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Intervention Review

Topical negative pressure for treating chronic wounds

  1. Dirk T Ubbink1,*,
  2. Stijn Joël Westerbos2,
  3. Debra Evans3,
  4. Lucy Land4,
  5. Hester Vermeulen5

Editorial Group: Cochrane Wounds Group

Published Online: 16 JUL 2008

Assessed as up-to-date: 13 DEC 2007

DOI: 10.1002/14651858.CD001898.pub2

How to Cite

Ubbink DT, Westerbos SJ, Evans D, Land L, Vermeulen H. Topical negative pressure for treating chronic wounds. Cochrane Database of Systematic Reviews 2008, Issue 3. Art. No.: CD001898. DOI: 10.1002/14651858.CD001898.pub2.

Author Information

  1. 1

    Academic Medical Centre, University of Amsterdam, Quality Assurance & Process Innovation, and Department of Surgery, Amsterdam, Netherlands

  2. 2

    Haarlem, Noord-Holland, Netherlands

  3. 3

    Birmingham City University, Division of Community Health and Social Work, Birmingham, West Midlands, UK

  4. 4

    Birmingham City University, Birmingham, West Midlands, UK

  5. 5

    Academic Medical Centre, University of Amsterdam & Amsterdam School of Health Professions, Quality & Process Innovation, Amsterdam, Noord-Holland, Netherlands

*Dirk T Ubbink, Quality Assurance & Process Innovation, and Department of Surgery, Academic Medical Centre, University of Amsterdam, J1b-215 Academic Medical Centre, Meibergdreef 9, PO Box 22700, Amsterdam, 1100 DE, Netherlands.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 16 JUL 2008


This is not the most recent version of the article. View current version (09 JUN 2015)



  1. Top of page
  2. Abstract
  3. Plain language summary
  4. アブストラクト
  5. 平易な要約
  6. 摘要


Chronic wounds mainly affect the elderly and those with multiple health problems. Despite the use of modern dressings, some of these wounds take a long time to heal, fail to heal, or recur, causing significant pain and discomfort to the person and cost to health services. Topical negative pressure (TNP) is used to promote healing of surgical wounds by using suction to drain excess fluid from wounds.


To assess the effects of TNP on chronic wound healing.

Search methods

For this second update of this review we searched the Cochrane Wounds Group Specialised Register (December 2007), The Cochrane Central Register of Controlled Trials (CENTRAL) - The Cochrane Library Issue 4, 2007, Ovid MEDLINE - 1950 to November Week 2 2007, Ovid EMBASE - 1982 to 2007 Week 50 and Ovid CINAHL - 1980 to December Week 1 2007. In addition, we contacted authors, companies, manufacturers, and distributors to identify relevant trials and information.

Selection criteria

All randomised controlled trials which evaluated the effects of TNP on people with chronic wounds.

Data collection and analysis

Selection of the trials, quality assessment, data abstraction, and data synthesis were done by two authors independently. Disagreements were solved by discussion.

Main results

Two trials were included in the original review. A further five trials were included in this second update resulting in a total of seven trials involving 205 participants.

The seven trials compared TNP with five different comparator treatments. Four trials compared TNP with gauze soaked in either 0.9% saline or Ringer's solution. The other three trials compared TNP with hydrocolloid gel plus gauze, a treatment package comprising papain-urea topical treatment, and cadexomer iodine or hydrocolloid, hydrogels, alginate and foam. These data do not show that TNP significantly increases the healing rate of chronic wounds compared with comparators.

Data on secondary outcomes such as infection rate, quality of life, oedema, hospitalisation and bacterial load were not reported.

Authors' conclusions

Trials comparing TNP with alternative treatments for chronic wounds have methodological flaws and data do demonstrate a beneficial effect of TNP on wound healing however more, better quality research is needed.


