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Single dose oral ibuprofen for acute postoperative pain in adults

  1. Christopher J Derry,
  2. Sheena Derry*,
  3. R Andrew Moore,
  4. Henry J McQuay

Editorial Group: Cochrane Pain, Palliative and Supportive Care Group

Published Online: 8 JUL 2009

Assessed as up-to-date: 11 MAY 2009

DOI: 10.1002/14651858.CD001548.pub2


How to Cite

Derry CJ, Derry S, Moore RA, McQuay HJ. Single dose oral ibuprofen for acute postoperative pain in adults. Cochrane Database of Systematic Reviews 2009, Issue 3. Art. No.: CD001548. DOI: 10.1002/14651858.CD001548.pub2.

Author Information

  1. University of Oxford, Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), Oxford, Oxfordshire, UK

*Sheena Derry, Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), University of Oxford, Pain Research Unit, Churchill Hospital, Oxford, Oxfordshire, OX3 7LJ, UK. sheena.derry@pru.ox.ac.uk.

Publication History

  1. Publication Status: Stable (no update expected for reasons given in 'What's new')
  2. Published Online: 8 JUL 2009

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Ahlstrom 1993 {published data only}
  • Ahlstrom U, Bakshi R, Nilsson P, Wahlander L. The analgesic efficacy of diclofenac dispersible and ibuprofen in postoperative pain after dental extraction. European Journal of Clinical Pharmacology 1993;44(6):587-8.
Arnold 1990 {published data only}
  • Arnold JD. Ketoprofen, ibuprofen, and placebo in the relief of postoperative pain. Advances in Therapy 1990;7(5):264-75.
Bakshi 1994 {published data only}
  • Bakshi R, Frenkel G, Dietlein G, Meurer Witt B, Schneider B, et al. A placebo-controlled comparative evaluation of diclofenac dispersible versus ibuprofen in postoperative pain after third molar surgery. The Journal of Clinical Pharmacology 1994;34(3):225-30.
Black 2002 {published data only}
  • Black P, Max MB, Desjardins P, Norwood T, Ardia A, Pallotta T. A randomized, double-blind, placebo-controlled comparison of the analgesic efficacy, onset of action, and tolerability of ibuprofen arginate and ibuprofen in postoperative dental pain. Clinical Therapeutics 2002;24(7):1072-89.
Cheung 2007 {published data only}
  • Cheung R, Krishnaswami S, Kowalski K. Analgesic efficacy of celecoxib in postoperative oral surgery pain: a single-dose, two-center, randomized, double-blind, active- and placebo-controlled study. Clinical Therapeutics 2007;29(Suppl):2498-510.
Cooper 1977 {published data only}
Cooper 1982 {published data only}
Cooper 1988a {published data only}
  • Cooper SA, Berrie R, Cohn P. Comparison of ketoprofen, ibuprofen, and placebo in a dental surgery pain model. Advances in Therapy 1988;5:43-53.
Cooper 1989 {published data only}
  • Cooper SA, Schachtel BP, Goldman E, Gelb S, Cohn P. Ibuprofen and acetaminophen in the relief of acute pain: a randomized, double blind, placebo controlled study. The Journal of Clinical Pharmacology 1989;29(11):1026-30.
Cooper 1996a {published data only}
  • Cooper SA, Cowan A, Tallarida RJ, Hargreaves K, Roszkowski M, Jamali F, et al. The analgesic interaction of misoprostol with nonsteroidal anti-Inflammatory drugs. American Journal of Therapeutics 1996;3(4):261-7.
De Miguel Rivero 1997 {published data only}
  • de Miguel Rivero C, Garcia Araujo C, Mella Sousa M. Comparative efficacy of oral ibuprofen-arginine, intramuscular magnesic dipyrone and placebo in patients with postoperative pain following total hip replacement. Clinical Drug Investigation 1997;14(4):276-85.
Desjardins 2002 {published data only}
  • Desjardins P, Black P, Papageorge M, Norwood T, Shen DD, Norris L, et al. Ibuprofen arginate provides effective relief from postoperative dental pain with a more rapid onset of action than ibuprofen. European Journal of Clinical Pharmacology 2002;58(6):387-94.
Dionne 1998 {published data only}
Edwards 2002 {published data only}
Ehrich 1999 {published data only}
  • Ehrich EW, Dallob A, De Lepeleire I, Van Hecken A, Riendeau D, Yuan W, et al. Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model. Clinical Pharmacology and Therapeutics 1999;65(3):336-47.
Forbes 1984 {published data only}
  • Forbes JA, Barkaszi BA, Ragland RN, Hankle JJ. Analgesic effect of fendosal, ibuprofen and aspirin in postoperative oral surgery pain. Pharmacotherapy 1984;4(6):385-91.
Forbes 1990 {published data only}
  • Forbes JA, Kehm CJ, Grodin CD, Beaver WT. Evaluation of ketorolac, ibuprofen, acetaminophen, and an acetaminophen codeine combination in postoperative oral surgery pain. Pharmacotherapy 1990;10(6(Pt 2)):94S-105S.
Forbes 1991a {published data only}
  • Forbes JA, Beaver WT, Jones KF, Kehm CJ, Smith WK, Gongloff CM, et al. Effect of caffeine on ibuprofen analgesia in postoperative oral surgery pain. Clinical Pharmacology and Therapeutics 1991;49(6):674-84.
Forbes 1991b {published data only}
