quality of life | 1 | | Mean Difference (IV, Fixed, 95% CI) | Subtotals only |

20.1 At 6 months follow up | 1 | 90 | Mean Difference (IV, Fixed, 95% CI) | -2.0 [-12.29, 8.29] |

20.2 At 12 months follow up | 1 | 78 | Mean Difference (IV, Fixed, 95% CI) | -9.0 [-18.77, 0.77] |

21 SDS Depression | 1 | | Mean Difference (IV, Fixed, 95% CI) | Subtotals only |

21.1 At 6 months follow up | 1 | 90 | Mean Difference (IV, Fixed, 95% CI) | 2.0 [-1.55, 5.55] |

21.2 At 12 months follow up | 1 | 78 | Mean Difference (IV, Fixed, 95% CI) | -1.0 [-5.24, 3.24] |

22 Multi-attribute utility tool | 1 | 51 | Mean Difference (IV, Fixed, 95% CI) | 8.80 [-6.08, 23.68] |

22.1 At 12 months follow up | 1 | 51 | Mean Difference (IV, Fixed, 95% CI) | 8.80 [-6.08, 23.68] |

23 Menorrhagia Outcome Questionnaire | 1 | 51 | Mean Difference (IV, Fixed, 95% CI) | -0.60 [-3.87, 2.67] |

23.1 At 12 months follow up | 1 | 51 | Mean Difference (IV, Fixed, 95% CI) | -0.60 [-3.87, 2.67] |

24 EQ 5-D utility | 1 | 49 | Mean Difference (IV, Fixed, 95% CI) | 0.03 [-0.16, 0.22] |

24.1 At 12 months follow up | 1 | 49 | Mean Difference (IV, Fixed, 95% CI) | 0.03 [-0.16, 0.22] |

25 Eq 5-D health thermometer | 1 | 43 | Mean Difference (IV, Fixed, 95% CI) | 4.8 [-10.07, 19.67] |

25.1 At 12 months follow up | 1 | 43 | Mean Difference (IV, Fixed, 95% CI) | 4.8 [-10.07, 19.67] |

26 Dysmenorrhoea rate | 1 | | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only |

26.1 At 6 months follow up | 1 | 126 | Risk Ratio (M-H, Fixed, 95% CI) | 0.69 [0.26, 1.86] |

26.2 At 12 months follow up | 1 | 126 | Risk Ratio (M-H, Fixed, 95% CI) | 0.52 [0.18, 1.51] |

26.3 At 2 to 5 years follow up | 1 | 97 | Risk Ratio (M-H, Fixed, 95% CI) | 0.61 [0.26, 1.44] |

27 Dysmenorrhoea rate (VAS score) | | | Other data | No numeric data |

27.1 At 12 months follow up | | | Other data | No numeric data |

28 Improvement in dysmenorrhoea | 1 | 44 | Risk Ratio (M-H, Fixed, 95% CI) | 1.37 [0.89, 2.10] |

28.1 At 12 months follow up | 1 | 44 | Risk Ratio (M-H, Fixed, 95% CI) | 1.37 [0.89, 2.10] |

29 PMS rate (VAS score) | | | Other data | No numeric data |

29.1 At 12 months follow up | | | Other data | No numeric data |

30 Improvement in PMS (emotional) | 1 | 36 | Risk Ratio (M-H, Fixed, 95% CI) | 0.8 [0.45, 1.43] |

30.1 At 12 months follow up | 1 | 36 | Risk Ratio (M-H, Fixed, 95% CI) | 0.8 [0.45, 1.43] |

31 Improvement in PMS (physical) | 1 | 36 | Risk Ratio (M-H, Fixed, 95% CI) | 1.3 [0.72, 2.34] |

31.1 At 12 months follow up | 1 | 36 | Risk Ratio (M-H, Fixed, 95% CI) | 1.3 [0.72, 2.34] |

32 Time taken off work (days) | | | Other data | No numeric data |

33 Time to resume normal activities (days) | | | Other data | No numeric data |

34 Postoperative complication rate | 1 | | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only |

34.1 Infection (endometritis) | 1 | 73 | Risk Ratio (M-H, Fixed, 95% CI) | 0.30 [0.06, 1.42] |

35 Requirement for further surgery (ablation or hyst) | 3 | | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only |

35.1 At 6 months follow up | 1 | 53 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |

35.2 At 12 months follow up | 2 | 135 | Risk Ratio (M-H, Fixed, 95% CI) | 1.36 [0.34, 5.42] |

35.3 At 2 to 5 years follow up | 1 | 120 | Risk Ratio (M-H, Fixed, 95% CI) | 0.72 [0.28, 1.89] |

36 Requirement for further surgery (hyst only) | 2 | | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only |

36.1 At 12 months follow up | 2 | 207 | Risk Ratio (M-H, Fixed, 95% CI) | 0.59 [0.18, 1.93] |

36.2 At 2 to 5 years follow up | 1 | 120 | Risk Ratio (M-H, Fixed, 95% CI) | 0.77 [0.27, 2.20] |