Intervention Review

Antibiotics for incomplete abortion

  1. Win May1,*,
  2. A Metin Gülmezoglu2,
  3. Katherine Ba-Thike3

Editorial Group: Cochrane Fertility Regulation Group

Published Online: 16 JUL 2008

Assessed as up-to-date: 1 JUL 2007

DOI: 10.1002/14651858.CD001779.pub2

Database Title

Additional Information

How to Cite

May W, Gülmezoglu AM, Ba-Thike K. Antibiotics for incomplete abortion. Cochrane Database of Systematic Reviews 2007, Issue 4. Art. No.: CD001779. DOI: 10.1002/14651858.CD001779.pub2.

Author Information

  1. 1

    Keck School of Medecine, University of Southern California, USC Division of Medical Education, Los Angeles, California 90089, USA

  2. 2

    World Health Organization, Department of Reproductive Health and Research, Geneva 1211, Switzerland

  3. 3

    World Health Organization, Dept. of Reproductive Health and Research, Geneva 27, Switzerland

*Win May, USC Division of Medical Education, Keck School of Medecine, University of Southern California, 1975 Zonal Avenue KAM 211, Los Angeles, California 90089, USA. win.may@keck.usc.edu.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 16 JUL 2008

SEARCH

ARTICLE TOOLS

View Full Article (HTML) Summary (56K)Standard (155K)Full (164K)
 

Abstract

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

Background

Unsafe abortions result not only in costs for acute care but may also be responsible for longer-term complications such as pelvic inflammatory disease, damage to reproductive organs, and secondary infertility. If effective, antibiotic prophylaxis at the time of the procedure can potentially prevent these adverse consequences.

Objectives

The value of routine antibiotics before surgical evacuation of the uterus in women with incomplete abortion is controversial. In some health centres antibiotic prophylaxis is advised; in others antibiotics are only prescribed when there are signs of infection. The objective of this review is to evaluate the effectiveness of routine antibiotic prophylaxis to women with incomplete abortion.

Search methods

We searched the Cochrane Controlled Trials Register, Pubmed/MEDLINE, EMBASE and Popline. Date of last search: January 2007.

Selection criteria

Randomised trials comparing a policy of routine antibiotic prophylaxis with no routine prophylaxis were eligible for inclusion.

Data collection and analysis

Data extraction was conducted by two reviewers independently. Trial quality was assessed.

Main results

One study involving 140 women was included. A second well-conducted trial was excluded because of high losses to follow-up. No differences were detected in postabortal infection rates with routine prophylaxis or control. However, compliance with antibiotic treatment was also low.

Authors' conclusions

There is not enough evidence to evaluate a policy of routine antibiotic prophylaxis to women with incomplete abortion.

 

Plain language summary

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

Not enough evidence on routine antibiotics to prevent infection for women seeking care after incomplete abortion, but a single dose may be more suitable

Incomplete abortions cause many complications and the deaths of tens of thousands of women each year. Women who seek health care after an incomplete abortion usually come for problems from bleeding too much or infection. Antibiotics are generally given when there are signs of infection. The review of trials showed difficulties for women in continuing to take antibiotics and returning for care, so single dose antibiotics may be more suitable in these circumstances. The trials did not provide enough evidence to show the effects of routine antibiotics for women after incomplete abortion.

 

摘要

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. 摘要

背景

不完全性流產的抗生素使用

不安全的流產不僅造成急性照顧的花費，也可能與長期併發症有關，如骨盆腔發炎，損害生殖器官和次發性不孕。在流產過程中使用預防性抗生素，如果有效，可以防止這些潛在的不良後果。

目標

在不完全流產的婦女術前例行使用抗生素的價值仍然有爭議。在一些健康中心的預防性抗生素被建議使用;在其他健康中心抗生素只在有感染徵象時使用。這篇回顧的目的在評估不完全流產的婦女例行使用預防性抗生素的效果。

搜尋策略

我們搜查了Cochrane對照試驗登記， Pubmed /medline， embase和popline。最後的搜索日期是2007年1月。

選擇標準

隨機試驗中比較例行使用預防性抗生素和未例行使用者才有資格列入。

資料收集與分析

兩位獨立的評審進行數據摘取。試驗質量也被評估。

主要結論

有一項研究涉及140名婦女。一項試驗因為後續追蹤的高流失率被排除在外。常規使用預防性抗生素流產後的感染率與控制組沒有差別。然而，抗生素治療的醫囑遵從性也很低。

作者結論

目前沒有足夠的證據來評估不完全流產的婦女例行使用預防性抗生素之政策。

翻譯人

本摘要由臺灣大學附設醫院林冠宏翻譯。

此翻譯計畫由臺灣國家衛生研究院(National Health Research Institutes, Taiwan)統籌。

總結

沒有足夠的證據顯示對尋求照顧的不完全流產後婦女，使用例行的抗生素可以避免感染，但單一劑量可能會更適合。每年不完全流產造成數以萬計的婦女的許多併發症和死亡。不完全流產後尋求健康照護的婦女，通常來的問題是出血太多或感染。抗生素一般有感染跡象才給予。試驗的回顧顯示，婦女在繼續服用抗生素和回診上常有困難，所以單一劑量抗生素，在這些情況下可能更適合。這些試驗沒有提供足夠的證據顯示，不完全流產後例行使用抗生素會有效果。

View Full Article (HTML) Summary (56K)Standard (155K)Full (164K)