  • Forbes JA, Edquist IA, Smith FG, Schwartz MK, Beaver WT. Evaluation of bromfenac, aspirin, and ibuprofen in postoperative oral surgery pain. Pharmacotherapy 1991;11(1):64-70.
Forbes 1992 {published data only}
  • Forbes JA, Beaver WT, Jones KF, Edquist IA, Gongloff CM, Smith WK, et al. Analgesic efficacy of bromfenac, ibuprofen, and aspirin in postoperative oral surgery pain. Clinical Pharmacology and Therapeutics 1992;51(3):343-52.
Frame 1989 {published data only}
Fricke 1993 {published data only}
  • Fricke JR, Halladay SC, Francisco CA. Efficacy and safety of naproxen sodium and ibuprofen for pain relief after oral surgery. Current Therapeutic Research 1993;54(6):619-27.
Gay 1996 {published data only}
  • Gay C, Planas E, Donado M, Martinez JM, Artigas R, Torres F, et al. Analgesic efficacy of low doses of dexketoprofen in the dental pain model: A randomised, double-blind, placebo-controlled study. Clinical Drug Investigation 1996;11(6):320-30.
Heidrich 1985 {published data only}
Hersch 1993a {published data only}
  • Hersh EV, Cooper S, Betts N, Wedell D, MacAfee K, Quinn P, et al. Single dose and multidose analgesic study of ibuprofen and meclofenamate sodium after third molar surgery. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology 1993;76(6):680-7.
Hersch 1993b {published data only}
  • Hersh EV, Ochs H, Quinn P, MacAfee K, Cooper SA. Narcotic receptor blockade and its effect on the analgesic response to placebo and ibuprofen after oral surgery. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology 1993;75(5):539-46.
Hersh 2000 {published data only}
Hill 2001 {published data only}
Jain 1986 {published data only}
  • Jain AK, Ryan JR, McMahon FG, Kuebel JO, Walters PJ, Noveck C. Analgesic efficacy of low dose ibuprofen in dental extraction pain. Pharmacotherapy 1986;6(6):318-22.
Jain 1988 {published data only}
  • Jain AK, Mcmahon FG, Ryan JR, Narcisse C. A double-blind study of ibuprofen 200 mg in combination with caffeine 100 mg, ibuprofen 400 mg, and placebo in episiotomy pain. Current Therapeutic Research 1988;43(4):762-79.
Johnson 1997 {published data only}
Kiersch 1993 {published data only}
  • Kiersch TA, Halladay SC, Koschik M. A double-blind, randomized study of naproxen sodium, ibuprofen, and placebo in postoperative dental pain. Clinical Therapeutics 1993;15(5):845-54.
Laska 1986 {published data only}
  • Laska EM, Sunshine A, Marrero I, Olson N, Siegel C, McCormick N. The correlation between blood levels of ibuprofen and clinical analgesic response. Clinical Pharmacology & Therapeutics 1986;40(1):1-7.
Laveneziana 1996 {published data only}
  • Laveneziana D, Riva A, Bonazzi M, Cipolla M, Migliavacca S. Comparative efficacy of oral ibuprofen arginine and intramuscular ketorolac in patients with postoperative pain. Clinical Drug Investigation 1996;11:8-14.
Malmstrom 1999 {published data only}
  • Malmstrom K, Daniels S, Kotey P, Seidenberg BC, Desjardins PJ. Comparison of rofecoxib and celecoxib, two cyclooxygenase-2 inhibitors, in postoperative dental pain: a randomized, placebo- and active-comparator-controlled clinical trial. Clinical Therapeutics 1999;21(10):1653-63.
Malmstrom 2002 {published data only}
  • Malmstrom K, Fricke JR, Kotey P, Kress B, Morrison B. A comparison of rofecoxib versus celecoxib in treating pain after dental surgery: a single-center, randomized, double-blind, placebo- and active-comparator-controlled, parallel-group, single-dose study using the dental impaction pain model. Clinical Therapeutics 2002;24(10):1549-60.
Malmstrom 2004 {published data only}
  • Malmstrom K, Sapre A, Couglin H, Agrawal NG, Mazenko RS, Fricke JR Jr. Etoricoxib in acute pain associated with dental surgery: a randomized, double-blind, placebo- and active comparator-controlled dose-ranging study. Clinical Therapeutics 2004;26(5):667-79.
McQuay 1996 {published data only}
Medve 2001 {published data only}
  • Medve RA, Wang J, Karim R. Tramadol and acetaminophen tablets for dental pain. Anesthesia Progress 2001;48(3):79-81.
Mehlisch 1990 {published data only}
  • Mehlisch DR, Sollecito WA, Helfrick JF, Leibold DG, Markowitz R, Schow CEJr, et al. Multicenter clinical trial of ibuprofen and acetaminophen in the treatment of postoperative dental pain. he Journal of the American Dental Association 1990;121(2):257-63.
Mehlisch 1995 {published data only}
  • Mehlisch DR, Jasper RD, Brown P, Korn SH, McCarroll K, Murakami AA. Comparative study of ibuprofen lysine and acetaminophen in patients with postoperative dental pain. Clinical Therapeutics 1995;17:852-60.
Mehlisch 2002 {published data only}
  • Mehlisch DR, Ardia A, Pallotta T. Analgesic efficacy of the cyclooxygenase-2-specific inhibitor rofecoxib in post-dental surgery pain: a randomized, controlled trial. Clinical Therapeutics 2002;21(6):943-53.
Morrison 1999 {published data only}
