Intervention Review

Early versus late antiepileptic drug withdrawal for people with epilepsy in remission

  1. Joseph Sirven1,*,
  2. Michael R Sperling2,
  3. Dean M Wingerchuk1

Editorial Group: Cochrane Epilepsy Group

Published Online: 23 JUL 2001

Assessed as up-to-date: 10 OCT 2011

DOI: 10.1002/14651858.CD001902

How to Cite

Sirven J, Sperling MR, Wingerchuk DM. Early versus late antiepileptic drug withdrawal for people with epilepsy in remission. Cochrane Database of Systematic Reviews 2001, Issue 3. Art. No.: CD001902. DOI: 10.1002/14651858.CD001902.

Author Information

  1. 1

    Mayo Clinic, Department of Neurology, Scotsdale, Arizona, USA

  2. 2

    Jefferson Medical College, Department of Neurology, Philadelphia, Pennsylvania, USA

*Joseph Sirven, Department of Neurology, Mayo Clinic, 13400 East Shea Boulevard, Scotsdale, Arizona, 85259, USA.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 23 JUL 2001


Cited in:


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  1. 1
    Lingying Su, Qing Di, Nian Yu, Yanfang Zhang, Predictors for relapse after antiepileptic drug withdrawal in seizure-free patients with epilepsy, Journal of Clinical Neuroscience, 2013, 20, 6, 790


  2. 2
    Ettore Beghi, Dieter Schmidt, When and how to stop antiepileptic drugs, Epileptology, 2013, 1, 1, 17


  3. 3
    Wolfgang Girisch, Christiane Willhelm, Sven Gottschling, Ludwig Gortner, Sascha Meyer, Role of Cochrane Reviews in Pediatric Neurology, Pediatric Neurology, 2012, 46, 2, 63


  4. 4
    Emilio Perucca, Torbjörn Tomson, The pharmacological treatment of epilepsy in adults, The Lancet Neurology, 2011, 10, 5, 446


  5. 5
    Clinical Neurology, 2010,


  6. 6
    Miquel Raspall-Chaure, Brian G Neville, Rod C Scott, The medical management of the epilepsies in children: conceptual and practical considerations, The Lancet Neurology, 2008, 7, 1, 57


  7. 7
    Dean M Wingerchuk, Joseph I Sirven, Remission, intractability, and antiepileptic-drug withdrawal, The Lancet Neurology, 2005, 4, 7, 390


  8. 8
    E. Raffo, Traitements au long cours des épilepsies de l’enfant, Revue Neurologique, 2004, 160, 272


  9. 9
    John D. Hixson, When and How to Stop Antiepileptic Drugs,