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Postnatal phenobarbital for the prevention of intraventricular haemorrhage in preterm infants

  1. Elisa Smit1,
  2. David Odd2,*,
  3. Andrew Whitelaw1

Editorial Group: Cochrane Neonatal Group

Published Online: 13 AUG 2013

Assessed as up-to-date: 17 DEC 2012

DOI: 10.1002/14651858.CD001691.pub3


How to Cite

Smit E, Odd D, Whitelaw A. Postnatal phenobarbital for the prevention of intraventricular haemorrhage in preterm infants. Cochrane Database of Systematic Reviews 2013, Issue 8. Art. No.: CD001691. DOI: 10.1002/14651858.CD001691.pub3.

Author Information

  1. 1

    University of Bristol, Neonatal Neuroscience, Bristol, UK

  2. 2

    University of Bristol Medical School, Neonatal Intensive Care Unit, Bristol, UK

*David Odd, Neonatal Intensive Care Unit, University of Bristol Medical School, Southmead Hospital, Bristol, BS10 5NB, UK. davidodd@doctors.org.uk.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 13 AUG 2013

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[Figure 1]
Figure 1. Funnel plot of comparison: 1 Phenobarbital versus control, Outcome: 1.1 All intraventricular haemorrhage.
[Figure 2]
Figure 2. Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
[Figure 3]
Figure 3. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Phenobarbital versus control, Outcome 1 All intraventricular haemorrhage.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Phenobarbital versus control, Outcome 2 Severe intraventricular haemorrhage.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Phenobarbital versus control, Outcome 3 Ventricular dilation or hydrocephalus.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Phenobarbital versus control, Outcome 4 Hypotension.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Phenobarbital versus control, Outcome 5 Pneumothorax/interstitial emphysema.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Phenobarbital versus control, Outcome 6 Hypercapnia.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Phenobarbital versus control, Outcome 7 Acidosis.
[Analysis 1.8]
Analysis 1.8. Comparison 1 Phenobarbital versus control, Outcome 8 Use of mechanical ventilation.
[Analysis 1.9]
Analysis 1.9. Comparison 1 Phenobarbital versus control, Outcome 9 Mild neurodevelopmental impairment.
[Analysis 1.10]
Analysis 1.10. Comparison 1 Phenobarbital versus control, Outcome 10 Severe neurodevelopmental impairment.
[Analysis 1.11]
Analysis 1.11. Comparison 1 Phenobarbital versus control, Outcome 11 Death before discharge.
[Analysis 1.12]
Analysis 1.12. Comparison 1 Phenobarbital versus control, Outcome 12 All deaths during study.