  • Morrison BW, Christensen S, Yuan W, Brown J, Amlani S, Seidenberg B. Analgesic efficacy of the cyclooxygenase-2-specific inhibitor rofecoxib in post-dental surgery pain: a randomized, controlled trial. Clinical Therapeutics 1999;21(6):943-53.
Nelson 1994 {published data only}
  • Nelson SL, Brahim JS, Korn SH, Greene SS, Suchower LJ. Comparison of single-dose ibuprofen lysine, acetylsalicylic acid, and placebo for moderate-to-severe postoperative dental pain. Clinical Therapeutics 1994;16(3):458-65.
Nørholt 1998 {published data only}
  • Nørholt SE, Aagaard E, Svensson P, Sindet-Pedersen S. Evaluation of trismus, bite force, and pressure algometry after third molar surgery: a placebo-controlled study of ibuprofen. Journal of Oral and Maxillofacial Surgery 1998;56(4):420-7.
Olson 2001 {published data only}
  • Olson NZ, Otero AM, Marrero I, Tirado S, Cooper S, Doyle G, Jayawardena S, Sunshine A. Onset of analgesia for liquigel ibuprofen 400 mg, acetaminophen 1000 mg, ketoprofen 25 mg, and placebo in the treatment of postoperative dental pain. Journal of Clinical Pharmacology 2001;41(11):1238-47.
Pagnoni 1996 {published data only}
  • Pagnoni B, Ravanelli A, Degrai L, Rossi R, Tiengo M. Clinical efficacy of ibuprofen arginine in the management of postoperative pain associated with suction termination of pregnancy. A double blind placebo controlled study. Clinical Drug Investigation 1996;11:27-32.
Parker 1986 {published data only}
  • Parker DA, Gibbin KP, Noyelle RM. Syrup formulations for post tonsillectomy analgesia: a double blind study comparing ibuprofen, aspirin and placebo. The Journal of Laryngology and Otology 1986;100(9):1055-60.
Schachtel 1989 {published data only}
Schou 1998 {published data only}
  • Schou S, Nielsen H, Nattestad A, Hillerup S, Ritzau M, Branebjerg PE, et al. Analgesic dose-response relationship of Ibuprofen 50, 100, 200 and 400 mg after surgical removal of third molars: a single-dose, randomized, placebo-controlled, and double-blind study of 304 patients. The Journal of Clinical Pharmacology 1998;38:447-54.
Schwartz 2007 {published data only}
  • Schwartz JI, Kotey PN, Fricke JR Jr, Gottesdiener K. MK-0703 (a cyclooxygenase-2 inhibitor) in acute pain associated with dental surgery: a randomized, double-blind, placebo- and active comparator-controlled dose-ranging study. American Journal of Therapeutics 2007;14(1):13-9.
Seymour 1991 (study 1) {published data only}
  • Seymour RA, Hawkesford JE, Weldon M, Brewster D. An evaluation of different ibuprofen preparations in the control of postoperative pain after third molar surgery. British Journal of Clinical Pharmacology 1991;31(1):83-7.
Seymour 1991 (study 2) {published data only}
  • Seymour RA, Hawkesford JE, Weldon M, Brewster D. An evaluation of different ibuprofen preparations in the control of postoperative pain after third molar surgery. British Journal of Clinical Pharmacology 1991;31(1):83-7.
Seymour 1996 {published data only}
  • Seymour RA, Ward Booth P, Kelly PJ. Evaluation of different doses of soluble ibuprofen and ibuprofen tablets in postoperative dental pain. The British Journal of Oral and Maxillofacial Surgery 1996;34(1):110-4.
Seymour 1998 {published data only}
  • Seymour RA, Frame J, Negus TW, Hawkesford JE, Marsden J, Matthew IR. The comparative efficacy of aceclofenac and ibuprofen in postoperative pain after third molar surgery. British Journal of Oral and Maxillofacial Surgery 1998;36(5):375-9.
Seymour 1999 {published data only}
Seymour 2000 {published data only}
  • Seymour RA, Watkinson H, Hawkesford JE, Moore U. The efficacy of buffered ketoprofen in postoperative pain after third molar surgery. European Journal of Clinical Pharmacology 2000;55(11-12):801-6.
Singla 2005 {published data only}
  • Singla N, Pong A, Newman K, MD-10 Study Group. Combination oxycodone 5 mg/ibuprofen 400 mg for the treatment of pain after abdominal or pelvic surgery in women: a randomized, double-blind, placebo- and active-controlled parallel-group study. Clinical Therapeutics 2005;27(1):45-57.
Sunshine 1983 {published data only}
  • Sunshine A, Olson NZ, Laska EM, Zighelboim I, De Castro A, De Sarrazin C. Ibuprofen, zomepirac, aspirin, and placebo in the relief of postepisiotomy pain. Clinical Pharmacology and Therapeutics 1983;34(2):254-8.
Sunshine 1987 {published data only}
  • Sunshine A, Roure C, Olson N, Laska EM, Zorrilla C, Rivera J. Analgesic efficacy of two ibuprofen codeine combinations for the treatment of postepisiotomy and postoperative pain. Clinical Pharmacology and Therapeutics 1987;42(4):374-80.
Sunshine 1996 {published data only}
  • Sunshine A, Zighelboim I, Bartizek RD. A double-blind, placebo-controlled, single-dose comparison study of ibuprofen, and ibuprofen in combination with caffeine, in the treatment of postopisiotomy pain. Royal Society of Medicine 1996;218:105-88.
Sunshine 1997 {published data only}