Plain language summary

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. アブストラクト
  5. 平易な要約
  6. 摘要

Topical negative pressure therapy for treating chronic wounds

Topical negative pressure (TNP) therapy is the application of negative pressure across a wound to aid wound healing. The pressure is thought to aid the drainage of excess fluid, reduce infection rates and increase localised blood flow. TNP is also known as vacuum assisted closure (VAC) and sealed surface wound suction. Seven trials compared TNP with either moistened gauze dressings or other topical agents and found no difference in effects. One very small, poor quality trial (7 wounds) showed a reduction in wound volume and depth in favour of TNP. There is no valid or reliable evidence that topical negative pressure increases chronic wound healing.



  1. Top of page
  2. Abstract
  3. Plain language summary
  4. アブストラクト
  5. 平易な要約
  6. 摘要







本レビューの第2回目の本更新では、Cochrane Wounds Group Specialised Register(2007年12月)、Cochrane Central Register of Controlled Trials(CENTRAL)、コクラン・ライブラリ(2007年第4号)、Ovid MEDLINE(1950年~2007年11月第2週)、Ovid EMBASE(1982年~2007年第50週)及びOvid CINAHL(1980年~2007年12月第1週)を検索した。さらに、著者、会社、製造業者及び販売者と連絡をとり、関連性のある試験及び情報を同定した。











  1. Top of page
  2. Abstract
  3. Plain language summary
  4. アブストラクト
  5. 平易な要約
  6. 摘要




監  訳: 浅田 真弓,2013.1.29

実施組織: 厚生労働省委託事業によりMindsが実施した。

ご注意 : この日本語訳は、臨床医、疫学研究者などによる翻訳のチェックを受けて公開していますが、訳語の間違いなどお気づきの点がございましたら、Minds事務局までご連絡ください。Mindsでは最新版の日本語訳を掲載するよう努めておりますが、編集作業に伴うタイム・ラグが生じている場合もあります。ご利用に際しては、最新版(英語版)の内容をご確認ください。



  1. Top of page
  2. Abstract
  3. Plain language summary
  4. アブストラクト
  5. 平易な要約
  6. 摘要





評估以局部負壓(topical negative pressure;TNP) 治療慢性傷口的效果,並找出TNP的最佳使用方式。


我們搜尋了The Cochrane Wounds Group Specialised Trials Register(截至2002年11月) 。我們連絡了這個領域的專家和公司,徵詢他們目前正在進行或剛完成的相關試驗。除此之外,我們還仔細檢查目前已找到文獻的參考書目,以找出更多的相關文獻。我們亦透過vacuum therapy website ( 來搜尋相關的試驗(截至2002年11月) ,此外也尋找了Library的Health Technology Assessment (HTA) database(截至2002年11月) 。


所有評估TNP用於慢性傷口之效果的隨機對照試驗 (randomised controlled trials) 都被納入。


由兩位作者獨立評估文獻是否納入、摘錄資料以及衡量試驗的品質。由於只有2個研究符合我們的選擇標準,且其測量結果的方法並不相同,因此我們採用了整合敘述 (narrative synthesis) 的方式來分析研究結果。


有2個小規模的試驗 (總共34位參與者) 評估以TNP治療慢性傷口的效果。第1個試驗納入了各種慢性傷口的患者,而第2個試驗則只探討糖尿病足部潰瘍。這2個試驗比較了TNP (亦即開放式泡綿敷料搭配持續抽吸) 和生理食鹽水紗布 (saline gauze dressings) 使用後48小時的效果。試驗1顯示使用TNP後,第6週傷口體積明顯變小。試驗2 (持續抽吸,48小時以後伴隨間歇性抽吸) 則顯示TNP縮短了痊癒天數,且傷口表面積於第2週有縮小,不過這項試驗並未呈現統計數據。





此翻譯計畫由臺灣國家衛生研究院 (National Health Research Institutes, Taiwan) 統籌。


沒有可靠證據顯示局部負壓敷料能促進慢性傷口痊癒。慢性傷口得花很長時間才能康復,而且有可能會復發。這2個小規模的試驗比較了TNP (吸取傷口所滲出過多的液體) 和生理食鹽水紗布的效果,發現TNP可以縮小傷口的體積和表面積,但證據強度較為薄弱。其中1個試驗只探討糖尿病足部潰瘍的患者,且這些研究皆未比較各種形式的TNP,亦沒有考量到疼痛或舒適度。