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Interventions for recurrent corneal erosions

  • Review
  • Intervention




Recurrent corneal erosion is a common cause of disabling ocular symptoms and predisposes the cornea to infection. It may follow corneal trauma. Measures to prevent the development of recurrent corneal erosion following corneal trauma have not been firmly established. Once recurrent corneal erosion develops simple medical therapy (standard treatment) may lead to resolution of the episode. However some patients continue to suffer when such therapy fails and once resolved further episodes of recurrent erosion may occur. A number of treatment and prophylactic options are then available but there is no agreement as to the best option.


To assess the effectiveness and safety of prophylactic and treatment regimens for recurrent corneal erosion.

Search methods

We searched CENTRAL, MEDLINE, EMBASE and LILACS in June 2007. The NRR was searched in April 2005. We also contacted researchers in the field.

Selection criteria

We included randomised and quasi-randomised trials that compared a prophylactic or treatment regimen with another prophylaxis/ treatment or no prophylaxis/ treatment for patients with recurrent corneal erosion.

Data collection and analysis

Both authors independently extracted data and assessed trial quality. We contacted study authors for additional information.

Main results

Five randomised and one quasi-randomised controlled trial were included in the review. The trials were heterogenous and of poor quality. Safety data presented were incomplete. For the treatment of recurrent corneal erosion there was limited evidence that oral tetracycline 250 mg twice daily for 12 weeks or topical prednisolone 0.5% four times daily for one week or both in addition to standard treatment; and excimer laser ablation in addition to mechanical debridement may be effective. Therapeutic contact lens wear was inferior to lubricant drops and ointment in abolishing the symptoms of recurrent corneal erosion and had a high complication rate. For prophylaxis of further episodes of recurrent corneal erosion there was no difference in the occurrence of objective signs of recurrent erosion between hypertonic saline ointment versus tetracycline ointment or lubricating ointment. Lubricating ointment at night in addition to standard treatment following traumatic corneal abrasion (erosion) caused by fingernail injury to prevent recurrence led to increased symptoms of recurrent corneal erosion compared to standard therapy alone.

Authors' conclusions

Well-designed masked randomised controlled trials using standardised methods are needed to establish the benefits of new and existing prophylactic and treatment regimes for recurrent corneal erosion.








2007年6月,我們搜尋CENTRAL, MEDLINE, EMBASE and LILACS. 2005年4月搜尋NRR. 我們也聯繫在此領域的研究人員。






回顧文獻包括5篇隨機和1篇類似隨機控制試驗。試驗不具同質性且品質不佳。提出的安全數據不完全。處理反覆性角膜磨損的證據有限,每天兩次的口服tetracycline 250毫克持續12 周或者局部prednisolone 0.5%,一天4次持續一周或兩種藥物都加入標準處理方法;此外準分子鐳射部分消除術合併清創可能有效。在處理反覆性角膜磨損的效果,治療性隱形眼鏡不如潤滑劑和藥膏,並且有高併發症比率。對於更進一步的疾病預防措施與角膜磨損的症狀,高張性生理食鹽水藥膏與tetracycline 藥膏或潤滑藥膏比較,並無差別。與單獨的標準治療相比,指甲引起的創傷性角膜磨損在晚上潤滑藥膏合併標準治療,會導致症狀更反覆出現。





此翻譯計畫由臺灣國家衛生研究院(National Health Research Institutes, Taiwan)統籌。



Plain language summary

Prophylactic and treatment regimens for recurrent corneal erosion

In recurrent corneal erosion repeated episodes of breakdown of the corneal surface produce disabling ocular symptoms and predispose the cornea to infection. Recurrent corneal erosion may follow corneal trauma. Prophylactic measures may be required to prevent the occurrence of recurrent erosion following trauma or to prevent further episodes of recurrent erosion once the diagnosis is made or both. Most episodes of recurrent corneal erosion resolve with simple medical therapy such as topical drops and ointment. Alternative treatment strategies are required when such simple measures fail. Randomised controlled trials of prophylactic and treatment regimens were of insufficient quality to provide evidence for the development of management guidelines. There was limited evidence that oral tetracycline or topical prednisolone or both, and excimer laser ablation may be effective treatments for recurrent corneal erosion. Further evidence is needed to guide the management of recurrent corneal erosion.