  • Sunshine A, Olson NZ, O'Neill E, Ramos I, Doyle R. Analgesic efficacy of a hydrocodone with ibuprofen combination compared with ibuprofen alone for the treatment of acute postoperative pain. The Journal of Clinical Pharmacology 1997;37:908-15.
Sunshine 1998 {published data only}
  • Sunshine A, Olson NZ, Marrero I, Tirado S. Onset and duration of analgesia for low-dose ketoprofen in the treatment of postoperative dental pain. Journal of Clinical Pharmacology 1998;38(12):1155-64.
Van Dyke 2004 {published data only}
  • Van Dyke T, Litkowski LJ, Kiersch TA, Zarringhalam NM, Zheng H, Newman K. Combination oxycodone 5 mg/ibuprofen 400 mg for the treatment of postoperative pain: a double-blind, placebo- and active-controlled parallel-group study. Clinical Therapeutics 2004;26(12):2003-14.
Wahl 1997 {published data only}
  • Wahl G, Becker J, Keller U. A comparison between a paracetamol/acetylsalicylic acid/caffeine combination and ibuprofen lysinate. Clinical Drug Investigation 1997;13(3):121-7.
Wideman 1999 (study 1) {published data only}
  • Wideman GL, Keffer M, Morris E, Doyle RT, Jiang JG, Beaver WT. Analgesic efficacy of a combination of hydrocodone with ibuprofen in postoperative pain. Clinical Pharmacology and Therapeutics 1999;65(1):66-76.
Wideman 1999 (study 2) {published data only}
  • Wideman GL, Keffer M, Morris E, Doyle RT, Jiang JG, Beaver WT. Analgesic efficacy of a combination of hydrocodone with ibuprofen in postoperative pain. Clinical Pharmacology and Therapeutics 1999;65(1):66-76.
Zelenakas 2004 {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Ahlstrom 1989 {published data only}
  • Ahlstrom U, Wahlander LA. Double-blind comparison of two different dosage recommendations for pain after surgical removal of a lower wisdom tooth. Current Therapeutic Research 1989;45(3):495-501.
Akural 2009 {published data only}
  • Akural EI, Järvimäki V, Länsineva A, Niinimaa A, Alahuhta S. Effects of combination treatment with ketoprofen 100 mg + acetaminophen 1000 mg on postoperative dental pain: A single-dose, 10-hour, randomized, double-blind, active- and placebo-controlled clinical trial. Clinical Therapeutics 2009;31(3):560-8. [DOI: 10.1016/j.clinthera.2009.03.017]
Anaokar 1993 {published data only}
  • Anaokar SM, Parulekar SV, Thatte UM, Dahanukar SA. A multiple dose comparison of ketorolac tromethamine with ibuprofen for analgesic activity. Journal of Postgraduate Medicine 1993;39(2):74-6.
Apaydin 1994 {published data only}
  • Apaydin A, Ozyuvaci H, Ordulu M, Disci R. Postoperative pain relief by single dose diclofenac kalium and etodolac. A comparative clinical study. Ağrı (Algoloji) Derneği'nin Yayın organıdır = The Journal of the Turkish Society of Algology 1994;6(4):28-34.
Apiou 1988 {published data only}
  • Apiou, Benque, Bertrand, Charon, Fourel, Guidicelli, et al. Multicentric study of fenalgic 400 in odonto-stomatology [Etude multicentrique du fenalgic 400 en odonto-stomatologie]. Gazette Medicale 1988;95(11):64-6.
Aranda 1989 {published data only}
  • Aranda B, Bor YM. Comparative study between the efficacy of aluminium acetotartrate poultice and diclofenac in the postoperative treatment of degenerative knees [Etude du cataplasme d'acetotartrate d'alumine versus diclofenac dans le traitmente post-operatoire des genoux degeneratifs]. Comptes Rendus de Therapeutique et de Pharmacologie Clinique 1989;7(80):11-7.
Averbuch 2000 {published data only}
Bailey 1993 {published data only}
  • Bailey BMW, Zaki G, Rotman H, Woodwards RT. A double-blind comparative study of soluble aspirin and diclofenac dispersible in the control of postextraction pain after removal of impacted third molars. International Journal of Oral and Maxillofacial Surgery 1993;22(4):238-41.
Behotas 1992 {published data only}
  • Behotas S, Chauvin A, Castiel J, Martin A, Boureau F, Barrat J, et al. Analgesic effect of ibuprofen in pain after episiotomy [Effets antalgiques de l'ibuprofene dans les douleurs apres episiotomie]. Annales Françaises d'anesthèsie et de Rèanimation 1992;11(1):22-6.
Bhounsule 1990 {published data only}
  • Bhounsule SA, Nevreker PR, Agshikar NV, Manindra NP, Dhume VG. A comparison of four analgesics in post-episiotomy pain. Indian Journal of Physiology and Pharmacology 1990;34(1):34-8.
Biehl 1981 {published data only}
  • Biehl G. Preventing postoperative edema with Irritren. Results of a double blind study [Prophylaxe postoperativer Schwellungen mit Irritren. Ergebnisse einer Dopelblind-Studie]. Fortschritte der Medizin 1981;99(19):745-8.
Bloomfield 1974 {published data only}
  • Bloomfield SS, Barden TP, Mitchell J. Comparative efficacy of ibuprofen and aspirin in episiotomy pain. Clinical Pharmacology and Therapeutics 1974;15(6):565-70.
Calanchini 1991 {published data only}
