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Single dose oral ibuprofen for acute postoperative pain in adults

  1. Christopher J Derry,
  2. Sheena Derry*,
  3. R Andrew Moore,
  4. Henry J McQuay

Editorial Group: Cochrane Pain, Palliative and Supportive Care Group

Published Online: 8 JUL 2009

Assessed as up-to-date: 11 MAY 2009

DOI: 10.1002/14651858.CD001548.pub2


How to Cite

Derry CJ, Derry S, Moore RA, McQuay HJ. Single dose oral ibuprofen for acute postoperative pain in adults. Cochrane Database of Systematic Reviews 2009, Issue 3. Art. No.: CD001548. DOI: 10.1002/14651858.CD001548.pub2.

Author Information

  1. University of Oxford, Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), Oxford, Oxfordshire, UK

*Sheena Derry, Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), University of Oxford, Pain Research Unit, Churchill Hospital, Oxford, Oxfordshire, OX3 7LJ, UK. sheena.derry@pru.ox.ac.uk.

Publication History

  1. Publication Status: Stable (no update expected for reasons given in 'What's new')
  2. Published Online: 8 JUL 2009

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[Figure 1]
Figure 1. Forest plot of comparison: 3 Ibuprofen 200 mg versus placebo, outcome: 3.1 Participants with at least 50% pain relief over 4 to 6 hours.
[Figure 2]
Figure 2. Forest plot of comparison: 4 Ibuprofen 400 mg versus placebo, outcome: 4.1 Participants with at least 50% pain relief over 4 to 6 hours.
[Figure 3]
Figure 3. Forest plot of comparison: 4 Ibuprofen 400 mg versus placebo, outcome: 4.2 Participants with at least 50% pain relief over 4 to 6 hours: type of surgery.
[Figure 4]
Figure 4. Forest plot of comparison: 4 Ibuprofen 400 mg versus placebo, outcome: 4.3 Participants with at least 50% pain relief over 4 to 6 hours, all surgery: formulation.
[Figure 5]
Figure 5. Forest plot of comparison: 4 Ibuprofen 400 mg versus placebo, outcome: 4.4 Participants with at least 50% pain relief over 4 to 6 hours, dental surgery: formulation.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Ibuprofen 50 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Ibuprofen 50 mg versus placebo, Outcome 2 Participants using rescue medication over 6 hours.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Ibuprofen 50 mg versus placebo, Outcome 3 Participants with any adverse event.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Ibuprofen 100 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Ibuprofen 100 mg versus placebo, Outcome 2 Participants using rescue medication over 6 hours.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Ibuprofen 100 mg versus placebo, Outcome 3 Participants with any adverse event.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Ibuprofen 200 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.
[Analysis 3.2]
Analysis 3.2. Comparison 3 Ibuprofen 200 mg versus placebo, Outcome 2 Participants with at least 50% pain relief over 4 to 6 hours: type of surgery.
[Analysis 3.3]
Analysis 3.3. Comparison 3 Ibuprofen 200 mg versus placebo, Outcome 3 Participants with at least 50% pain relief over 4 to 6 hours, all surgery: formulation.
[Analysis 3.4]
Analysis 3.4. Comparison 3 Ibuprofen 200 mg versus placebo, Outcome 4 Participants with at least 50% pain relief over 4 to 6 hours, dental surgery: formulation.
[Analysis 3.5]
Analysis 3.5. Comparison 3 Ibuprofen 200 mg versus placebo, Outcome 5 Participants with at least 50% pain relief over 4 to 6 hours, dental surgery: study size.
[Analysis 3.6]
Analysis 3.6. Comparison 3 Ibuprofen 200 mg versus placebo, Outcome 6 Participants using rescue medication over 6 hours.
[Analysis 3.7]
Analysis 3.7. Comparison 3 Ibuprofen 200 mg versus placebo, Outcome 7 Participants using rescue medication over 6 hours, dental surgery.
[Analysis 3.8]
Analysis 3.8. Comparison 3 Ibuprofen 200 mg versus placebo, Outcome 8 Participants using rescue medication over 6 hours, dental surgery: formulation.
[Analysis 3.9]
Analysis 3.9. Comparison 3 Ibuprofen 200 mg versus placebo, Outcome 9 Participants with any adverse event.
[Analysis 4.1]
Analysis 4.1. Comparison 4 Ibuprofen 400 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.
[Analysis 4.2]
Analysis 4.2. Comparison 4 Ibuprofen 400 mg versus placebo, Outcome 2 Participants with at least 50% pain relief over 4 to 6 hours: type of surgery.
[Analysis 4.3]
Analysis 4.3. Comparison 4 Ibuprofen 400 mg versus placebo, Outcome 3 Participants with at least 50% pain relief over 4 to 6 hours, all surgery: formulation.
[Analysis 4.4]
Analysis 4.4. Comparison 4 Ibuprofen 400 mg versus placebo, Outcome 4 Participants with at least 50% pain relief over 4 to 6 hours, dental surgery: formulation.
[Analysis 4.5]
Analysis 4.5. Comparison 4 Ibuprofen 400 mg versus placebo, Outcome 5 Participants with at least 50% pain relief over 4 to 6 hours, dental surgery: study size.
[Analysis 4.6]
Analysis 4.6. Comparison 4 Ibuprofen 400 mg versus placebo, Outcome 6 Participants using rescue medication over 6 hours.
[Analysis 4.7]
Analysis 4.7. Comparison 4 Ibuprofen 400 mg versus placebo, Outcome 7 Participants using rescue medication over 6 hours, dental surgery.
[Analysis 4.8]
Analysis 4.8. Comparison 4 Ibuprofen 400 mg versus placebo, Outcome 8 Participants using rescue medication over 6 hours, dental surgery: formulation.
[Analysis 4.9]
Analysis 4.9. Comparison 4 Ibuprofen 400 mg versus placebo, Outcome 9 Participants with any adverse event.
[Analysis 5.1]
Analysis 5.1. Comparison 5 Ibuprofen 600 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.
[Analysis 6.1]
Analysis 6.1. Comparison 6 Ibuprofen 800 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.