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Intervention Review

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Antibiotics for trachoma

  1. D Mabey Consultant Ophthalmologist*,
  2. N Fraser-Hurt,
  3. C Powell

Editorial Group: Cochrane Eyes and Vision Group

Published Online: 21 JAN 2002

DOI: 10.1002/14651858.CD001860


How to Cite

Mabey D, Fraser-Hurt N, Powell C. Antibiotics for trachoma. The Cochrane Database of Systematic Reviews 2002, Issue 1. Art. No.: CD001860. DOI: 10.1002/14651858.CD001860.

Author Information

  1. St Thomas' Hospital, South Wing Eye Department, London, UK

*D Mabey, Consultant Ophthalmologist, South Wing Eye Department, St Thomas' Hospital, Lambeth Palace Road, London, SE1 7EH, UK. Denise.Mabey@gstt.sthames.nhs.uk.

Publication History

  1. Published Online: 21 JAN 2002

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This is not the most recent version of the article. View current version (16 MAR 2011)

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Attiah 1973{published data only}
  • Attiah MA, el Kohly AM. Clinical assessment of the comparative effect of terramycin and GS 2989 in the mass treatment of trachoma. International Review of Trachoma 1973;50(3):11-20.
Bowman 2000{published data only}
  • Bowman RJC, Sillah A, van Debn C, Goode V, Muquit M, Johnson GJ, et al. Operational comparison of single-dose azithromycin and topical tetracycline for trachoma. Investigative Ophthalmology & Visual Sciences 2000;41(13):4074-9.
Darougar 1980b{published data only}
  • Darougar S, Jones BR, Viswalingam N, Poirier RH, Allami J, Houshmand A, et al. Family-based suppressive intermittent therapy of hyperendemic trachoma with topical oxytetracycline or oral doxycycline. British Journal of Ophthalmology 1980;64(4):291-5.
Dawson 1969i{published data only}
  • Dawson CR, Hanna L, Wood TR, Coleman V, Briones OC, Jawetz E. Controlled trials with trisulfapyrimidines in the treatment of chronic trachoma. Journal of Infectious Diseases 1969;119(6):581-90.
Dawson 1969ii{published data only}
  • Dawson CR, Hanna L, Wood TR, Coleman V, Briones OC, Jawetz E. Controlled trials with trisulfapyrimidines in the treatment of chronic trachoma. Journal of Infectious Diseases 1969;119(6):581-90.
Dawson 1997{published data only}
  • Dawson CR, Schachter J, Sallam S, Sheta A, Rubinstein RA, Washton H. A comparison of oral azithromycin with topical oxytetracycline/polymyxin for the treatment of trachoma in children. Clinical Infectious Diseases 1997;24(3):363-8.
Foster 1966{published data only}
  • Foster SO, Powers DK, Thygeson P. Trachoma therapy: a controlled study. American Journal of Ophthalmology 1966;61(3):451-5.
Hoshiwara 1973{published data only}
  • Hoshiwara I, Ostler HB, Hanna L, Cignetti F, Coleman VR, Jawetz E. Doxycycline treatment of chronic trachoma. JAMA 1973;224(2):220-3.
Peach 1986{published and unpublished data}
  • Peach H, Piper S, Devanesen D, Dixon B, Jeffries C, Braun P, et al. Northern Territory trachoma control and eye health committee's randomised controlled trial of the effect of eye drops and eye washing on follicular trachoma among aboriginal children. Annual Report of the Menzies School of Health Research 1986: 74-6.
Schachter 1999i{published and unpublished data}
  • Schachter J, West SK, Mabey DC, Dawson CR, Bobo L, Bailey R, et al. Azithromycin in control of trachoma. Lancet 1999;354:630-5.
Schachter 1999ii{published and unpublished data}
  • Fraser-Hurt N, Bailey RL, Cousens S, Mabey D, Faal H, Mabey DC. Efficacy of oral azithromycin versus topical tetracycline in mass treatment of endemic trachoma. Bulletin of the World Health Organization 2001;79(7):632-40.
  • Schachter J, West SK, Mabey DC, Dawson CR, Bobo L, Bailey R, et al. Azithromycin in control of trachoma. Lancet 1999;354:630-5.
Schachter 1999iii{published and unpublished data}
  • Schachter J, West SK, Mabey DC, Dawson CR, Bobo L, Bailey R, et al. Azithromycin in control of trachoma. Lancet 1999;354:630-35.
Shukla 1966{published data only}