  • Calanchini B, Gazzaniga A, Ziegler SJ. Pharmacologic and therapeutic properties of a new ibuprofen formula [Pharmakologische und therapeutische eigenschaften einer neuen ibuprofen- formulierung]. Therapiewoche Schweiz 1991;7(8):554-60.
Carlos 1984 {published data only}
  • Carlos DE. Comparative study of the efficacy of diclofenac NA, meperidine HCL and nalbuphine HCL in post-operative analgesia. Philippine Journal of Internal Medicine 1984;22(1):51-5.
Carrillo 1990 {published data only}
  • Carrillo JS, Calatayud J, Manso FJ, Barberia E, Martinez JM, Donado M. A randomized double blind clinical trial on the effectiveness of helium neon laser in the prevention of pain, swelling and trismus after removal of impacted third molars. International Dental Journal 1990;40(1):31-6.
Chopra 2009 {published data only}
  • Chopra D, Rehan HS, Mehra P, Kakkar AK. A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of paracetamol, serratiopeptidase, ibuprofen and betamethasone using the dental impaction pain model. International Journal of Oral and Maxillofacial Surgery 2009;38(4):350-5. [DOI: 10.1016/j.ijom.2008.12.013]
Cooper 1984 {published data only}
  • Cooper SA. Five studies on ibuprofen for postsurgical dental pain. The American Journal of Medicine 1984;Suppl:70-7.
Cooper 1988b {published data only}
  • Cooper SA. Ketoprofen in oral surgery pain: a review. The Journal of Clinical Pharmacology 1988;28(12 Suppl):S40-6.
Cooper 1993 {published data only}
  • Cooper SA, Quinn PD, MacAfee K, Hersh EV, Sullivan D, Lamp C. Ibuprofen controlled-release formulation. A clinical trial in dental impaction pain. Oral Surgery, Oral Medicine, and Oral Pathology 1993;75(6):677-83.
Cooper 1996b {published data only}
Darsow 1988 {published data only}
  • Darsow F, Witt M. Treatment of postoperative synovitis following meniscus operations with ibuprofen [Zur Behandlung der postoperativen Synovialitis nach Meniskusoperationen mit Ibuprofen]. Beiträge zur Orthopädie und Traumatologie 1988 Dec;35(12):616-20.
Dorfmann 1991 {published data only}
  • Dorfmann H. Controlled therapeutic trial of diclofenac in meniscectomy under arthroscopy [Essai therapeutique controle du diclofenac dans les meniscectomies sous arthroscopie]. Revue du Rhumatisme et des Maladies Osteo-Articulaires 1991;58(1):59-61.
Doyle 2002 {published data only}
El-Tanany 1993 {published data only}
  • El-Tanany H, Boghdady W. A double blind comparative study of Diclofenac-K and Glafenine in the management of acute dental pain. Cairo Dental Journal 1993;9(2):117-20.
Fleiss 1979 {published data only}
Forbes 1991 {published data only}
  • Forbes JA, Moore EM, Allen HW, Beaver WT. Evaluation of an ibuprofen controlled-release tablet and placebo in postoperative oral surgery pain. Pharmacotherapy 1991;11(3):242-8.
Frezza 1985 {published data only}
  • Frezza R, Bolognesi P, Bernardi F. Comparison of the action of 3 non-steroidal anti-inflammatory agents in the control of post-operative pain. Effectiveness of NSAID against pain [Confronto sull'azione di tre antinfiammatori non steroidei nel controllo de dolore odontoiatrico post-chirurgico. Efficaci i FANS contro il dolore]. Attualita Dentale 1985;1(30):40-2.
Gallardo 1980 {published data only}
  • Gallardo F, Rossi E. Double blind evaluation of naproxen and ibuprofen in periodontal surgery. Pharmacology and Therapeutics in Dentistry 1980;5(3-4):69-72.
Gallardo 1981 {published data only}
  • Gallardo F, Lobo R, Pino M, Martino LE. Double blind evaluation of naproxen and Ibuprofen in oral surgery outpatients. IRCS Medical Science 1981;9:440-1.
Garwood 1983 {published data only}
  • Garwood AJ, Lownie JF, Cleaton Jones PE, Butz SJ. The effect of ibuprofen (Brufen) following the removal of impacted third molar teeth. The Journal of the Dental Association of South Africa = Die Tydskrif van die Tandheelkundige Vereniging van Suid-Afrika 1983;38(12):739-42.
Giles 1981 {published data only}
Giles 1985 {published data only}
  • Giles AD, Pickvance NJ. Combination analgesia following oral surgery; administered pre-operatively double blind comparison of ibuprofen, codeine phosphate and two combination ratios. Clinical Trials Journal 1985;22(4):300-13.
Hazra 1982 {published data only}
  • Hazra DK, Elhence IP. Double blind comparative trial to study efficacy of various analgesic formulations. Clinician 1982;46(5):218-22.
Henderson 1994 {published data only}
  • Henderson RC. A double-blind comparison of diclofenac potassium and naproxen sodium in the treatment of pain due to orthopedic skeletal surgery. Today's Therapeutic Trends 1994;12(S1):81-95.
Henrikson 1982 {published data only}
  • Henrikson PA, Thilander H, Wahlander LA. Absorption and effect of diclofenac-sodium after surgical removal of a lower wisdom tooth. Current Therapeutic Research 1982;31(1):20-6.
Henrikson 1985 {published data only}
Hopkinson 1980 {published data only}
  • Hopkinson JH. Ibuprofen versus propoxyphene hydrochloride and placebo in the relief of postepisiotomy pain. Current Therapeutic Research 1980;27(1):55-63.
Hultin 1978 {published data only}
Hyrkas 1992 {published data only}
  • Hyrkas T, Ylipaavalniemi P, Oikarinen VJ, Hampf G. Postoperative pain prevention by a single-dose formulation of diclofenac producing a steady plasma concentration. Journal of Oral Maxillofacial Surgery 1992;50(2):124-7.
Hyrkas 1993 {published data only}
  • Hyrkas T, Ylipaavalniemi P, Oikarinen VJ, Paakkari I. A comparison of diclofenac with and without single-dose intravenous steroid to prevent postoperative pain after third molar removal. Journal of Oral Maxillofacial Surgery 1993;51(6):634-6.
Hyrkas 1994 {published data only}
  • Hyrkas T. Effect of preoperative single doses of diclofenac and methylprednisolone on wound healing. Scandinavian journal of plastic and reconstructive surgery and hand surgery 1994;28(4):275-8.
Iles 1980 {published data only}
Iqbal 1986 {published data only}
  • Iqbal KM, Biswas GK, Mondo SK, Afzalunnessa B. Assessment of post operative analgesia: A comparative study of pethidine and diclofenac sodium. Journal of Bangladesh College of Physicians and Surgeons 1986;4(1):1-7.
Iwabuchi 1980 {published data only}
  • Iwabuchi T, Soma S. [Use of Voltaren for relief of post- extraction pain]. Shikai Tenbo = Dental outlook 1980;55(2):367-70.
Joubert 1977 {published data only}
  • Joubert JJ. An assessment of the efficacy and tolerability of Voltaren in the treatment of inflammation after extraction of teeth. The Journal of the Dental Association of South Africa 1977;32:581-3.
Katharia 1992 {published data only}
  • Katharia SK, Singh SP, Kulshreshtha VK. A clinical assessment of ibuprofen and a new herbal compound in oral surgical procedures. Indian Journal of Pharmacology 1992;24(1):29-31.
Khan 1992 {published data only}
  • Khan AA, Malik S, Zuberi NIS. Double-blind study on emorfazone and ibuprofen in dental pain and inflammation. Journal of the Pakistan Medical Association 1992;42:17-8.
Kittala 1972 {published data only}
  • Kittala S, Aizawa M, Tokue I, Suge Y. Efficacy of GP-45840 on after-pains. Clinical trial with double blind method. Shinryo To Shinyaku. (Shinryo To Shinyaku) Medical Consultation and New Remedies 1972;9(6):1123.
Klein 1994 {published data only}
  • Klein RL, Woll S. A postoperative analgesia comparison of intramuscular and oral ketorolac (Tromethamine) with ibuprofen in patients with foot and ankle surgery. Regional Anaesthesia 1994;19(2S):67.
Mastronardi 1988 {published data only}
  • Mastronardi P, D'Onofrio M, Scanni E, Pinto M, Frontespezi S, Ceccarelli MG, et al. Analgesic activity of flupirtine maleate: a controlled double blind study with diclofenac sodium in orthopaedics. The Journal of International Medical Research 1988;16(5):338-48.
Matthews 1984 {published data only}
  • Matthews RW, Scully CM, Levers BG. The efficacy of diclofenac sodium (Voltarol) with and without paracetamol in the control of post surgical dental pain. British Dental Journal 1984;157(10):357-9.
McEvoy 1996 {published data only}
  • McEvoy A, Livingstone JI, Cahill CJ. Comparison of diclofenac sodium and morphine sulphate for postoperative analgesia after day case inguinal hernia surgery. Annals of the Royal College of Surgeons England 1996;78(4):363-6.
McQuay 1993 {published data only}
  • McQuay HJ, Carroll D, Guest PG, Robson S, Wiffen PJ, Juniper RP. A multiple dose comparison of ibuprofen and dihydrocodeine after third molar surgery. The British Journal of Oral and Maxillofacial Surgery 1993;31(2):95-100.
Movilia 1990 {published data only}
  • Movilia P, Restelli L, Miriano F, Vaiani G, Grossi E. Analgesic activity of nabumetone in postoperative pain. Drugs 1990;40 Supp(5):71-4.
Nakanishi 1990 {published data only}
  • Nakanishi M, Mizukawa N, Koyama S, Takagi S, Nishijima K. Clinical evaluation of Amfenac sodium compared with Diclofenac sodium. Journal of Oral Therapeutics and Pharmacology 1990;9(2):85-92.
Negm 1989 {published data only}
  • Negm MM. Management of endodontic pain with nonsteroidal anti inflammatory agents: a double blind, placebo controlled study. Oral Surgery, Oral Medicine, and Oral Pathology 1989;67(1):88-95.
Rondeau 1980 {published data only}
  • Rondeau PL, Yeung E, Nelson P. Dental surgery pain analgesic. Journal Canadian Dental Association 1980;46(7):433-9.
Rossi 1981 {published data only}
  • Rossi E, Gallardo F. Analgesic efficacy of naproxen and Ibuprofen in patients undergoing mucogingival surgery. IRCS Medical Science 1981;9:272-3.
Schleier 2007 {published data only}
  • Schleier P, Prochnau A, Schmidt-Westhausen AM, Peters H, Becker J, Latz T, et al. Ibuprofen sodium dihydrate, an ibuprofen formulation with improved absorption characteristics, provides faster and greater pain relief than ibuprofen acid. International Journal of Clinical Pharmacology and Therapeutics 2007;45(2):89-97.