  • Shukla BR, Nema HV, Mathur JS, Nath K. Gantrisin and madribon in trachoma. British Journal of Ophthalmology 1966;50(4):218-21.
Tabbara 1996{published data only}
  • Tabbara KF, el Abu Asrar A, al Omar O, Choudhury AH, al Faisal Z. Single-dose azithromycin in the treatment of trachoma. A randomized, controlled study. Ophthalmology 1996;103(5):842-6.
Woolridge 1967{published data only}
  • Woolridge RL, Cheng KH, Chang IH, Yang CY, Hsu TC, Grayston JT. Failure of trachoma treatment with ophthalmic antibiotics and systemic sulfonamides used alone or in combination with trachoma vaccine. American Journal of Ophthalmology 1967;63(5 Suppl):1577-86.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Assaad 1968
  • Assaad FA, Maxwell Lyons F, Sundaresan T. Report of 4 years' follow-up of a trachoma clinical trial in Taiwan. Bulletin of the World Health Organization 1968;38(4):565-76.
Babbar 1982
  • Babbar OP, Chhatwal VK, Ray IB, Mehra MK. Effect of berberine chloride eye drops on clinically positive trachoma patients. Indian Journal of Medical Research 1982;76(Suppl):83-8.
Bailey 1993b
  • Bailey RL, Arullendran P, Whittle HC, Mabey DC. Randomised controlled trial of single-dose azithromycin in treatment of trachoma. Lancet 1993;342(8819):453-6.
Bietti 1967
  • Bietti GB. Further contributions on the value of osmotic substances as means to reduce intra-ocular pressure. Transactions of the Ophthalmological Society of Australia 1967;26:61-71.
Cerulli 1983
  • Cerulli L, Cedrone C, Assefa C, Scuderi GL. Evaluation of treatment against trachoma in two regions of Ethiopia. Revue Internationale du Trachome et de Pathologie Oculaire Tropicale et Subtropicale et de Sante Publique 1983:67-83.
Chumbley 1988
  • Chumbley LC, Viswalingam ND, Thomson IM, Zeidan MA. Treatment of trachoma in the West Bank. Eye 1988;2(Pt 5):471-5.
Daghfous 1974
  • Daghfous T, Dawson CR, Messadi M, Hoshiwara I, Vastine D. Comparative study of the effect of rifampicin and tetracycline versus placebo in the treatment of trachoma [Etude comparative de l'action de la rifampicine et de tetracycline et d'un placebo dans le traitement du trachome]. International Review of Trachoma 1974;51:71-80.
Daghfous 1985
  • Daghfous MT, Dawson CR, Kammoun M, Romdhane K, Djerad A. Effect of oral doxycycline and 1% tetracycline ointment in the treatment of severe trachoma [Action de la doxycycline par voie orale et de la tetracycline pommade 1% dans le traitement du trachome severe]. Revue Internationale du Trachome et de Pathologie Oculaire Tropicale et Subtropicale et de Sante Publique 1985;62(1-2):47-51.
Darougar 1980a
  • Darougar S, Jones BR, Viswalingam N, Allami J, Minassian D, Farahmandian MA, et al. Topical therapy of hyperendemic trachoma with rifampicin, oxytetracycline, or spiramycin eye ointments. British Journal of Ophthalmology 1980;64(1):37-42.
Darougar 1981
  • Darougar S, Viswalingam N, El Sheikh H, Hunter PA, Yearsley P. A double-blind comparison of topical therapy of chlamydial ocular infection (TRIC infection) with rifampicin or chlortetracycline. British Journal of Ophthalmology 1981;65(8):549-52.
Dawson 1967a
  • Dawson CR, Hanna L, Jawetz E. Controlled treatment trials of trachoma in American Indian children. Lancet 1967;2(7523):961-4.
Dawson 1967b
  • Dawson CR, Hanna L, Wood TR, Jawetz E. Double-blind treatment trials in chronic trachoma of American Indian children. Antimicrobial Agents Chemotherapy 1967;7:137-42.
Dawson 1968
  • Dawson CR, Elashoff R, Hanna L, Wood R. The evaluation of controlled trachoma chemotherapy trials. International Review of Trachoma 1968;45(1):77-85.
Dawson 1971
  • Dawson CR, Ostler HB, Hanna L, Hoshiwara I, Jawetz E. Tetracyclines in the treatment of chronic trachoma in American Indians. Journal of Infectious Diseases 1971;124(3):255-63.
Dawson 1972a
  • Dawson CR, Elashoff R, Hanna L, Wood R. The evaluation of controlled trachoma chimiotherapy trial. International Review of Trachoma 1972;49(1):67-84.
Dawson 1972b