Shimura 1981 {published data only}
  • Shimura T, Otaka Y, Ando N, Nagao H. [Voltaren tablets for the pain following tooth extraction - studies of its analgesic effects]. Shikai Tenbo = Dental outlook 1981;58(1):175-83.
Squires 1981 {published data only}
  • Squires DJ, Masson EL. A double blind comparison of ibuprofen, ASA codeine caffeine compound and placebo in the treatment of dental surgery pain. The Journal of International Medical Research 1981;9(4):257-60.
Tai 1992 {published data only}
  • Tai YMA, Baker R. Comparison of controlled-release ketoprofen and diclofenac in the control of post-surgical dental pain. Journal of the Royal Society of Medicine 1992;85(1):16-8.
Tani 1974 {published data only}
  • Tani I. Therapeutic results of Voltaren tablets an analgesic anti-inflammatory agent in pain following tonsillectomy. (Shinryo To Shinyaku) Medical Consultation and New Remedies 1974;11(8):274.
Tesseroli 1986 {published data only}
  • Tesseroli de Siqueira JT, Potenza BJ, Basta D. Evaluation of the analgesic efficacy of potassium diclofenac and placebo in postoperative treatment of dental surgery. Multicentre, double blind study [Avaliacao do eficacia analgesicado diclofenaco potassico e placebo no pos-operatorio de cirurgias para extracoes dentarias. Estudo multicentrico, dupl-cego]. Revista Paulista de Odontologia 1986;6:2-7.
Troullos 1990 {published data only}
  • Troullos ES, Hargreaves KM, Butler DP, Dionne RA. Comparison of nonsteroidal anti inflammatory drugs, ibuprofen and flurbiprofen, with methylprednisolone and placebo for acute pain, swelling, and trismus. Journal of Oral Maxillofacial Surgery 1990;48(9):945-52.
Turcotte 1986 {published data only}
  • Turcotte JY. Ibuprofen pre and postoperatively in oral surgery [L'ibuprofene en post et en pre-operatoire en chirurgie buccale]. Journal Canadian Dental Association 1986;52(4):325-8.
Van Der Zwan 1982 {published data only}
  • Van Der Zwan J, Boering G, Wesseling H, et al. The lower third molar and antiphlogistics. Effects of betamethasone, ibuprofen, indomethacin, naproxen, niflumic acid, oxyphenylbutazone, tranexamic acid and glafenine on the patient's condition after surgical removal of a lower third molar. International Journal of Oral Surgery 1982;11(6):340-50.
Van Wering 1972 {published data only}
  • Van Wering RF, Bleker OP. Oral analgesia in post partum pain: a comparison of ibuprofen ("brufen") and dextropropoxyphene. Current Medical Research and Opinion 1972;1(1):49-52.
Vigneron 1977 {published data only}
  • Vigneron JR, Thys R. Study of the anti-inflammatory and analgesic actions of diclofenac in traumatology and orthopedic surgery [Etude de l'action anti-inflammatoire et antalgique du diclofenac en traumatologie et chirurgie orthopedique]. Revue Medicale de Liege 1977;32(1):10-14.
Vogel 1984 {published data only}
Von Mayer 1980 {published data only}
  • Von Mayer M, Weiss P. Antiphlogistic and analgesic effect of diclofenac sodium after maxillofacial interventions in a double-blind trial [Uber die antiphlogistische und analgetische Wirkung von Diclofenac-Na nach kieferchirurgischen Eingriffen im Doppelblindversuch]. Deutsche  Zahnarztliche Zeitschrift 1980;35(5):559-63.
Walker 1976 {published data only}
Walton 1990 {published data only}
Walton 1993 {published data only}
  • Walton GM, Rood JP, Snowdon AT, Rickwood D. Ketorolac and diclofenac for postoperative pain relief following oral surgery. The British Journal of Oral and Maxillofacial Surgery 1993;31(3):158-60.
Weber 1990 {published data only}
  • Weber F, Wentorp W, Hadjianghelou O. Ibuprofen for pain treatment following dental surgery. A comparative prospective randomized study [Schmerztherapie mit Ibuprofen nach zahnarztlich-chirurgischen eingriffen. Eine vergleichende prospektiv randomisierte studie]. Deutsche Zeitschrift für Mund-, Kiefer- und Gesichts-Chirurgie 1990;14(3):206-9.
Winter 1978 {published data only}
  • Winter LJr, Bass E, Recant B, Cahaly JF. Analgesic activity of ibuprofen (Motrin) in postoperative oral surgical pain. Oral Surgery, Oral Medicine, and Oral Pathology 1978;45(2):159-66.
Wuolijoki 1987 {published data only}
  • Wuolijoki E, Oikarinen VJ, Ylipaavalniemi P, Hampf G, Tolvanen M. Effective postoperative pain control by preoperative injection of diclofenac. European Journal of Clinical Pharmacology 1987;32(3):249-52.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Daniels 2009 {published data only}
  • Daniels S, Reader S, Berry P, Goulder M. Onset of analgesia with sodium ibuprofen, ibuprofen acid incorporating poloxamer and acetaminophen--a single-dose, double-blind, placebo-controlled study in patients with post-operative dental pain. European Journal of Clinical Pharmacology 2009;65(4):343-53. [DOI: 10.1007/s00228-009-0614-y]
Kleinert 2008 {published data only}

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Aranda 2006
Barden 2004
Barden 2005
BNF 2002
  • Non-steroidal anti-inflammatory drugs. In: Mehta DK editor(s). British National Formulary. 43. Vol. March, London: BMJ Publishing Group Ltd, 2002:482.
Collins 1997
Collins 2001
Cook 1995
Cooper 1991
  • Cooper SA. Single-dose analgesic studies: the upside and downside of assay sensitivity. In: Max MB, Portenoy RK, Laska EM editor(s). The design of analgesic clinical trials. Advances in Pain Research and Therapy. Vol. 18, New York: Raven Press, 1991:117-24.
Derry 2008
Derry C 2009
  • Derry C, Derry S, Moore RA, McQuay HJ. Single dose oral naproxen and naproxen sodium for acute postoperative pain in adults. Cochrane Database of Systematic Reviews 2009, Issue 1. [DOI: 10.1002/14651858.CD004234.pub3]
Derry P 2009
  • Derry P, Derry S, Moore RA, McQuay HJ. Single dose oral diclofenac for acute postoperative pain in adults. Cochrane Database of Systematic Reviews 2009, Issue 2.
Edwards 1999
  • Edwards JE, McQuay HJ, Moore RA, Collins SL. Reporting of adverse effects in clinical trials should be improved: lessons from acute postoperative pain. Journal of Pain and Symptom Management 1999;18(6):427-37.
Edwards 2000
  • Edwards JE, Moore RA, McQuay HJ. Single dose oxycodone and oxycodone plus paracetamol (acetaminophen) for acute postoperative pain. Cochrane Database of Systematic Reviews 2000, Issue 2. [DOI: 10.1002/14651858.CD002763]
FitzGerald 2001
Forrest 2002
  • Forrest JB, Camu F, Greer IA, Kehlet H, Abdalla M, Bonnet F. Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery. British Journal of Anaesthesia 2002;88(2):227-33.
Grahame-Smith 2002
  • Grahame-Smith DG, Aronson JK. Oxford textbook of clinical pharmacology and drug therapy. 3. Oxford: Oxford University Press, 2002. [: ISBN: 13: 978-0-19-263234-0]
Hawkey 1999
Hernandez-Diaz 2001
  • Hernández-Díaz S, García-Rodríguez LA. Epidemiologic assessment of the safety of conventional nonsteroidal anti-inflammatory drugs. The American Journal of Medicine 2001;110(Suppl 3A):20S-7S.
Jadad 1996a
Jadad 1996b
  • Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJM, Gavaghan DJ, McQuay HJ. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Controlled Clinical Trials 1996;17:1-12.
L'Abbé 1987
Lloyd 2009
McQuay 1982
  • McQuay HJ, Bullingham RE, Moore RA, Evans PJ, Lloyd JW. Some patients don't need analgesics after surgery. Journal of the Royal Society of Medicine 1982;75(9):705-8.
McQuay 2005
McQuay 2007
Moher 1999
Moore 1996
Moore 1997a
  • Moore A, McQuay H, Gavaghan D. Deriving dichotomous outcome measures from continuous data in randomised controlled trials of analgesics: Verification from independent data. Pain 1997;69(1-2):127-30.
Moore 1997b
  • Moore A, Moore O, McQuay H, Gavaghan D. Deriving dichotomous outcome measures from continuous data in randomised controlled trials of analgesics: Use of pain intensity and visual analogue scales. Pain 1997;69(3):311-5.
Moore 1998
  • Moore RA, Gavaghan D, Tramer MR, Collins SL, McQuay HJ. Size is everything-large amounts of information are needed to overcome random effects in estimating direction and magnitude of treatment effects. Pain 1998;78(3):209-16.
Moore 2003
  • Moore RA, Edwards J, Barden J, McQuay HJ. Bandolier's Little Book of Pain. Oxford: Oxford University Press, 2003. [: ISBN: 0-19-263247-7]
Moore 2005
Moore 2006
  • Moore A, McQuay H. Bandolier's Little Book of Making Sense of the Medical Evidence. Oxford: Oxford University Press, 2006. [: ISBN: 0-19-856604-2]
Morris 1995
  • Morris JA, Gardner MJ. Calculating confidence intervals for relative risk, odds ratios and standardised ratios and rates. In: Gardner MJ, Altman DG editor(s). Statistics with confidence - confidence intervals and statistical guidelines. London: British Medical Journal, 1995:50-63.
Oldman 1999
PACT 2007
  • Prescription Cost Analysis. England, 2007. [: ISBN: 978-1-84636-210-1]
Rapoport 1999
  • Rapoport RJ. The Safety of NSAIDs and Related Drugs for the Management of Acute Pain: Maximizing Benefits and Minimizing Risks. Cancer Control 1999;6(2 Suppl 1):18-21.
Roy 2007
Sheen 2002
Toms 2008
Tramèr 1997

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Collins 1998
Collins 1999
McQuay 1998
  • McQuay HJ, Moore RA. An evidence-based resource for pain relief. Oxford: Oxford University Press, 1998.