  • Dawson CR, Hanna L. Controlled treatment trials in trachoma: a resume of experience with topical and systemic tetracycline and systemic sulfonamide. International Review of Trachoma 1972;49(1):53-66.
Dawson 1974a
  • Dawson CR, Daghfous T, Messadi M, Hoshiwara I, Vastine DW, Yoneda C, et al. Microbiologic findings in a controlled trial of rifampicin and tetracycline for the treatment of severe endemic trachoma in Tunisia. International Review of Trachoma 1974;51(4):59-69.
Dawson 1974b
  • Dawson CR, Daghfous T, Messadi M, Hoshiwara I, Vastine DW, Yoneda C, et al. Severe endemic trachoma in Tunisia. II. A controlled therapy trial of topically applied chlortetracycline and erythromycin. Archives of Ophthalmology 1974;92(3):198-203.
Dawson 1975a
  • Dawson CR, Hoshiwara I, Daghfous T, Messadi M, Vastine DW, Schachter J. Topical tetracycline and rifampicin therapy of endemic trachoma in Tunisia. American Journal of Ophthalmology 1975;79(5):803-11.
Dawson 1981a
  • Dawson CR, Daghfous T, Whitcher J, Messadi M, Hoshiwara T, Triki F, et al. Intermittent trachoma chemotherapy: a controlled trial of topical tetracycline or erythromycin. Bulletin of the World Health Organization 1981;59(1):91-7.
Dawson 1982
  • Dawson CR, Daghfous T, Hoshiwara I, Ramdhane K, Kamoun M, Yoneda C, et al. Trachoma therapy with topical tetracycline and oral erythromycin: a comparative trial. Bulletin of the World Health Organization 1982;60(3):347-55.
Gupta 1966
  • Gupta UC. Study on the role of sulphamethoxypyridazine (oral) in trachoma control. British Journal Ophthalmology 1966;50(5):262-7.
Gupta 1968
  • Gupta UC, Parthasarathy NR, Gupta CK. Study of broad-spectrum antibiotic kajal in mass control of trachoma. American Journal of Ophthalmology 1968;65(5):778-81.
Guzey 2000
  • Guzey M, Aslan G, Ozardali I, Basar E, Satici A, Karadede S. Three-day course of oral azithromycin vs topical oxytetracycline/polymyxin in treatment of active endemic trachoma. Japanese Journal of Ophthalmology 2000;44:381-6.
Hasan 1976
  • Hasan MM. New drug for the treatment of trachoma (clinical trial report). Revue Internationale du Trachome et de Pathologie Oculaire Tropicale et Subtropicale et de Sante Publique 1976;53(3-4):105-17.
Isenberg 2002
  • Isenberg S J, Apt L, Valenton M, Del Signore M, Cubillan L, Labrador MA, et al. A controlled trial of povodine-Iodine to treat infectious conjunctivitis in children. American Journal of Ophthalmology 2002;134:681-8.
Ji 1986
  • Ji MS. Evaluation of trachoma treatment by the cytological examination of scrapings. Chung Hua Yen Ko Tsa Chih [Chinese Journal of Ophthalmology] 1986;22(5):294-6.
Kamiya 1956
  • Kamiya S. Mass treatment of trachoma. American Journal of Ophthalmology 1956;42:269-283.
Litricin 1968
  • Litricin O, Talanyi Feifer L. Mass trachoma treatment in areas with low endemicity. International Review of Trachoma 1968;45(2):143-53.
Mohan 1982
  • Mohan M, Pant CR, Angra SK, Mahajan VM. Berberine in trachoma (A clinical trial). Indian Journal of Ophthalmology 1982;30(2):69-75.
Nabli 1988
  • Nabli B, Daghfous MT. A preliminary study of norfloxacin in the treatment of trachoma [Etude preliminaire de la Norfloxacine dans le traitement du trachome]. Revue Internationale du Trachome et de Pathologie Oculaire Tropicale et Subtropicale et de Sante Publique 1988;65(1-2):123-7.
Nisbet 1979
  • Nisbet IT, Graham DM, Spicer PE, Tibbs GJ. Chlorhexidine as an effective agent against Chlamydia trachomatis in vitro and in vivo. Antimicrobial Agents and Chemotherapy 1979;16(6):855-7.
Obikili 1988
  • Obikili AG, Oji EO, Shonekan RO, Otti P. A double-blind comparison of picloxydine dihydrochloride (Vitabact eye drops) and sulfacetamide eye drops in the topical therapy of trachoma. Revue Internationale du Trachome et de Pathologie Oculaire Tropicale et Subtropicale et de Sante Publique 1988;65(3-4):119-32.
Reinhards 1959
  • Reinhards J. Collective antibiotic treatment of Trachoma. Bulletin of the World Health Organization 1959;21:665-702.
Resnikoff 1994
  • Resnikoff S, Castan R, Peyramaure F, Bagayogo C, Huguet P. Course of trachoma under treatment with 1% oxytetracycline ophthalmic solution [Evolution du trachome sous traitement par collyre a l'oxytetracycline 1%]. Journal of French Ophthalmology 1994;17(10):591-5.
Resnikoff 1995
  • Resnikoff S, Peyramaure F, Bagayogo CO, Huguet P. Health education and antibiotic therapy in trachoma control. Revue Internationale du trachome et de Pathologie Oculaire Tropicale et Subtropicale et de Sante Publique 1995;7289-98:101-10.
Tabbara 1988
  • Tabbara KF, Summanen P, Taylor PB, Burd EM, al Omar O. Minocycline effects in patients with active trachoma. International Ophthalmology 1988;12(1):59-63.
Toufic 1968
  • Toufic N. Antitrachoma campaigns of the O.C.C.G.E [Campagnes antitrachomateuses de l'O.C.C.G.E]. International Review of Trachoma 1968;45(3):219-27.
Wadia 1980
  • Wadia I, Bell WJ, Gaber A. Topical meclocycline in the treatment of trachoma in lower Egypt. Revue Internationale du Trachome et de Pathologie Oculaire Tropicale et Subtropicale et de Sante Publique 1980;57(4):77-86.
Werner 1977
  • Werner GT, Sareen DK. Trachoma in Punjab: a study of the prevalence and of mass treatment. Tropical and Geographical Medicine 1977;29(2):135-40.
Whitcher 1974
  • Whitcher JP, Dawson CR, Messadi M, Daghfous T, Abdullah NB, Triki F, et al. Severe endemic trachoma in Tunisia: changes in ocular bacterial pathogens in children treated by the intermittent antibiotic regimen. International Review of Trachoma 1974;51(4):49-58.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Humet 1989
  • Humet RM, Fresnadillo A, Fresnadillo E, Piqueras M, Alegre D. Comparative efficacy of two anti-biotics: doxycycline and ioamicine for the treatment of infections caused by Chlamydia trachomatis. The importance of screening in the diagnosis. AnaLisis Clinicos 1989;14:140 - 4.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Alderson 2004
  • Alderson P, Green S, Higgins JPT, editors. Cochrane Reviewers’ Handbook 4.2.2 [updated March 2004]. The Cochrane Library, Issue 1, 2004. Chichester, UK: John Wiley & Sons, Ltd, 2004.
Bailey 1993a
  • Bailey RL, Arullendran P, Whittle HC, Mabey DC. Randomised controlled trial of single-dose azithromycin in treatment of trachoma. Lancet 1993;342:453-6.
Bland 1997
  • Bland JM, Kerry SM. Trials randomised in clusters. BMJ 1997;315(7108):600.
Brechner 1956
  • Brechner RJ, West SK, Lynch M. Trachoma and flies. Individual vs environmental risk factors. Archives of Ophthalmology 1956;42:269-283.
Dawson 1975b
  • Dawson CR, Jones BR, Darougar S. Blinding and non-blinding trachoma: assessment of intensity of upper tarsal inflammatory disease and disabling lesions. Bulletin of the World Health Organization 1975;52:279-282.
Dawson 1981b
  • Dawson CR, Jones BR, Tarizzo ML. A guide to trachoma control. Geneva: World Health Organization, 1981.
Donner 1982
  • Donner A. An empirical study of cluster randomization. International Journal of Epidemiology 1982;11(3):283-6.
Hauck 1991
  • Hauck WW, Gilliss CL, Donner A, Gortner S. Randomisation by cluster. Nursing Research 1991;40(6):356-8.
Kamiya 1956
  • Kamiya S. Mass treatment of trachoma. American Journal of Ophthalmology 1956;42:269-283.
Kerry 1998
  • Kerry SM, Bland JM. The intracluster correlation coefficient in cluster randomisation. BMJ 1998;316(7142):1455.
MacCallan 1936
  • MacCallan AF. Trachoma. London: Butterworth, 1936.
RevMan 2004
  • . Review Manager. 4.2 Edition. Oxford: Update Software, 2004.
Sutter 1983
  • Sutter EE, Ballard RC. Community participation in the control of trachoma in Gazankulu. Social Science and Medicine 1983;17:1813-7.
Thylefors 1987
  • Thylefors B, Dawson CR, Jones BR, West SK, Taylor HR. A simple system for the assessment of trachoma and its complications. Bulletin of the World Health Organization 1987;65:477-83.
Thylefors 1995
  • Thylefors B, Negrel AD, Pararajasegaram R, Dadzie KY. Global data on blindness. Bulletin of the World Health Organization 1995;73:115-121.
WHO 1962
  • World Health Organization. Criteria of clinical diagnosis. Expert Committee in Trachoma. 1962;Third report:8.